{"id":"https://openalex.org/W2551386615","doi":null,"title":"DISSOLUTION ENHANCEMENT OF POORLY WATER-SOLUBLE DRUG BY CYCLODEXTRINS INCLUSION COMPLEXATION","display_name":"DISSOLUTION ENHANCEMENT OF POORLY WATER-SOLUBLE DRUG BY CYCLODEXTRINS INCLUSION COMPLEXATION","publication_year":2016,"publication_date":"2016-10-01","ids":{"openalex":"https://openalex.org/W2551386615","mag":"2551386615"},"language":"en","primary_location":{"id":"mag:2551386615","doi":null,"is_oa":true,"landing_page_url":"https://innovareacademics.in/journals/index.php/ijap/article/viewFile/14156/pdf","pdf_url":null,"source":{"id":"https://openalex.org/S2764477652","display_name":"International Journal of Applied Pharmaceutics","issn_l":"0975-7058","issn":["0975-7058"],"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":["poland-100","russia-white-list-3"],"host_organization":"https://openalex.org/P4322697801","host_organization_name":"Innovare Academic Sciences","host_organization_lineage":["https://openalex.org/P4322697801"],"host_organization_lineage_names":["Innovare Academic Sciences"],"type":"journal"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"International Journal of Applied Pharmaceutics","raw_type":null},"volume":null,"type":"article","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":true,"oa_status":"diamond","oa_url":"https://innovareacademics.in/journals/index.php/ijap/article/viewFile/14156/pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5053417675","display_name":"A. A. Mendhe","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"A. A. Mendhe","raw_affiliation_strings":["Ambe Durga Education Society\u2019s , Dadasaheb Balpande college of Pharmacy, Besa, Nagpur"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Ambe Durga Education Society\u2019s , Dadasaheb Balpande college of Pharmacy, Besa, Nagpur","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5079465768","display_name":"Rohini Kharwade","orcid":"https://orcid.org/0000-0002-8133-8083","observed_orcids":["https://orcid.org/0000-0002-8133-8083"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Rohini Kharwade","raw_affiliation_strings":["Ambe Durga Education Society\u2019s , Dadasaheb Balpande college of Pharmacy, Besa, Nagpur"],"raw_orcid":"https://orcid.org/0000-0002-8133-8083","affiliations":[{"raw_affiliation_string":"Ambe Durga Education Society\u2019s , Dadasaheb Balpande college of Pharmacy, Besa, Nagpur","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5038831634","display_name":"Ujwala Mahajan","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Ujwala Mahajan","raw_affiliation_strings":["Ambe Durga Education Society\u2019s , Dadasaheb Balpande college of Pharmacy, Besa, Nagpur"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Ambe Durga Education Society\u2019s , Dadasaheb Balpande college of Pharmacy, Besa, Nagpur","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":1.4747,"has_fulltext":false,"cited_by_count":15,"citation_normalized_percentile":{"value":0.76917088,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"8","issue":"4","first_page":"60","last_page":"65"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10256","display_name":"Drug Solubulity and Delivery Systems","score":1.0,"subfield":{"id":"https://openalex.org/subfields/3003","display_name":"Pharmaceutical Science"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10256","display_name":"Drug Solubulity and Delivery Systems","score":1.0,"subfield":{"id":"https://openalex.org/subfields/3003","display_name":"Pharmaceutical Science"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11881","display_name":"Crystallization and Solubility Studies","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2505","display_name":"Materials Chemistry"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10920","display_name":"Advanced Drug Delivery Systems","score":0.0,"subfield":{"id":"https://openalex.org/subfields/3003","display_name":"Pharmaceutical Science"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/ezetimibe","display_name":"ezetimibe","score":1.0},{"id":"https://openalex.org/keywords/hydroxypropyl-beta-cyclodextrin","display_name":"hydroxypropyl-\u03b2-cyclodextrin","score":0.9409999847412109},{"id":"https://openalex.org/keywords/inclusion-complexes","display_name":"inclusion complexes","score":0.8040000200271606},{"id":"https://openalex.org/keywords/solubility-enhancement","display_name":"solubility enhancement","score":0.9330000281333923},{"id":"https://openalex.org/keywords/poorly-water-soluble-drugs","display_name":"poorly water-soluble drugs","score":0.9950000047683716},{"id":"https://openalex.org/keywords/oral-bioavailability","display_name":"oral bioavailability","score":0.8970000147819519},{"id":"https://openalex.org/keywords/co-grinding","display_name":"co-grinding","score":0.8949999809265137},{"id":"https://openalex.org/keywords/physical-mixtures","display_name":"physical mixtures","score":0.7789999842643738},{"id":"https://openalex.org/keywords/direct-compression-tablets","display_name":"direct compression tablets","score":0.6899999976158142},{"id":"https://openalex.org/keywords/drug-release","display_name":"drug release","score":0.7080000042915344},{"id":"https://openalex.org/keywords/stability","display_name":"stability","score":0.6050000190734863}],"concepts":[{"id":"https://openalex.org/C181389837","wikidata":"https://www.wikidata.org/wiki/Q461809","display_name":"Bioavailability","level":2,"score":0.9071705341339111},{"id":"https://openalex.org/C2778657065","wikidata":"https://www.wikidata.org/wiki/Q417997","display_name":"Ezetimibe","level":3,"score":0.8869377374649048},{"id":"https://openalex.org/C155574463","wikidata":"https://www.wikidata.org/wiki/Q170731","display_name":"Solubility","level":2,"score":0.8154382705688477},{"id":"https://openalex.org/C88380143","wikidata":"https://www.wikidata.org/wiki/Q416674","display_name":"Dissolution","level":2,"score":0.782864511013031},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.7096168994903564},{"id":"https://openalex.org/C39519442","wikidata":"https://www.wikidata.org/wiki/Q904893","display_name":"Differential scanning calorimetry","level":2,"score":0.5765252113342285},{"id":"https://openalex.org/C160892712","wikidata":"https://www.wikidata.org/wiki/Q901559","display_name":"Fourier transform infrared spectroscopy","level":2,"score":0.5597561001777649},{"id":"https://openalex.org/C184651966","wikidata":"https://www.wikidata.org/wiki/Q906356","display_name":"Aqueous solution","level":2,"score":0.5477050542831421},{"id":"https://openalex.org/C2779433975","wikidata":"https://www.wikidata.org/wiki/Q40417805","display_name":"Cyclodextrin","level":2,"score":0.48012351989746094},{"id":"https://openalex.org/C13965031","wikidata":"https://www.wikidata.org/wiki/Q243545","display_name":"Nuclear chemistry","level":1,"score":0.44899457693099976},{"id":"https://openalex.org/C43617362","wikidata":"https://www.wikidata.org/wiki/Q170050","display_name":"Chromatography","level":1,"score":0.4224669337272644},{"id":"https://openalex.org/C42360764","wikidata":"https://www.wikidata.org/wiki/Q83588","display_name":"Chemical engineering","level":1,"score":0.287229061126709},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.24360167980194092},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.20139092206954956},{"id":"https://openalex.org/C2778163477","wikidata":"https://www.wikidata.org/wiki/Q43656","display_name":"Cholesterol","level":2,"score":0.12636440992355347},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.08671671152114868},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.05858910083770752},{"id":"https://openalex.org/C127413603","wikidata":"https://www.wikidata.org/wiki/Q11023","display_name":"Engineering","level":0,"score":0.0},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.0},{"id":"https://openalex.org/C97355855","wikidata":"https://www.wikidata.org/wiki/Q11473","display_name":"Thermodynamics","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"mag:2551386615","doi":null,"is_oa":true,"landing_page_url":"https://innovareacademics.in/journals/index.php/ijap/article/viewFile/14156/pdf","pdf_url":null,"source":{"id":"https://openalex.org/S2764477652","display_name":"International Journal of Applied Pharmaceutics","issn_l":"0975-7058","issn":["0975-7058"],"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":["poland-100","russia-white-list-3"],"host_organization":"https://openalex.org/P4322697801","host_organization_name":"Innovare Academic Sciences","host_organization_lineage":["https://openalex.org/P4322697801"],"host_organization_lineage_names":["Innovare Academic Sciences"],"type":"journal"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"International Journal of Applied Pharmaceutics","raw_type":null}],"best_oa_location":{"id":"mag:2551386615","doi":null,"is_oa":true,"landing_page_url":"https://innovareacademics.in/journals/index.php/ijap/article/viewFile/14156/pdf","pdf_url":null,"source":{"id":"https://openalex.org/S2764477652","display_name":"International Journal of Applied Pharmaceutics","issn_l":"0975-7058","issn":["0975-7058"],"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":["poland-100","russia-white-list-3"],"host_organization":"https://openalex.org/P4322697801","host_organization_name":"Innovare Academic Sciences","host_organization_lineage":["https://openalex.org/P4322697801"],"host_organization_lineage_names":["Innovare Academic Sciences"],"type":"journal"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"International Journal of Applied Pharmaceutics","raw_type":null},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.8371999859809875}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W4407615765","https://openalex.org/W2078886686","https://openalex.org/W599924083","https://openalex.org/W2782881291","https://openalex.org/W3040335187","https://openalex.org/W3004520478","https://openalex.org/W4414377885","https://openalex.org/W4386191402","https://openalex.org/W2159895683","https://openalex.org/W2551961919"],"abstract_inverted_index":{"Objective":[0],":":[1,98,160,276],"Solubility":[4,282],"of":[5,17,21,24,33,52,67,86,105,127,132,167,179,227,252],"a":[6,59,113,250],"drug":[7,34,70,233],"is":[8,28,37,58,71],"an":[9],"important":[10,39],"property":[11],"that":[12,175,232],"mainly":[13],"influences":[14],"the":[15,29,47,65,79,84,128,164,176,224,256,270],"extent":[16],"oral":[18,22],"bioavailability.":[19],"Enhancement":[20],"bioavailability":[23,51,85],"poorly":[25,53],"water-soluble":[26],"drugs":[27],"most":[30],"challenging":[31],"aspects":[32],"development.":[35],"It":[36],"very":[38],"to":[40,45,78,212,243,269],"find":[41],"appropriate":[42],"formulation":[43,248],"approaches":[44],"improve":[46],"aqueous":[48,54],"solubility":[49,104],"and":[50,74,120,150,171,246],"soluble":[55],"drugs.":[56],"Ezetimibe":[57],"new":[60],"lipid":[61],"lowering":[62],"agent":[63],"in":[64,152,193,197,200,237,249],"management":[66],"hypercholesterolemia.":[68],"The":[69,124],"water-insoluble,":[72],"lipophilic,":[73],"highly":[75],"permeable":[76],"according":[77],"pharmaceutical":[80],"classification":[81],"system.":[82],"Therefore,":[83],"ezetimibe":[87,106,133,168,180,204,245],"may":[88],"be":[89],"improved":[90],"by":[91,112,136,184,215],"increasing":[92],"its":[93],"solubility.":[94],"Methods":[97],"In":[101],"present":[102],"work":[103],"was":[107,210,230,235,254],"increased":[108],"with":[109,169,181,205],"inclusion":[110,130,208],"complexes":[111,178],"different":[114],"technique":[115],"like":[116],"physical":[117,125],"mixture,":[118],"co-grinding":[119],"modified":[121,185],"kneading":[122,186],"method.":[123,218],"properties":[126],"prepared":[129,177],"complex":[131,209],"were":[134],"characterised":[135],"Differential":[137],"scanning":[138],"calorimetry":[139],"(DSC),":[140],"X-ray":[141],"diffraction":[142],"spectroscopy":[143,148],"(XRD),":[144],"Fourier":[145],"transform":[146],"infra-red":[147],"(FTIR)":[149],"vitro":[153],"dissolution":[155,165,225],"studies.":[156],"Results":[159],"From":[163,223],"studies":[166],"HP-\u03b2-cyclodextrin(1:1":[170],"1:2),":[172],"we":[173],"conclude":[174],"HP-\u03b2-cyclodextrin":[182,206,284],"(1:2)":[183,207],"method":[187],"showed":[188],"higher":[189],"release":[190,234],"i.e.":[191],"88.35%":[192],"60":[194,201],"min.":[195,202],"than":[196],"(1:1)":[198],"76.75%":[199],"So,":[203],"used":[211],"formulate":[213],"tablet":[214,238],"direct":[216],"compression":[217],"Conclusion:":[221],"data":[226,263],"formulated":[228],"tablets":[229],"observed":[231],"more":[236],"dosage":[239],"form":[240],"as":[241],"compared":[242,268],"plain":[244],"especially":[247],"ratio":[251],"1:2":[253],"found":[255],"promising":[257],"result.":[258,272],"Also":[259],"from":[260],"one-month":[261],"stability":[262],"shows":[264],"no":[265],"significant":[266],"change":[267],"initial":[271],"Keywords":[275],"Ezetimibe,":[279],"Cyclodextrin":[280],"complex,":[281],"enhancement,":[283]},"counts_by_year":[{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":5},{"year":2016,"cited_by_count":1}],"updated_date":"2026-10-28T10:33:24.094632","created_date":"2016-11-30T00:00:00"}