{"id":"https://openalex.org/W2550192787","doi":"https://doi.org/10.1111/bjh.14430","title":"Ocular extramedullary myeloid leukaemia","display_name":"Ocular extramedullary myeloid leukaemia","publication_year":2016,"publication_date":"2016-11-23","ids":{"openalex":"https://openalex.org/W2550192787","doi":"https://doi.org/10.1111/bjh.14430","mag":"2550192787","pmid":"https://pubmed.ncbi.nlm.nih.gov/27879987"},"language":"en","primary_location":{"id":"doi:10.1111/bjh.14430","doi":"https://doi.org/10.1111/bjh.14430","is_oa":false,"landing_page_url":"https://doi.org/10.1111/bjh.14430","pdf_url":null,"source":{"id":"https://openalex.org/S153015021","display_name":"British Journal of Haematology","issn_l":"0007-1048","issn":["0007-1048","1365-2141"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"British Journal of Haematology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5009316700","display_name":"Maro N. Ohanian","orcid":"https://orcid.org/0000-0002-1689-4470","observed_orcids":["https://orcid.org/0000-0002-1689-4470"]},"institutions":[{"id":"https://openalex.org/I1343551460","display_name":"The University of Texas MD Anderson Cancer Center","ror":"https://ror.org/04twxam07","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1343551460"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Maro Ohanian","raw_affiliation_strings":["Department of Leukemia, The University of Texas M.D. Anderson Cancer Center, Houston, TX, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Leukemia, The University of Texas M.D. Anderson Cancer Center, Houston, TX, USA","institution_ids":["https://openalex.org/I1343551460"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5088307376","display_name":"Naveen Pemmaraju","orcid":"https://orcid.org/0000-0002-1670-6513","observed_orcids":["https://orcid.org/0000-0002-1670-6513"]},"institutions":[{"id":"https://openalex.org/I1343551460","display_name":"The University of Texas MD Anderson Cancer Center","ror":"https://ror.org/04twxam07","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1343551460"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Naveen Pemmaraju","raw_affiliation_strings":["Department of Leukemia, The University of Texas M.D. Anderson Cancer Center, Houston, TX, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Leukemia, The University of Texas M.D. Anderson Cancer Center, Houston, TX, USA","institution_ids":["https://openalex.org/I1343551460"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5050422684","display_name":"Uri Rozovski","orcid":"https://orcid.org/0000-0001-6521-1587","observed_orcids":["https://orcid.org/0000-0001-6521-1587"]},"institutions":[{"id":"https://openalex.org/I1343551460","display_name":"The University of Texas MD Anderson Cancer Center","ror":"https://ror.org/04twxam07","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1343551460"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Uri Rozovski","raw_affiliation_strings":["Department of Leukemia, The University of Texas M.D. Anderson Cancer Center, Houston, TX, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Leukemia, The University of Texas M.D. Anderson Cancer Center, Houston, TX, USA","institution_ids":["https://openalex.org/I1343551460"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5002756413","display_name":"Mona Lisa Alattar","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1343551460","display_name":"The University of Texas MD Anderson Cancer Center","ror":"https://ror.org/04twxam07","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1343551460"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Mona L. Alattar","raw_affiliation_strings":["Department of Leukemia, The University of Texas M.D. Anderson Cancer Center, Houston, TX, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Leukemia, The University of Texas M.D. Anderson Cancer Center, Houston, TX, USA","institution_ids":["https://openalex.org/I1343551460"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5084290698","display_name":"Zeev E. Estrov","orcid":"https://orcid.org/0000-0002-1623-3613","observed_orcids":["https://orcid.org/0000-0002-1623-3613"]},"institutions":[{"id":"https://openalex.org/I1343551460","display_name":"The University of Texas MD Anderson Cancer Center","ror":"https://ror.org/04twxam07","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1343551460"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Zeev Estrov","raw_affiliation_strings":["Department of Leukemia, The University of Texas M.D. Anderson Cancer Center, Houston, TX, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Leukemia, The University of Texas M.D. Anderson Cancer Center, Houston, TX, USA","institution_ids":["https://openalex.org/I1343551460"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5067033760","display_name":"Vikas Kundra","orcid":"https://orcid.org/0000-0002-3262-4059","observed_orcids":["https://orcid.org/0000-0002-3262-4059"]},"institutions":[{"id":"https://openalex.org/I1343551460","display_name":"The University of Texas MD Anderson Cancer Center","ror":"https://ror.org/04twxam07","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1343551460"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Vikas Kundra","raw_affiliation_strings":["Department of Leukemia, The University of Texas M.D. Anderson Cancer Center, Houston, TX, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Leukemia, The University of Texas M.D. Anderson Cancer Center, Houston, TX, USA","institution_ids":["https://openalex.org/I1343551460"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Cynthia Tung","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1343551460","display_name":"The University of Texas MD Anderson Cancer Center","ror":"https://ror.org/04twxam07","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1343551460"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Cynthia Tung","raw_affiliation_strings":["Department of Ophthalmology, The University of Texas M.D. Anderson Cancer Center, Houston, TX, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Ophthalmology, The University of Texas M.D. Anderson Cancer Center, Houston, TX, USA","institution_ids":["https://openalex.org/I1343551460"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5000750846","display_name":"Farhad Ravandi","orcid":"https://orcid.org/0000-0002-7621-377X","observed_orcids":["https://orcid.org/0000-0002-7621-377X"]},"institutions":[{"id":"https://openalex.org/I1343551460","display_name":"The University of Texas MD Anderson Cancer Center","ror":"https://ror.org/04twxam07","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1343551460"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Farhad Ravandi","raw_affiliation_strings":["Department of Leukemia, The University of Texas M.D. Anderson Cancer Center, Houston, TX, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Leukemia, The University of Texas M.D. Anderson Cancer Center, Houston, TX, USA","institution_ids":["https://openalex.org/I1343551460"]}]},{"author_position":"middle","author":{"id":null,"display_name":"John Manning","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1343551460","display_name":"The University of Texas MD Anderson Cancer Center","ror":"https://ror.org/04twxam07","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1343551460"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"John Manning","raw_affiliation_strings":["Department of Hematopathology, The University of Texas M.D. Anderson Cancer Center, Houston, TX, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Hematopathology, The University of Texas M.D. Anderson Cancer Center, Houston, TX, USA","institution_ids":["https://openalex.org/I1343551460"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5059138314","display_name":"Lynne V. Abruzzo","orcid":"https://orcid.org/0000-0001-6113-7447","observed_orcids":["https://orcid.org/0000-0001-6113-7447"]},"institutions":[{"id":"https://openalex.org/I2802841970","display_name":"The Ohio State University Wexner Medical Center","ror":"https://ror.org/00c01js51","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2802841970"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Lynne V. Abruzzo","raw_affiliation_strings":["Department of Pathology, The Ohio State University Wexner Medical Center, Columbus, OH, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology, The Ohio State University Wexner Medical Center, Columbus, OH, USA","institution_ids":["https://openalex.org/I2802841970"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5009316700"],"corresponding_institution_ids":["https://openalex.org/I1343551460"],"apc_list":{"value":5190,"currency":"USD","value_usd":5190},"apc_paid":null,"fwci":1.0226,"has_fulltext":false,"cited_by_count":10,"citation_normalized_percentile":{"value":0.79486202,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":96},"biblio":{"volume":"180","issue":"5","first_page":"738","last_page":"740"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10309","display_name":"Acute Myeloid Leukemia Research","score":0.826200008392334,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10309","display_name":"Acute Myeloid Leukemia Research","score":0.826200008392334,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11328","display_name":"Ocular Oncology and Treatments","score":0.12720000743865967,"subfield":{"id":"https://openalex.org/subfields/2731","display_name":"Ophthalmology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11559","display_name":"Retinoids in leukemia and cellular processes","score":0.01889999955892563,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/acute-myeloid-leukemia","display_name":"acute myeloid leukemia","score":0.9509999752044678},{"id":"https://openalex.org/keywords/21-q22","display_name":"21)(q22","score":0.949999988079071},{"id":"https://openalex.org/keywords/cytogenetics","display_name":"cytogenetics","score":0.5699999928474426},{"id":"https://openalex.org/keywords/molecular-genetics","display_name":"molecular genetics","score":0.8080000281333923},{"id":"https://openalex.org/keywords/relapse","display_name":"relapse","score":0.4359999895095825},{"id":"https://openalex.org/keywords/treatment-response","display_name":"treatment response","score":0.4309999942779541},{"id":"https://openalex.org/keywords/prognostic-factors","display_name":"prognostic factors","score":0.6700000166893005}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.7930173873901367},{"id":"https://openalex.org/C2779282312","wikidata":"https://www.wikidata.org/wiki/Q1956561","display_name":"Myeloid","level":2,"score":0.5546021461486816},{"id":"https://openalex.org/C2780007613","wikidata":"https://www.wikidata.org/wiki/Q546523","display_name":"Bone marrow","level":2,"score":0.46908751130104065},{"id":"https://openalex.org/C2778729363","wikidata":"https://www.wikidata.org/wiki/Q11688946","display_name":"Myeloid leukemia","level":2,"score":0.4397680163383484},{"id":"https://openalex.org/C2778461978","wikidata":"https://www.wikidata.org/wiki/Q29496","display_name":"Leukemia","level":2,"score":0.4168759286403656},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.36288875341415405},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.3457597494125366},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.3427799344062805}],"mesh":[{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000971","descriptor_name":"Antineoplastic Combined Chemotherapy Protocols","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D005134","descriptor_name":"Eye Neoplasms","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":true},{"descriptor_ui":"D005134","descriptor_name":"Eye Neoplasms","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007951","descriptor_name":"Leukemia, Myeloid","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":true},{"descriptor_ui":"D007951","descriptor_name":"Leukemia, Myeloid","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D007951","descriptor_name":"Leukemia, Myeloid","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D008279","descriptor_name":"Magnetic Resonance Imaging","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019046","descriptor_name":"Bone Marrow Neoplasms","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":true},{"descriptor_ui":"D019046","descriptor_name":"Bone Marrow Neoplasms","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D019046","descriptor_name":"Bone Marrow Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D055815","descriptor_name":"Young Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1111/bjh.14430","doi":"https://doi.org/10.1111/bjh.14430","is_oa":false,"landing_page_url":"https://doi.org/10.1111/bjh.14430","pdf_url":null,"source":{"id":"https://openalex.org/S153015021","display_name":"British Journal of Haematology","issn_l":"0007-1048","issn":["0007-1048","1365-2141"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"British Journal of Haematology","raw_type":"journal-article"},{"id":"pmid:27879987","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/27879987","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"British journal of haematology","raw_type":"Letter"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9940000176429749}],"study_designs":[],"awards":[{"id":"https://openalex.org/G293715275","display_name":null,"funder_award_id":"P30-CA-016672","funder_id":"https://openalex.org/F4320332521","funder_display_name":"University of Texas MD Anderson Cancer Center"},{"id":"https://openalex.org/G9000878657","display_name":"Cancer Center Support Grant","funder_award_id":"P30CA016672","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"}],"funders":[{"id":"https://openalex.org/F4320332521","display_name":"University of Texas MD Anderson Cancer Center","ror":"https://ror.org/04twxam07"},{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":10,"referenced_works":["https://openalex.org/W1771040628","https://openalex.org/W1809168908","https://openalex.org/W1814813202","https://openalex.org/W1983769365","https://openalex.org/W1984338974","https://openalex.org/W2018566128","https://openalex.org/W2021407059","https://openalex.org/W2023407523","https://openalex.org/W2046875451","https://openalex.org/W4313146863"],"related_works":["https://openalex.org/W2922272882","https://openalex.org/W2559428862","https://openalex.org/W3094654971","https://openalex.org/W4296529953","https://openalex.org/W2922014191","https://openalex.org/W2153452426","https://openalex.org/W2555573919","https://openalex.org/W2013308704","https://openalex.org/W1814813202","https://openalex.org/W3211687687"],"abstract_inverted_index":{"Given":[0,955],"that":[1,704,740,956,1025,1076],"the":[2,5,10,46,66,149,230,243,349,358,362,570,589,622,824,903,943,957,1009,1028,1042,1089,1105,1109,1112,1119,1129,1133,1138,1145],"eye":[3],"is":[4,316,663,691,874,971,975,1033,1084],"only":[6,931],"organ":[7],"in":[8,354,483,524,533,561,621,642,671,680,699,796,867,879,963,1021,1027,1047,1051,1086],"which":[9,315,553],"vasculature":[11],"can":[12,18],"be":[13,988],"visualized":[14],"directly,":[15],"ocular":[16,49,57,77,146,160,188,249,333,425,480,573,596,669,791,859,961,1056,1061,1134],"examination":[17,1001,1050],"reveal":[19],"systemic":[20,435,461],"disease.":[21],"Retinal":[22],"and":[23,48,51,69,85,131,162,175,227,260,302,408,414,427,432,436,462,473,475,493,501,506,601,631,779,861,894,913,1002,1055,1072,1100,1103,1126,1136,1143],"optic":[24],"nerve":[25],"involvement":[26,153,334],"by":[27,457,466,559,1088],"leukaemia":[28,43,125,215,924],"are":[29,37,598,794,829,847,1005],"well-documented":[30],"(Karesh":[31],"et":[32,61,95,321,607,611,683,687,733,748,840,852,883,899,952,993,1036],"al,":[33,62,96,322,608,612,684,688,734,749,841,884,900,953,994,1037],"1989),":[34],"but":[35,576,653],"there":[36],"few":[38],"reports":[39],"of":[40,45,73,135,152,192,211,232,332,572,625,714,758,770,782,790,806,816,823,870,921,960,1011,1030,1044,1060],"extramedullary":[41],"myeloid":[42,214],"(EML)":[44],"orbit":[47],"adnexae,":[50],"no":[52,743,1150],"standard":[53,381],"treatment":[54,210,578],"guidelines":[55],"for":[56,281,330,356,579,595,717,725,907,946,990,1111],"EML":[58,78,147,161,174,189,319,426,444,481,574,597,694,705,720,728,741,860,1026,1062],"exist":[59],"(Ohanian":[60,94,320,1035],"2013a).":[63,97],"We":[64],"present":[65],"clinicopathological,":[67],"cytogenetic":[68,592,837],"molecular":[70,514],"genetic":[71],"features":[72],"10":[74,90],"patients":[75,244,269,325,370,440,718,726,755,818,1023,1052],"with":[76,106,120,145,247,318,373,423,443,639,666,709,719,831,925,948,968,983,1053,1063],"treated":[79],"at":[80,220,522,569,767,803,932],"our":[81,615],"institution":[82],"between":[83,858],"1999":[84],"2011":[86],"(Table":[87,266,335],"1).":[88,267,336,368],"Case":[89,535,538,543,546,550,565],"was":[91,351],"reported":[92,594,677,703,739,855],"previously":[93],"Our":[98,1039],"Institutional":[99,1113],"Review":[100,1114],"Board":[101],"approved":[102],"this":[103,673],"study.":[104,1116],"AML":[105,115,119,273,382,872,880,947,1022,1054],"t(8;21)(q22;q22)":[107,121],"(AML-M4)":[108,126],"t-AML":[109,111,113],"(RAEB-T)":[110],"(AML-M5a)":[112],"(AML-M5b)":[114],"without":[116,235,727],"maturation":[117],"(AML-M1)":[118,122],"Acute":[123],"myelomonocytic":[124,311,890,923],"At":[127,751],"presentation":[128,523],"six":[129,754],"men":[130],"four":[132,487],"women":[133],"were":[134,531,915],"median":[136,711,769,781,805,1068],"age":[137],"49":[138],"years":[139],"(range,":[140,773,785,809],"19\u201379":[141],"years).":[142],"Two":[143,815,843],"presented":[144,246,372,422,442],"as":[148,229,271,981],"sole":[150,248],"site":[151,231],"(Cases":[154,167,178,182,224,239,275,345,364,376,391,418,445,527,628,635,658,760,798,844,911],"6,":[155,447,529,801],"7);":[156],"two":[157,170,219,228,355,384,617,632,654,910],"had":[158,171,278,742,819],"concurrent":[159,172,221,236,424],"bone":[163],"marrow":[164],"(BM)":[165],"disease":[166,177,194,238,254,375,429,759,1032],"2,":[168,539,659,799,845],"4);":[169],"extra-ocular":[173,490],"BM":[176,193,222,237,253,374,428,519,1031],"5,":[179,185,365,566,636,800],"10).":[180,420,511,645],"Six":[181,369],"1,":[183,225,377,392,536,761],"3,":[184,378,544,629,762],"8\u201310)":[186,379,530],"developed":[187,252,489],"after":[190],"diagnosis":[191,350,789,959,974,1010],"(median":[195],"interval,":[196],"5\u00b73":[197],"months;":[198],"range,":[199],"0\u00b79\u201342\u00b79":[200],"months):":[201],"one":[202,208,251,261,643],"before":[203,577],"chemotherapy":[204,280,399,407,413,417,464,470,474],"initiation":[205],"(Case":[206,217,258,264,289,296,300,305,400,405,410,430,459,468,471,477,495,498,504,510,644],"5),":[207,469,630],"during":[209],"resistant":[212],"acute":[213,922],"(AML)":[216],"3),":[218,297,411],"relapse":[223,234],"10),":[226,637],"isolated":[233],"8,":[240,765],"9).":[241,660],"Of":[242,902],"who":[245,371,441],"EML,":[250,396,667,670],"10\u00b77":[255],"months":[256,716,724,772,784,808],"later":[257],"7)":[259,448,505],"remains":[262],"disease-free":[263],"6)":[265,472,846],"Four":[268,793],"classified":[270],"therapy-related":[272],"(t-AML)":[274],"1\u20135,":[276],"7\u201310)":[277],"received":[279,380,398,449],"a":[282,452,556,582,696,710,768,780,804,832,895,926,1079],"previous":[283,647],"malignancy:":[284],"diffuse":[285],"large":[286],"B-cell":[287],"lymphoma":[288,295],"1),":[290,401,496],"nodular":[291],"sclerosis":[292],"classical":[293],"Hodgkin":[294],"breast":[298,497],"adenocarcinoma":[299,304],"5)":[301],"rectal":[303],"7).":[306,478],"Overall,":[307],"five":[308],"cases":[309,526,618,887,905],"showed":[310,555,619,633,650,655],"or":[312,341,412,891],"monocytic":[313,892],"differentiation,":[314,893],"associated":[317,638,665,830],"2013b).":[323,1038],"All":[324],"underwent":[326,338,385,433],"comprehensive":[327],"ophthalmological":[328,1000,1049],"examinations":[329],"signs/symptoms":[331],"Eight":[337],"surgical":[339],"biopsy":[340,359,991],"fine":[342],"needle":[343],"aspiration":[344],"1\u20134,":[346,528],"6\u20138,":[347],"10);":[348],"established":[352],"clinically":[353],"whom":[357],"risks":[360],"outweighed":[361],"benefits":[363],"9)":[366,802,914],"(Fig":[367],"chemotherapy;":[383],"allogeneic":[386],"stem":[387],"cell":[388],"transplant":[389],"(alloSCT)":[390],"8).":[393],"After":[394],"developing":[395],"they":[397],"radiation":[402],"therapy":[403],"(RT)":[404],"8),":[406],"RT":[409,476],"intrathecal":[415],"(IT)":[416],"9,":[419,551],"One":[421,701,917],"2)":[431],"surgery,":[434],"IT":[437,463],"chemotherapy.":[438],"Three":[439],"4,":[446,547,763],"chemotherapy,":[450],"including":[451,966],"tyrosine":[453],"kinase":[454],"inhibitor,":[455],"followed":[456,465],"alloSCT":[458,467],"4),":[460],"The":[479,661,1058,1147],"resolved":[482],"all":[484],"patients.":[485],"However,":[486,736,977],"subsequently":[488],"EML:":[491],"skin":[492,500],"lung":[494],"2),":[499],"lymph":[502],"nodes":[503],"central":[507],"nervous":[508],"system":[509],"Cytogenetic":[512],"and/or":[513],"diagnostic":[515,944],"analyses":[516],"performed":[517,568],"on":[518,745],"specimens":[520],"obtained":[521],"eight":[525],"abnormal":[532,584],"four:":[534],"46,XY,t(10;11)(p13;q21)[20];":[537],"RUNX1/RUNX1T1":[540,656,820],"(ETO/AML1)":[541],"rearrangement;":[542,549],"46,XY,add(1)(q12),der(3)t(1;3)(q21;q21),add(3)(q26.2),del(7)(q11.2)[8]/47,idem,+7,r(7)(p11.2q11.2)[12];":[545],"BCR/ABL1":[548],"46,XY,del(9)(q13q22)[14]/46,XY[6],":[552],"also":[554],"cryptic":[557],"t(8;21)":[558,662],"fluorescence":[560],"situ":[562],"hybridization.":[563],"In":[564,587,614,996],"karyotyping":[567],"time":[571],"diagnosis,":[575],"AML,":[580],"demonstrated":[581,935],"complex":[583,1070],"karyotype:":[585],"47,XX,del(7)(q22q34),+8[1]/46,XX,del(7)(q22q34),+8,\u221210[15]/46,XX[4].":[586],"adults,":[588],"most":[590],"common":[591],"abnormalities":[593],"\u22127,":[599],"+8,":[600],"11q23":[602],"[KMT2A":[603],"(MLL)]":[604],"rearrangement":[605,657],"(Byrd":[606,732],"1997;":[609],"Pileri":[610],"2007).":[613],"series,":[616],"loss":[620],"long":[623],"arm":[624],"chromosome":[626],"7":[627],"+8":[634],"clonal":[640,1073],"evolution":[641,1074],"Unlike":[646],"reports,":[648],"none":[649],"KMT2A":[651],"rearrangement,":[652],"commonly":[664],"particularly":[668],"children;":[672],"association":[674,857,1059],"has":[675],"been":[676],"less":[678],"often":[679,888],"adults":[681],"(Felice":[682,747,992],"2000;":[685],"Fleckenstein":[686],"2003).":[689],"It":[690],"unclear":[692],"if":[693],"confers":[695],"poor":[697,1080],"prognosis":[698,746,834],"AML.":[700],"group":[702,738],"adversely":[706],"affected":[707],"survival,":[708,1069],"overall":[712],"survival":[713],"5\u00b74":[715],"compared":[721],"to":[722,849,1007],"59\u00b75":[723],"(P":[729],"=":[730],"0\u00b7002)":[731],"1997).":[735],"another":[737],"effect":[744],"2000).":[750,995],"last":[752],"follow-up,":[753],"have":[756],"died":[757],"7,":[764],"10)":[766,920],"21":[771],"8\u201344":[774],"months)":[775,787,811],"from":[776,788,812],"initial":[777,813],"presentation,":[778],"9":[783],"1\u201327":[786],"EML.":[792,1012],"alive":[795],"remission":[797],"66":[807],"10\u201391":[810],"diagnosis.":[814],"these":[817,997],"rearrangement.":[821],"Rearrangements":[822],"core":[825],"binding":[826],"factor":[827],"genes":[828],"better":[833],"than":[835],"other":[836],"subtypes":[838],"(Swerdlow":[839,898,951],"2008).":[842,901,954],"lost":[848],"follow-up.":[850],"Falini":[851],"al":[853],"(2007)":[854],"an":[856,876],"NPM1":[862,864,908,936,949],"mutation.":[863,937],"mutation,":[865,909],"detected":[866],"about":[868],"one-third":[869],"adult":[871],"cases,":[873,998],"likely":[875],"early":[877],"event":[878],"pathogenesis":[881],"(Schnittger":[882],"2009).":[885],"These":[886],"show":[889],"normal":[896,927],"karyotype":[897],"three":[904],"tested":[906,930],"3":[912],"negative.":[916],"case":[918,939],"(case":[919],"diploid":[928],"karyotype,":[929,1071],"second":[933],"relapse,":[934],"This":[938,1082],"would":[940],"probably":[941],"meet":[942],"criteria":[945],"mutation":[950],"differential":[958],"lesions":[962],"immune-compromised":[964],"patients,":[965,979],"those":[967,982],"haematological":[969],"malignancies,":[970],"broad,":[972],"tissue":[973],"invaluable.":[976],"some":[978],"such":[980],"retinal":[984],"infiltrates,":[985],"may":[986],"not":[987],"candidates":[989],"thorough":[999],"imaging":[1003,1020],"studies":[1004,1015],"crucial":[1006],"establish":[1008],"Several":[1013],"small":[1014],"using":[1016],"positron":[1017],"emission":[1018],"tomography":[1019],"suggest":[1024],"absence":[1029],"underreported":[1034],"findings":[1040,1135],"emphasize":[1041],"importance":[1043],"physical":[1045],"and,":[1046],"particular,":[1048],"abnormalities.":[1057],"t-AML,":[1064],"relapsed":[1065],"disease,":[1066],"short":[1067],"suggests":[1075],"it":[1077],"portends":[1078],"prognosis.":[1081],"research":[1083],"supported":[1085],"part":[1087],"MD":[1090],"Anderson":[1091],"Cancer":[1092],"Center":[1093],"Support":[1094],"Grant":[1095],"P30":[1096],"CA016672.":[1097],"MO":[1098],"collected":[1099,1122],"analysed":[1101,1118,1141],"data":[1102,1142],"prepared":[1104,1137,1144],"manuscript.":[1106,1130,1139,1146],"NP":[1107],"wrote":[1108],"protocol":[1110],"Board-approved":[1115],"UR":[1117],"data.":[1120,1123],"MLA":[1121],"ZE,":[1124],"FR":[1125],"JM":[1127],"reviewed":[1128,1132],"CT":[1131],"LVA":[1140],"authors":[1148],"declare":[1149],"competing":[1151],"interests.":[1152]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":2},{"year":2018,"cited_by_count":2}],"updated_date":"2026-11-08T12:12:28.789561","created_date":"2016-11-30T00:00:00"}
