{"id":"https://openalex.org/W2551002004","doi":"https://doi.org/10.1016/j.jad.2016.11.029","title":"Cognitive effects of creatine monohydrate adjunctive therapy in patients with bipolar depression: Results from a randomized, double-blind, placebo-controlled trial","display_name":"Cognitive effects of creatine monohydrate adjunctive therapy in patients with bipolar depression: Results from a randomized, double-blind, placebo-controlled trial","publication_year":2016,"publication_date":"2016-11-20","ids":{"openalex":"https://openalex.org/W2551002004","doi":"https://doi.org/10.1016/j.jad.2016.11.029","mag":"2551002004","pmid":"https://pubmed.ncbi.nlm.nih.gov/27890303"},"language":"en","primary_location":{"id":"doi:10.1016/j.jad.2016.11.029","doi":"https://doi.org/10.1016/j.jad.2016.11.029","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.jad.2016.11.029","pdf_url":null,"source":{"id":"https://openalex.org/S113871862","display_name":"Journal of Affective Disorders","issn_l":"0165-0327","issn":["0165-0327","1573-2517"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","erih-plus","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Affective Disorders","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5005806404","display_name":"Ricardo Alexandre Toniolo","orcid":"https://orcid.org/0000-0003-1477-9900","observed_orcids":["https://orcid.org/0000-0003-1477-9900"]},"institutions":[{"id":"https://openalex.org/I17974374","display_name":"Universidade de S\u00e3o Paulo","ror":"https://ror.org/036rp1748","country_code":"BR","type":"education","lineage":["https://openalex.org/I17974374"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Ricardo Alexandre Toniolo","raw_affiliation_strings":["Bipolar Disorder Research Program (PROMAN), Institute of Psychiatry, University of S\u00e3o Paulo Medical School, Brazil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Bipolar Disorder Research Program (PROMAN), Institute of Psychiatry, University of S\u00e3o Paulo Medical School, Brazil","institution_ids":["https://openalex.org/I17974374"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5046077119","display_name":"Francy de Brito Ferreira Fernandes","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I17974374","display_name":"Universidade de S\u00e3o Paulo","ror":"https://ror.org/036rp1748","country_code":"BR","type":"education","lineage":["https://openalex.org/I17974374"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Francy de Brito Ferreira Fernandes","raw_affiliation_strings":["Bipolar Disorder Research Program (PROMAN), Institute of Psychiatry, University of S\u00e3o Paulo Medical School, Brazil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Bipolar Disorder Research Program (PROMAN), Institute of Psychiatry, University of S\u00e3o Paulo Medical School, Brazil","institution_ids":["https://openalex.org/I17974374"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102870034","display_name":"Michelle Silva","orcid":"https://orcid.org/0000-0001-8174-683X","observed_orcids":["https://orcid.org/0000-0001-8174-683X"]},"institutions":[{"id":"https://openalex.org/I17974374","display_name":"Universidade de S\u00e3o Paulo","ror":"https://ror.org/036rp1748","country_code":"BR","type":"education","lineage":["https://openalex.org/I17974374"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Michelle Silva","raw_affiliation_strings":["Bipolar Disorder Research Program (PROMAN), Institute of Psychiatry, University of S\u00e3o Paulo Medical School, Brazil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Bipolar Disorder Research Program (PROMAN), Institute of Psychiatry, University of S\u00e3o Paulo Medical School, Brazil","institution_ids":["https://openalex.org/I17974374"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5015948879","display_name":"Rodrigo da Silva Dias","orcid":"https://orcid.org/0000-0002-1315-7205","observed_orcids":["https://orcid.org/0000-0002-1315-7205"]},"institutions":[{"id":"https://openalex.org/I17974374","display_name":"Universidade de S\u00e3o Paulo","ror":"https://ror.org/036rp1748","country_code":"BR","type":"education","lineage":["https://openalex.org/I17974374"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Rodrigo da Silva Dias","raw_affiliation_strings":["Bipolar Disorder Research Program (PROMAN), Institute of Psychiatry, University of S\u00e3o Paulo Medical School, Brazil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Bipolar Disorder Research Program (PROMAN), Institute of Psychiatry, University of S\u00e3o Paulo Medical School, Brazil","institution_ids":["https://openalex.org/I17974374"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5012165160","display_name":"Beny Lafer","orcid":"https://orcid.org/0000-0002-6132-9999","observed_orcids":["https://orcid.org/0000-0002-6132-9999"]},"institutions":[{"id":"https://openalex.org/I17974374","display_name":"Universidade de S\u00e3o Paulo","ror":"https://ror.org/036rp1748","country_code":"BR","type":"education","lineage":["https://openalex.org/I17974374"]}],"countries":["BR"],"is_corresponding":true,"raw_author_name":"Beny Lafer","raw_affiliation_strings":["Bipolar Disorder Research Program (PROMAN), Institute of Psychiatry, University of S\u00e3o Paulo Medical School, Brazil. Electronic address: blafer@usp.br","Bipolar Disorder Research Program (PROMAN), Institute of Psychiatry, University of S\u00e3o Paulo Medical School, Brazil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Bipolar Disorder Research Program (PROMAN), Institute of Psychiatry, University of S\u00e3o Paulo Medical School, Brazil. Electronic address: blafer@usp.br","institution_ids":["https://openalex.org/I17974374"]},{"raw_affiliation_string":"Bipolar Disorder Research Program (PROMAN), Institute of Psychiatry, University of S\u00e3o Paulo Medical School, Brazil","institution_ids":["https://openalex.org/I17974374"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5012165160"],"corresponding_institution_ids":["https://openalex.org/I17974374"],"apc_list":{"value":3790,"currency":"USD","value_usd":3790},"apc_paid":null,"fwci":2.2927,"has_fulltext":false,"cited_by_count":54,"citation_normalized_percentile":{"value":0.87549527,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":94,"max":100},"biblio":{"volume":"224","issue":null,"first_page":"69","last_page":"75"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10854","display_name":"Bipolar Disorder and Treatment","score":0.9970999956130981,"subfield":{"id":"https://openalex.org/subfields/2738","display_name":"Psychiatry and Mental health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10854","display_name":"Bipolar Disorder and Treatment","score":0.9970999956130981,"subfield":{"id":"https://openalex.org/subfields/2738","display_name":"Psychiatry and Mental health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11071","display_name":"Treatment of Major Depression","score":0.002199999988079071,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10023","display_name":"Schizophrenia research and treatment","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/2738","display_name":"Psychiatry and Mental health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/creatine-monohydrate","display_name":"creatine monohydrate","score":0.9909999966621399},{"id":"https://openalex.org/keywords/bipolar-depression","display_name":"bipolar depression","score":0.984000027179718},{"id":"https://openalex.org/keywords/adjunctive-therapy","display_name":"adjunctive therapy","score":0.8339999914169312},{"id":"https://openalex.org/keywords/nutraceuticals","display_name":"nutraceuticals","score":0.7919999957084656},{"id":"https://openalex.org/keywords/cognitive-impairment","display_name":"cognitive impairment","score":0.9210000038146973},{"id":"https://openalex.org/keywords/verbal-fluency","display_name":"verbal fluency","score":0.9909999966621399},{"id":"https://openalex.org/keywords/neuropsychological-assessment","display_name":"neuropsychological assessment","score":0.7940000295639038},{"id":"https://openalex.org/keywords/bipolar-disorder","display_name":"bipolar disorder","score":0.49799999594688416}],"concepts":[{"id":"https://openalex.org/C97530452","wikidata":"https://www.wikidata.org/wiki/Q7920939","display_name":"Verbal fluency test","level":4,"score":0.6593693494796753},{"id":"https://openalex.org/C2778355293","wikidata":"https://www.wikidata.org/wiki/Q3997285","display_name":"Trail Making Test","level":4,"score":0.6276880502700806},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.5879209041595459},{"id":"https://openalex.org/C2778420670","wikidata":"https://www.wikidata.org/wiki/Q549525","display_name":"Wisconsin Card Sorting Test","level":4,"score":0.5607941746711731},{"id":"https://openalex.org/C27081682","wikidata":"https://www.wikidata.org/wiki/Q269829","display_name":"Placebo","level":3,"score":0.5338889956474304},{"id":"https://openalex.org/C14216870","wikidata":"https://www.wikidata.org/wiki/Q3872","display_name":"Neuropsychology","level":3,"score":0.5239025354385376},{"id":"https://openalex.org/C2776174506","wikidata":"https://www.wikidata.org/wiki/Q131755","display_name":"Bipolar disorder","level":3,"score":0.5109309554100037},{"id":"https://openalex.org/C2910054578","wikidata":"https://www.wikidata.org/wiki/Q223600","display_name":"Creatine Monohydrate","level":4,"score":0.4985489845275879},{"id":"https://openalex.org/C2780046773","wikidata":"https://www.wikidata.org/wiki/Q4948008","display_name":"Boston Naming Test","level":4,"score":0.49834442138671875},{"id":"https://openalex.org/C168563851","wikidata":"https://www.wikidata.org/wiki/Q1436668","display_name":"Randomized controlled trial","level":2,"score":0.47101080417633057},{"id":"https://openalex.org/C2776867660","wikidata":"https://www.wikidata.org/wiki/Q1814941","display_name":"Depression (economics)","level":2,"score":0.438972145318985},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.38589388132095337},{"id":"https://openalex.org/C118552586","wikidata":"https://www.wikidata.org/wiki/Q7867","display_name":"Psychiatry","level":1,"score":0.3679793179035187},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.35165324807167053},{"id":"https://openalex.org/C1862650","wikidata":"https://www.wikidata.org/wiki/Q186005","display_name":"Physical therapy","level":1,"score":0.34129709005355835},{"id":"https://openalex.org/C169900460","wikidata":"https://www.wikidata.org/wiki/Q2200417","display_name":"Cognition","level":2,"score":0.28132539987564087},{"id":"https://openalex.org/C162324750","wikidata":"https://www.wikidata.org/wiki/Q8134","display_name":"Economics","level":0,"score":0.0},{"id":"https://openalex.org/C139719470","wikidata":"https://www.wikidata.org/wiki/Q39680","display_name":"Macroeconomics","level":1,"score":0.0},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.0},{"id":"https://openalex.org/C204787440","wikidata":"https://www.wikidata.org/wiki/Q188504","display_name":"Alternative medicine","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000928","descriptor_name":"Antidepressive Agents","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D001714","descriptor_name":"Bipolar Disorder","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D001714","descriptor_name":"Bipolar Disorder","qualifier_ui":"Q000523","qualifier_name":"psychology","is_major_topic":false},{"descriptor_ui":"D003071","descriptor_name":"Cognition","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003131","descriptor_name":"Combined Modality Therapy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003401","descriptor_name":"Creatine","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D004311","descriptor_name":"Double-Blind Method","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009483","descriptor_name":"Neuropsychological Tests","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D060825","descriptor_name":"Cognitive Dysfunction","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1016/j.jad.2016.11.029","doi":"https://doi.org/10.1016/j.jad.2016.11.029","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.jad.2016.11.029","pdf_url":null,"source":{"id":"https://openalex.org/S113871862","display_name":"Journal of Affective Disorders","issn_l":"0165-0327","issn":["0165-0327","1573-2517"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","erih-plus","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Affective Disorders","raw_type":"journal-article"},{"id":"pmid:27890303","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/27890303","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of affective disorders","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9940000176429749,"display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/randomized-controlled-trial","display_name":"Randomized Controlled Trial"},{"id":"https://openalex.org/study-designs/clinical-trial","display_name":"Clinical Trial"}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":66,"referenced_works":["https://openalex.org/W1504925078","https://openalex.org/W1539586688","https://openalex.org/W1578087489","https://openalex.org/W1849159432","https://openalex.org/W1959849744","https://openalex.org/W1962454315","https://openalex.org/W1968963299","https://openalex.org/W1972620014","https://openalex.org/W1975066065","https://openalex.org/W1976123087","https://openalex.org/W1989117980","https://openalex.org/W2004786369","https://openalex.org/W2005244676","https://openalex.org/W2005405662","https://openalex.org/W2009485462","https://openalex.org/W2018527646","https://openalex.org/W2027687863","https://openalex.org/W2029666918","https://openalex.org/W2030431065","https://openalex.org/W2037810552","https://openalex.org/W2037914981","https://openalex.org/W2041174073","https://openalex.org/W2045724813","https://openalex.org/W2048121589","https://openalex.org/W2048922260","https://openalex.org/W2061378977","https://openalex.org/W2066993348","https://openalex.org/W2069125243","https://openalex.org/W2069678189","https://openalex.org/W2071182308","https://openalex.org/W2071744520","https://openalex.org/W2072529815","https://openalex.org/W2077455126","https://openalex.org/W2083733140","https://openalex.org/W2084693379","https://openalex.org/W2097812147","https://openalex.org/W2100557677","https://openalex.org/W2104870705","https://openalex.org/W2104973711","https://openalex.org/W2108080286","https://openalex.org/W2112136342","https://openalex.org/W2113955924","https://openalex.org/W2117463469","https://openalex.org/W2119349901","https://openalex.org/W2127575529","https://openalex.org/W2131823335","https://openalex.org/W2134017403","https://openalex.org/W2137242866","https://openalex.org/W2138191431","https://openalex.org/W2139463702","https://openalex.org/W2142476463","https://openalex.org/W2146170358","https://openalex.org/W2146736563","https://openalex.org/W2148191063","https://openalex.org/W2155476557","https://openalex.org/W2161147049","https://openalex.org/W2161282771","https://openalex.org/W2162234541","https://openalex.org/W2163398210","https://openalex.org/W2167659819","https://openalex.org/W2277797383","https://openalex.org/W2323058690","https://openalex.org/W2345186616","https://openalex.org/W2413082415","https://openalex.org/W2735928575","https://openalex.org/W3214872913"],"related_works":["https://openalex.org/W2770274569","https://openalex.org/W7120315655","https://openalex.org/W7204193861","https://openalex.org/W2152699744","https://openalex.org/W4403976315","https://openalex.org/W7125141557","https://openalex.org/W2616529935","https://openalex.org/W7162492286","https://openalex.org/W2072183485","https://openalex.org/W2041174073"],"abstract_inverted_index":null,"counts_by_year":[{"year":2026,"cited_by_count":11},{"year":2025,"cited_by_count":12},{"year":2024,"cited_by_count":6},{"year":2023,"cited_by_count":4},{"year":2022,"cited_by_count":5},{"year":2021,"cited_by_count":4},{"year":2020,"cited_by_count":3},{"year":2019,"cited_by_count":4},{"year":2018,"cited_by_count":3},{"year":2017,"cited_by_count":2}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-11-30T00:00:00"}
