{"id":"https://openalex.org/W2551514716","doi":"https://doi.org/10.1038/onc.2016.380","title":"LMP1 signaling pathway activates IRF4 in latent EBV infection and a positive circuit between PI3K and Src is required","display_name":"LMP1 signaling pathway activates IRF4 in latent EBV infection and a positive circuit between PI3K and Src is required","publication_year":2016,"publication_date":"2016-11-07","ids":{"openalex":"https://openalex.org/W2551514716","doi":"https://doi.org/10.1038/onc.2016.380","mag":"2551514716","pmid":"https://pubmed.ncbi.nlm.nih.gov/27819673","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/5685659"},"language":"en","primary_location":{"id":"doi:10.1038/onc.2016.380","doi":"https://doi.org/10.1038/onc.2016.380","is_oa":false,"landing_page_url":"https://doi.org/10.1038/onc.2016.380","pdf_url":null,"source":{"id":"https://openalex.org/S128439998","display_name":"Oncogene","issn_l":"0950-9232","issn":["0950-9232","1476-5594"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319965","host_organization_name":"Springer Nature","host_organization_lineage":["https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Oncogene","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/5685659","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5102022942","display_name":"Lin Wang","orcid":"https://orcid.org/0000-0002-8857-0379","observed_orcids":["https://orcid.org/0000-0002-8857-0379"]},"institutions":[{"id":"https://openalex.org/I119443389","display_name":"East Tennessee State University","ror":"https://ror.org/05rfqv493","country_code":"US","type":"education","lineage":["https://openalex.org/I119443389"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"L Wang","raw_affiliation_strings":["Center of Excellence for Inflammation, Infectious Disease and Immunity, Quillen College of Medicine, East Tennessee State University, Johnson City, TN, USA","Division of Infectious Diseases, Department of Internal Medicine, Quillen College of Medicine, East Tennessee State University, Johnson City, TN, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center of Excellence for Inflammation, Infectious Disease and Immunity, Quillen College of Medicine, East Tennessee State University, Johnson City, TN, USA","institution_ids":["https://openalex.org/I119443389"]},{"raw_affiliation_string":"Division of Infectious Diseases, Department of Internal Medicine, Quillen College of Medicine, East Tennessee State University, Johnson City, TN, USA","institution_ids":["https://openalex.org/I119443389"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5114230453","display_name":"J Ren","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I119443389","display_name":"East Tennessee State University","ror":"https://ror.org/05rfqv493","country_code":"US","type":"education","lineage":["https://openalex.org/I119443389"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"J Ren","raw_affiliation_strings":["Center of Excellence for Inflammation, Infectious Disease and Immunity, Quillen College of Medicine, East Tennessee State University, Johnson City, TN, USA","Division of Infectious Diseases, Department of Internal Medicine, Quillen College of Medicine, East Tennessee State University, Johnson City, TN, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center of Excellence for Inflammation, Infectious Disease and Immunity, Quillen College of Medicine, East Tennessee State University, Johnson City, TN, USA","institution_ids":["https://openalex.org/I119443389"]},{"raw_affiliation_string":"Division of Infectious Diseases, Department of Internal Medicine, Quillen College of Medicine, East Tennessee State University, Johnson City, TN, USA","institution_ids":["https://openalex.org/I119443389"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100398918","display_name":"Guoping Li","orcid":"https://orcid.org/0000-0003-3874-0744","observed_orcids":["https://orcid.org/0000-0003-3874-0744"]},"institutions":[{"id":"https://openalex.org/I119443389","display_name":"East Tennessee State University","ror":"https://ror.org/05rfqv493","country_code":"US","type":"education","lineage":["https://openalex.org/I119443389"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"G Li","raw_affiliation_strings":["Center of Excellence for Inflammation, Infectious Disease and Immunity, Quillen College of Medicine, East Tennessee State University, Johnson City, TN, USA","Division of Infectious Diseases, Department of Internal Medicine, Quillen College of Medicine, East Tennessee State University, Johnson City, TN, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center of Excellence for Inflammation, Infectious Disease and Immunity, Quillen College of Medicine, East Tennessee State University, Johnson City, TN, USA","institution_ids":["https://openalex.org/I119443389"]},{"raw_affiliation_string":"Division of Infectious Diseases, Department of Internal Medicine, Quillen College of Medicine, East Tennessee State University, Johnson City, TN, USA","institution_ids":["https://openalex.org/I119443389"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5048888623","display_name":"Jonathan P. Moorman","orcid":"https://orcid.org/0000-0002-6102-6541","observed_orcids":["https://orcid.org/0000-0002-6102-6541"]},"institutions":[{"id":"https://openalex.org/I119443389","display_name":"East Tennessee State University","ror":"https://ror.org/05rfqv493","country_code":"US","type":"education","lineage":["https://openalex.org/I119443389"]},{"id":"https://openalex.org/I4210112176","display_name":"James H. Quillen VA Medical Center","ror":"https://ror.org/0246m8g89","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1322918889","https://openalex.org/I2799886695","https://openalex.org/I4210112176","https://openalex.org/I4210112672","https://openalex.org/I4210127243"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"J P Moorman","raw_affiliation_strings":["Center of Excellence for Inflammation, Infectious Disease and Immunity, Quillen College of Medicine, East Tennessee State University, Johnson City, TN, USA","Division of Infectious Diseases, Department of Internal Medicine, Quillen College of Medicine, East Tennessee State University, Johnson City, TN, USA","Hepatitis (HCV/HIV) Program, James H Quillen VA Medical Center, Johnson City, TN, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center of Excellence for Inflammation, Infectious Disease and Immunity, Quillen College of Medicine, East Tennessee State University, Johnson City, TN, USA","institution_ids":["https://openalex.org/I119443389"]},{"raw_affiliation_string":"Division of Infectious Diseases, Department of Internal Medicine, Quillen College of Medicine, East Tennessee State University, Johnson City, TN, USA","institution_ids":["https://openalex.org/I119443389"]},{"raw_affiliation_string":"Hepatitis (HCV/HIV) Program, James H Quillen VA Medical Center, Johnson City, TN, USA","institution_ids":["https://openalex.org/I4210112176"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Z Q Yao","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I119443389","display_name":"East Tennessee State University","ror":"https://ror.org/05rfqv493","country_code":"US","type":"education","lineage":["https://openalex.org/I119443389"]},{"id":"https://openalex.org/I4210112176","display_name":"James H. Quillen VA Medical Center","ror":"https://ror.org/0246m8g89","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1322918889","https://openalex.org/I2799886695","https://openalex.org/I4210112176","https://openalex.org/I4210112672","https://openalex.org/I4210127243"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Z Q Yao","raw_affiliation_strings":["Center of Excellence for Inflammation, Infectious Disease and Immunity, Quillen College of Medicine, East Tennessee State University, Johnson City, TN, USA","Division of Infectious Diseases, Department of Internal Medicine, Quillen College of Medicine, East Tennessee State University, Johnson City, TN, USA","Hepatitis (HCV/HIV) Program, James H Quillen VA Medical Center, Johnson City, TN, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center of Excellence for Inflammation, Infectious Disease and Immunity, Quillen College of Medicine, East Tennessee State University, Johnson City, TN, USA","institution_ids":["https://openalex.org/I119443389"]},{"raw_affiliation_string":"Division of Infectious Diseases, Department of Internal Medicine, Quillen College of Medicine, East Tennessee State University, Johnson City, TN, USA","institution_ids":["https://openalex.org/I119443389"]},{"raw_affiliation_string":"Hepatitis (HCV/HIV) Program, James H Quillen VA Medical Center, Johnson City, TN, USA","institution_ids":["https://openalex.org/I4210112176"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5006834993","display_name":"Shunbin Ning","orcid":"https://orcid.org/0000-0001-5484-5779","observed_orcids":["https://orcid.org/0000-0001-5484-5779"]},"institutions":[{"id":"https://openalex.org/I119443389","display_name":"East Tennessee State University","ror":"https://ror.org/05rfqv493","country_code":"US","type":"education","lineage":["https://openalex.org/I119443389"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"S Ning","raw_affiliation_strings":["Center of Excellence for Inflammation, Infectious Disease and Immunity, Quillen College of Medicine, East Tennessee State University, Johnson City, TN, USA","Division of Infectious Diseases, Department of Internal Medicine, Quillen College of Medicine, East Tennessee State University, Johnson City, TN, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center of Excellence for Inflammation, Infectious Disease and Immunity, Quillen College of Medicine, East Tennessee State University, Johnson City, TN, USA","institution_ids":["https://openalex.org/I119443389"]},{"raw_affiliation_string":"Division of Infectious Diseases, Department of Internal Medicine, Quillen College of Medicine, East Tennessee State University, Johnson City, TN, USA","institution_ids":["https://openalex.org/I119443389"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5006834993"],"corresponding_institution_ids":["https://openalex.org/I119443389"],"apc_list":{"value":5990,"currency":"USD","value_usd":5990},"apc_paid":null,"fwci":2.0195,"has_fulltext":false,"cited_by_count":33,"citation_normalized_percentile":{"value":0.86189449,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":98},"biblio":{"volume":"36","issue":"16","first_page":"2265","last_page":"2274"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11668","display_name":"interferon and immune responses","score":0.5932999849319458,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11668","display_name":"interferon and immune responses","score":0.5932999849319458,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10685","display_name":"Viral-associated cancers and disorders","score":0.18709999322891235,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11503","display_name":"Cytokine Signaling Pathways and Interactions","score":0.09570000320672989,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/epstein-barr-virus","display_name":"Epstein-Barr virus","score":0.8650000095367432},{"id":"https://openalex.org/keywords/latent-membrane-protein-1","display_name":"latent membrane protein 1","score":0.9660000205039978},{"id":"https://openalex.org/keywords/irf4","display_name":"IRF4","score":0.9580000042915344},{"id":"https://openalex.org/keywords/src-kinase","display_name":"Src kinase","score":0.8730000257492065},{"id":"https://openalex.org/keywords/pi3k-p85","display_name":"PI3K p85","score":0.8820000290870667},{"id":"https://openalex.org/keywords/akt","display_name":"Akt","score":0.5550000071525574},{"id":"https://openalex.org/keywords/protein-protein-interaction","display_name":"protein-protein interaction","score":0.7110000252723694},{"id":"https://openalex.org/keywords/viral-latency","display_name":"viral latency","score":0.6259999871253967},{"id":"https://openalex.org/keywords/hematologic-malignancies","display_name":"hematologic malignancies","score":0.8930000066757202},{"id":"https://openalex.org/keywords/signaling-pathways","display_name":"signaling pathways","score":0.5139999985694885}],"concepts":[{"id":"https://openalex.org/C12652872","wikidata":"https://www.wikidata.org/wiki/Q18027997","display_name":"IRF4","level":4,"score":0.837510347366333},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.7471986413002014},{"id":"https://openalex.org/C108636557","wikidata":"https://www.wikidata.org/wiki/Q21109354","display_name":"Proto-oncogene tyrosine-protein kinase Src","level":3,"score":0.6340010762214661},{"id":"https://openalex.org/C86554907","wikidata":"https://www.wikidata.org/wiki/Q285613","display_name":"PI3K/AKT/mTOR pathway","level":3,"score":0.6159732341766357},{"id":"https://openalex.org/C11960822","wikidata":"https://www.wikidata.org/wiki/Q242736","display_name":"Phosphorylation","level":2,"score":0.5836323499679565},{"id":"https://openalex.org/C9173399","wikidata":"https://www.wikidata.org/wiki/Q6046461","display_name":"Interferon regulatory factors","level":4,"score":0.5634351968765259},{"id":"https://openalex.org/C90059517","wikidata":"https://www.wikidata.org/wiki/Q423572","display_name":"Bruton's tyrosine kinase","level":4,"score":0.5529404878616333},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.5360380411148071},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.524605393409729},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.5190290212631226},{"id":"https://openalex.org/C75217442","wikidata":"https://www.wikidata.org/wiki/Q423650","display_name":"Protein kinase B","level":3,"score":0.5112557411193848},{"id":"https://openalex.org/C2777553839","wikidata":"https://www.wikidata.org/wiki/Q14330986","display_name":"Tyrosine phosphorylation","level":3,"score":0.4541260302066803},{"id":"https://openalex.org/C184235292","wikidata":"https://www.wikidata.org/wiki/Q421851","display_name":"Kinase","level":2,"score":0.4121081829071045},{"id":"https://openalex.org/C42362537","wikidata":"https://www.wikidata.org/wiki/Q87099740","display_name":"Tyrosine kinase","level":3,"score":0.41124340891838074},{"id":"https://openalex.org/C86339819","wikidata":"https://www.wikidata.org/wiki/Q407384","display_name":"Transcription factor","level":3,"score":0.31245607137680054},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.09804344177246094},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.06335142254829407}],"mesh":[{"descriptor_ui":"D000099218","descriptor_name":"Interferon Regulatory Factor-4","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002460","descriptor_name":"Cell Line","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010766","descriptor_name":"Phosphorylation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014763","descriptor_name":"Viral Matrix Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015533","descriptor_name":"Transcriptional Activation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016392","descriptor_name":"Proto-Oncogene Proteins pp60(c-src)","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":false},{"descriptor_ui":"D016392","descriptor_name":"Proto-Oncogene Proteins pp60(c-src)","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D020031","descriptor_name":"Epstein-Barr Virus Infections","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D050835","descriptor_name":"Interferon Regulatory Factors","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D050835","descriptor_name":"Interferon Regulatory Factors","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D057809","descriptor_name":"HEK293 Cells","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D058543","descriptor_name":"Class Ia Phosphatidylinositol 3-Kinase","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true}],"locations_count":5,"locations":[{"id":"doi:10.1038/onc.2016.380","doi":"https://doi.org/10.1038/onc.2016.380","is_oa":false,"landing_page_url":"https://doi.org/10.1038/onc.2016.380","pdf_url":null,"source":{"id":"https://openalex.org/S128439998","display_name":"Oncogene","issn_l":"0950-9232","issn":["0950-9232","1476-5594"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319965","host_organization_name":"Springer Nature","host_organization_lineage":["https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Oncogene","raw_type":"journal-article"},{"id":"pmid:27819673","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/27819673","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Oncogene","raw_type":"Journal Article"},{"id":"pmh:oai:europepmc.org:4598571","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/5685659","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:5685659","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/5685659","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Oncogene","raw_type":"Text"},{"id":"pmh:oai:dc.etsu.edu:etsu-works-7781","doi":null,"is_oa":false,"landing_page_url":"https://dc.etsu.edu/etsu-works/6530","pdf_url":null,"source":{"id":"https://openalex.org/S4377196424","display_name":"Digital Commons - East Tennessee State University (East Tennessee State University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I119443389","host_organization_name":"East Tennessee State University","host_organization_lineage":["https://openalex.org/I119443389"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"ETSU Faculty Works","raw_type":"text"}],"best_oa_location":{"id":"pmh:oai:europepmc.org:4598571","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/5685659","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":null,"raw_type":"Text"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9074000120162964}],"study_designs":[],"awards":[{"id":"https://openalex.org/G3807840639","display_name":"Tim-3-mediated IL-12 dysregulation in antiviral responses to HCV infection","funder_award_id":"R01DK093526","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"},{"id":"https://openalex.org/G3827214285","display_name":"miRNA-mediated premature T cell aging in vaccine failure during viral infection","funder_award_id":"R01AI114748","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"}],"funders":[{"id":"https://openalex.org/F4320306127","display_name":"U.S. Department of Veterans Affairs","ror":"https://ror.org/05rsv9s98"},{"id":"https://openalex.org/F4320306571","display_name":"American Society of Hematology","ror":"https://ror.org/02nw48b86"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337355","display_name":"National Institute of Allergy and Infectious Diseases","ror":"https://ror.org/043z4tv69"},{"id":"https://openalex.org/F4320337357","display_name":"National Institute of Diabetes and Digestive and Kidney Diseases","ror":"https://ror.org/00adh9b73"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":57,"referenced_works":["https://openalex.org/W38542969","https://openalex.org/W1541495599","https://openalex.org/W1964664555","https://openalex.org/W1966240259","https://openalex.org/W1972799478","https://openalex.org/W1979187651","https://openalex.org/W1979476707","https://openalex.org/W1981403111","https://openalex.org/W1992057818","https://openalex.org/W1992089657","https://openalex.org/W1992782604","https://openalex.org/W1995175817","https://openalex.org/W1995637295","https://openalex.org/W1998025335","https://openalex.org/W2006406228","https://openalex.org/W2006539626","https://openalex.org/W2008539931","https://openalex.org/W2019565481","https://openalex.org/W2021219384","https://openalex.org/W2023245305","https://openalex.org/W2033212544","https://openalex.org/W2041343298","https://openalex.org/W2043833032","https://openalex.org/W2054361236","https://openalex.org/W2055988969","https://openalex.org/W2056257811","https://openalex.org/W2063201149","https://openalex.org/W2063448523","https://openalex.org/W2065054476","https://openalex.org/W2070828393","https://openalex.org/W2074978411","https://openalex.org/W2086517030","https://openalex.org/W2089732642","https://openalex.org/W2091646547","https://openalex.org/W2101092447","https://openalex.org/W2101588170","https://openalex.org/W2108581914","https://openalex.org/W2112547972","https://openalex.org/W2112757981","https://openalex.org/W2116815941","https://openalex.org/W2126398329","https://openalex.org/W2128788344","https://openalex.org/W2138319005","https://openalex.org/W2142487031","https://openalex.org/W2143916173","https://openalex.org/W2144857397","https://openalex.org/W2158068794","https://openalex.org/W2159147754","https://openalex.org/W2159327683","https://openalex.org/W2164492333","https://openalex.org/W2164814207","https://openalex.org/W2168531609","https://openalex.org/W2170510081","https://openalex.org/W2195279179","https://openalex.org/W2275533696","https://openalex.org/W2323519842","https://openalex.org/W2901531201"],"related_works":["https://openalex.org/W1972799478","https://openalex.org/W7096674217","https://openalex.org/W1976826286","https://openalex.org/W1964664555","https://openalex.org/W2159117635","https://openalex.org/W2133247083","https://openalex.org/W7099436538","https://openalex.org/W2112708549","https://openalex.org/W2065054476","https://openalex.org/W2790335021"],"abstract_inverted_index":null,"counts_by_year":[{"year":2026,"cited_by_count":3},{"year":2025,"cited_by_count":4},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":6},{"year":2022,"cited_by_count":3},{"year":2021,"cited_by_count":3},{"year":2020,"cited_by_count":2},{"year":2019,"cited_by_count":3},{"year":2018,"cited_by_count":3},{"year":2017,"cited_by_count":3},{"year":2016,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-11-30T00:00:00"}
