{"id":"https://openalex.org/W2552006487","doi":"https://doi.org/10.1182/blood.v124.21.4233.4233","title":"Modulating the Antithrombin-Mediated in Vivo Clearance of Coagulation Factor VIIa","display_name":"Modulating the Antithrombin-Mediated in Vivo Clearance of Coagulation Factor VIIa","publication_year":2014,"publication_date":"2014-12-06","ids":{"openalex":"https://openalex.org/W2552006487","doi":"https://doi.org/10.1182/blood.v124.21.4233.4233","mag":"2552006487"},"language":"en","primary_location":{"id":"doi:10.1182/blood.v124.21.4233.4233","doi":"https://doi.org/10.1182/blood.v124.21.4233.4233","is_oa":false,"landing_page_url":"https://doi.org/10.1182/blood.v124.21.4233.4233","pdf_url":null,"source":{"id":"https://openalex.org/S200071133","display_name":"Blood","issn_l":"0006-4971","issn":["0006-4971","1528-0020"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Blood","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":null,"display_name":"Henrik \u00d8stergaard","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I189090001","display_name":"Novo Nordisk (Denmark)","ror":"https://ror.org/0435rc536","country_code":"DK","type":"company","lineage":["https://openalex.org/I189090001","https://openalex.org/I2801134892","https://openalex.org/I4210159963"]}],"countries":["DK"],"is_corresponding":true,"raw_author_name":"Henrik \u00d8stergaard","raw_affiliation_strings":["Novo Nordisk A/S, M\u00e5l\u00f8v, Denmark"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Novo Nordisk A/S, M\u00e5l\u00f8v, Denmark","institution_ids":["https://openalex.org/I189090001"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110156186","display_name":"Lene Hansen","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I189090001","display_name":"Novo Nordisk (Denmark)","ror":"https://ror.org/0435rc536","country_code":"DK","type":"company","lineage":["https://openalex.org/I189090001","https://openalex.org/I2801134892","https://openalex.org/I4210159963"]}],"countries":["DK"],"is_corresponding":true,"raw_author_name":"Lene Hansen","raw_affiliation_strings":["Novo Nordisk A/S, M\u00e5l\u00f8v, Denmark"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Novo Nordisk A/S, M\u00e5l\u00f8v, Denmark","institution_ids":["https://openalex.org/I189090001"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5058441917","display_name":"Hermann Pelzer","orcid":"https://orcid.org/0000-0002-7810-4171","observed_orcids":["https://orcid.org/0000-0002-7810-4171"]},"institutions":[{"id":"https://openalex.org/I189090001","display_name":"Novo Nordisk (Denmark)","ror":"https://ror.org/0435rc536","country_code":"DK","type":"company","lineage":["https://openalex.org/I189090001","https://openalex.org/I2801134892","https://openalex.org/I4210159963"]}],"countries":["DK"],"is_corresponding":true,"raw_author_name":"Hermann Pelzer","raw_affiliation_strings":["Novo Nordisk A/S, M\u00e5l\u00f8v, Denmark"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Novo Nordisk A/S, M\u00e5l\u00f8v, Denmark","institution_ids":["https://openalex.org/I189090001"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5041967179","display_name":"Henrik Agers\u00f8","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I189090001","display_name":"Novo Nordisk (Denmark)","ror":"https://ror.org/0435rc536","country_code":"DK","type":"company","lineage":["https://openalex.org/I189090001","https://openalex.org/I2801134892","https://openalex.org/I4210159963"]}],"countries":["DK"],"is_corresponding":true,"raw_author_name":"Henrik Agers\u00f8","raw_affiliation_strings":["Novo Nordisk A/S, M\u00e5l\u00f8v, Denmark"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Novo Nordisk A/S, M\u00e5l\u00f8v, Denmark","institution_ids":["https://openalex.org/I189090001"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5025391754","display_name":"Anette Amstrup Pedersen","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I189090001","display_name":"Novo Nordisk (Denmark)","ror":"https://ror.org/0435rc536","country_code":"DK","type":"company","lineage":["https://openalex.org/I189090001","https://openalex.org/I2801134892","https://openalex.org/I4210159963"]}],"countries":["DK"],"is_corresponding":true,"raw_author_name":"Anette A. Pedersen","raw_affiliation_strings":["Novo Nordisk A/S, M\u00e5l\u00f8v, Denmark"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Novo Nordisk A/S, M\u00e5l\u00f8v, Denmark","institution_ids":["https://openalex.org/I189090001"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5076745297","display_name":"Tina H. Glue","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I189090001","display_name":"Novo Nordisk (Denmark)","ror":"https://ror.org/0435rc536","country_code":"DK","type":"company","lineage":["https://openalex.org/I189090001","https://openalex.org/I2801134892","https://openalex.org/I4210159963"]}],"countries":["DK"],"is_corresponding":true,"raw_author_name":"Tina H. Glue","raw_affiliation_strings":["Novo Nordisk A/S, M\u00e5l\u00f8v, Denmark"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Novo Nordisk A/S, M\u00e5l\u00f8v, Denmark","institution_ids":["https://openalex.org/I189090001"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5019731265","display_name":"Laust Bruun Johnsen","orcid":"https://orcid.org/0000-0003-2953-2804","observed_orcids":["https://orcid.org/0000-0003-2953-2804"]},"institutions":[{"id":"https://openalex.org/I189090001","display_name":"Novo Nordisk (Denmark)","ror":"https://ror.org/0435rc536","country_code":"DK","type":"company","lineage":["https://openalex.org/I189090001","https://openalex.org/I2801134892","https://openalex.org/I4210159963"]}],"countries":["DK"],"is_corresponding":true,"raw_author_name":"Laust B. Johnsen","raw_affiliation_strings":["Novo Nordisk A/S, M\u00e5l\u00f8v, Denmark"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Novo Nordisk A/S, M\u00e5l\u00f8v, Denmark","institution_ids":["https://openalex.org/I189090001"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5030368878","display_name":"Gorm Andersen","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I189090001","display_name":"Novo Nordisk (Denmark)","ror":"https://ror.org/0435rc536","country_code":"DK","type":"company","lineage":["https://openalex.org/I189090001","https://openalex.org/I2801134892","https://openalex.org/I4210159963"]}],"countries":["DK"],"is_corresponding":true,"raw_author_name":"Gorm Andersen","raw_affiliation_strings":["Novo Nordisk A/S, M\u00e5l\u00f8v, Denmark"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Novo Nordisk A/S, M\u00e5l\u00f8v, Denmark","institution_ids":["https://openalex.org/I189090001"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5046833055","display_name":"Jais Rose Bjelke","orcid":"https://orcid.org/0000-0002-8105-2050","observed_orcids":["https://orcid.org/0000-0002-8105-2050"]},"institutions":[{"id":"https://openalex.org/I189090001","display_name":"Novo Nordisk (Denmark)","ror":"https://ror.org/0435rc536","country_code":"DK","type":"company","lineage":["https://openalex.org/I189090001","https://openalex.org/I2801134892","https://openalex.org/I4210159963"]}],"countries":["DK"],"is_corresponding":true,"raw_author_name":"Jais R. Bjelke","raw_affiliation_strings":["Novo Nordisk A/S, M\u00e5l\u00f8v, Denmark"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Novo Nordisk A/S, M\u00e5l\u00f8v, Denmark","institution_ids":["https://openalex.org/I189090001"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113870933","display_name":"Jens Breinholt","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I189090001","display_name":"Novo Nordisk (Denmark)","ror":"https://ror.org/0435rc536","country_code":"DK","type":"company","lineage":["https://openalex.org/I189090001","https://openalex.org/I2801134892","https://openalex.org/I4210159963"]}],"countries":["DK"],"is_corresponding":true,"raw_author_name":"Jens Breinholt","raw_affiliation_strings":["Novo Nordisk A/S, M\u00e5l\u00f8v, Denmark"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Novo Nordisk A/S, M\u00e5l\u00f8v, Denmark","institution_ids":["https://openalex.org/I189090001"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108192816","display_name":"Henning R. Stennicke","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I189090001","display_name":"Novo Nordisk (Denmark)","ror":"https://ror.org/0435rc536","country_code":"DK","type":"company","lineage":["https://openalex.org/I189090001","https://openalex.org/I2801134892","https://openalex.org/I4210159963"]}],"countries":["DK"],"is_corresponding":true,"raw_author_name":"Henning Stennicke","raw_affiliation_strings":["Novo Nordisk A/S, S\u00f8borg, Denmark"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Novo Nordisk A/S, S\u00f8borg, Denmark","institution_ids":["https://openalex.org/I189090001"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5058422580","display_name":"Prafull S. Gandhi","orcid":"https://orcid.org/0000-0001-7949-4899","observed_orcids":["https://orcid.org/0000-0001-7949-4899"]},"institutions":[{"id":"https://openalex.org/I189090001","display_name":"Novo Nordisk (Denmark)","ror":"https://ror.org/0435rc536","country_code":"DK","type":"company","lineage":["https://openalex.org/I189090001","https://openalex.org/I2801134892","https://openalex.org/I4210159963"]}],"countries":["DK"],"is_corresponding":true,"raw_author_name":"Prafull S. Gandhi","raw_affiliation_strings":["Novo Nordisk A/S, M\u00e5l\u00f8v, Denmark"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Novo Nordisk A/S, M\u00e5l\u00f8v, Denmark","institution_ids":["https://openalex.org/I189090001"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5056948258","display_name":"Ole Hvilsted Olsen","orcid":"https://orcid.org/0000-0003-1216-7521","observed_orcids":["https://orcid.org/0000-0003-1216-7521"]},"institutions":[{"id":"https://openalex.org/I189090001","display_name":"Novo Nordisk (Denmark)","ror":"https://ror.org/0435rc536","country_code":"DK","type":"company","lineage":["https://openalex.org/I189090001","https://openalex.org/I2801134892","https://openalex.org/I4210159963"]}],"countries":["DK"],"is_corresponding":true,"raw_author_name":"Ole H. Olsen","raw_affiliation_strings":["Novo Nordisk A/S, M\u00e5l\u00f8v, Denmark"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Novo Nordisk A/S, M\u00e5l\u00f8v, Denmark","institution_ids":["https://openalex.org/I189090001"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5029395558","display_name":"Mette Brunsgaard Hermit","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I189090001","display_name":"Novo Nordisk (Denmark)","ror":"https://ror.org/0435rc536","country_code":"DK","type":"company","lineage":["https://openalex.org/I189090001","https://openalex.org/I2801134892","https://openalex.org/I4210159963"]}],"countries":["DK"],"is_corresponding":true,"raw_author_name":"Mette B. Hermit","raw_affiliation_strings":["Novo Nordisk A/S, M\u00e5l\u00f8v, Denmark"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Novo Nordisk A/S, M\u00e5l\u00f8v, Denmark","institution_ids":["https://openalex.org/I189090001"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5019731265","https://openalex.org/A5025391754","https://openalex.org/A5029395558","https://openalex.org/A5030368878","https://openalex.org/A5041967179","https://openalex.org/A5046833055","https://openalex.org/A5056948258","https://openalex.org/A5058422580","https://openalex.org/A5058441917","https://openalex.org/A5076745297","https://openalex.org/A5108192816","https://openalex.org/A5110156186","https://openalex.org/A5113870933"],"corresponding_institution_ids":["https://openalex.org/I189090001"],"apc_list":{"value":5500,"currency":"USD","value_usd":5500},"apc_paid":null,"fwci":0.2121,"has_fulltext":false,"cited_by_count":1,"citation_normalized_percentile":{"value":0.62680367,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":93},"biblio":{"volume":"124","issue":"21","first_page":"4233","last_page":"4233"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11280","display_name":"Hemophilia Treatment and Research","score":0.5170999765396118,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11280","display_name":"Hemophilia Treatment and Research","score":0.5170999765396118,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10881","display_name":"Blood Coagulation and Thrombosis Mechanisms","score":0.44749999046325684,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11917","display_name":"Coagulation, Bradykinin, Polyphosphates, and Angioedema","score":0.02319999970495701,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/coagulation-factor-viia","display_name":"coagulation factor VIIa","score":0.9129999876022339},{"id":"https://openalex.org/keywords/antithrombin-iii","display_name":"antithrombin III","score":0.9879999756813049},{"id":"https://openalex.org/keywords/tissue-factor","display_name":"tissue factor","score":0.6029999852180481},{"id":"https://openalex.org/keywords/heparin-like-glycosaminoglycans","display_name":"heparin-like glycosaminoglycans","score":0.9399999976158142},{"id":"https://openalex.org/keywords/site-directed-mutagenesis","display_name":"site-directed mutagenesis","score":0.8230000138282776},{"id":"https://openalex.org/keywords/pharmacokinetics","display_name":"pharmacokinetics","score":0.796999990940094},{"id":"https://openalex.org/keywords/sprague-dawley-rats","display_name":"Sprague-Dawley rats","score":0.7009999752044678}],"concepts":[{"id":"https://openalex.org/C207001950","wikidata":"https://www.wikidata.org/wiki/Q141124","display_name":"In vivo","level":2,"score":0.8349005579948425},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.6935807466506958},{"id":"https://openalex.org/C186738567","wikidata":"https://www.wikidata.org/wiki/Q412841","display_name":"Tissue factor","level":3,"score":0.6832484006881714},{"id":"https://openalex.org/C2779026020","wikidata":"https://www.wikidata.org/wiki/Q416336","display_name":"Antithrombin","level":3,"score":0.6374027132987976},{"id":"https://openalex.org/C2778382381","wikidata":"https://www.wikidata.org/wiki/Q179217","display_name":"Coagulation","level":2,"score":0.5929853916168213},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.5829826593399048},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.576528012752533},{"id":"https://openalex.org/C112705442","wikidata":"https://www.wikidata.org/wiki/Q323936","display_name":"Pharmacokinetics","level":2,"score":0.513235330581665},{"id":"https://openalex.org/C16613235","wikidata":"https://www.wikidata.org/wiki/Q285982","display_name":"Endogeny","level":2,"score":0.5116518139839172},{"id":"https://openalex.org/C2777292125","wikidata":"https://www.wikidata.org/wiki/Q409166","display_name":"Thrombin","level":3,"score":0.5043128728866577},{"id":"https://openalex.org/C144594695","wikidata":"https://www.wikidata.org/wiki/Q6153218","display_name":"Thromboplastin","level":3,"score":0.4191124439239502},{"id":"https://openalex.org/C2777557582","wikidata":"https://www.wikidata.org/wiki/Q190016","display_name":"Heparin","level":2,"score":0.4033471941947937},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.3337510824203491},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.23630866408348083},{"id":"https://openalex.org/C89560881","wikidata":"https://www.wikidata.org/wiki/Q101026","display_name":"Platelet","level":2,"score":0.19855165481567383},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.17464163899421692},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.15189814567565918},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.14543116092681885},{"id":"https://openalex.org/C150903083","wikidata":"https://www.wikidata.org/wiki/Q7108","display_name":"Biotechnology","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1182/blood.v124.21.4233.4233","doi":"https://doi.org/10.1182/blood.v124.21.4233.4233","is_oa":false,"landing_page_url":"https://doi.org/10.1182/blood.v124.21.4233.4233","pdf_url":null,"source":{"id":"https://openalex.org/S200071133","display_name":"Blood","issn_l":"0006-4971","issn":["0006-4971","1528-0020"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Blood","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9391000270843506}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W7095872707","https://openalex.org/W2035589437","https://openalex.org/W2129609495","https://openalex.org/W2587170994","https://openalex.org/W2152778552","https://openalex.org/W2096392154","https://openalex.org/W2026906240","https://openalex.org/W2024207765","https://openalex.org/W4390511789","https://openalex.org/W1569674809"],"abstract_inverted_index":{"Abstract":[0],"The":[1,148],"short":[2],"half-life":[3],"of":[4,14,19,34,43,56,63,87,109,129,143,151,166,177,190,200,208,251,254,350,357,380,417,425,447,459,476,483,488,506],"coagulation":[5],"factor":[6,91],"VIIa":[7],"(FVIIa)":[8],"in":[9,38,45,58,67,120,133,136,156,171,193,226,244,259,268,303,323,347,354,414,421,436,444,473,480,493,509],"circulation":[10],"is":[11,47,195],"the":[12,23,35,41,53,61,85,104,124,127,141,164,186,209,221,225,252,258,275,299,308,330,348,355,360,364,369,374,378,413,419,435,442,445,452,457,472,481,486,501],"result":[13],"elimination":[15],"through":[16,490],"multiple":[17],"pathways":[18],"which":[20,93],"inactivation":[21,189,416],"by":[22],"plasma":[24],"inhibitor":[25],"antithrombin":[26],"(AT)":[27],"accounts":[28],"for":[29,175,274,298,392,441],"as":[30,32,138,140,160,197,397,500],"much":[31],"65%":[33],"total":[36,217],"clearance":[37,169,487],"humans.":[39],"Remarkably,":[40],"rate":[42,55,64,145,379,438,503],"inhibition":[44,57,342,381,508],"vivo":[46,68,137,227,415,422],"about":[48],"30":[49],"times":[50],"greater":[51,339],"than":[52],"uncatalyzed":[54],"vitro":[59,134,245,260,304,324,437,474],"suggesting":[60],"presence":[62,349,356,446,482],"enhancing":[65,146,504],"components":[66],"(Agers\u00f8":[69],"et":[70],"al.":[71],"(2011)":[72],"J":[73],"Thromb":[74],"Haemost,":[75],"9:333-338).":[76],"Prime":[77],"candidates":[78],"include":[79],"endogenous":[80,144,181,410],"heparin-like":[81,498],"glycosaminoglycans":[82],"(GAGs)":[83],"potentiating":[84],"reactivity":[86,119,128,246,325,475],"antithrombin,":[88],"or":[89,241,456],"tissue":[90],"(TF)":[92],"upon":[94],"binding":[95],"to":[96,101,113,122,185,223,272,341,344,371,383,395,404,412,431],"FVIIa":[97,110,130,152,168,179,192,213,218,236,310,346,477,489,507],"increases":[98],"its":[99],"susceptibility":[100,340],"inhibition.":[102],"In":[103],"present":[105],"study":[106],"site-directed":[107],"mutagenesis":[108],"was":[111,232,296,454],"undertaken":[112],"identify":[114,497],"variants":[115,153,237,311,386,443],"with":[116,131,180,230,247,280,312,326,368,399,434,478],"altered":[117,313],"AT":[118,132,231,276,284,289,314,327,400,479],"order":[121],"explore":[123],"relationship":[125,470],"between":[126,471],"and":[135,173,204,216,264,292,461,485,495],"well":[139],"nature":[142],"components.":[147],"pharmacokinetic":[149,210],"properties":[150],"were":[154,270,318,390,429],"determined":[155,440],"Sprague":[157],"Dawley":[158],"rats":[159,269],"this":[161,491],"model":[162],"recapitulates":[163],"aspects":[165],"AT-mediated":[167],"observed":[170,297],"humans":[172],"allows":[174],"interaction":[176],"human":[178,187],"rat":[182,194],"TF.":[183],"Similar":[184],"situation,":[188],"wild-type":[191,345,384],"evident":[196],"an":[198],"accumulation":[199],"circulating":[201],"FVIIa-AT":[202,427],"complexes":[203,398,428],"a":[205,338,407,468],"progressive":[206],"divergence":[207],"profiles":[211,267],"representing":[212],"clot":[214,262,293],"activity":[215,263],"antigen.":[219],"Initially,":[220],"ability":[222,370],"modulate":[224],"complex":[228,285,290],"formation":[229,291],"investigated":[233],"using":[234],"two":[235,316],"exhibiting":[238,301],"enhanced":[239,302],"(>200%)":[240],"reduced":[242],"(<10%)":[243],"AT,":[248],"respectively,":[249],"regardless":[250],"type":[253,331],"cofactor":[255,332,375,453],"present.":[256,333],"Reflecting":[257],"reactivity,":[261,315],"antigen":[265],"PK":[266],"found":[271,430],"coincide":[273],"resistant":[277],"variant":[278,300],"along":[279],"essentially":[281],"no":[282],"detectable":[283],"formation,":[286],"whereas":[287],"exacerbated":[288],"activity:antigen":[294],"discrepancy":[295],"reactivity.":[305],"Interestingly,":[306],"among":[307],"generated":[309],"subsets":[317],"identified":[319],"that":[320],"displayed":[321],"differential":[322],"depending":[328],"on":[329,373],"Accordingly,":[334],"one":[335],"group":[336,362,389],"exhibited":[337],"relative":[343,382],"heparin":[351,484],"but":[352,449],"not":[353,450],"TF,":[358],"while":[359],"other":[361],"demonstrated":[363],"opposite":[365],"behavior.":[366],"Endowed":[367],"report":[372],"identity":[376],"from":[377,387,409],"FVIIa,":[385,418],"each":[388],"tested":[391],"their":[393],"tendency":[394],"accumulate":[396],"following":[401],"intravenous":[402],"administration":[403],"rats.":[405],"Supporting":[406],"contribution":[408],"GAGs":[411,499],"measured":[420],"peak":[423],"levels":[424],"accumulated":[426],"directly":[432],"correlate":[433],"constants":[439],"heparin,":[448],"when":[451],"TF":[455,460],"combination":[458],"heparin.":[462],"Altogether,":[463],"these":[464],"results":[465],"1)":[466],"demonstrate":[467],"direct":[469],"pathway":[492],"vivo,":[494],"2)":[496],"likely":[502],"component":[505],"vivo.":[510],"Disclosures":[511],"\u00d8stergaard:":[512],"Novo":[513],"Nordisk":[514,518,522,526,530,534,538,542,546,550,554,558,562,566],"A/S:":[515,519,523,527,531,535,539,543,547,551,555,559,563,567],"Employment.":[516,520,524,528,532,536,540,544,548,552,556,560,564,568],"Hansen:Novo":[517],"Pelzer:Novo":[521],"Agers\u00f8:Novo":[525],"Pedersen:Novo":[529],"Glue:Novo":[533],"Johnsen:Novo":[537],"Andersen:Novo":[541],"Bjelke:Novo":[545],"Breinholt:Novo":[549],"Stennicke:Novo":[553],"Gandhi:Novo":[557],"Olsen:Novo":[561],"Hermit:Novo":[565]},"counts_by_year":[{"year":2017,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-11-30T00:00:00"}