{"id":"https://openalex.org/W2550134727","doi":"https://doi.org/10.1371/journal.pone.0165125","title":"Measuring Sperm DNA Fragmentation and Clinical Outcomes of Medically Assisted Reproduction: A Systematic Review and Meta-Analysis","display_name":"Measuring Sperm DNA Fragmentation and Clinical Outcomes of Medically Assisted Reproduction: A Systematic Review and Meta-Analysis","publication_year":2016,"publication_date":"2016-11-10","ids":{"openalex":"https://openalex.org/W2550134727","doi":"https://doi.org/10.1371/journal.pone.0165125","mag":"2550134727","pmid":"https://pubmed.ncbi.nlm.nih.gov/27832085","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/5104467"},"language":"en","primary_location":{"id":"doi:10.1371/journal.pone.0165125","doi":"https://doi.org/10.1371/journal.pone.0165125","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pone.0165125","pdf_url":"https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0165125&type=printable","source":{"id":"https://openalex.org/S202381698","display_name":"PLoS ONE","issn_l":"1932-6203","issn":["1932-6203"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","erih-plus","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS ONE","raw_type":"journal-article"},"volume":null,"type":"review","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0165125&type=printable","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5112051189","display_name":"Maartje Cissen","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210160169","display_name":"Jeroen Bosch Ziekenhuis","ror":"https://ror.org/04rr42t68","country_code":"NL","type":"healthcare","lineage":["https://openalex.org/I4210160169"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Maartje Cissen","raw_affiliation_strings":["Department of Obstetrics & Gynaecology, Jeroen Bosch Hospital, 's-Hertogenbosch, The Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Obstetrics & Gynaecology, Jeroen Bosch Hospital, 's-Hertogenbosch, The Netherlands","institution_ids":["https://openalex.org/I4210160169"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5018646147","display_name":"Madelon van Wely","orcid":"https://orcid.org/0000-0001-8263-213X","observed_orcids":["https://orcid.org/0000-0001-8263-213X","https://orcid.org/0000-0003-1682-6862"]},"institutions":[{"id":"https://openalex.org/I2802928900","display_name":"Amsterdam UMC Location University of Amsterdam","ror":"https://ror.org/03t4gr691","country_code":"NL","type":"healthcare","lineage":["https://openalex.org/I2802928900","https://openalex.org/I4210151833"]},{"id":"https://openalex.org/I887064364","display_name":"University of Amsterdam","ror":"https://ror.org/04dkp9463","country_code":"NL","type":"education","lineage":["https://openalex.org/I887064364"]}],"countries":["NL"],"is_corresponding":true,"raw_author_name":"Madelon van Wely","raw_affiliation_strings":["Center for Reproductive Medicine, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Reproductive Medicine, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands","institution_ids":["https://openalex.org/I2802928900","https://openalex.org/I887064364"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111974983","display_name":"Irma Scholten","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2802928900","display_name":"Amsterdam UMC Location University of Amsterdam","ror":"https://ror.org/03t4gr691","country_code":"NL","type":"healthcare","lineage":["https://openalex.org/I2802928900","https://openalex.org/I4210151833"]},{"id":"https://openalex.org/I887064364","display_name":"University of Amsterdam","ror":"https://ror.org/04dkp9463","country_code":"NL","type":"education","lineage":["https://openalex.org/I887064364"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Irma Scholten","raw_affiliation_strings":["Center for Reproductive Medicine, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Reproductive Medicine, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands","institution_ids":["https://openalex.org/I2802928900","https://openalex.org/I887064364"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109238384","display_name":"Steven A. Mansell","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I95457486","display_name":"University of California, Berkeley","ror":"https://ror.org/01an7q238","country_code":"US","type":"education","lineage":["https://openalex.org/I95457486"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Steven Mansell","raw_affiliation_strings":["Department of Molecular and Cell Biology, University of California, Berkeley, California, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Molecular and Cell Biology, University of California, Berkeley, California, United States of America","institution_ids":["https://openalex.org/I95457486"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5019000020","display_name":"Jan Peter de Bruin","orcid":"https://orcid.org/0000-0002-6909-5912","observed_orcids":["https://orcid.org/0000-0002-6909-5912"]},"institutions":[{"id":"https://openalex.org/I4210160169","display_name":"Jeroen Bosch Ziekenhuis","ror":"https://ror.org/04rr42t68","country_code":"NL","type":"healthcare","lineage":["https://openalex.org/I4210160169"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Jan Peter de Bruin","raw_affiliation_strings":["Department of Obstetrics & Gynaecology, Jeroen Bosch Hospital, 's-Hertogenbosch, The Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Obstetrics & Gynaecology, Jeroen Bosch Hospital, 's-Hertogenbosch, The Netherlands","institution_ids":["https://openalex.org/I4210160169"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5090795384","display_name":"Ben W. Mol","orcid":"https://orcid.org/0000-0001-8337-550X","observed_orcids":["https://orcid.org/0000-0001-8337-550X"]},"institutions":[{"id":"https://openalex.org/I5681781","display_name":"The University of Adelaide","ror":"https://ror.org/00892tw58","country_code":"AU","type":"education","lineage":["https://openalex.org/I4405259444","https://openalex.org/I5681781"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"Ben Willem Mol","raw_affiliation_strings":["The Robinson Institute/School of Paediatrics and Reproductive Health, University of Adelaide, Adelaide, Australia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Robinson Institute/School of Paediatrics and Reproductive Health, University of Adelaide, Adelaide, Australia","institution_ids":["https://openalex.org/I5681781"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5020207122","display_name":"Didi D.M. Braat","orcid":"https://orcid.org/0000-0002-0847-3684","observed_orcids":["https://orcid.org/0000-0002-0847-3684"]},"institutions":[{"id":"https://openalex.org/I2802934949","display_name":"Radboud University Medical Center","ror":"https://ror.org/05wg1m734","country_code":"NL","type":"healthcare","lineage":["https://openalex.org/I2802934949"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Didi Braat","raw_affiliation_strings":["Department of Obstetrics and Gynaecology, Radboud University Medical Center, Nijmegen, The Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Obstetrics and Gynaecology, Radboud University Medical Center, Nijmegen, The Netherlands","institution_ids":["https://openalex.org/I2802934949"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5002367526","display_name":"Sjoerd Repping","orcid":"https://orcid.org/0000-0002-6959-149X","observed_orcids":["https://orcid.org/0000-0002-6959-149X"]},"institutions":[{"id":"https://openalex.org/I2802928900","display_name":"Amsterdam UMC Location University of Amsterdam","ror":"https://ror.org/03t4gr691","country_code":"NL","type":"healthcare","lineage":["https://openalex.org/I2802928900","https://openalex.org/I4210151833"]},{"id":"https://openalex.org/I887064364","display_name":"University of Amsterdam","ror":"https://ror.org/04dkp9463","country_code":"NL","type":"education","lineage":["https://openalex.org/I887064364"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Sjoerd Repping","raw_affiliation_strings":["Center for Reproductive Medicine, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Reproductive Medicine, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands","institution_ids":["https://openalex.org/I2802928900","https://openalex.org/I887064364"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5079310734","display_name":"Geert Hamer","orcid":"https://orcid.org/0000-0002-9583-6796","observed_orcids":["https://orcid.org/0000-0002-9583-6796"]},"institutions":[{"id":"https://openalex.org/I2802928900","display_name":"Amsterdam UMC Location University of Amsterdam","ror":"https://ror.org/03t4gr691","country_code":"NL","type":"healthcare","lineage":["https://openalex.org/I2802928900","https://openalex.org/I4210151833"]},{"id":"https://openalex.org/I887064364","display_name":"University of Amsterdam","ror":"https://ror.org/04dkp9463","country_code":"NL","type":"education","lineage":["https://openalex.org/I887064364"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Geert Hamer","raw_affiliation_strings":["Center for Reproductive Medicine, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Reproductive Medicine, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands","institution_ids":["https://openalex.org/I2802928900","https://openalex.org/I887064364"]}]}],"institutions":[],"countries_distinct_count":3,"institutions_distinct_count":6,"corresponding_author_ids":["https://openalex.org/A5018646147"],"corresponding_institution_ids":["https://openalex.org/I2802928900","https://openalex.org/I887064364"],"apc_list":{"value":2382,"currency":"USD","value_usd":2382},"apc_paid":{"value":2382,"currency":"USD","value_usd":2382},"fwci":4.0227,"has_fulltext":true,"cited_by_count":343,"citation_normalized_percentile":{"value":0.97282609,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":99,"max":100},"biblio":{"volume":"11","issue":"11","first_page":"e0165125","last_page":"e0165125"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10116","display_name":"Sperm and Testicular Function","score":0.9940999746322632,"subfield":{"id":"https://openalex.org/subfields/2743","display_name":"Reproductive Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10116","display_name":"Sperm and Testicular Function","score":0.9940999746322632,"subfield":{"id":"https://openalex.org/subfields/2743","display_name":"Reproductive Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11156","display_name":"Reproductive Health and Technologies","score":0.0031999999191612005,"subfield":{"id":"https://openalex.org/subfields/2743","display_name":"Reproductive Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10364","display_name":"Reproductive Biology and Fertility","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2743","display_name":"Reproductive Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/sperm-dna-fragmentation","display_name":"sperm DNA fragmentation","score":1.0},{"id":"https://openalex.org/keywords/sperm-chromatin-structure-assay","display_name":"sperm chromatin structure assay","score":0.8119999766349792},{"id":"https://openalex.org/keywords/sperm-chromatin-dispersion","display_name":"sperm chromatin dispersion test","score":0.9549999833106995},{"id":"https://openalex.org/keywords/tunel-assay","display_name":"TUNEL","score":0.9919999837875366},{"id":"https://openalex.org/keywords/comet-assay","display_name":"comet assay","score":0.8939999938011169},{"id":"https://openalex.org/keywords/in-vitro-fertilization","display_name":"in vitro fertilization","score":0.6209999918937683},{"id":"https://openalex.org/keywords/intracytoplasmic-sperm-injection","display_name":"intracytoplasmic sperm injection","score":0.9860000014305115},{"id":"https://openalex.org/keywords/assisted-reproductive-technology","display_name":"assisted reproduction","score":0.5889999866485596},{"id":"https://openalex.org/keywords/diagnostic-accuracy","display_name":"diagnostic accuracy","score":0.6140000224113464},{"id":"https://openalex.org/keywords/sensitivity-and-specificity","display_name":"sensitivity and specificity","score":0.6909999847412109}],"concepts":[{"id":"https://openalex.org/C43759708","wikidata":"https://www.wikidata.org/wiki/Q3749256","display_name":"DNA fragmentation","level":4,"score":0.8125332593917847},{"id":"https://openalex.org/C2781087480","wikidata":"https://www.wikidata.org/wiki/Q17145","display_name":"Sperm","level":2,"score":0.6923515200614929},{"id":"https://openalex.org/C16685009","wikidata":"https://www.wikidata.org/wiki/Q335057","display_name":"Andrology","level":1,"score":0.5978116989135742},{"id":"https://openalex.org/C2780358455","wikidata":"https://www.wikidata.org/wiki/Q903780","display_name":"Comet assay","level":4,"score":0.5229262113571167},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5081872940063477},{"id":"https://openalex.org/C2777589648","wikidata":"https://www.wikidata.org/wiki/Q1501844","display_name":"Semen analysis","level":4,"score":0.43896064162254333},{"id":"https://openalex.org/C2777338322","wikidata":"https://www.wikidata.org/wiki/Q280156","display_name":"Male infertility","level":4,"score":0.4260748624801636},{"id":"https://openalex.org/C196795494","wikidata":"https://www.wikidata.org/wiki/Q1624817","display_name":"TUNEL assay","level":3,"score":0.4159262180328369},{"id":"https://openalex.org/C143425029","wikidata":"https://www.wikidata.org/wiki/Q5205747","display_name":"DNA damage","level":3,"score":0.32342082262039185},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.2724727392196655},{"id":"https://openalex.org/C2777688143","wikidata":"https://www.wikidata.org/wiki/Q179399","display_name":"Infertility","level":3,"score":0.26389995217323303},{"id":"https://openalex.org/C2779234561","wikidata":"https://www.wikidata.org/wiki/Q11995","display_name":"Pregnancy","level":2,"score":0.26368772983551025},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.17543014883995056},{"id":"https://openalex.org/C552990157","wikidata":"https://www.wikidata.org/wiki/Q7430","display_name":"DNA","level":2,"score":0.14832711219787598},{"id":"https://openalex.org/C190283241","wikidata":"https://www.wikidata.org/wiki/Q14599311","display_name":"Apoptosis","level":2,"score":0.09041896462440491},{"id":"https://openalex.org/C31573885","wikidata":"https://www.wikidata.org/wiki/Q304484","display_name":"Programmed cell death","level":3,"score":0.08980122208595276}],"mesh":[{"descriptor_ui":"D000022","descriptor_name":"Abortion, Spontaneous","qualifier_ui":"Q000453","qualifier_name":"epidemiology","is_major_topic":false},{"descriptor_ui":"D002843","descriptor_name":"Chromatin","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005307","descriptor_name":"Fertilization in Vitro","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011247","descriptor_name":"Pregnancy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013094","descriptor_name":"Spermatozoa","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D013094","descriptor_name":"Spermatozoa","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D018873","descriptor_name":"Pregnancy Rate","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020287","descriptor_name":"In Situ Nick-End Labeling","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020552","descriptor_name":"Comet Assay","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D053938","descriptor_name":"DNA Fragmentation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D055101","descriptor_name":"Semen Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":10,"locations":[{"id":"doi:10.1371/journal.pone.0165125","doi":"https://doi.org/10.1371/journal.pone.0165125","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pone.0165125","pdf_url":"https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0165125&type=printable","source":{"id":"https://openalex.org/S202381698","display_name":"PLoS ONE","issn_l":"1932-6203","issn":["1932-6203"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","erih-plus","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS ONE","raw_type":"journal-article"},{"id":"pmid:27832085","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/27832085","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PloS one","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:5104467","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC5104467/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS One","raw_type":"Text"},{"id":"pmh:oai:pure.amsterdamumc.nl:openaire/845ae5d4-b343-41a6-902e-ffdbcfc47dbd","doi":null,"is_oa":true,"landing_page_url":"https://pure.amsterdamumc.nl/en/publications/845ae5d4-b343-41a6-902e-ffdbcfc47dbd","pdf_url":"https://pure.amsterdamumc.nl/ws/files/173143827/Measuring-sperm-dna-fragmentation-and-clinical-outcomes-of-medically-assisted-reproduction-a-systematic-review-and-meta.pdf","source":{"id":"https://openalex.org/S7407055222","display_name":"Pure Amsterdam UMC","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Cissen, M, Wely, M V, Scholten, I, Mansell, S, Bruin, J P D, Mol, B W, Braat, D, Repping, S & Hamer, G 2016, 'Measuring Sperm DNA Fragmentation and Clinical Outcomes of Medically Assisted Reproduction: A Systematic Review and Meta-Analysis', PLoS ONE, vol. 11, no. 11, pp. e0165125. https://doi.org/10.1371/journal.pone.0165125","raw_type":"info:eu-repo/semantics/review"},{"id":"pmh:ru:oai:repository.ubn.ru.nl:2066/170951","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/2066/170951","pdf_url":"http://hdl.handle.net/2066/170951","source":{"id":"https://openalex.org/S4306401067","display_name":"Radboud Repository (Radboud University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I145872427","host_organization_name":"Radboud University Nijmegen","host_organization_lineage":["https://openalex.org/I145872427"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS One, 11","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:amcpub:oai:pure.amc.nl:publications/ac5e3ec7-3446-47e0-8619-426f682b1d4d","doi":null,"is_oa":false,"landing_page_url":"https://pure.amc.nl/en/publications/measuring-sperm-dna-fragmentation-and-clinical-outcomes-of-medically-assisted-reproduction-a-systematic-review-and-metaanalysis(ac5e3ec7-3446-47e0-8619-426f682b1d4d).html","pdf_url":null,"source":{"id":"https://openalex.org/S4306401843","display_name":"Data Archiving and Networked Services (DANS)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1322597698","host_organization_name":"Royal Netherlands Academy of Arts and Sciences","host_organization_lineage":["https://openalex.org/I1322597698"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS ONE, 11(11). Public Library of Science","raw_type":"info:eu-repo/semantics/other"},{"id":"pmh:oai:RePEc:plo:pone00:0165125","doi":null,"is_oa":false,"landing_page_url":"https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0165125","pdf_url":null,"source":{"id":"https://openalex.org/S4306401271","display_name":"RePEc: Research Papers in Economics","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I77793887","host_organization_name":"Federal Reserve Bank of St. Louis","host_organization_lineage":["https://openalex.org/I77793887"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"article"},{"id":"pmh:oai:digital.library.adelaide.edu.au:2440/113239","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/2440/113239","pdf_url":null,"source":{"id":"https://openalex.org/S4306401835","display_name":"Adelaide Research & Scholarship (AR&S) (University of Adelaide)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I5681781","host_organization_name":"The University of Adelaide","host_organization_lineage":["https://openalex.org/I5681781"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"http://dx.doi.org/10.1371/journal.pone.0165125","raw_type":"Journal article"},{"id":"pmh:oai:doaj.org/article:943093144c3f407bb6c2f3dc40b658d6","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/943093144c3f407bb6c2f3dc40b658d6","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS ONE, Vol 11, Iss 11, p e0165125 (2016)","raw_type":"article"},{"id":"pmh:oai:repository.ubn.ru.nl:2066/170951","doi":null,"is_oa":false,"landing_page_url":"https://hdl.handle.net/2066/170951","pdf_url":null,"source":{"id":"https://openalex.org/S4306401067","display_name":"Radboud Repository (Radboud University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I145872427","host_organization_name":"Radboud University Nijmegen","host_organization_lineage":["https://openalex.org/I145872427"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Article / Letter to editor"}],"best_oa_location":{"id":"doi:10.1371/journal.pone.0165125","doi":"https://doi.org/10.1371/journal.pone.0165125","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pone.0165125","pdf_url":"https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0165125&type=printable","source":{"id":"https://openalex.org/S202381698","display_name":"PLoS ONE","issn_l":"1932-6203","issn":["1932-6203"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","erih-plus","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS ONE","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9391000270843506}],"study_designs":[{"display_name":"Systematic Review","id":"https://openalex.org/study-designs/systematic-review"},{"display_name":"Meta-Analysis","id":"https://openalex.org/study-designs/meta-analysis"}],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2550134727.pdf","grobid_xml":"https://content.openalex.org/works/W2550134727.grobid-xml"},"referenced_works_count":171,"referenced_works":["https://openalex.org/W152641690","https://openalex.org/W183879405","https://openalex.org/W231483825","https://openalex.org/W1509964493","https://openalex.org/W1548635780","https://openalex.org/W1830759764","https://openalex.org/W1964809984","https://openalex.org/W1966863746","https://openalex.org/W1968861058","https://openalex.org/W1976197226","https://openalex.org/W1978366943","https://openalex.org/W1979554267","https://openalex.org/W1982602899","https://openalex.org/W1982674658","https://openalex.org/W1984236721","https://openalex.org/W1987119501","https://openalex.org/W1987501673","https://openalex.org/W1988440950","https://openalex.org/W1989750109","https://openalex.org/W1990205404","https://openalex.org/W1990832616","https://openalex.org/W1994736923","https://openalex.org/W1995291371","https://openalex.org/W1997707791","https://openalex.org/W2003919353","https://openalex.org/W2006450021","https://openalex.org/W2013491075","https://openalex.org/W2013754108","https://openalex.org/W2013836642","https://openalex.org/W2015522320","https://openalex.org/W2015889922","https://openalex.org/W2020156123","https://openalex.org/W2021718668","https://openalex.org/W2025044215","https://openalex.org/W2025956556","https://openalex.org/W2027938108","https://openalex.org/W2032704919","https://openalex.org/W2034531715","https://openalex.org/W2035634522","https://openalex.org/W2037727972","https://openalex.org/W2041615416","https://openalex.org/W2041661126","https://openalex.org/W2042379310","https://openalex.org/W2043573731","https://openalex.org/W2046695951","https://openalex.org/W2051479473","https://openalex.org/W2052701225","https://openalex.org/W2053051649","https://openalex.org/W2053124727","https://openalex.org/W2053622652","https://openalex.org/W2054476512","https://openalex.org/W2058129868","https://openalex.org/W2059600866","https://openalex.org/W2059729582","https://openalex.org/W2063544723","https://openalex.org/W2064469565","https://openalex.org/W2065749814","https://openalex.org/W2065778773","https://openalex.org/W2067126948","https://openalex.org/W2068268237","https://openalex.org/W2068288921","https://openalex.org/W2068489682","https://openalex.org/W2069290653","https://openalex.org/W2074719979","https://openalex.org/W2075442591","https://openalex.org/W2076185882","https://openalex.org/W2078166612","https://openalex.org/W2079337014","https://openalex.org/W2079425973","https://openalex.org/W2080501017","https://openalex.org/W2082216522","https://openalex.org/W2083055659","https://openalex.org/W2084023226","https://openalex.org/W2086695319","https://openalex.org/W2087166650","https://openalex.org/W2088415847","https://openalex.org/W2090163605","https://openalex.org/W2091518382","https://openalex.org/W2091896310","https://openalex.org/W2093970579","https://openalex.org/W2094740082","https://openalex.org/W2095654239","https://openalex.org/W2096036771","https://openalex.org/W2096191845","https://openalex.org/W2097286099","https://openalex.org/W2097670206","https://openalex.org/W2097811951","https://openalex.org/W2098505353","https://openalex.org/W2099828491","https://openalex.org/W2101675918","https://openalex.org/W2101890931","https://openalex.org/W2106779317","https://openalex.org/W2107638293","https://openalex.org/W2107825545","https://openalex.org/W2109041986","https://openalex.org/W2109269254","https://openalex.org/W2110363880","https://openalex.org/W2112400063","https://openalex.org/W2113027063","https://openalex.org/W2116280149","https://openalex.org/W2120885879","https://openalex.org/W2122407132","https://openalex.org/W2124593776","https://openalex.org/W2124753637","https://openalex.org/W2124963884","https://openalex.org/W2125435699","https://openalex.org/W2126055638","https://openalex.org/W2126232879","https://openalex.org/W2126579017","https://openalex.org/W2126727011","https://openalex.org/W2127048828","https://openalex.org/W2127123730","https://openalex.org/W2128265819","https://openalex.org/W2128487912","https://openalex.org/W2130802111","https://openalex.org/W2130820799","https://openalex.org/W2132038320","https://openalex.org/W2133060396","https://openalex.org/W2133643189","https://openalex.org/W2134224716","https://openalex.org/W2134307997","https://openalex.org/W2134414426","https://openalex.org/W2135328203","https://openalex.org/W2137770230","https://openalex.org/W2138045662","https://openalex.org/W2138519096","https://openalex.org/W2139016687","https://openalex.org/W2139577083","https://openalex.org/W2143929345","https://openalex.org/W2145352726","https://openalex.org/W2145562657","https://openalex.org/W2146324542","https://openalex.org/W2148380483","https://openalex.org/W2149913116","https://openalex.org/W2150753660","https://openalex.org/W2151012925","https://openalex.org/W2152511071","https://openalex.org/W2152541243","https://openalex.org/W2152807192","https://openalex.org/W2154379294","https://openalex.org/W2154789237","https://openalex.org/W2155585378","https://openalex.org/W2156101504","https://openalex.org/W2157023068","https://openalex.org/W2157825442","https://openalex.org/W2157920027","https://openalex.org/W2162767305","https://openalex.org/W2163674504","https://openalex.org/W2164224283","https://openalex.org/W2165485624","https://openalex.org/W2165526450","https://openalex.org/W2166755477","https://openalex.org/W2166893883","https://openalex.org/W2167082343","https://openalex.org/W2170608785","https://openalex.org/W2184367486","https://openalex.org/W2240033380","https://openalex.org/W2280728720","https://openalex.org/W2303826943","https://openalex.org/W2347981775","https://openalex.org/W2355517071","https://openalex.org/W2362685093","https://openalex.org/W2365534639","https://openalex.org/W2394909133","https://openalex.org/W2410095571","https://openalex.org/W2415843969","https://openalex.org/W2416843528","https://openalex.org/W2417835605","https://openalex.org/W2441892933","https://openalex.org/W2890156120","https://openalex.org/W4253247267"],"related_works":["https://openalex.org/W2982227727","https://openalex.org/W1997707791","https://openalex.org/W2041661126","https://openalex.org/W1966863746","https://openalex.org/W2109041986","https://openalex.org/W4308928677","https://openalex.org/W2154379294","https://openalex.org/W2096036771","https://openalex.org/W1607376463","https://openalex.org/W7100939738"],"abstract_inverted_index":{"Sperm":[0],"DNA":[1,24,74,105,226,245,274,322],"fragmentation":[2,25,75,106,227,246,275,323],"has":[3],"been":[4],"associated":[5],"with":[6,82,334],"reduced":[7],"fertilization":[8],"rates,":[9],"embryo":[10],"quality,":[11],"pregnancy":[12,81,237,286,328,338],"rates":[13],"and":[14,52,65,95,163,176,191,203,215,258,287,300,304],"increased":[15],"miscarriage":[16],"rates.":[17],"Various":[18],"methods":[19],"exist":[20],"to":[21,67,111,129,161,172,232,267],"test":[22,179,190],"sperm":[23,29,35,73,104,225,244,273,321],"such":[26],"as":[27],"the":[28,34,40,53,69,100,103,123,148,153,177,186,206,210,234,239,269,283,289,294,298,301,307,317,325],"chromatin":[30,36],"structure":[31],"assay":[32,51,150,165],"(SCSA),":[33],"dispersion":[37],"(SCD)":[38],"test,":[39],"terminal":[41],"deoxynucleotidyl":[42],"transferase":[43],"mediated":[44],"deoxyuridine":[45],"triphosphate":[46],"nick":[47],"end":[48],"labelling":[49],"(TUNEL)":[50],"single":[54],"cell":[55],"gel":[56],"electrophoresis":[57],"(Comet)":[58],"assay.":[59],"We":[60],"performed":[61],"a":[62,109,143],"systematic":[63],"review":[64,221],"meta-analysis":[66],"assess":[68],"value":[70,200,255,319],"of":[71,79,87,117,147,156,167,236,241,272,285,291,297,306,320,327,337],"measuring":[72],"in":[76,99,198,238,253,277,332],"predicting":[77],"chance":[78,235,326],"ongoing":[80],"IVF":[83,202,214,257],"or":[84,250],"ICSI.":[85,204,259],"Out":[86],"658":[88],"unique":[89],"studies,":[90,309],"30":[91],"had":[92,108,180],"extractable":[93],"data":[94],"were":[96,217],"thus":[97],"included":[98,308],"meta-analysis.":[101],"Overall,":[102],"tests":[107,228,247,276],"reasonable":[110],"good":[112],"sensitivity.":[113],"A":[114],"wide":[115],"variety":[116],"other":[118,335],"factors":[119],"may":[120],"also":[121,331],"affect":[122],"IVF/ICSI":[124],"outcome,":[125],"reflected":[126],"by":[127],"limited":[128,230],"very":[130],"low":[131],"specificity.":[132],"The":[133,174,219],"constructed":[134],"hierarchical":[135],"summary":[136],"receiver":[137],"operating":[138],"characteristic":[139],"(HSROC)":[140],"curve":[141,154],"indicated":[142,209],"fair":[144],"discriminatory":[145],"capacity":[146,231],"TUNEL":[149,187],"(area":[151],"under":[152],"(AUC)":[155],"0.71;":[157],"95%":[158,169],"CI":[159,170],"0.66":[160],"0.74)":[162],"Comet":[164,192],"(AUC":[166],"0.73;":[168],"0.19":[171],"0.97).":[173],"SCSA":[175,207],"SCD":[178,189],"poor":[181],"predictive":[182,199,211,254,318],"capacity.":[183],"Importantly,":[184],"for":[185,213,282,288,313,324],"assay,":[188,193],"meta-regression":[194,208],"showed":[195],"no":[196,251],"differences":[197],"between":[201,256],"For":[205],"values":[212],"ICSI":[216],"different.":[218],"present":[220],"suggests":[222],"that":[223],"current":[224],"have":[229,248],"predict":[233],"context":[240],"MAR.":[242,340],"Furthermore,":[243],"little":[249],"difference":[252],"At":[260],"this":[261],"moment,":[262],"there":[263],"is":[264],"insufficient":[265],"evidence":[266,299],"recommend":[268],"routine":[270],"use":[271],"couples":[278],"undergoing":[279],"MAR":[280],"both":[281],"prediction":[284],"choice":[290],"treatment.":[292],"Given":[293],"significant":[295],"limitations":[296],"methodological":[302],"weakness":[303],"design":[305],"we":[310],"do":[311],"urge":[312],"further":[314],"research":[315],"on":[316],"after":[329,339],"MAR,":[330],"comparison":[333],"predictors":[336]},"counts_by_year":[{"year":2026,"cited_by_count":26},{"year":2025,"cited_by_count":21},{"year":2024,"cited_by_count":28},{"year":2023,"cited_by_count":49},{"year":2022,"cited_by_count":31},{"year":2021,"cited_by_count":49},{"year":2020,"cited_by_count":49},{"year":2019,"cited_by_count":34},{"year":2018,"cited_by_count":32},{"year":2017,"cited_by_count":24}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2016-11-30T00:00:00"}