{"id":"https://openalex.org/W2551849413","doi":"https://doi.org/10.1002/em.22064","title":"Transcriptomic responses in the oral cavity of F344 rats and B6C3F1 mice following exposure to Cr(VI): Implications for risk assessment","display_name":"Transcriptomic responses in the oral cavity of F344 rats and B6C3F1 mice following exposure to Cr(VI): Implications for risk assessment","publication_year":2016,"publication_date":"2016-11-15","ids":{"openalex":"https://openalex.org/W2551849413","doi":"https://doi.org/10.1002/em.22064","mag":"2551849413","pmid":"https://pubmed.ncbi.nlm.nih.gov/27859739","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/5215477"},"language":"en","primary_location":{"id":"doi:10.1002/em.22064","doi":"https://doi.org/10.1002/em.22064","is_oa":true,"landing_page_url":"https://doi.org/10.1002/em.22064","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/em.22064","source":{"id":"https://openalex.org/S204663187","display_name":"Environmental and Molecular Mutagenesis","issn_l":"0893-6692","issn":["0893-6692","1098-2280"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Environmental and Molecular Mutagenesis","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/em.22064","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5086232184","display_name":"Chad M. Thompson","orcid":"https://orcid.org/0000-0002-2265-7420","observed_orcids":["https://orcid.org/0000-0002-2265-7420"]},"institutions":[{"id":"https://openalex.org/I4403928214","display_name":"ToxStrategies LLC (United States)","ror":"https://ror.org/02cfpj844","country_code":"US","type":"company","lineage":["https://openalex.org/I4403928214"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Chad M. Thompson","raw_affiliation_strings":["ToxStrategies, Inc, Katy, Texas"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"ToxStrategies, Inc, Katy, Texas","institution_ids":["https://openalex.org/I4403928214"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5074912970","display_name":"Julia E. Rager","orcid":"https://orcid.org/0000-0002-2882-5042","observed_orcids":["https://orcid.org/0000-0002-2882-5042"]},"institutions":[{"id":"https://openalex.org/I4403928214","display_name":"ToxStrategies LLC (United States)","ror":"https://ror.org/02cfpj844","country_code":"US","type":"company","lineage":["https://openalex.org/I4403928214"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Julia E. Rager","raw_affiliation_strings":["ToxStrategies, Inc, Austin, Texas"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"ToxStrategies, Inc, Austin, Texas","institution_ids":["https://openalex.org/I4403928214"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5021266876","display_name":"Mina Suh","orcid":"https://orcid.org/0000-0002-9557-4933","observed_orcids":["https://orcid.org/0000-0002-9557-4933"]},"institutions":[{"id":"https://openalex.org/I4403928214","display_name":"ToxStrategies LLC (United States)","ror":"https://ror.org/02cfpj844","country_code":"US","type":"company","lineage":["https://openalex.org/I4403928214"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Mina Suh","raw_affiliation_strings":["ToxStrategies, Inc, Mission Viejo, California"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"ToxStrategies, Inc, Mission Viejo, California","institution_ids":["https://openalex.org/I4403928214"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5014849102","display_name":"Caroline Ring","orcid":"https://orcid.org/0000-0002-0463-1251","observed_orcids":["https://orcid.org/0000-0002-0463-1251"]},"institutions":[{"id":"https://openalex.org/I4403928214","display_name":"ToxStrategies LLC (United States)","ror":"https://ror.org/02cfpj844","country_code":"US","type":"company","lineage":["https://openalex.org/I4403928214"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Caroline L. Ring","raw_affiliation_strings":["ToxStrategies, Inc, Austin, Texas"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"ToxStrategies, Inc, Austin, Texas","institution_ids":["https://openalex.org/I4403928214"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5052737783","display_name":"Deborah M. Proctor","orcid":"https://orcid.org/0000-0002-1596-7455","observed_orcids":["https://orcid.org/0000-0002-1596-7455"]},"institutions":[{"id":"https://openalex.org/I4403928214","display_name":"ToxStrategies LLC (United States)","ror":"https://ror.org/02cfpj844","country_code":"US","type":"company","lineage":["https://openalex.org/I4403928214"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Deborah M. Proctor","raw_affiliation_strings":["ToxStrategies, Inc, Mission Viejo, California"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"ToxStrategies, Inc, Mission Viejo, California","institution_ids":["https://openalex.org/I4403928214"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110278334","display_name":"Laurie C. Haws","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4403928214","display_name":"ToxStrategies LLC (United States)","ror":"https://ror.org/02cfpj844","country_code":"US","type":"company","lineage":["https://openalex.org/I4403928214"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Laurie C. Haws","raw_affiliation_strings":["ToxStrategies, Inc, Austin, Texas"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"ToxStrategies, Inc, Austin, Texas","institution_ids":["https://openalex.org/I4403928214"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5080112312","display_name":"Rebecca C. Fry","orcid":"https://orcid.org/0000-0003-0899-9018","observed_orcids":["https://orcid.org/0000-0003-0899-9018"]},"institutions":[{"id":"https://openalex.org/I114027177","display_name":"University of North Carolina at Chapel Hill","ror":"https://ror.org/0130frc33","country_code":"US","type":"education","lineage":["https://openalex.org/I114027177"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Rebecca C. Fry","raw_affiliation_strings":["Curriculum in Toxicology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina","Department of Environmental Sciences and Engineering, Gillings School of Global Public Health, Chapel Hill, North Carolina"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Curriculum in Toxicology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina","institution_ids":["https://openalex.org/I114027177"]},{"raw_affiliation_string":"Department of Environmental Sciences and Engineering, Gillings School of Global Public Health, Chapel Hill, North Carolina","institution_ids":["https://openalex.org/I114027177"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5072625370","display_name":"Mark Anglin Harris","orcid":"https://orcid.org/0000-0002-9007-1587","observed_orcids":["https://orcid.org/0000-0002-9007-1587"]},"institutions":[{"id":"https://openalex.org/I4403928214","display_name":"ToxStrategies LLC (United States)","ror":"https://ror.org/02cfpj844","country_code":"US","type":"company","lineage":["https://openalex.org/I4403928214"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Mark A. Harris","raw_affiliation_strings":["ToxStrategies, Inc, Katy, Texas"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"ToxStrategies, Inc, Katy, Texas","institution_ids":["https://openalex.org/I4403928214"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5086232184"],"corresponding_institution_ids":["https://openalex.org/I4403928214"],"apc_list":{"value":3750,"currency":"USD","value_usd":3750},"apc_paid":{"value":3750,"currency":"USD","value_usd":3750},"fwci":1.1047,"has_fulltext":true,"cited_by_count":17,"citation_normalized_percentile":{"value":0.72995199,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":97},"biblio":{"volume":"57","issue":"9","first_page":"706","last_page":"716"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11972","display_name":"Chromium effects and bioremediation","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/2307","display_name":"Health, Toxicology and Mutagenesis"},"field":{"id":"https://openalex.org/fields/23","display_name":"Environmental Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T11972","display_name":"Chromium effects and bioremediation","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/2307","display_name":"Health, Toxicology and Mutagenesis"},"field":{"id":"https://openalex.org/fields/23","display_name":"Environmental Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10433","display_name":"Carcinogens and Genotoxicity Assessment","score":0.0017999999690800905,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10790","display_name":"Heavy Metal Exposure and Toxicity","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2307","display_name":"Health, Toxicology and Mutagenesis"},"field":{"id":"https://openalex.org/fields/23","display_name":"Environmental Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/hexavalent-chromium","display_name":"hexavalent chromium","score":0.9990000128746033},{"id":"https://openalex.org/keywords/oral-mucosa","display_name":"oral mucosa","score":0.7089999914169312},{"id":"https://openalex.org/keywords/transcriptomic-response","display_name":"transcriptomic response","score":0.722000002861023},{"id":"https://openalex.org/keywords/differentially-expressed-genes","display_name":"differentially expressed genes","score":0.7559999823570251},{"id":"https://openalex.org/keywords/benchmark-dose-modeling","display_name":"benchmark dose modeling","score":0.8669999837875366},{"id":"https://openalex.org/keywords/dose-response-relationship","display_name":"dose-response relationship","score":0.7940000295639038},{"id":"https://openalex.org/keywords/oral-tumors","display_name":"oral tumors","score":0.40799999237060547},{"id":"https://openalex.org/keywords/fischer-344-rats","display_name":"F344 rats","score":0.8889999985694885},{"id":"https://openalex.org/keywords/b6c3f1-mice","display_name":"B6C3F1 mice","score":1.0},{"id":"https://openalex.org/keywords/species-comparison","display_name":"species comparison","score":0.6499999761581421},{"id":"https://openalex.org/keywords/tissue-specific-toxicity","display_name":"tissue-specific toxicity","score":0.43700000643730164},{"id":"https://openalex.org/keywords/risk-assessment","display_name":"risk assessment","score":0.6539999842643738},{"id":"https://openalex.org/keywords/drinking-water-contamination","display_name":"drinking water contamination","score":0.625}],"concepts":[{"id":"https://openalex.org/C2779409057","wikidata":"https://www.wikidata.org/wiki/Q1776131","display_name":"Oral mucosa","level":2,"score":0.6820747256278992},{"id":"https://openalex.org/C114246631","wikidata":"https://www.wikidata.org/wiki/Q187661","display_name":"Carcinogen","level":2,"score":0.6540249586105347},{"id":"https://openalex.org/C162317418","wikidata":"https://www.wikidata.org/wiki/Q252857","display_name":"Transcriptome","level":4,"score":0.6340057253837585},{"id":"https://openalex.org/C186836561","wikidata":"https://www.wikidata.org/wiki/Q1931516","display_name":"Microarray","level":4,"score":0.5769069790840149},{"id":"https://openalex.org/C29730261","wikidata":"https://www.wikidata.org/wiki/Q274160","display_name":"Toxicity","level":2,"score":0.5416292548179626},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.45599621534347534},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.3446144461631775},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.3391783833503723},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.3306199908256531},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3267139196395874},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.2930147647857666},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.2865452170372009},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.2215215265750885},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.16493907570838928}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002274","descriptor_name":"Carcinogens, Environmental","qualifier_ui":"Q000493","qualifier_name":"pharmacokinetics","is_major_topic":false},{"descriptor_ui":"D002274","descriptor_name":"Carcinogens, Environmental","qualifier_ui":"Q000633","qualifier_name":"toxicity","is_major_topic":true},{"descriptor_ui":"D002857","descriptor_name":"Chromium","qualifier_ui":"Q000493","qualifier_name":"pharmacokinetics","is_major_topic":false},{"descriptor_ui":"D002857","descriptor_name":"Chromium","qualifier_ui":"Q000633","qualifier_name":"toxicity","is_major_topic":true},{"descriptor_ui":"D004305","descriptor_name":"Dose-Response Relationship, Drug","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008815","descriptor_name":"Mice, Inbred Strains","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009061","descriptor_name":"Mouth Mucosa","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D009061","descriptor_name":"Mouth Mucosa","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D011916","descriptor_name":"Rats, Inbred F344","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013045","descriptor_name":"Species Specificity","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014874","descriptor_name":"Water Pollutants, Chemical","qualifier_ui":"Q000493","qualifier_name":"pharmacokinetics","is_major_topic":false},{"descriptor_ui":"D014874","descriptor_name":"Water Pollutants, Chemical","qualifier_ui":"Q000633","qualifier_name":"toxicity","is_major_topic":true},{"descriptor_ui":"D018570","descriptor_name":"Risk Assessment","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020869","descriptor_name":"Gene Expression Profiling","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D055106","descriptor_name":"Genome-Wide Association Study","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D059467","descriptor_name":"Transcriptome","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true}],"locations_count":4,"locations":[{"id":"doi:10.1002/em.22064","doi":"https://doi.org/10.1002/em.22064","is_oa":true,"landing_page_url":"https://doi.org/10.1002/em.22064","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/em.22064","source":{"id":"https://openalex.org/S204663187","display_name":"Environmental and Molecular Mutagenesis","issn_l":"0893-6692","issn":["0893-6692","1098-2280"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Environmental and Molecular Mutagenesis","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:4130516","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/5215477","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:5215477","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/5215477","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Environ Mol Mutagen","raw_type":"Text"},{"id":"pmid:27859739","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/27859739","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Environmental and molecular mutagenesis","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1002/em.22064","doi":"https://doi.org/10.1002/em.22064","is_oa":true,"landing_page_url":"https://doi.org/10.1002/em.22064","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/em.22064","source":{"id":"https://openalex.org/S204663187","display_name":"Environmental and Molecular Mutagenesis","issn_l":"0893-6692","issn":["0893-6692","1098-2280"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Environmental and Molecular Mutagenesis","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.8999999761581421}],"study_designs":[],"awards":[{"id":"https://openalex.org/G9000883576","display_name":"UNC Center for Environmental Health and Susceptibility","funder_award_id":"P30ES010126","funder_id":"https://openalex.org/F4320337361","funder_display_name":"National Institute of Environmental Health Sciences"}],"funders":[{"id":"https://openalex.org/F4320310101","display_name":"American Chemistry Council","ror":"https://ror.org/03rzy3090"},{"id":"https://openalex.org/F4320337361","display_name":"National Institute of Environmental Health Sciences","ror":"https://ror.org/00j4k1h63"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2551849413.pdf","grobid_xml":"https://content.openalex.org/works/W2551849413.grobid-xml"},"referenced_works_count":47,"referenced_works":["https://openalex.org/W38644661","https://openalex.org/W107010345","https://openalex.org/W1517257035","https://openalex.org/W1538175956","https://openalex.org/W1543269491","https://openalex.org/W1810400203","https://openalex.org/W1975059057","https://openalex.org/W1981552996","https://openalex.org/W1982090985","https://openalex.org/W1988973871","https://openalex.org/W1989013166","https://openalex.org/W1990347758","https://openalex.org/W1998956244","https://openalex.org/W2001683961","https://openalex.org/W2002308480","https://openalex.org/W2009658086","https://openalex.org/W2009931083","https://openalex.org/W2013528197","https://openalex.org/W2013638172","https://openalex.org/W2016734087","https://openalex.org/W2020541351","https://openalex.org/W2021074697","https://openalex.org/W2025493780","https://openalex.org/W2026255144","https://openalex.org/W2040977096","https://openalex.org/W2044723891","https://openalex.org/W2045678865","https://openalex.org/W2053478107","https://openalex.org/W2071518600","https://openalex.org/W2079365091","https://openalex.org/W2086752426","https://openalex.org/W2091705039","https://openalex.org/W2103411994","https://openalex.org/W2106502953","https://openalex.org/W2120523825","https://openalex.org/W2129167503","https://openalex.org/W2150278032","https://openalex.org/W2158217645","https://openalex.org/W2169994394","https://openalex.org/W2402774294","https://openalex.org/W2417721777","https://openalex.org/W2460590705","https://openalex.org/W2468654925","https://openalex.org/W2748268306","https://openalex.org/W4285719527","https://openalex.org/W4292293116","https://openalex.org/W4299551392"],"related_works":["https://openalex.org/W1998956244","https://openalex.org/W1810400203","https://openalex.org/W4413109477","https://openalex.org/W4200396114","https://openalex.org/W2103411994","https://openalex.org/W2611052709","https://openalex.org/W2044723891","https://openalex.org/W2040977096","https://openalex.org/W4205720612","https://openalex.org/W2731470939"],"abstract_inverted_index":{"Exposure":[0],"to":[1,11,44,91,102,230],"hexavalent":[2],"chromium":[3,204,208],"[Cr(VI)]":[4],"in":[5,16,30,116,148,157,172,182,210,248],"drinking":[6],"water":[7],"was":[8,135],"previously":[9],"reported":[10],"increase":[12],"oral":[13,31,119,159,174,212,246],"tumor":[14],"incidence":[15],"F344":[17,35],"rats.":[18,249],"To":[19],"investigate":[20],"the":[21,117,158,166,173,183,188,211,232,245],"mode":[22],"of":[23,34,83,121,129,161,165,169,176,185,202,223,234],"action":[24],"for":[25,48,106,239],"these":[26],"tumors,":[27],"transcriptomic":[28],"profiles":[29],"mucosa":[32,160,175,213],"samples":[33],"rats":[36,177],"and":[37,72,80,113,125,178,197,214,236,260],"B6C3F1":[38],"mice":[39,179],"were":[40,75,89,146],"analyzed":[41],"following":[42],"exposure":[43],"0.1-180":[45],"ppm":[46],"Cr(VI)":[47],"7":[49,79,126],"or":[50,140],"90":[51,81],"days.":[52],"In":[53,69],"rats,":[54],"genome-wide":[55],"microarray":[56],"analyses":[57,151],"identified":[58,77,111],"no":[59],"significantly":[60],"differentially":[61],"expressed":[62],"genes":[63],"(DEGs)":[64],"at":[65],"either":[66,138],"time":[67],"point.":[68],"mice,":[70],"14":[71],"1":[73],"DEGs":[74,94],"respectively":[76],"after":[78],"days":[82],"exposure.":[84],"Therefore,":[85],"relaxed":[86],"statistical":[87],"criteria":[88,242],"employed":[90],"identify":[92,103],"potential":[93],"(pDEGs),":[95],"followed":[96],"by":[97,264],"high-throughput":[98],"benchmark":[99],"dose":[100],"modeling":[101],"responsive":[104],"pDEGs":[105,115],"pathway":[107,133],"enrichment":[108,134],"analysis.":[109],"This":[110],"288":[112],"168":[114],"rat":[118],"mucosa,":[120],"which":[122],"only":[123],"20":[124],"showed":[127],"evidence":[128],"dose-response.":[130],"No":[131],"significant":[132],"obtained":[136,147],"with":[137,180,220],"pDEG":[139,142],"dose-responsive":[141],"lists.":[143],"Similar":[144],"results":[145],"mice.":[149],"These":[150,226],"indicate":[152],"a":[153,200],"negligible":[154,215],"transcriptional":[155],"response":[156,217],"both":[162],"species.":[163],"Comparison":[164],"total":[167],"number":[168],"gene":[170],"changes":[171],"responses":[181],"duodenum":[184],"animals":[186],"from":[187],"same":[189],"study":[190],"demonstrated":[191],"remarkable":[192],"dose-response":[193],"concordance":[194],"across":[195],"tissues":[196],"species":[198],"as":[199],"function":[201],"tissue":[203,224],"concentration.":[205],"The":[206,257],"low":[207],"levels":[209],"transcript":[216],"are":[218,228],"consistent":[219],"an":[221],"absence":[222],"lesions.":[225],"findings":[227],"used":[229],"compare":[231],"merits":[233],"linear":[235],"nonlinear":[237],"approaches":[238],"deriving":[240],"toxicity":[241],"based":[243],"on":[244],"tumors":[247],"Environ.":[250],"Mol.":[251],"Mutagen.":[252],"57:706-716,":[253],"2016.":[254],"\u00a9":[255],"2016":[256],"Authors.":[258],"Environmental":[259],"Molecular":[261],"Mutagenesis":[262],"Published":[263],"Wiley":[265],"Periodicals,":[266],"Inc.":[267]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":3},{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":2},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":2},{"year":2017,"cited_by_count":3}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-11-30T00:00:00"}