{"id":"https://openalex.org/W2550763558","doi":"https://doi.org/10.1182/blood.v104.11.674.674","title":"Incorporation of Bone Marrow Derived Cells in Colonic Adenoma.","display_name":"Incorporation of Bone Marrow Derived Cells in Colonic Adenoma.","publication_year":2004,"publication_date":"2004-11-16","ids":{"openalex":"https://openalex.org/W2550763558","doi":"https://doi.org/10.1182/blood.v104.11.674.674","mag":"2550763558"},"language":"en","primary_location":{"id":"doi:10.1182/blood.v104.11.674.674","doi":"https://doi.org/10.1182/blood.v104.11.674.674","is_oa":false,"landing_page_url":"https://doi.org/10.1182/blood.v104.11.674.674","pdf_url":null,"source":{"id":"https://openalex.org/S200071133","display_name":"Blood","issn_l":"0006-4971","issn":["0006-4971","1528-0020"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Blood","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5042492175","display_name":"Christopher Ramin Cogle","orcid":"https://orcid.org/0000-0001-5422-6863","observed_orcids":["https://orcid.org/0000-0001-5422-6863"]},"institutions":[{"id":"https://openalex.org/I4390039331","display_name":"UF Health Cancer Center","ror":"https://ror.org/044vhe029","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2800717037","https://openalex.org/I33213144","https://openalex.org/I4390039331"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Christopher R. Cogle","raw_affiliation_strings":["Program in Stem Cell Biology and Regenerative Medicine, University of Florida Shands Cancer Center, Gainesville, FL, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Program in Stem Cell Biology and Regenerative Medicine, University of Florida Shands Cancer Center, Gainesville, FL, USA","institution_ids":["https://openalex.org/I4390039331"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5065110693","display_name":"Neil David Theise","orcid":"https://orcid.org/0000-0002-4048-5140","observed_orcids":["https://orcid.org/0000-0002-4048-5140"]},"institutions":[{"id":"https://openalex.org/I129975664","display_name":"Albert Einstein College of Medicine","ror":"https://ror.org/05cf8a891","country_code":"US","type":"education","lineage":["https://openalex.org/I129975664","https://openalex.org/I4210112371"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Neil D. Theise","raw_affiliation_strings":["Liver and Stem Cell Research Laboratory, Albert Einstein College of Medicine, New York, NY, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Liver and Stem Cell Research Laboratory, Albert Einstein College of Medicine, New York, NY, USA","institution_ids":["https://openalex.org/I129975664"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5038468334","display_name":"Marda Jorgensen","orcid":"https://orcid.org/0000-0002-7250-3569","observed_orcids":["https://orcid.org/0000-0002-7250-3569"]},"institutions":[{"id":"https://openalex.org/I4390039331","display_name":"UF Health Cancer Center","ror":"https://ror.org/044vhe029","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2800717037","https://openalex.org/I33213144","https://openalex.org/I4390039331"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Marda L. Jorgensen","raw_affiliation_strings":["Program in Stem Cell Biology and Regenerative Medicine, University of Florida Shands Cancer Center, Gainesville, FL, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Program in Stem Cell Biology and Regenerative Medicine, University of Florida Shands Cancer Center, Gainesville, FL, USA","institution_ids":["https://openalex.org/I4390039331"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5040843630","display_name":"Doug Smith","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4390039331","display_name":"UF Health Cancer Center","ror":"https://ror.org/044vhe029","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2800717037","https://openalex.org/I33213144","https://openalex.org/I4390039331"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Doug Smith","raw_affiliation_strings":["Program in Stem Cell Biology and Regenerative Medicine, University of Florida Shands Cancer Center, Gainesville, FL, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Program in Stem Cell Biology and Regenerative Medicine, University of Florida Shands Cancer Center, Gainesville, FL, USA","institution_ids":["https://openalex.org/I4390039331"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110904187","display_name":"Swan Thung","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I98704320","display_name":"Icahn School of Medicine at Mount Sinai","ror":"https://ror.org/04a9tmd77","country_code":"US","type":"education","lineage":["https://openalex.org/I1320796813","https://openalex.org/I98704320"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Swan L. Thung","raw_affiliation_strings":["Mount Sinai School of Medicine, New York, NY, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Mount Sinai School of Medicine, New York, NY, USA","institution_ids":["https://openalex.org/I98704320"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100322216","display_name":"Chen Liu","orcid":"https://orcid.org/0009-0003-0430-6146","observed_orcids":["https://orcid.org/0009-0003-0430-6146","https://orcid.org/0009-0008-6552-1719"]},"institutions":[{"id":"https://openalex.org/I4390039331","display_name":"UF Health Cancer Center","ror":"https://ror.org/044vhe029","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2800717037","https://openalex.org/I33213144","https://openalex.org/I4390039331"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Chen Liu","raw_affiliation_strings":["Program in Stem Cell Biology and Regenerative Medicine, University of Florida Shands Cancer Center, Gainesville, FL, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Program in Stem Cell Biology and Regenerative Medicine, University of Florida Shands Cancer Center, Gainesville, FL, USA","institution_ids":["https://openalex.org/I4390039331"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5001898266","display_name":"John R. Wingard","orcid":"https://orcid.org/0000-0001-7478-5398","observed_orcids":["https://orcid.org/0000-0001-7478-5398"]},"institutions":[{"id":"https://openalex.org/I4390039331","display_name":"UF Health Cancer Center","ror":"https://ror.org/044vhe029","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2800717037","https://openalex.org/I33213144","https://openalex.org/I4390039331"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"John R. Wingard","raw_affiliation_strings":["Program in Stem Cell Biology and Regenerative Medicine, University of Florida Shands Cancer Center, Gainesville, FL, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Program in Stem Cell Biology and Regenerative Medicine, University of Florida Shands Cancer Center, Gainesville, FL, USA","institution_ids":["https://openalex.org/I4390039331"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5087667645","display_name":"Edward W. Scott","orcid":"https://orcid.org/0000-0002-5668-1795","observed_orcids":["https://orcid.org/0000-0002-5668-1795"]},"institutions":[{"id":"https://openalex.org/I4390039331","display_name":"UF Health Cancer Center","ror":"https://ror.org/044vhe029","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2800717037","https://openalex.org/I33213144","https://openalex.org/I4390039331"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Edward W. Scott","raw_affiliation_strings":["Program in Stem Cell Biology and Regenerative Medicine, University of Florida Shands Cancer Center, Gainesville, FL, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Program in Stem Cell Biology and Regenerative Medicine, University of Florida Shands Cancer Center, Gainesville, FL, USA","institution_ids":["https://openalex.org/I4390039331"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5038468334","https://openalex.org/A5040843630","https://openalex.org/A5100322216","https://openalex.org/A5110904187"],"corresponding_institution_ids":["https://openalex.org/I4390039331","https://openalex.org/I98704320"],"apc_list":{"value":5500,"currency":"USD","value_usd":5500},"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.29091255,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"104","issue":"11","first_page":"674","last_page":"674"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10345","display_name":"Hematopoietic Stem Cell Transplantation","score":0.8198000192642212,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10345","display_name":"Hematopoietic Stem Cell Transplantation","score":0.8198000192642212,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10336","display_name":"Cancer Cells and Metastasis","score":0.05660000070929527,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10176","display_name":"Mesenchymal stem cell research","score":0.01140000019222498,"subfield":{"id":"https://openalex.org/subfields/2716","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/colon-adenoma","display_name":"colonic adenoma","score":0.8479999899864197},{"id":"https://openalex.org/keywords/bone-marrow-derived-cells","display_name":"bone marrow-derived cells","score":0.718999981880188},{"id":"https://openalex.org/keywords/donor-derived-cells","display_name":"donor-derived cells","score":0.6100000143051147},{"id":"https://openalex.org/keywords/bone-marrow-transplantation","display_name":"bone marrow transplantation","score":0.7289999723434448},{"id":"https://openalex.org/keywords/cell-fusion","display_name":"cell fusion","score":0.5180000066757202},{"id":"https://openalex.org/keywords/cytokeratin-20","display_name":"CK20","score":0.7950000166893005},{"id":"https://openalex.org/keywords/cd45","display_name":"CD45","score":0.8560000061988831},{"id":"https://openalex.org/keywords/cxcl12","display_name":"CXCL12","score":0.8880000114440918},{"id":"https://openalex.org/keywords/phagocytosis-of-apoptotic-cells","display_name":"phagocytosis of apoptotic cells","score":0.7229999899864197},{"id":"https://openalex.org/keywords/engraftment","display_name":"engraftment","score":0.5149999856948853}],"concepts":[{"id":"https://openalex.org/C2780007613","wikidata":"https://www.wikidata.org/wiki/Q546523","display_name":"Bone marrow","level":2,"score":0.7038334012031555},{"id":"https://openalex.org/C16930146","wikidata":"https://www.wikidata.org/wiki/Q4381253","display_name":"Stromal cell","level":2,"score":0.6677475571632385},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.6509279012680054},{"id":"https://openalex.org/C2779012181","wikidata":"https://www.wikidata.org/wiki/Q2750567","display_name":"Cytokeratin","level":3,"score":0.6194002032279968},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5009787082672119},{"id":"https://openalex.org/C28328180","wikidata":"https://www.wikidata.org/wiki/Q48196","display_name":"Stem cell","level":2,"score":0.479099303483963},{"id":"https://openalex.org/C201750760","wikidata":"https://www.wikidata.org/wiki/Q1896218","display_name":"Progenitor cell","level":3,"score":0.4317224621772766},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.28188759088516235},{"id":"https://openalex.org/C204232928","wikidata":"https://www.wikidata.org/wiki/Q899285","display_name":"Immunohistochemistry","level":2,"score":0.27120286226272583},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.08297345042228699}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1182/blood.v104.11.674.674","doi":"https://doi.org/10.1182/blood.v104.11.674.674","is_oa":false,"landing_page_url":"https://doi.org/10.1182/blood.v104.11.674.674","pdf_url":null,"source":{"id":"https://openalex.org/S200071133","display_name":"Blood","issn_l":"0006-4971","issn":["0006-4971","1528-0020"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Blood","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9940000176429749}],"sustainable_development_goals_aurora":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.6700000166893005}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2148096805","https://openalex.org/W1996666277","https://openalex.org/W2091016455","https://openalex.org/W2051877723","https://openalex.org/W3174092998","https://openalex.org/W1598017427","https://openalex.org/W2989485062","https://openalex.org/W2025001649","https://openalex.org/W2089686747","https://openalex.org/W1756912296"],"abstract_inverted_index":{"Abstract":[0],"Bone":[1],"marrow":[2,34,44,174,188,228,260],"contains":[3],"stem":[4],"cells":[5,57,66,115,121,130,162,176,190,230,261,305,367],"that":[6,332,356],"can":[7],"engraft":[8],"in":[9,28,78,82,131,243,290,323,343,378],"various":[10],"distant":[11],"organs.":[12],"These":[13],"observations":[14],"prompted":[15],"us":[16],"to":[17,94,125,193,196,252,339],"investigate":[18],"the":[19,68,73,117,128,168,239,265,283,302,307,315,349,354,395],"cellular":[20],"origin":[21],"of":[22,55,63,98,105,110,127,138,143,159,198,238,285,293,334,351,362,374,390,399],"post-transplant":[23],"solid":[24],"tumor":[25,199],"neoplasias":[26,194],"found":[27,50,166,242],"women":[29,40],"having":[30,41],"received":[31,42],"a":[32,61,291,369],"bone":[33,43,173,187,227,259],"transplant":[35],"at":[36],"our":[37,244,400],"facility.":[38],"In":[39,101,280,314],"transplantation":[45],"from":[46],"male":[47,120,149,161],"siblings":[48],"we":[49,357],"colonic":[51,179,240,254],"adenomas":[52,241,308],"post-transplant.":[53],"Presence":[54],"donor-derived":[56,258,303,335,365],"were":[58,165],"examined":[59],"using":[60],"combination":[62],"immunohistochemistry":[64],"for":[65,85,96,123,231],"expressing":[67,163],"pan-leukocyte":[69],"antigen,":[70,75],"CD45,":[71],"and":[72,87,146,208,387],"colonocyte":[74],"cytokeratin":[76,113,164],"20,":[77],"conjunction":[79],"with":[80,151],"fluorescent":[81],"situ":[83],"hybridization":[84],"X":[86,155,312],"Y":[88],"chromosomes.":[89,313],"Confocal":[90,134],"microscopy":[91,135],"was":[92],"used":[93],"evaluate":[95],"evidence":[97,109],"cell":[99,150,272,318],"fusion.":[100],"these":[102,281],"cases,":[103],"recipients":[104],"gender-mismatched":[106],"transplants":[107],"showed":[108],"Y-chromosome":[111],"positive,":[112],"positive":[114],"within":[116,306],"adenomas.":[118,169],"The":[119],"accounted":[122],"1":[124,215],"4%":[126],"adenoma":[129,267,278],"histologic":[132],"section.":[133],"permitted":[136],"evaluation":[137],"entire":[139],"nuclei":[140],"(Z-stack":[141],"steps":[142],"0.25":[144],"microns)":[145],"demonstrated":[147,246,309,322],"no":[148,310],"more":[152],"than":[153],"one":[154,377],"chromosome.":[156],"A":[157,269],"total":[158],"40":[160,360,363],"throughout":[167],"When":[170],"considering":[171],"how":[172],"derived":[175,189,213],"incorporate":[177],"into":[178],"adenomas,":[180],"two":[181],"possibilities":[182],"should":[183,288],"be":[184],"regarded.":[185],"First,":[186],"may":[191,262],"migrate":[192],"due":[195,338],"upregulation":[197],"growth":[200],"factors,":[201],"which":[202],"also":[203],"act":[204],"as":[205,211,233,300],"inflammatory":[206],"cytokines":[207],"chemokines,":[209],"such":[210],"stromal":[212],"factor":[214],"(SDF-1).":[216],"Up-":[217],"or":[218,297],"down-regulating":[219],"SDF-1":[220,236,249],"has":[221,320,329],"profound":[222],"effects":[223],"on":[224,348],"recruiting":[225],"circulating":[226],"stem/progenitor":[229],"engraftment":[232],"end-organ":[234],"epithelia.":[235,255],"staining":[237],"patients":[245],"intense,":[247],"patchy":[248],"expression":[250],"compared":[251],"normal":[253],"Second,":[256],"roving":[257],"have":[263,274],"engulfed":[264],"recipient":[266],"cells.":[268,346],"donor":[270],"scavenger":[271],"could":[273],"phagocytosed":[275],"an":[276],"apoptotic":[277],"cell.":[279],"situations":[282],"fusion":[284,319,371,392],"nuclear":[286],"material":[287],"result":[289],"multiplicity":[292],"sex":[294],"chromosomes":[295],"(XXY":[296],"XXXY).":[298],"However,":[299],"noted,":[301],"epithelial":[304,366],"extra":[311],"liver,":[316],"where":[317],"been":[321,330],"severe":[324],"disease":[325],"stress":[326],"states,":[327],"it":[328],"postulated":[331],"28%":[333,375],"hepatocytes":[336],"are":[337],"reduction":[340],"division,":[341],"resulting":[342],"diploid":[344,364],"daughter":[345],"Based":[347],"probability":[350],"binomial":[352],"distribution,":[353],"chance":[355],"would":[358],"find":[359],"out":[361],"amidst":[368],"background":[370],"resolution":[372,389],"rate":[373],"is":[376,394],"1x10e22.":[379],"Thus,":[380],"direct":[381],"differentiation,":[382],"rather":[383],"then":[384],"absolutely":[385],"complete":[386],"perfect":[388],"every":[391],"event":[393],"most":[396],"likely":[397],"explanation":[398],"current":[401],"findings.":[402]},"counts_by_year":[],"updated_date":"2026-10-27T15:51:10.671819","created_date":"2016-11-30T00:00:00"}
