{"id":"https://openalex.org/W2551825559","doi":null,"title":"Designing Inhibitors against HOX domain mutations of PDX-1 and studying its association in Diabetes","display_name":"Designing Inhibitors against HOX domain mutations of PDX-1 and studying its association in Diabetes","publication_year":2012,"publication_date":"2012-01-01","ids":{"openalex":"https://openalex.org/W2551825559","mag":"2551825559"},"language":"en","primary_location":{"id":"pmh:oai:CiteSeerX.psu:10.1.1.402.8434","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.402.8434","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"http://www.ijcsi.org/papers/IJCSI-9-2-2-207-215.pdf","raw_type":"text"},"volume":null,"type":"article","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5108229863","display_name":"Allam Appa Rao","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Allam Appa Rao","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5088977146","display_name":"Anupam Bhattacharya","orcid":"https://orcid.org/0000-0002-2152-1994","observed_orcids":["https://orcid.org/0000-0002-2152-1994","https://orcid.org/0009-0009-8962-4453"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Anupam Bhattacharya","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-2152-1994","affiliations":[]},{"author_position":"middle","author":{"id":null,"display_name":"Amit Kumar","orcid":"https://orcid.org/0000-0001-8391-6812","observed_orcids":["https://orcid.org/0000-0001-8391-6812"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Amit Kumar","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0001-8391-6812","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5020866434","display_name":"Amita Kashyap","orcid":"https://orcid.org/0000-0003-1642-8397","observed_orcids":["https://orcid.org/0000-0003-1642-8397"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Amita Kashyap","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0003-1642-8397","affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5058352840","display_name":"Gumpeny Ramachandra Sridhar","orcid":"https://orcid.org/0000-0002-7446-1251","observed_orcids":["https://orcid.org/0000-0002-7446-1251"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"GR Sridhar","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-7446-1251","affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10839","display_name":"Pancreatic function and diabetes","score":0.7997999787330627,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10839","display_name":"Pancreatic function and diabetes","score":0.7997999787330627,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11171","display_name":"Diabetes and associated disorders","score":0.06849999725818634,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10211","display_name":"Computational Drug Discovery Methods","score":0.04170000180602074,"subfield":{"id":"https://openalex.org/subfields/3002","display_name":"Drug Discovery"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/pdx1","display_name":"PDX1","score":0.9900000095367432},{"id":"https://openalex.org/keywords/type-1-diabetes","display_name":"type 1 diabetes","score":0.9110000133514404},{"id":"https://openalex.org/keywords/small-molecule-inhibitors","display_name":"small molecule inhibitors","score":0.6110000014305115},{"id":"https://openalex.org/keywords/homeodomain-mutations","display_name":"homeodomain mutations","score":0.7149999737739563},{"id":"https://openalex.org/keywords/transcription-factors","display_name":"transcription factors","score":0.5490000247955322},{"id":"https://openalex.org/keywords/pancreas-development","display_name":"pancreatic development","score":0.5950000286102295},{"id":"https://openalex.org/keywords/insulin-production","display_name":"insulin production","score":0.6669999957084656},{"id":"https://openalex.org/keywords/glucose-homeostasis","display_name":"glucose homeostasis","score":0.9160000085830688},{"id":"https://openalex.org/keywords/mutation-hotspots","display_name":"mutational hotspots","score":0.5569999814033508},{"id":"https://openalex.org/keywords/binding-sites","display_name":"binding sites","score":0.5329999923706055}],"concepts":[{"id":"https://openalex.org/C41685203","wikidata":"https://www.wikidata.org/wiki/Q1974042","display_name":"Docking (animal)","level":2,"score":0.7464998960494995},{"id":"https://openalex.org/C111039654","wikidata":"https://www.wikidata.org/wiki/Q253149","display_name":"Hox gene","level":4,"score":0.6840431094169617},{"id":"https://openalex.org/C121587040","wikidata":"https://www.wikidata.org/wiki/Q898769","display_name":"Homeobox","level":4,"score":0.5720621943473816},{"id":"https://openalex.org/C98335778","wikidata":"https://www.wikidata.org/wiki/Q425185","display_name":"Glucokinase","level":3,"score":0.4961932301521301},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4522243142127991},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.37801593542099},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.3642065227031708},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.3517330288887024},{"id":"https://openalex.org/C86339819","wikidata":"https://www.wikidata.org/wiki/Q407384","display_name":"Transcription factor","level":3,"score":0.3394774794578552},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.17345672845840454},{"id":"https://openalex.org/C159110408","wikidata":"https://www.wikidata.org/wiki/Q121176","display_name":"Nursing","level":1,"score":0.0}],"mesh":[],"locations_count":2,"locations":[{"id":"pmh:oai:CiteSeerX.psu:10.1.1.402.8434","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.402.8434","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"http://www.ijcsi.org/papers/IJCSI-9-2-2-207-215.pdf","raw_type":"text"},{"id":"mag:2551825559","doi":null,"is_oa":false,"landing_page_url":"http://ijcsi.org/papers/IJCSI-9-2-2-207-215.pdf","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.504800021648407,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":19,"referenced_works":["https://openalex.org/W1485277922","https://openalex.org/W1552592481","https://openalex.org/W1752045965","https://openalex.org/W1888719990","https://openalex.org/W1944302200","https://openalex.org/W1977481910","https://openalex.org/W1981458452","https://openalex.org/W1999179141","https://openalex.org/W2034056702","https://openalex.org/W2041739600","https://openalex.org/W2050395079","https://openalex.org/W2059893763","https://openalex.org/W2064546248","https://openalex.org/W2102915416","https://openalex.org/W2126064524","https://openalex.org/W2140937253","https://openalex.org/W2144958072","https://openalex.org/W2156678798","https://openalex.org/W4322703507"],"related_works":["https://openalex.org/W2030384642","https://openalex.org/W2105633341","https://openalex.org/W1979610088","https://openalex.org/W2137532129","https://openalex.org/W298045478","https://openalex.org/W2158824492","https://openalex.org/W4241760136","https://openalex.org/W2788334722","https://openalex.org/W7166491142","https://openalex.org/W2156562915"],"abstract_inverted_index":{"Type":[0,15],"1":[1,16],"diabetes":[2],"mellitus":[3],"was":[4],"formally":[5],"known":[6],"as":[7],"IDDM,":[8],"type":[9,64],"I,":[10],"or":[11,96],"juvenile":[12],"onset":[13],"diabetes.":[14],"DM":[17],"can":[18],"occur":[19],"at":[20],"any":[21],"age.":[22],"In":[23],"this":[24],"study,we":[25],"analyzed":[26],"the":[27,107,120,126],"involvement":[28],"of":[29,32,51,82,112,119,131],"HOX":[30,77,113],"domain":[31,78,114],"PDX-1":[33,44],"protein.The":[34],"homeodomain":[35],"transcription":[36],"factor,":[37],"pancreas":[38,69],"duodenum":[39],"homeobox":[40],"(PDX)-1,":[41],"encoded":[42],"by":[43,93],"gene,":[45],"which":[46,123],"is":[47],"a":[48,80],"transcriptional":[49],"activator":[50],"several":[52],"genes,":[53],"including":[54],"insulin,":[55],"somatostatin,":[56],"glucokinase,":[57],"islet":[58],"amyloid":[59],"polypeptide,":[60],"and":[61,66,73,84,88,115],"glucose":[62,74],"transporter":[63],"2":[65],"essential":[67],"for":[68],"development,":[70],"insulin":[71],"production,":[72],"homeostasis.":[75],"[1,13].":[76],"has":[79],"length":[81],"63aa":[83],"control":[85],"developmental":[86],"patterns":[87],"cell":[89],"differentiation":[90],"in":[91,125],"vertebrates":[92],"acting":[94],"positive":[95],"negative":[97],"regulators":[98],"[4,9,16].":[99],"Different":[100],"approached":[101],"had":[102],"been":[103],"applied":[104],"to":[105],"identify":[106],"mutational":[108,117],"hot":[109],"spot":[110],"region":[111],"calculate":[116],"frequency":[118],"amino":[121],"acids":[122],"resides":[124],"hotspot":[127],"region.":[128],"Binding":[129],"site":[130]},"counts_by_year":[],"updated_date":"2026-11-08T12:12:28.789561","created_date":"2016-11-30T00:00:00"}