{"id":"https://openalex.org/W2551998204","doi":"https://doi.org/10.1002/cbic.201600359","title":"Copper is a Cofactor of the Formylglycine\u2010Generating Enzyme","display_name":"Copper is a Cofactor of the Formylglycine\u2010Generating Enzyme","publication_year":2016,"publication_date":"2016-11-16","ids":{"openalex":"https://openalex.org/W2551998204","doi":"https://doi.org/10.1002/cbic.201600359","mag":"2551998204","pmid":"https://pubmed.ncbi.nlm.nih.gov/27862795","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/5324649"},"language":"en","primary_location":{"id":"doi:10.1002/cbic.201600359","doi":"https://doi.org/10.1002/cbic.201600359","is_oa":true,"landing_page_url":"https://doi.org/10.1002/cbic.201600359","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/cbic.201600359","source":{"id":"https://openalex.org/S154285657","display_name":"ChemBioChem","issn_l":"1439-4227","issn":["1439-4227","1439-7633"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"ChemBioChem","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","datacite","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/cbic.201600359","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5057659007","display_name":"Matthias Knop","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1850255","display_name":"University of Basel","ror":"https://ror.org/02s6k3f65","country_code":"CH","type":"education","lineage":["https://openalex.org/I1850255"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"Matthias Knop","raw_affiliation_strings":["Department of Chemistry, University of Basel, St. Johanns-Ring 19, 4056 Basel, Switzerland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry, University of Basel, St. Johanns-Ring 19, 4056 Basel, Switzerland","institution_ids":["https://openalex.org/I1850255"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5064642002","display_name":"Thanh Quy Dang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1850255","display_name":"University of Basel","ror":"https://ror.org/02s6k3f65","country_code":"CH","type":"education","lineage":["https://openalex.org/I1850255"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"Thanh Quy Dang","raw_affiliation_strings":["Department of Chemistry, University of Basel, St. Johanns-Ring 19, 4056 Basel, Switzerland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry, University of Basel, St. Johanns-Ring 19, 4056 Basel, Switzerland","institution_ids":["https://openalex.org/I1850255"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5013565453","display_name":"Gunnar Jeschke","orcid":"https://orcid.org/0000-0001-6853-8585","observed_orcids":["https://orcid.org/0000-0001-6853-8585"]},"institutions":[{"id":"https://openalex.org/I35440088","display_name":"ETH Zurich","ror":"https://ror.org/05a28rw58","country_code":"CH","type":"education","lineage":["https://openalex.org/I2799323385","https://openalex.org/I35440088"]},{"id":"https://openalex.org/I4405253565","display_name":"Laboratory of Physical Chemistry","ror":"https://ror.org/00v171g37","country_code":"CH","type":"facility","lineage":["https://openalex.org/I2799323385","https://openalex.org/I35440088","https://openalex.org/I4405253565"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"Gunnar Jeschke","raw_affiliation_strings":["Laboratory of Physical Chemistry ETH Z\u00fcrich  Vladimir-Prelog-Weg 2 8093 Z\u00fcrich Switzerland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Physical Chemistry ETH Z\u00fcrich  Vladimir-Prelog-Weg 2 8093 Z\u00fcrich Switzerland","institution_ids":["https://openalex.org/I35440088","https://openalex.org/I4405253565"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5065756369","display_name":"Florian P. Seebeck","orcid":"https://orcid.org/0000-0003-4625-1369","observed_orcids":["https://orcid.org/0000-0003-4625-1369"]},"institutions":[{"id":"https://openalex.org/I1850255","display_name":"University of Basel","ror":"https://ror.org/02s6k3f65","country_code":"CH","type":"education","lineage":["https://openalex.org/I1850255"]}],"countries":["CH"],"is_corresponding":true,"raw_author_name":"Florian P. Seebeck","raw_affiliation_strings":["Department of Chemistry, University of Basel, St. Johanns-Ring 19, 4056 Basel, Switzerland"],"raw_orcid":"https://orcid.org/0000-0003-4625-1369","affiliations":[{"raw_affiliation_string":"Department of Chemistry, University of Basel, St. Johanns-Ring 19, 4056 Basel, Switzerland","institution_ids":["https://openalex.org/I1850255"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5065756369"],"corresponding_institution_ids":["https://openalex.org/I1850255"],"apc_list":{"value":4430,"currency":"USD","value_usd":4430},"apc_paid":{"value":4430,"currency":"USD","value_usd":4430},"fwci":2.6234,"has_fulltext":true,"cited_by_count":59,"citation_normalized_percentile":{"value":0.90094058,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":89,"max":99},"biblio":{"volume":"18","issue":"2","first_page":"161","last_page":"165"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11747","display_name":"Metal-Catalyzed Oxygenation Mechanisms","score":0.9976000189781189,"subfield":{"id":"https://openalex.org/subfields/1604","display_name":"Inorganic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T11747","display_name":"Metal-Catalyzed Oxygenation Mechanisms","score":0.9976000189781189,"subfield":{"id":"https://openalex.org/subfields/1604","display_name":"Inorganic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T11626","display_name":"Metalloenzymes and iron-sulfur proteins","score":0.0006000000284984708,"subfield":{"id":"https://openalex.org/subfields/2105","display_name":"Renewable Energy, Sustainability and the Environment"},"field":{"id":"https://openalex.org/fields/21","display_name":"Energy"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T11162","display_name":"Enzyme Structure and Function","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2505","display_name":"Materials Chemistry"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/formylglycine-generating-enzyme","display_name":"formylglycine-generating enzyme","score":0.996999979019165},{"id":"https://openalex.org/keywords/copper-cofactor","display_name":"copper cofactor","score":0.8550000190734863},{"id":"https://openalex.org/keywords/cui","display_name":"CuI","score":0.5910000205039978},{"id":"https://openalex.org/keywords/cysteine-oxidation","display_name":"cysteine oxidation","score":0.6740000247955322},{"id":"https://openalex.org/keywords/formylglycine","display_name":"formylglycine","score":0.7739999890327454},{"id":"https://openalex.org/keywords/active-site-cysteine","display_name":"active site cysteine","score":0.8939999938011169},{"id":"https://openalex.org/keywords/copper-enzymes","display_name":"copper enzymes","score":0.5130000114440918}],"concepts":[{"id":"https://openalex.org/C197957613","wikidata":"https://www.wikidata.org/wiki/Q407280","display_name":"Cofactor","level":3,"score":0.8401618003845215},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.7624579668045044},{"id":"https://openalex.org/C2779201268","wikidata":"https://www.wikidata.org/wiki/Q186474","display_name":"Cysteine","level":3,"score":0.7321903705596924},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.6791510581970215},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.6035813689231873},{"id":"https://openalex.org/C41183919","wikidata":"https://www.wikidata.org/wiki/Q423026","display_name":"Active site","level":3,"score":0.5283982157707214},{"id":"https://openalex.org/C71240020","wikidata":"https://www.wikidata.org/wiki/Q186011","display_name":"Stereochemistry","level":1,"score":0.48585769534111023}],"mesh":[{"descriptor_ui":"D003300","descriptor_name":"Copper","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D003300","descriptor_name":"Copper","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D003545","descriptor_name":"Cysteine","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D003545","descriptor_name":"Cysteine","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D004578","descriptor_name":"Electron Spin Resonance Spectroscopy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005998","descriptor_name":"Glycine","qualifier_ui":"Q000031","qualifier_name":"analogs & derivatives","is_major_topic":true},{"descriptor_ui":"D005998","descriptor_name":"Glycine","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D005998","descriptor_name":"Glycine","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007700","descriptor_name":"Kinetics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013429","descriptor_name":"Sulfatases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D013429","descriptor_name":"Sulfatases","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D020134","descriptor_name":"Catalytic Domain","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D039903","descriptor_name":"Actinobacteria","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":false},{"descriptor_ui":"D055162","descriptor_name":"Biocatalysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D056004","descriptor_name":"Molecular Dynamics Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":7,"locations":[{"id":"doi:10.1002/cbic.201600359","doi":"https://doi.org/10.1002/cbic.201600359","is_oa":true,"landing_page_url":"https://doi.org/10.1002/cbic.201600359","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/cbic.201600359","source":{"id":"https://openalex.org/S154285657","display_name":"ChemBioChem","issn_l":"1439-4227","issn":["1439-4227","1439-7633"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"ChemBioChem","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:4195294","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/5324649","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:5324649","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/5324649","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Chembiochem","raw_type":"Text"},{"id":"pmid:27862795","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/27862795","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Chembiochem : a European journal of chemical biology","raw_type":"Journal Article"},{"id":"pmh:oai:edoc.unibas.ch:58311","doi":null,"is_oa":true,"landing_page_url":"https://edoc.unibas.ch/58311/1/cbic.201600359.pdf","pdf_url":"https://edoc.unibas.ch/58311/1/cbic.201600359.pdf","source":{"id":"https://openalex.org/S4306401836","display_name":"edoc (University of Basel)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1850255","host_organization_name":"University of Basel","host_organization_lineage":["https://openalex.org/I1850255"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"","raw_type":"Article"},{"id":"pmh:oai:www.research-collection.ethz.ch:20.500.11850/209047","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/20.500.11850/209047","pdf_url":null,"source":{"id":"https://openalex.org/S4306402302","display_name":"Repository for Publications and Research Data (ETH Zurich)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I35440088","host_organization_name":"ETH Zurich","host_organization_lineage":["https://openalex.org/I35440088"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"ChemBioChem, 18 (2)","raw_type":"info:eu-repo/semantics/article"},{"id":"doi:10.3929/ethz-b-000194066","doi":"https://doi.org/10.3929/ethz-b-000194066","is_oa":true,"landing_page_url":"https://doi.org/10.3929/ethz-b-000194066","pdf_url":null,"source":{"id":"https://openalex.org/S7407051236","display_name":"ETH Z\u00fcrich Research Collection","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"article-journal"}],"best_oa_location":{"id":"doi:10.1002/cbic.201600359","doi":"https://doi.org/10.1002/cbic.201600359","is_oa":true,"landing_page_url":"https://doi.org/10.1002/cbic.201600359","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/cbic.201600359","source":{"id":"https://openalex.org/S154285657","display_name":"ChemBioChem","issn_l":"1439-4227","issn":["1439-4227","1439-7633"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"ChemBioChem","raw_type":"journal-article"},"sustainable_development_goals":[],"sustainable_development_goals_aurora":[{"id":"https://metadata.un.org/sdg/6","score":0.5600000023841858,"display_name":"Clean water and sanitation"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2551998204.pdf","grobid_xml":"https://content.openalex.org/works/W2551998204.grobid-xml"},"referenced_works_count":43,"referenced_works":["https://openalex.org/W159800169","https://openalex.org/W1856913850","https://openalex.org/W1923025228","https://openalex.org/W1931904185","https://openalex.org/W1963874808","https://openalex.org/W1970713347","https://openalex.org/W1980099457","https://openalex.org/W1983639577","https://openalex.org/W1987807750","https://openalex.org/W1988534538","https://openalex.org/W1989052747","https://openalex.org/W1990859503","https://openalex.org/W2001521415","https://openalex.org/W2013945680","https://openalex.org/W2022035827","https://openalex.org/W2022897757","https://openalex.org/W2023487832","https://openalex.org/W2050782835","https://openalex.org/W2054905327","https://openalex.org/W2055212608","https://openalex.org/W2072463598","https://openalex.org/W2072471477","https://openalex.org/W2078349137","https://openalex.org/W2082635962","https://openalex.org/W2082867535","https://openalex.org/W2083921257","https://openalex.org/W2086367200","https://openalex.org/W2104999764","https://openalex.org/W2107108579","https://openalex.org/W2129774902","https://openalex.org/W2131032705","https://openalex.org/W2138582177","https://openalex.org/W2140511045","https://openalex.org/W2148956195","https://openalex.org/W2149640957","https://openalex.org/W2152301430","https://openalex.org/W2169442257","https://openalex.org/W2169527211","https://openalex.org/W2320446052","https://openalex.org/W2321426138","https://openalex.org/W2329077447","https://openalex.org/W2551998204","https://openalex.org/W4255324350"],"related_works":["https://openalex.org/W4242819400","https://openalex.org/W1856913850","https://openalex.org/W2920095441","https://openalex.org/W2922511278","https://openalex.org/W4409161028","https://openalex.org/W6950417429","https://openalex.org/W4312193857","https://openalex.org/W2763376447","https://openalex.org/W2022897757","https://openalex.org/W2950399791"],"abstract_inverted_index":{"Abstract":[0],"Formylglycine\u2010generating":[1],"enzyme":[2,28],"(FGE)":[3],"is":[4,22],"an":[5,23],"O2\u2010utilizing":[6],"oxidase":[7],"that":[8,20],"converts":[9],"specific":[10],"cysteine":[11],"residues":[12],"of":[13,26,40,51],"client":[14],"proteins":[15],"to":[16,37],"formylglycine.":[17],"We":[18],"show":[19],"CuI":[21],"integral":[24],"cofactor":[25],"this":[27],"and":[29],"binds":[30],"with":[31],"high":[32],"affinity":[33],"(KD=of":[34],"10\u221217":[35],"m)":[36],"a":[38,48],"pair":[39],"active\u2010site":[41],"cysteines.":[42],"These":[43],"findings":[44],"establish":[45],"FGE":[46],"as":[47],"novel":[49],"type":[50],"copper":[52],"enzyme.":[53]},"counts_by_year":[{"year":2026,"cited_by_count":6},{"year":2025,"cited_by_count":6},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":3},{"year":2022,"cited_by_count":5},{"year":2021,"cited_by_count":10},{"year":2020,"cited_by_count":7},{"year":2019,"cited_by_count":6},{"year":2018,"cited_by_count":10},{"year":2017,"cited_by_count":3},{"year":2016,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-11-30T00:00:00"}