{"id":"https://openalex.org/W2551168096","doi":"https://doi.org/10.58088/hr7w-ee44","title":"Alterations to hippocampal neuroplasticity across the lifespan in a rodent model of FASD","display_name":"Alterations to hippocampal neuroplasticity across the lifespan in a rodent model of FASD","publication_year":2024,"publication_date":"2024-06-04","ids":{"openalex":"https://openalex.org/W2551168096","doi":"https://doi.org/10.58088/hr7w-ee44","mag":"2551168096"},"language":"en","primary_location":{"id":"pmh:oai:udspace.udel.edu:19716/19870","doi":null,"is_oa":true,"landing_page_url":"http://udspace.udel.edu/handle/19716/19870","pdf_url":"http://udspace.udel.edu/handle/19716/19870","source":{"id":"https://openalex.org/S4377196565","display_name":"Library, Museums and Press - UDSpace (University of Delaware)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I86501945","host_organization_name":"University of Delaware","host_organization_lineage":["https://openalex.org/I86501945"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Thesis"},"volume":null,"type":"dissertation","indexed_in":["datacite"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"http://udspace.udel.edu/handle/19716/19870","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5029457476","display_name":"Karen E. Boschen","orcid":"https://orcid.org/0000-0001-5838-0016","observed_orcids":["https://orcid.org/0000-0001-5838-0016"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Boschen, Karen E.","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5029457476"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11633","display_name":"Prenatal Substance Exposure Effects","score":0.9810000061988831,"subfield":{"id":"https://openalex.org/subfields/2735","display_name":"Pediatrics, Perinatology and Child Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11633","display_name":"Prenatal Substance Exposure Effects","score":0.9810000061988831,"subfield":{"id":"https://openalex.org/subfields/2735","display_name":"Pediatrics, Perinatology and Child Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10608","display_name":"Neurogenesis and neuroplasticity mechanisms","score":0.01269999984651804,"subfield":{"id":"https://openalex.org/subfields/2806","display_name":"Developmental Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12963","display_name":"Anesthesia and Neurotoxicity Research","score":0.001500000013038516,"subfield":{"id":"https://openalex.org/subfields/2806","display_name":"Developmental Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/fetal-alcohol-spectrum-disorders","display_name":"fetal alcohol spectrum disorders","score":0.8320000171661377},{"id":"https://openalex.org/keywords/prenatal-alcohol-exposure","display_name":"prenatal alcohol exposure","score":0.972000002861023},{"id":"https://openalex.org/keywords/hippocampal-plasticity","display_name":"hippocampal plasticity","score":0.921999990940094},{"id":"https://openalex.org/keywords/brain-derived-neurotrophic-factor","display_name":"brain-derived neurotrophic factor","score":0.8949999809265137},{"id":"https://openalex.org/keywords/trkb-receptor","display_name":"TrkB receptor","score":0.8349999785423279},{"id":"https://openalex.org/keywords/microglial-activation","display_name":"microglial activation","score":0.7910000085830688},{"id":"https://openalex.org/keywords/neuroinflammation","display_name":"neuroinflammation","score":0.8930000066757202},{"id":"https://openalex.org/keywords/adult-neurogenesis","display_name":"adult neurogenesis","score":0.6679999828338623},{"id":"https://openalex.org/keywords/dentate-granule-cells","display_name":"dentate gyrus granule cells","score":0.9710000157356262},{"id":"https://openalex.org/keywords/long-term-potentiation","display_name":"long-term potentiation","score":0.7289999723434448},{"id":"https://openalex.org/keywords/synaptic-plasticity","display_name":"synaptic plasticity","score":0.6190000176429749},{"id":"https://openalex.org/keywords/learning-and-memory-impairment","display_name":"learning and memory impairment","score":0.6000000238418579},{"id":"https://openalex.org/keywords/rodent-models","display_name":"rodent models","score":0.6539999842643738}],"concepts":[{"id":"https://openalex.org/C2992558993","wikidata":"https://www.wikidata.org/wiki/Q213907","display_name":"Rodent model","level":2,"score":0.8083404302597046},{"id":"https://openalex.org/C47611674","wikidata":"https://www.wikidata.org/wiki/Q849491","display_name":"Neuroplasticity","level":2,"score":0.7983770370483398},{"id":"https://openalex.org/C148762608","wikidata":"https://www.wikidata.org/wiki/Q3748185","display_name":"Hippocampal formation","level":2,"score":0.6627565622329712},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.6409052014350891},{"id":"https://openalex.org/C2778914748","wikidata":"https://www.wikidata.org/wiki/Q10850","display_name":"Rodent","level":2,"score":0.585845947265625},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.48910337686538696},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3128267824649811},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.28833168745040894},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.1475570797920227},{"id":"https://openalex.org/C18903297","wikidata":"https://www.wikidata.org/wiki/Q7150","display_name":"Ecology","level":1,"score":0.0}],"mesh":[],"locations_count":3,"locations":[{"id":"pmh:oai:udspace.udel.edu:19716/19870","doi":null,"is_oa":true,"landing_page_url":"http://udspace.udel.edu/handle/19716/19870","pdf_url":"http://udspace.udel.edu/handle/19716/19870","source":{"id":"https://openalex.org/S4377196565","display_name":"Library, Museums and Press - UDSpace (University of Delaware)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I86501945","host_organization_name":"University of Delaware","host_organization_lineage":["https://openalex.org/I86501945"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Thesis"},{"id":"mag:2551168096","doi":null,"is_oa":false,"landing_page_url":"https://dspace.udel.edu/handle/19716/19870","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null},{"id":"doi:10.58088/hr7w-ee44","doi":"https://doi.org/10.58088/hr7w-ee44","is_oa":true,"landing_page_url":"https://doi.org/10.58088/hr7w-ee44","pdf_url":null,"source":{"id":"https://openalex.org/S7407052053","display_name":"University of Delaware","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I86501945","host_organization_name":"University of Delaware","host_organization_lineage":["https://openalex.org/I86501945"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Dissertation"}],"best_oa_location":{"id":"pmh:oai:udspace.udel.edu:19716/19870","doi":null,"is_oa":true,"landing_page_url":"http://udspace.udel.edu/handle/19716/19870","pdf_url":"http://udspace.udel.edu/handle/19716/19870","source":{"id":"https://openalex.org/S4377196565","display_name":"Library, Museums and Press - UDSpace (University of Delaware)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I86501945","host_organization_name":"University of Delaware","host_organization_lineage":["https://openalex.org/I86501945"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Thesis"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.98580002784729,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2551168096.pdf","grobid_xml":"https://content.openalex.org/works/W2551168096.grobid-xml"},"referenced_works_count":55,"referenced_works":["https://openalex.org/W198155002","https://openalex.org/W1498689470","https://openalex.org/W1642619469","https://openalex.org/W1688233106","https://openalex.org/W1934034828","https://openalex.org/W1940208475","https://openalex.org/W1946041813","https://openalex.org/W1966798058","https://openalex.org/W1968996283","https://openalex.org/W1969854375","https://openalex.org/W1969866098","https://openalex.org/W1982528484","https://openalex.org/W1985403257","https://openalex.org/W1990596248","https://openalex.org/W1990923337","https://openalex.org/W2000757833","https://openalex.org/W2007655172","https://openalex.org/W2011724363","https://openalex.org/W2013450214","https://openalex.org/W2021552563","https://openalex.org/W2028018776","https://openalex.org/W2031045752","https://openalex.org/W2032755846","https://openalex.org/W2034233086","https://openalex.org/W2035448068","https://openalex.org/W2041490149","https://openalex.org/W2042041104","https://openalex.org/W2043466944","https://openalex.org/W2046708720","https://openalex.org/W2048626628","https://openalex.org/W2050042714","https://openalex.org/W2051005796","https://openalex.org/W2056097444","https://openalex.org/W2059389832","https://openalex.org/W2065958702","https://openalex.org/W2073811030","https://openalex.org/W2074515925","https://openalex.org/W2074764259","https://openalex.org/W2075855559","https://openalex.org/W2079031927","https://openalex.org/W2089753821","https://openalex.org/W2092603433","https://openalex.org/W2093694233","https://openalex.org/W2099899980","https://openalex.org/W2126415643","https://openalex.org/W2130189043","https://openalex.org/W2130309422","https://openalex.org/W2130743873","https://openalex.org/W2131573635","https://openalex.org/W2136322496","https://openalex.org/W2141114982","https://openalex.org/W2143437800","https://openalex.org/W2149006337","https://openalex.org/W2150348173","https://openalex.org/W2153038533"],"related_works":["https://openalex.org/W2516205131","https://openalex.org/W7198679932","https://openalex.org/W2106537812","https://openalex.org/W3107551572","https://openalex.org/W299990565","https://openalex.org/W2734597836","https://openalex.org/W2056097444","https://openalex.org/W2305789679","https://openalex.org/W1946041813","https://openalex.org/W2028787364"],"abstract_inverted_index":{"Alcohol":[0,8],"exposure":[1,94,171,199,414,566,658],"in":[2,6,12,22,32,56,73,95,121,147,212,235,274,284,308,321,335,359,369,382,426,450,505,510,543,559,608,628,638,665,674,679],"utero":[3],"can":[4],"result":[5],"Fetal":[7],"Spectrums":[9],"Disorders":[10],"(FASD)":[11],"the":[13,27,96,100,122,134,192,209,213,285,309,322,342,408,427,594,629,652,666,686],"child.":[14],"Patients":[15],"with":[16,75,177,279,540,698],"FASD":[17],"exhibit":[18],"permanent":[19],"structural":[20],"changes":[21],"various":[23],"brain":[24,193],"regions,":[25],"including":[26,43],"hippocampus":[28,98,428],"and":[29,37,47,50,69,99,118,124,183,208,222,231,248,257,267,292,311,325,329,338,350,355,361,388,396,418,422,469,489,522,556,564,600,614,621,632,640,643,690],"functional":[30],"impairments":[31],"many":[33],"aspects":[34],"of":[35,40,59,136,206,220,255,290,327,376,394,411,429,518,585,593,612,616,655,662,688],"cognition":[36],"behavior.":[38],"Measures":[39],"hippocampal":[41,519,553],"neuroplasticity,":[42],"long-term":[44,409],"potentiation,":[45],"synaptic":[46],"dendritic":[48,119,557,591,609,626,660],"organization,":[49],"adult":[51,125,430,470,554,560],"neurogenesis,":[52],"are":[53],"consistently":[54],"disrupted":[55],"rodent":[57],"models":[58],"FASD.":[60,699],"Alterations":[61,484],"to":[62,67,143,196,204,341,373,386,401,438,466,485,567,598,671],"these":[63,573],"neuroplastic":[64],"processes":[65],"contribute":[66,670],"learning":[68],"memory":[70],"deficits":[71,673],"observed":[72,678],"individuals":[74,697],"prenatal":[76],"alcohol":[77,93,170,198,413,657],"exposure.":[78],"This":[79,159,390],"dissertation":[80,160],"examines":[81],"brain-derived":[82],"neurotrophic":[83],"factor":[84],"(BDNF)":[85],"as":[86,103,251,345,398,495,693],"a":[87,104,162,440,451],"molecule":[88],"potentially":[89],"altered":[90,532],"following":[91,240],"neonatal":[92,148,236,412,534,656],"rat":[97,172],"neuroimmune":[101,210],"response":[102,211],"potential":[105],"pathway":[106],"that":[107,133],"exacerbates":[108],"alcohol-induced":[109],"damage.":[110],"BDNF":[111,207,221,265,395,416,468,487,520],"is":[112,145],"critical":[113],"for":[114,696],"cell":[115,348,581,676],"proliferation,":[116],"maturation,":[117],"outgrowth":[120],"developing":[123],"brain.":[126],"Previous":[127],"work":[128],"from":[129,501],"our":[130],"lab":[131],"demonstrated":[132],"number":[135,247,584,611,615],"adult-born":[137],"dentate":[138,323],"gyrus":[139,324],"granule":[140,675],"cells":[141],"surviving":[142],"maturation":[144],"impaired":[146],"alcohol-exposed":[149],"rats":[150,431,563],"(Klintsova":[151],"et":[152,156,473,477,481],"al.,":[153,157,474,478,482],"2007;":[154],"Hamilton":[155,480],"2012).":[158,483],"utilizes":[161],"third":[163],"trimester-equivalent":[164],"(postnatal":[165],"day":[166],"[PD]":[167],"4-9)":[168],"binge-like":[169,197],"model":[173],"(AE;":[174],"5.25":[175],"g/kg/day)":[176],"two":[178],"control":[179,185,544],"groups,":[180],"sham-intubated":[181,286],"(SI)":[182],"undisturbed/suckle":[184],"(SC).":[186],"Specific":[187,404,546,648],"Aim":[188,391,405,547],"1":[189,216],"investigated":[190,549],"how":[191],"initially":[194],"responds":[195],"by":[200,347,448,533],"analyzing":[201],"short-term":[202],"alterations":[203],"expression":[205,254,270,297,358,421,491],"hippocampus.":[214],"Experiment":[215,243,263,315],"examined":[217,407],"protein":[218,266,417,488,521],"levels":[219,271,492,517],"its":[223],"high-affinity":[224],"receptor":[225],"TrkB,":[226],"Bdnf":[227,232,293,301,423,526],"exon-specific":[228,419],"gene":[229,253,269,296,357,420,490,523],"expression,":[230],"DNA":[233,304,424],"methylation":[234,305,425,529,542],"animals":[237,276,371,384,435,497,642],"24":[238],"hours":[239],"AE":[241,275,310,328,343,360,370,383,496,551,577,630],"(PD10).":[242],"2":[244,406],"analyzed":[245],"microglial":[246],"activation":[249,334],"state,":[250],"well":[252],"pro-":[256],"anti-inflammatory":[258,377],"cytokines":[259],"on":[260,415,503,659],"PD10.":[261],"For":[262,314],"1,":[264],"total":[268],"were":[272,318,380,436,493,605],"increased":[273,332,351,381,636],"at":[277],"PD10,":[278],"increases":[280],"also":[281,299,684],"being":[282],"found":[283],"animals.":[287,313,363,545],"Alcohol-specific":[288],"upregulation":[289],"TrkB":[291],"exon":[294,302,527],"I-specific":[295],"was":[298,306,365,530,538],"found.":[300],"I":[303,528],"decreased":[307,590],"SI":[312,330,362,387,599,639],"2,":[316],"there":[317,604],"fewer":[319],"microglia":[320,333],"CA1":[326],"animals,":[331,631],"CA1,":[336],"DG":[337],"CA3":[339],"specific":[340],"group":[344],"measured":[346],"territory,":[349],"IL-1\u03b2,":[352],"TNF-\u03b1,":[353],"CCL4":[354,364],"CD11b":[356],"even":[366],"further":[367],"elevated":[368],"compared":[372,385,597],"SI.":[374],"Levels":[375],"cytokine":[378],"TGF-\u03b2":[379,397],"SC.":[389],"supports":[392],"investigation":[393],"neuroprotective":[399],"responses":[400],"alcohol-related":[402,672],"insult.":[403],"effects":[410],"(PD72).":[432],"In":[433],"addition,":[434],"exposed":[437],"either":[439,568],"\u201csuper-intervention\u201d":[441],"(WREC;":[442],"voluntary":[443],"wheel":[444,457],"running":[445,458],"(PD30-42)":[446],"followed":[447],"housing":[449],"complex":[452,691],"environment":[453],"(PD42-72))":[454],"or":[455,570,583],"continuous":[456],"(WRWR;":[459],"PD30-72).":[460],"Both":[461],"interventions":[462,695],"have":[463],"been":[464],"shown":[465],"enhance":[467],"neurogenesis":[471,555],"(Vivar":[472],"2013;":[475],"Olson":[476],"2006;":[479],"basal":[486],"transient":[494],"do":[498],"not":[499,513,531,579],"differ":[500],"controls":[502],"PD72":[504],"standard":[506],"housing.":[507],"Rats":[508],"housed":[509],"WRWR,":[511],"but":[512,588],"WREC,":[514],"show":[515],"higher":[516],"expression.":[524],"Steady-state":[525],"condition,":[535],"however,":[536],"WRWR":[537,571,622,634],"associated":[539],"less":[541],"3":[548,650],"whether":[550,565],"affects":[552],"morphology":[558,661],"(PD72)":[561],"male":[562],"WREC":[569,620,644],"impacts":[572],"measures.":[574],"As":[575],"expected,":[576],"did":[578],"affect":[580],"proliferation":[582],"immature":[586,595,663],"neurons,":[587],"significantly":[589],"complexity":[592,627,637],"neurons":[596,664],"SC":[601,641],"groups.":[602],"Specifically,":[603],"significant":[606],"decreases":[607],"material,":[610],"intersections,":[613],"bifurcations":[617],"per":[618],"radius.":[619],"both":[623],"robustly":[624],"enhanced":[625],"while":[633],"modestly":[635],"had":[645],"little":[646],"effect.":[647],"Aims":[649],"demonstrates":[651],"long-lasting":[653],"impact":[654],"hippocampus,":[667],"which":[668],"could":[669],"survival":[677],"this":[680],"model.":[681],"These":[682],"studies":[683],"support":[685],"implementation":[687],"exercise":[689],"environments":[692],"therapeutic":[694]},"counts_by_year":[],"updated_date":"2026-10-03T13:16:28.481748","created_date":"2016-11-30T00:00:00"}