{"id":"https://openalex.org/W2551751997","doi":null,"title":"Molecular Targeted Functional, Cellular and Molecular Imaging of Atherosclerosis With Antibody-Conjugated Superparamagnetic Particles Using Magnetic Resonance","display_name":"Molecular Targeted Functional, Cellular and Molecular Imaging of Atherosclerosis With Antibody-Conjugated Superparamagnetic Particles Using Magnetic Resonance","publication_year":2006,"publication_date":"2006-05-07","ids":{"openalex":"https://openalex.org/W2551751997","mag":"2551751997"},"language":"en","primary_location":{"id":"mag:2551751997","doi":null,"is_oa":false,"landing_page_url":"https://briefs.techconnect.org/wp-content/volumes/Nanotech2006v1/pdf/801.pdf","pdf_url":null,"source":{"id":"https://openalex.org/S4306531643","display_name":"TechConnect Briefs","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"TechConnect Briefs","raw_type":null},"volume":null,"type":"article","indexed_in":[],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5022025952","display_name":"Rakesh D. Sharma","orcid":"https://orcid.org/0000-0002-9418-2655","observed_orcids":["https://orcid.org/0000-0002-9418-2655"]},"institutions":[{"id":"https://openalex.org/I103163165","display_name":"Florida State University","ror":"https://ror.org/05g3dte14","country_code":"US","type":"education","lineage":["https://openalex.org/I103163165"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Rakesh Sharma","raw_affiliation_strings":["FLORIDA STATE UNIV"],"raw_orcid":"https://orcid.org/0000-0002-9418-2655","affiliations":[{"raw_affiliation_string":"FLORIDA STATE UNIV","institution_ids":["https://openalex.org/I103163165"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5057133172","display_name":"JK Katz","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"JK Katz","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5039023347","display_name":"Yousef Haik","orcid":"https://orcid.org/0000-0002-3665-7456","observed_orcids":["https://orcid.org/0000-0002-3665-7456"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Yousef Haik","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-3665-7456","affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5084736066","display_name":"Ching J. Chen","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Ching J. Chen","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":1,"citation_normalized_percentile":{"value":0.37992601,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":94},"biblio":{"volume":"1","issue":"2006","first_page":"464","last_page":"466"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12405","display_name":"Characterization and Applications of Magnetic Nanoparticles","score":0.5835000276565552,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T12405","display_name":"Characterization and Applications of Magnetic Nanoparticles","score":0.5835000276565552,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10378","display_name":"Advanced MRI Techniques and Applications","score":0.14309999346733093,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12955","display_name":"Atherosclerosis and Cardiovascular Diseases","score":0.08919999748468399,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/atherosclerosis","display_name":"atherosclerosis","score":0.9819999933242798},{"id":"https://openalex.org/keywords/molecular-imaging","display_name":"molecular imaging","score":0.7350000143051147},{"id":"https://openalex.org/keywords/mri-contrast-agents","display_name":"MRI contrast agents","score":0.7960000038146973},{"id":"https://openalex.org/keywords/high-field-mri","display_name":"high-field MRI","score":0.656000018119812},{"id":"https://openalex.org/keywords/atherosclerotic-plaque","display_name":"atherosclerotic plaque","score":0.7609999775886536},{"id":"https://openalex.org/keywords/inflammation-imaging","display_name":"inflammation imaging","score":0.460999995470047},{"id":"https://openalex.org/keywords/thrombosis-imaging","display_name":"thrombosis imaging","score":0.9490000009536743},{"id":"https://openalex.org/keywords/fibrin","display_name":"fibrin","score":0.6899999976158142},{"id":"https://openalex.org/keywords/glycoprotein-iib-iiia","display_name":"integrin \u03b1IIb\u03b23","score":0.9190000295639038},{"id":"https://openalex.org/keywords/phage-display-antibodies","display_name":"phage display antibodies","score":0.843999981880188},{"id":"https://openalex.org/keywords/arterial-injury","display_name":"arterial injury","score":0.7300000190734863},{"id":"https://openalex.org/keywords/neointimal-hyperplasia","display_name":"intimal hyperplasia","score":0.9649999737739563},{"id":"https://openalex.org/keywords/atherothrombosis","display_name":"atherothrombosis","score":0.9769999980926514}],"concepts":[{"id":"https://openalex.org/C136339569","wikidata":"https://www.wikidata.org/wiki/Q1142297","display_name":"Molecular imaging","level":3,"score":0.783197820186615},{"id":"https://openalex.org/C143409427","wikidata":"https://www.wikidata.org/wiki/Q161238","display_name":"Magnetic resonance imaging","level":2,"score":0.7415839433670044},{"id":"https://openalex.org/C207001950","wikidata":"https://www.wikidata.org/wiki/Q141124","display_name":"In vivo","level":2,"score":0.4958566129207611},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.4695834517478943},{"id":"https://openalex.org/C2779179121","wikidata":"https://www.wikidata.org/wiki/Q559362","display_name":"Fibrous cap","level":2,"score":0.4570562541484833},{"id":"https://openalex.org/C145169222","wikidata":"https://www.wikidata.org/wiki/Q9339485","display_name":"Molecular probe","level":3,"score":0.44425278902053833},{"id":"https://openalex.org/C29331040","wikidata":"https://www.wikidata.org/wiki/Q7239554","display_name":"Preclinical imaging","level":3,"score":0.44057267904281616},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.4333612620830536},{"id":"https://openalex.org/C136229726","wikidata":"https://www.wikidata.org/wiki/Q327092","display_name":"Biomedical engineering","level":1,"score":0.3844376504421234},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3717542886734009},{"id":"https://openalex.org/C126838900","wikidata":"https://www.wikidata.org/wiki/Q77604","display_name":"Radiology","level":1,"score":0.24758055806159973},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.19783934950828552},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.12993481755256653},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.08740741014480591},{"id":"https://openalex.org/C150903083","wikidata":"https://www.wikidata.org/wiki/Q7108","display_name":"Biotechnology","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"mag:2551751997","doi":null,"is_oa":false,"landing_page_url":"https://briefs.techconnect.org/wp-content/volumes/Nanotech2006v1/pdf/801.pdf","pdf_url":null,"source":{"id":"https://openalex.org/S4306531643","display_name":"TechConnect Briefs","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"TechConnect Briefs","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9537000060081482}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":2,"referenced_works":["https://openalex.org/W2094218283","https://openalex.org/W2123253454"],"related_works":["https://openalex.org/W2792630749","https://openalex.org/W2922051319","https://openalex.org/W1972437157","https://openalex.org/W196012414","https://openalex.org/W2090956597","https://openalex.org/W4236143664","https://openalex.org/W7095942100","https://openalex.org/W3034011793","https://openalex.org/W2889025427","https://openalex.org/W1979563643"],"abstract_inverted_index":{"Background:":[0],"Magnetic":[1],"Resonance":[2],"Imaging":[3],"(MRI)":[4],"is":[5],"a":[6,186],"powerful":[7],"non-invasive":[8],"technique":[9],"that":[10,59,103,193],"provides":[11],"highresolution":[12],"anatomical":[13],"images":[14],"of":[15,43,74,143,166,188,230,244,254,259,272],"biological":[16],"tissue":[17],"based":[18],"on":[19],"their":[20,85],"inherent":[21],"physio-chemical":[22],"properties.":[23],"The":[24,257],"signal":[25],"from":[26],"MRI":[27,64,136],"can":[28,35,89,151],"be":[29,36,90,152],"modulated":[30],"by":[31,160,262],"contrast":[32,113,266],"agents,":[33],"which":[34],"specifically":[37],"directed":[38],"to":[39,55,65,87,97,140,240,250],"cells":[40,75],"and":[41,76,84,99,145,156,168,177,190,217,249],"molecules":[42,77],"interest,":[44],"thereby":[45],"providing":[46],"an":[47,236],"opportunity":[48,271],"for":[49,111],"targeted":[50,72],"imaging.":[51],"Aims:":[52],"We":[53],"propose":[54],"extend":[56],"previous":[57],"work":[58],"has":[60],"used":[61],"very":[62],"high-resolution":[63],"characterize":[66],"atherosclerotic":[67],"plaque":[68],"in":[69,79,92,147,179,195,199,205,224,247,274],"mice.":[70],"Through":[71],"imaging":[73,130,173,213,238,261],"involved":[78],"mouse":[80],"atherosclerosis,":[81],"pathological":[82],"processes":[83,142],"response":[86],"interventions":[88],"imaged":[91],"vivo.":[93],"Aim":[94,115,124],"1":[95],"was":[96,117,126,183,220],"develop":[98],"refine":[100],"gadoliniumapoferritin":[101],"nano-particles":[102],"have":[104],"shown":[105],"great":[106],"potential":[107],"as":[108],"relaxivity":[109],"agents":[110,267],"MR":[112],"studies.":[114],"2":[116],"image":[118],"antibody-conjugated":[119,264],"iron-oxide":[120],"micro-beads":[121],"(0.9":[122],"\u00b5m)).":[123],"3":[125],"applied":[127],"using":[128,132,263],"these":[129],"strategies":[131],"high":[133],"field":[134],"strength":[135],"(11.7":[137],"T/21":[138],"T)":[139],"interrogate":[141],"inflammation":[144],"thrombosis":[146],"vascular":[148],"models.":[149],"Targeting":[150],"accomplished":[153],"with":[154,185,226],"established":[155],"novel":[157],"antibodies":[158],"developed":[159],"phage":[161],"display":[162],"(against":[163],"active":[164],"forms":[165],"fibrin":[167],"glycoprotein":[169],"IIbIIIa).":[170],"Methods:":[171],"Molecular":[172],"probes":[174],"were":[175],"synthesized":[176],"characterized":[178],"vitro.":[180],"Arterial":[181],"injury":[182],"associated":[184],"sequence":[187],"molecular":[189,212,260],"cellular":[191],"events":[192],"result":[194],"intimal":[196],"hyperplasia":[197],"and,":[198],"the":[200,231,242,252],"apolipoprotein":[201],"E-deficient":[202],"mouse,":[203],"results":[204],"accelerated":[206],"atherosclerosis.":[207],"Results:":[208],"This":[209],"model":[210],"exhibited":[211],"targets":[214],"whose":[215],"spatial":[216],"temporal":[218],"expression":[219],"established.":[221],"These":[222],"features,":[223],"conjunction":[225],"straight,":[227],"superficial":[228],"course":[229],"femoral":[232],"artery":[233],"makes":[234],"it":[235],"ideal":[237],"target":[239],"examine":[241],"pathology":[243],"atherothrombosis":[245],"noninvasively":[246],"vivo":[248],"measure":[251],"effects":[253],"interventions.":[255],"Conclusion:":[256],"approach":[258],"superparamagnetic":[265],"may":[268],"provide":[269],"unique":[270],"microimaging":[273],"clinical":[275],"set":[276],"up.":[277]},"counts_by_year":[{"year":2018,"cited_by_count":1}],"updated_date":"2026-09-22T06:50:58.402377","created_date":"2016-11-30T00:00:00"}