{"id":"https://openalex.org/W2551065714","doi":"https://doi.org/10.1364/acpc.2016.as2j.4","title":"Real-time In Vivo Tissue Raman Spectroscopy for Early Cancer Detection","display_name":"Real-time In Vivo Tissue Raman Spectroscopy for Early Cancer Detection","publication_year":2016,"publication_date":"2016-01-01","ids":{"openalex":"https://openalex.org/W2551065714","doi":"https://doi.org/10.1364/acpc.2016.as2j.4","mag":"2551065714"},"language":"en","primary_location":{"id":"doi:10.1364/acpc.2016.as2j.4","doi":"https://doi.org/10.1364/acpc.2016.as2j.4","is_oa":false,"landing_page_url":"https://doi.org/10.1364/acpc.2016.as2j.4","pdf_url":null,"source":{"id":"https://openalex.org/S4363608265","display_name":"Asia Communications and Photonics Conference","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"conference"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Asia Communications and Photonics Conference 2016","raw_type":"proceedings-article"},"volume":null,"type":"conference-paper","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5034358596","display_name":"Haishan Zeng","orcid":"https://orcid.org/0000-0003-3557-2407","observed_orcids":["https://orcid.org/0000-0003-3557-2407"]},"institutions":[{"id":"https://openalex.org/I1289530486","display_name":"BC Cancer Agency","ror":"https://ror.org/03sfybe47","country_code":"CA","type":"healthcare","lineage":["https://openalex.org/I1289530486"]},{"id":"https://openalex.org/I141945490","display_name":"University of British Columbia","ror":"https://ror.org/03rmrcq20","country_code":"CA","type":"education","lineage":["https://openalex.org/I141945490"]},{"id":"https://openalex.org/I4210150180","display_name":"Vancouver Coastal Health Research Institute","ror":"https://ror.org/04htzww22","country_code":"CA","type":"facility","lineage":["https://openalex.org/I141074466","https://openalex.org/I4210150180"]}],"countries":["CA"],"is_corresponding":true,"raw_author_name":"Haishan Zeng","raw_affiliation_strings":["Imaging Unit \u2013 Integrative Oncology Department, BC Cancer Agency Research Centre, Vancouver, BC, Canada V5Z 1L3","Photomedicine Institute \u2013 Department of Dermatology and Skin Science, University of British Columbia and Vancouver Coastal Health Research Institute, Vancouver. Canada V5Z 4E8"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Imaging Unit \u2013 Integrative Oncology Department, BC Cancer Agency Research Centre, Vancouver, BC, Canada V5Z 1L3","institution_ids":["https://openalex.org/I1289530486"]},{"raw_affiliation_string":"Photomedicine Institute \u2013 Department of Dermatology and Skin Science, University of British Columbia and Vancouver Coastal Health Research Institute, Vancouver. Canada V5Z 4E8","institution_ids":["https://openalex.org/I141945490","https://openalex.org/I4210150180"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5001001511","display_name":"Jianhua Zhao","orcid":"https://orcid.org/0000-0002-9848-0983","observed_orcids":["https://orcid.org/0000-0002-9848-0983"]},"institutions":[{"id":"https://openalex.org/I1289530486","display_name":"BC Cancer Agency","ror":"https://ror.org/03sfybe47","country_code":"CA","type":"healthcare","lineage":["https://openalex.org/I1289530486"]},{"id":"https://openalex.org/I141945490","display_name":"University of British Columbia","ror":"https://ror.org/03rmrcq20","country_code":"CA","type":"education","lineage":["https://openalex.org/I141945490"]},{"id":"https://openalex.org/I4210150180","display_name":"Vancouver Coastal Health Research Institute","ror":"https://ror.org/04htzww22","country_code":"CA","type":"facility","lineage":["https://openalex.org/I141074466","https://openalex.org/I4210150180"]}],"countries":["CA"],"is_corresponding":true,"raw_author_name":"Jianhua Zhao","raw_affiliation_strings":["Imaging Unit \u2013 Integrative Oncology Department, BC Cancer Agency Research Centre, Vancouver, BC, Canada V5Z 1L3","Photomedicine Institute \u2013 Department of Dermatology and Skin Science, University of British Columbia and Vancouver Coastal Health Research Institute, Vancouver. Canada V5Z 4E8"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Imaging Unit \u2013 Integrative Oncology Department, BC Cancer Agency Research Centre, Vancouver, BC, Canada V5Z 1L3","institution_ids":["https://openalex.org/I1289530486"]},{"raw_affiliation_string":"Photomedicine Institute \u2013 Department of Dermatology and Skin Science, University of British Columbia and Vancouver Coastal Health Research Institute, Vancouver. Canada V5Z 4E8","institution_ids":["https://openalex.org/I141945490","https://openalex.org/I4210150180"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Michael A. Short","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1289530486","display_name":"BC Cancer Agency","ror":"https://ror.org/03sfybe47","country_code":"CA","type":"healthcare","lineage":["https://openalex.org/I1289530486"]}],"countries":["CA"],"is_corresponding":true,"raw_author_name":"Michael A. Short","raw_affiliation_strings":["Imaging Unit \u2013 Integrative Oncology Department, BC Cancer Agency Research Centre, Vancouver, BC, Canada V5Z 1L3"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Imaging Unit \u2013 Integrative Oncology Department, BC Cancer Agency Research Centre, Vancouver, BC, Canada V5Z 1L3","institution_ids":["https://openalex.org/I1289530486"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111368997","display_name":"David I. McLean","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I141945490","display_name":"University of British Columbia","ror":"https://ror.org/03rmrcq20","country_code":"CA","type":"education","lineage":["https://openalex.org/I141945490"]},{"id":"https://openalex.org/I4210150180","display_name":"Vancouver Coastal Health Research Institute","ror":"https://ror.org/04htzww22","country_code":"CA","type":"facility","lineage":["https://openalex.org/I141074466","https://openalex.org/I4210150180"]}],"countries":["CA"],"is_corresponding":true,"raw_author_name":"David I. McLean","raw_affiliation_strings":["Photomedicine Institute \u2013 Department of Dermatology and Skin Science, University of British Columbia and Vancouver Coastal Health Research Institute, Vancouver. Canada V5Z 4E8"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Photomedicine Institute \u2013 Department of Dermatology and Skin Science, University of British Columbia and Vancouver Coastal Health Research Institute, Vancouver. Canada V5Z 4E8","institution_ids":["https://openalex.org/I141945490","https://openalex.org/I4210150180"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5005876352","display_name":"Stephen C. Lam","orcid":"https://orcid.org/0000-0002-3964-1492","observed_orcids":["https://orcid.org/0000-0002-3964-1492"]},"institutions":[{"id":"https://openalex.org/I1289530486","display_name":"BC Cancer Agency","ror":"https://ror.org/03sfybe47","country_code":"CA","type":"healthcare","lineage":["https://openalex.org/I1289530486"]},{"id":"https://openalex.org/I141945490","display_name":"University of British Columbia","ror":"https://ror.org/03rmrcq20","country_code":"CA","type":"education","lineage":["https://openalex.org/I141945490"]}],"countries":["CA"],"is_corresponding":true,"raw_author_name":"Stephen Lam","raw_affiliation_strings":["Imaging Unit \u2013 Integrative Oncology Department, BC Cancer Agency Research Centre, Vancouver, BC, Canada V5Z 1L3","Respiratory Medicine Division \u2013 Department of Medicine, University of British Columbia, Vancouver, BC, Canada V5Z 1M9"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Imaging Unit \u2013 Integrative Oncology Department, BC Cancer Agency Research Centre, Vancouver, BC, Canada V5Z 1L3","institution_ids":["https://openalex.org/I1289530486"]},{"raw_affiliation_string":"Respiratory Medicine Division \u2013 Department of Medicine, University of British Columbia, Vancouver, BC, Canada V5Z 1M9","institution_ids":["https://openalex.org/I141945490"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5000129599","display_name":"Hanna C. McGregor","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1289530486","display_name":"BC Cancer Agency","ror":"https://ror.org/03sfybe47","country_code":"CA","type":"healthcare","lineage":["https://openalex.org/I1289530486"]}],"countries":["CA"],"is_corresponding":true,"raw_author_name":"Hanna C. McGregor","raw_affiliation_strings":["Imaging Unit \u2013 Integrative Oncology Department, BC Cancer Agency Research Centre, Vancouver, BC, Canada V5Z 1L3"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Imaging Unit \u2013 Integrative Oncology Department, BC Cancer Agency Research Centre, Vancouver, BC, Canada V5Z 1L3","institution_ids":["https://openalex.org/I1289530486"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5089195756","display_name":"Sunil Kalia","orcid":"https://orcid.org/0000-0002-5271-5273","observed_orcids":["https://orcid.org/0000-0002-5271-5273"]},"institutions":[{"id":"https://openalex.org/I141945490","display_name":"University of British Columbia","ror":"https://ror.org/03rmrcq20","country_code":"CA","type":"education","lineage":["https://openalex.org/I141945490"]},{"id":"https://openalex.org/I4210150180","display_name":"Vancouver Coastal Health Research Institute","ror":"https://ror.org/04htzww22","country_code":"CA","type":"facility","lineage":["https://openalex.org/I141074466","https://openalex.org/I4210150180"]}],"countries":["CA"],"is_corresponding":true,"raw_author_name":"Sunil Kalia","raw_affiliation_strings":["Photomedicine Institute \u2013 Department of Dermatology and Skin Science, University of British Columbia and Vancouver Coastal Health Research Institute, Vancouver. Canada V5Z 4E8"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Photomedicine Institute \u2013 Department of Dermatology and Skin Science, University of British Columbia and Vancouver Coastal Health Research Institute, Vancouver. Canada V5Z 4E8","institution_ids":["https://openalex.org/I141945490","https://openalex.org/I4210150180"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5018389530","display_name":"Annette M. McWilliams","orcid":"https://orcid.org/0000-0002-3799-8527","observed_orcids":["https://orcid.org/0000-0002-3799-8527"]},"institutions":[{"id":"https://openalex.org/I1289530486","display_name":"BC Cancer Agency","ror":"https://ror.org/03sfybe47","country_code":"CA","type":"healthcare","lineage":["https://openalex.org/I1289530486"]}],"countries":["CA"],"is_corresponding":true,"raw_author_name":"Annette McWilliams","raw_affiliation_strings":["Imaging Unit \u2013 Integrative Oncology Department, BC Cancer Agency Research Centre, Vancouver, BC, Canada V5Z 1L3"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Imaging Unit \u2013 Integrative Oncology Department, BC Cancer Agency Research Centre, Vancouver, BC, Canada V5Z 1L3","institution_ids":["https://openalex.org/I1289530486"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5010183292","display_name":"Wenbo Wang","orcid":"https://orcid.org/0000-0001-5999-4124","observed_orcids":["https://orcid.org/0000-0001-5999-4124"]},"institutions":[{"id":"https://openalex.org/I1289530486","display_name":"BC Cancer Agency","ror":"https://ror.org/03sfybe47","country_code":"CA","type":"healthcare","lineage":["https://openalex.org/I1289530486"]}],"countries":["CA"],"is_corresponding":true,"raw_author_name":"Wenbo Wang","raw_affiliation_strings":["Imaging Unit \u2013 Integrative Oncology Department, BC Cancer Agency Research Centre, Vancouver, BC, Canada V5Z 1L3"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Imaging Unit \u2013 Integrative Oncology Department, BC Cancer Agency Research Centre, Vancouver, BC, Canada V5Z 1L3","institution_ids":["https://openalex.org/I1289530486"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5021772111","display_name":"Harvey Lui","orcid":"https://orcid.org/0000-0002-0584-5980","observed_orcids":["https://orcid.org/0000-0002-0584-5980"]},"institutions":[{"id":"https://openalex.org/I1289530486","display_name":"BC Cancer Agency","ror":"https://ror.org/03sfybe47","country_code":"CA","type":"healthcare","lineage":["https://openalex.org/I1289530486"]},{"id":"https://openalex.org/I141945490","display_name":"University of British Columbia","ror":"https://ror.org/03rmrcq20","country_code":"CA","type":"education","lineage":["https://openalex.org/I141945490"]},{"id":"https://openalex.org/I4210150180","display_name":"Vancouver Coastal Health Research Institute","ror":"https://ror.org/04htzww22","country_code":"CA","type":"facility","lineage":["https://openalex.org/I141074466","https://openalex.org/I4210150180"]}],"countries":["CA"],"is_corresponding":true,"raw_author_name":"Harvey Lui","raw_affiliation_strings":["Imaging Unit \u2013 Integrative Oncology Department, BC Cancer Agency Research Centre, Vancouver, BC, Canada V5Z 1L3","Photomedicine Institute \u2013 Department of Dermatology and Skin Science, University of British Columbia and Vancouver Coastal Health Research Institute, Vancouver. Canada V5Z 4E8"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Imaging Unit \u2013 Integrative Oncology Department, BC Cancer Agency Research Centre, Vancouver, BC, Canada V5Z 1L3","institution_ids":["https://openalex.org/I1289530486"]},{"raw_affiliation_string":"Photomedicine Institute \u2013 Department of Dermatology and Skin Science, University of British Columbia and Vancouver Coastal Health Research Institute, Vancouver. Canada V5Z 4E8","institution_ids":["https://openalex.org/I141945490","https://openalex.org/I4210150180"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5000129599","https://openalex.org/A5001001511","https://openalex.org/A5005876352","https://openalex.org/A5010183292","https://openalex.org/A5018389530","https://openalex.org/A5021772111","https://openalex.org/A5034358596","https://openalex.org/A5089195756","https://openalex.org/A5111368997"],"corresponding_institution_ids":["https://openalex.org/I1289530486","https://openalex.org/I141945490","https://openalex.org/I4210150180"],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":4,"citation_normalized_percentile":{"value":0.27260813,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":96},"biblio":{"volume":"26","issue":null,"first_page":"AS2J.4","last_page":"AS2J.4"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11324","display_name":"Spectroscopy Techniques in Biomedical and Chemical Research","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1304","display_name":"Biophysics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11324","display_name":"Spectroscopy Techniques in Biomedical and Chemical Research","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1304","display_name":"Biophysics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10977","display_name":"Optical Imaging and Spectroscopy Techniques","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12050","display_name":"Optical Polarization and Ellipsometry","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/in-vivo-raman-spectroscopy","display_name":"in vivo Raman spectroscopy","score":0.8679999709129333},{"id":"https://openalex.org/keywords/early-cancer-detection","display_name":"early cancer detection","score":0.8830000162124634},{"id":"https://openalex.org/keywords/skin-cancer-diagnosis","display_name":"skin cancer diagnosis","score":0.8679999709129333},{"id":"https://openalex.org/keywords/lung-cancer-diagnosis","display_name":"lung cancer diagnosis","score":0.9940000176429749},{"id":"https://openalex.org/keywords/sensitivity-and-specificity","display_name":"sensitivity and specificity","score":0.7639999985694885},{"id":"https://openalex.org/keywords/non-invasive-cancer-diagnosis","display_name":"non-invasive cancer diagnosis","score":0.5669999718666077}],"concepts":[{"id":"https://openalex.org/C40003534","wikidata":"https://www.wikidata.org/wiki/Q862228","display_name":"Raman spectroscopy","level":2,"score":0.6468312740325928},{"id":"https://openalex.org/C2985322473","wikidata":"https://www.wikidata.org/wiki/Q3044843","display_name":"Cancer detection","level":3,"score":0.6115611791610718},{"id":"https://openalex.org/C207001950","wikidata":"https://www.wikidata.org/wiki/Q141124","display_name":"In vivo","level":2,"score":0.605317234992981},{"id":"https://openalex.org/C32891209","wikidata":"https://www.wikidata.org/wiki/Q483666","display_name":"Spectroscopy","level":2,"score":0.5007717609405518},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.4957748353481293},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.44707953929901123},{"id":"https://openalex.org/C192562407","wikidata":"https://www.wikidata.org/wiki/Q228736","display_name":"Materials science","level":0,"score":0.4147745370864868},{"id":"https://openalex.org/C46141821","wikidata":"https://www.wikidata.org/wiki/Q209402","display_name":"Nuclear magnetic resonance","level":1,"score":0.321658730506897},{"id":"https://openalex.org/C120665830","wikidata":"https://www.wikidata.org/wiki/Q14620","display_name":"Optics","level":1,"score":0.2370586097240448},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.19244980812072754},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.18283280730247498},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.1706365942955017},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.09247097373008728},{"id":"https://openalex.org/C150903083","wikidata":"https://www.wikidata.org/wiki/Q7108","display_name":"Biotechnology","level":1,"score":0.0},{"id":"https://openalex.org/C62520636","wikidata":"https://www.wikidata.org/wiki/Q944","display_name":"Quantum mechanics","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1364/acpc.2016.as2j.4","doi":"https://doi.org/10.1364/acpc.2016.as2j.4","is_oa":false,"landing_page_url":"https://doi.org/10.1364/acpc.2016.as2j.4","pdf_url":null,"source":{"id":"https://openalex.org/S4363608265","display_name":"Asia Communications and Photonics Conference","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"conference"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Asia Communications and Photonics Conference 2016","raw_type":"proceedings-article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.8371999859809875,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":7,"referenced_works":["https://openalex.org/W969608678","https://openalex.org/W1972230007","https://openalex.org/W2005636037","https://openalex.org/W2088159530","https://openalex.org/W2091998550","https://openalex.org/W2226029907","https://openalex.org/W2239880116"],"related_works":["https://openalex.org/W1992880649","https://openalex.org/W2325984104","https://openalex.org/W2125024721","https://openalex.org/W2149018056","https://openalex.org/W1571376410","https://openalex.org/W2088397949","https://openalex.org/W2544933902","https://openalex.org/W2005636037","https://openalex.org/W7112586793","https://openalex.org/W2131864221"],"abstract_inverted_index":{"A":[0],"platform":[1],"technology":[2],"for":[3,42],"real-time":[4],"in":[5],"vivo":[6],"tissue":[7],"Raman":[8],"spectroscopy":[9],"was":[10,22],"developed":[11],"that":[12],"takes":[13],"1-2":[14],"seconds":[15],"to":[16],"obtain":[17],"a":[18],"spectrum.":[19],"The":[20],"system":[21],"tested":[23],"over":[24],"900":[25],"skin":[26,43],"patients":[27],"and":[28,37,45],"80":[29],"lung":[30,46],"patients,":[31],"achieved":[32],"high":[33],"diagnostic":[34],"sensitivity":[35],"(90%)":[36],"good":[38],"specificities":[39],"(73%,":[40],"65%)":[41],"cancer":[44,47],"detection.":[48]},"counts_by_year":[{"year":2024,"cited_by_count":1},{"year":2022,"cited_by_count":3}],"updated_date":"2026-10-16T09:59:22.235173","created_date":"2016-11-30T00:00:00"}