{"id":"https://openalex.org/W2551625281","doi":null,"title":"TOEPASSING VAN THIOPENTAL BIJ VERHOOGDE INTRACRANIELE DRUK. KLINISCHE STUDIE EN VERGELIJKING VAN DIVERSE DOSEERSCHEMA'S MET COMPUTERSIMULATIE","display_name":"TOEPASSING VAN THIOPENTAL BIJ VERHOOGDE INTRACRANIELE DRUK. KLINISCHE STUDIE EN VERGELIJKING VAN DIVERSE DOSEERSCHEMA'S MET COMPUTERSIMULATIE","publication_year":1991,"publication_date":"1991-10-16","ids":{"openalex":"https://openalex.org/W2551625281","mag":"2551625281"},"language":"en","primary_location":{"id":"pmh:oai:pure.rug.nl:openaire_cris_publications/924f096a-c803-437e-90d0-36a9da887273","doi":null,"is_oa":false,"landing_page_url":"https://research.rug.nl/en/publications/924f096a-c803-437e-90d0-36a9da887273","pdf_url":null,"source":{"id":"https://openalex.org/S4306400420","display_name":"University of Groningen research database (University of Groningen / Centre for Information Technology)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I169381384","host_organization_name":"University of Groningen","host_organization_lineage":["https://openalex.org/I169381384"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Touw, D J, Vinks, A A T M M & Tans, J T J 1991, 'TOEPASSING VAN THIOPENTAL BIJ VERHOOGDE INTRACRANIELE DRUK. KLINISCHE STUDIE EN VERGELIJKING VAN DIVERSE DOSEERSCHEMA'S MET COMPUTERSIMULATIE', Pharmaceutisch Weekblad, vol. 126, no. 38, pp. 959-966.","raw_type":"info:eu-repo/semantics/publishedVersion"},"volume":null,"type":"article","indexed_in":[],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5018163150","display_name":"Daan Johannes Touw","orcid":"https://orcid.org/0000-0002-1429-4789","observed_orcids":["https://orcid.org/0000-0002-1429-4789"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Touw, D.J.; id_orcid 0000-0002-1429-4789","raw_affiliation_strings":["Pharmacokinetics, Toxicology and Targeting"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Pharmacokinetics, Toxicology and Targeting","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5040060343","display_name":"Alexander A. T. M. M. Vinks","orcid":"https://orcid.org/0000-0003-4224-2967","observed_orcids":["https://orcid.org/0000-0003-4224-2967"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Vinks, A.A.T.M.M.","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5113657371","display_name":"J. T. J. Tans","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Tans, J.T.J.","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.5674,"has_fulltext":false,"cited_by_count":1,"citation_normalized_percentile":{"value":0.72155459,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10436","display_name":"Anesthesia and Sedative Agents","score":0.676800012588501,"subfield":{"id":"https://openalex.org/subfields/2703","display_name":"Anesthesiology and Pain Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10436","display_name":"Anesthesia and Sedative Agents","score":0.676800012588501,"subfield":{"id":"https://openalex.org/subfields/2703","display_name":"Anesthesiology and Pain Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10706","display_name":"Traumatic Brain Injury and Neurovascular Disturbances","score":0.25220000743865967,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11036","display_name":"Antibiotics Pharmacokinetics and Efficacy","score":0.04129999876022339,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/thiopental","display_name":"thiopental","score":0.996999979019165},{"id":"https://openalex.org/keywords/intracranial-hypertension","display_name":"intracranial hypertension","score":0.9049999713897705},{"id":"https://openalex.org/keywords/maintenance-dose","display_name":"maintenance dose","score":0.5099999904632568},{"id":"https://openalex.org/keywords/loading-dose","display_name":"loading dose","score":0.8870000243186951},{"id":"https://openalex.org/keywords/induction-dose","display_name":"induction dose","score":0.6570000052452087},{"id":"https://openalex.org/keywords/serum-levels","display_name":"serum concentration","score":0.6399999856948853},{"id":"https://openalex.org/keywords/pharmacokinetic-simulation","display_name":"pharmacokinetic simulation","score":0.6899999976158142},{"id":"https://openalex.org/keywords/linear-kinetics","display_name":"linear kinetics","score":0.6859999895095825},{"id":"https://openalex.org/keywords/dose-adjustment","display_name":"dose adjustment","score":0.6690000295639038}],"concepts":[{"id":"https://openalex.org/C2781413609","wikidata":"https://www.wikidata.org/wiki/Q7308373","display_name":"Regimen","level":2,"score":0.7881984710693359},{"id":"https://openalex.org/C27924281","wikidata":"https://www.wikidata.org/wiki/Q17126475","display_name":"Maintenance dose","level":2,"score":0.701900064945221},{"id":"https://openalex.org/C2777288759","wikidata":"https://www.wikidata.org/wiki/Q4164182","display_name":"Dosing","level":2,"score":0.6170946955680847},{"id":"https://openalex.org/C112705442","wikidata":"https://www.wikidata.org/wiki/Q323936","display_name":"Pharmacokinetics","level":2,"score":0.6104346513748169},{"id":"https://openalex.org/C35294091","wikidata":"https://www.wikidata.org/wiki/Q6663385","display_name":"Loading dose","level":2,"score":0.5329182147979736},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.48809587955474854},{"id":"https://openalex.org/C2778283404","wikidata":"https://www.wikidata.org/wiki/Q6736822","display_name":"Maintenance therapy","level":3,"score":0.45803454518318176},{"id":"https://openalex.org/C42219234","wikidata":"https://www.wikidata.org/wiki/Q131130","display_name":"Anesthesia","level":1,"score":0.35083135962486267},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.33802974224090576},{"id":"https://openalex.org/C2776694085","wikidata":"https://www.wikidata.org/wiki/Q974135","display_name":"Chemotherapy","level":2,"score":0.21295860409736633},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.18999865651130676}],"mesh":[],"locations_count":2,"locations":[{"id":"pmh:oai:pure.rug.nl:openaire_cris_publications/924f096a-c803-437e-90d0-36a9da887273","doi":null,"is_oa":false,"landing_page_url":"https://research.rug.nl/en/publications/924f096a-c803-437e-90d0-36a9da887273","pdf_url":null,"source":{"id":"https://openalex.org/S4306400420","display_name":"University of Groningen research database (University of Groningen / Centre for Information Technology)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I169381384","host_organization_name":"University of Groningen","host_organization_lineage":["https://openalex.org/I169381384"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Touw, D J, Vinks, A A T M M & Tans, J T J 1991, 'TOEPASSING VAN THIOPENTAL BIJ VERHOOGDE INTRACRANIELE DRUK. KLINISCHE STUDIE EN VERGELIJKING VAN DIVERSE DOSEERSCHEMA'S MET COMPUTERSIMULATIE', Pharmaceutisch Weekblad, vol. 126, no. 38, pp. 959-966.","raw_type":"info:eu-repo/semantics/publishedVersion"},{"id":"pmh:rug:oai:pure.rug.nl:publications/924f096a-c803-437e-90d0-36a9da887273","doi":null,"is_oa":false,"landing_page_url":"https://research.rug.nl/en/publications/924f096a-c803-437e-90d0-36a9da887273","pdf_url":null,"source":{"id":"https://openalex.org/S4306400420","display_name":"University of Groningen research database (University of Groningen / Centre for Information Technology)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I169381384","host_organization_name":"University of Groningen","host_organization_lineage":["https://openalex.org/I169381384"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Pharmaceutisch Weekblad, 126(38), 959 - 966. Kon. Ned. Mij. ter Bevordering der Pharmacie (KNMP)","raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.98580002784729,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W7025449853","https://openalex.org/W4379513328","https://openalex.org/W2093234745","https://openalex.org/W4300433661","https://openalex.org/W2044689901","https://openalex.org/W2065627314","https://openalex.org/W2397015314","https://openalex.org/W2030562545","https://openalex.org/W2037500960","https://openalex.org/W2191350161"],"abstract_inverted_index":{"Eight":[0],"infusion":[1,18,86],"regimens":[2,19],"for":[3],"thiopental":[4,17,43],"in":[5],"patients":[6],"with":[7],"increased":[8],"intracranial":[9],"pressure":[10],"were":[11,20],"evaluated":[12],"by":[13,55,73,130],"computer":[14],"simulation.":[15],"Seven":[16],"taken":[21],"from":[22],"the":[23,117,123,133],"literature":[24],"and":[25,39,83],"one":[26],"was":[27,101],"developed":[28],"using":[29,144],"published":[30],"pharmacokinetic":[31],"parameters.":[32],"The":[33,97,138],"optimal":[34,98,124],"regimen":[35,64],"to":[36,103,120],"rapidly":[37],"achieve":[38],"maintain":[40],"a":[41,56,62,74,84],"predetermined":[42],"serum":[44,95,134],"concentration":[45,135],"of":[46,50,61,69,77,87,116,132,136],"20-40":[47],"mg/l":[48],"consisted":[49],"two":[51],"loading":[52,75],"doses":[53],"followed":[54,72],"maintenance":[57,85,99,125,139],"infusion.":[58],"Clinical":[59],"evaluation":[60],"dosing":[63],"comprising":[65],"an":[66],"induction":[67],"dose":[68,76,100,126,140],"10":[70],"mg/kg":[71,79],"20":[78],"over":[80],"30":[81],"min":[82],"1.5":[88],"mg":[89,106],"\u00b7":[90,107],"kg-1\u00b7":[91,108],"h-1gave":[92],"inadequate":[93],"steady-state":[94],"concentrations.":[96],"found":[102],"be":[104,128,142],"2.5":[105],"h-1or":[109],"more.":[110],"Within":[111],"6":[112],"h":[113],"after":[114],"initiation":[115],"therapy":[118],"according":[119],"this":[121],"regimen,":[122],"can":[127,141],"calculated":[129],"determination":[131],"thiopental.":[137],"adjusted":[143],"linear":[145],"kinetics.":[146]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-11-30T00:00:00"}