{"id":"https://openalex.org/W2550123383","doi":"https://doi.org/10.1186/s12919-016-0021-1","title":"Comparison of parametric and machine methods for variable selection in simulated Genetic Analysis Workshop 19 data","display_name":"Comparison of parametric and machine methods for variable selection in simulated Genetic Analysis Workshop 19 data","publication_year":2016,"publication_date":"2016-10-01","ids":{"openalex":"https://openalex.org/W2550123383","doi":"https://doi.org/10.1186/s12919-016-0021-1","mag":"2550123383","pmid":"https://pubmed.ncbi.nlm.nih.gov/27980627","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/5133476"},"language":"en","primary_location":{"id":"doi:10.1186/s12919-016-0021-1","doi":"https://doi.org/10.1186/s12919-016-0021-1","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s12919-016-0021-1","pdf_url":"https://bmcproc.biomedcentral.com/track/pdf/10.1186/s12919-016-0021-1","source":{"id":"https://openalex.org/S49206733","display_name":"BMC Proceedings","issn_l":"1753-6561","issn":["1753-6561"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","jufo-1","norway-1","poland-40","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Proceedings","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://bmcproc.biomedcentral.com/track/pdf/10.1186/s12919-016-0021-1","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5070328286","display_name":"Emily Rose Holzinger","orcid":"https://orcid.org/0000-0002-1298-4508","observed_orcids":["https://orcid.org/0000-0002-1298-4508"]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210090236","display_name":"National Human Genome Research Institute","ror":"https://ror.org/00baak391","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210090236"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Emily R. Holzinger","raw_affiliation_strings":["Computational and Statistical Genomics Branch, National Human Genome Research Institute, National Institutes of Health, 333 Cassell Drive, Suite 1200, Baltimore, MD, 21224, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Computational and Statistical Genomics Branch, National Human Genome Research Institute, National Institutes of Health, 333 Cassell Drive, Suite 1200, Baltimore, MD, 21224, USA","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210090236"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5054264459","display_name":"Silke Szymczak","orcid":"https://orcid.org/0000-0002-8897-9035","observed_orcids":["https://orcid.org/0000-0002-8897-9035"]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I32021983","display_name":"Christian-Albrechts-Universit\u00e4t zu Kiel","ror":"https://ror.org/04v76ef78","country_code":"DE","type":"education","lineage":["https://openalex.org/I32021983"]},{"id":"https://openalex.org/I4210090236","display_name":"National Human Genome Research Institute","ror":"https://ror.org/00baak391","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210090236"]}],"countries":["DE","US"],"is_corresponding":false,"raw_author_name":"Silke Szymczak","raw_affiliation_strings":["Computational and Statistical Genomics Branch, National Human Genome Research Institute, National Institutes of Health, 333 Cassell Drive, Suite 1200, Baltimore, MD 21224 USA ; Institute of Clinical Molecular Biology, Christian-Albrechts-University of Kiel, Christian-Albrechts-Platz 4, 24118 Kiel, Germany","Computational and Statistical Genomics Branch, National Human Genome Research Institute, National Institutes of Health, 333 Cassell Drive, Suite 1200, Baltimore, MD, 21224, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Computational and Statistical Genomics Branch, National Human Genome Research Institute, National Institutes of Health, 333 Cassell Drive, Suite 1200, Baltimore, MD 21224 USA ; Institute of Clinical Molecular Biology, Christian-Albrechts-University of Kiel, Christian-Albrechts-Platz 4, 24118 Kiel, Germany","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I32021983","https://openalex.org/I4210090236"]},{"raw_affiliation_string":"Computational and Statistical Genomics Branch, National Human Genome Research Institute, National Institutes of Health, 333 Cassell Drive, Suite 1200, Baltimore, MD, 21224, USA","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210090236"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5060440195","display_name":"James D. Malley","orcid":"https://orcid.org/0000-0002-9895-7454","observed_orcids":["https://orcid.org/0000-0002-9895-7454"]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I29955533","display_name":"Center for Information Technology","ror":"https://ror.org/03jh5a977","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I29955533"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"James Malley","raw_affiliation_strings":["Division of Computational Bioscience, Center for Information Technology, National Institutes of Health, 9000 Rockville Pike, Building 12A, Bethesda, MD, 20892, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Computational Bioscience, Center for Information Technology, National Institutes of Health, 9000 Rockville Pike, Building 12A, Bethesda, MD, 20892, USA","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I29955533"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112419294","display_name":"Elizabeth Pugh","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I145311948","display_name":"Johns Hopkins University","ror":"https://ror.org/00za53h95","country_code":"US","type":"education","lineage":["https://openalex.org/I145311948"]},{"id":"https://openalex.org/I2799853436","display_name":"Johns Hopkins Medicine","ror":"https://ror.org/037zgn354","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799853436"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Elizabeth W. Pugh","raw_affiliation_strings":["Center for Inherited Disease Research, IGM, Johns Hopkins School of Medicine, 333 Cassell Drive, Suite 1200, Baltimore, MD, 21224, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Inherited Disease Research, IGM, Johns Hopkins School of Medicine, 333 Cassell Drive, Suite 1200, Baltimore, MD, 21224, USA","institution_ids":["https://openalex.org/I145311948","https://openalex.org/I2799853436"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Hua Ling","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I145311948","display_name":"Johns Hopkins University","ror":"https://ror.org/00za53h95","country_code":"US","type":"education","lineage":["https://openalex.org/I145311948"]},{"id":"https://openalex.org/I2799853436","display_name":"Johns Hopkins Medicine","ror":"https://ror.org/037zgn354","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799853436"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Hua Ling","raw_affiliation_strings":["Center for Inherited Disease Research, IGM, Johns Hopkins School of Medicine, 333 Cassell Drive, Suite 1200, Baltimore, MD, 21224, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Inherited Disease Research, IGM, Johns Hopkins School of Medicine, 333 Cassell Drive, Suite 1200, Baltimore, MD, 21224, USA","institution_ids":["https://openalex.org/I145311948","https://openalex.org/I2799853436"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5032128488","display_name":"Sean Griffith","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I145311948","display_name":"Johns Hopkins University","ror":"https://ror.org/00za53h95","country_code":"US","type":"education","lineage":["https://openalex.org/I145311948"]},{"id":"https://openalex.org/I2799853436","display_name":"Johns Hopkins Medicine","ror":"https://ror.org/037zgn354","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799853436"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Sean Griffith","raw_affiliation_strings":["Center for Inherited Disease Research, IGM, Johns Hopkins School of Medicine, 333 Cassell Drive, Suite 1200, Baltimore, MD, 21224, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Inherited Disease Research, IGM, Johns Hopkins School of Medicine, 333 Cassell Drive, Suite 1200, Baltimore, MD, 21224, USA","institution_ids":["https://openalex.org/I145311948","https://openalex.org/I2799853436"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100364153","display_name":"Peng Zhang","orcid":"https://orcid.org/0000-0002-6129-567X","observed_orcids":["https://orcid.org/0000-0002-6129-567X","https://orcid.org/0000-0002-6218-1885"]},"institutions":[{"id":"https://openalex.org/I145311948","display_name":"Johns Hopkins University","ror":"https://ror.org/00za53h95","country_code":"US","type":"education","lineage":["https://openalex.org/I145311948"]},{"id":"https://openalex.org/I2799853436","display_name":"Johns Hopkins Medicine","ror":"https://ror.org/037zgn354","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799853436"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Peng Zhang","raw_affiliation_strings":["Center for Inherited Disease Research, IGM, Johns Hopkins School of Medicine, 333 Cassell Drive, Suite 1200, Baltimore, MD, 21224, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Inherited Disease Research, IGM, Johns Hopkins School of Medicine, 333 Cassell Drive, Suite 1200, Baltimore, MD, 21224, USA","institution_ids":["https://openalex.org/I145311948","https://openalex.org/I2799853436"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100404194","display_name":"Qing Li","orcid":"https://orcid.org/0009-0005-1327-4347","observed_orcids":["https://orcid.org/0009-0005-1327-4347"]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210090236","display_name":"National Human Genome Research Institute","ror":"https://ror.org/00baak391","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210090236"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Qing Li","raw_affiliation_strings":["Computational and Statistical Genomics Branch, National Human Genome Research Institute, National Institutes of Health, 333 Cassell Drive, Suite 1200, Baltimore, MD, 21224, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Computational and Statistical Genomics Branch, National Human Genome Research Institute, National Institutes of Health, 333 Cassell Drive, Suite 1200, Baltimore, MD, 21224, USA","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210090236"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5009315889","display_name":"Cheryl D. Cropp","orcid":"https://orcid.org/0000-0001-7662-9567","observed_orcids":["https://orcid.org/0000-0001-7662-9567"]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210090236","display_name":"National Human Genome Research Institute","ror":"https://ror.org/00baak391","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210090236"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Cheryl D. Cropp","raw_affiliation_strings":["Computational and Statistical Genomics Branch, National Human Genome Research Institute, National Institutes of Health, 333 Cassell Drive, Suite 1200, Baltimore, MD, 21224, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Computational and Statistical Genomics Branch, National Human Genome Research Institute, National Institutes of Health, 333 Cassell Drive, Suite 1200, Baltimore, MD, 21224, USA","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210090236"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5067921126","display_name":"Joan Wilson","orcid":"https://orcid.org/0000-0002-9153-2920","observed_orcids":["https://orcid.org/0000-0002-9153-2920"]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210090236","display_name":"National Human Genome Research Institute","ror":"https://ror.org/00baak391","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210090236"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Joan E. Bailey-Wilson","raw_affiliation_strings":["Computational and Statistical Genomics Branch, National Human Genome Research Institute, National Institutes of Health, 333 Cassell Drive, Suite 1200, Baltimore, MD, 21224, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Computational and Statistical Genomics Branch, National Human Genome Research Institute, National Institutes of Health, 333 Cassell Drive, Suite 1200, Baltimore, MD, 21224, USA","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210090236"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":6,"corresponding_author_ids":["https://openalex.org/A5070328286"],"corresponding_institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210090236"],"apc_list":{"value":2290,"currency":"USD","value_usd":2290},"apc_paid":{"value":2290,"currency":"USD","value_usd":2290},"fwci":0.1698,"has_fulltext":true,"cited_by_count":4,"citation_normalized_percentile":{"value":0.51447153,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":95},"biblio":{"volume":"10","issue":"S7","first_page":"147","last_page":"152"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10261","display_name":"Genetic Associations and Epidemiology","score":0.9106000065803528,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10261","display_name":"Genetic Associations and Epidemiology","score":0.9106000065803528,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10136","display_name":"Statistical Methods and Inference","score":0.041999999433755875,"subfield":{"id":"https://openalex.org/subfields/2613","display_name":"Statistics and Probability"},"field":{"id":"https://openalex.org/fields/26","display_name":"Mathematics"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T11468","display_name":"Genetic Mapping and Diversity in Plants and Animals","score":0.009999999776482582,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/feature-selection","display_name":"feature selection","score":0.9800000190734863},{"id":"https://openalex.org/keywords/random-forest","display_name":"random forest","score":0.8029999732971191},{"id":"https://openalex.org/keywords/genetic-association","display_name":"genetic association","score":0.42500001192092896},{"id":"https://openalex.org/keywords/systolic-blood-pressure","display_name":"systolic blood pressure","score":0.8820000290870667},{"id":"https://openalex.org/keywords/bonferroni-correction","display_name":"Bonferroni correction","score":0.890999972820282},{"id":"https://openalex.org/keywords/significance-threshold","display_name":"significance threshold","score":0.671999990940094},{"id":"https://openalex.org/keywords/functional-variants","display_name":"functional variants","score":0.6729999780654907},{"id":"https://openalex.org/keywords/complex-human-traits","display_name":"complex human traits","score":0.6309999823570251}],"concepts":[{"id":"https://openalex.org/C127808970","wikidata":"https://www.wikidata.org/wiki/Q385989","display_name":"Bonferroni correction","level":2,"score":0.7541999816894531},{"id":"https://openalex.org/C176217482","wikidata":"https://www.wikidata.org/wiki/Q860554","display_name":"Metric (unit)","level":2,"score":0.6832116842269897},{"id":"https://openalex.org/C148483581","wikidata":"https://www.wikidata.org/wiki/Q446488","display_name":"Feature selection","level":2,"score":0.5989022254943848},{"id":"https://openalex.org/C151956035","wikidata":"https://www.wikidata.org/wiki/Q1132755","display_name":"Logistic regression","level":2,"score":0.5446902513504028},{"id":"https://openalex.org/C169258074","wikidata":"https://www.wikidata.org/wiki/Q245748","display_name":"Random forest","level":2,"score":0.5421865582466125},{"id":"https://openalex.org/C81917197","wikidata":"https://www.wikidata.org/wiki/Q628760","display_name":"Selection (genetic algorithm)","level":2,"score":0.5393971800804138},{"id":"https://openalex.org/C182365436","wikidata":"https://www.wikidata.org/wiki/Q50701","display_name":"Variable (mathematics)","level":2,"score":0.508834183216095},{"id":"https://openalex.org/C48921125","wikidata":"https://www.wikidata.org/wiki/Q10861030","display_name":"Linear regression","level":2,"score":0.5023164749145508},{"id":"https://openalex.org/C117251300","wikidata":"https://www.wikidata.org/wiki/Q1849855","display_name":"Parametric statistics","level":2,"score":0.499131441116333},{"id":"https://openalex.org/C183905921","wikidata":"https://www.wikidata.org/wiki/Q1038757","display_name":"Multiple comparisons problem","level":2,"score":0.4822445809841156},{"id":"https://openalex.org/C119857082","wikidata":"https://www.wikidata.org/wiki/Q2539","display_name":"Machine learning","level":1,"score":0.45377570390701294},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.4489884376525879},{"id":"https://openalex.org/C105795698","wikidata":"https://www.wikidata.org/wiki/Q12483","display_name":"Statistics","level":1,"score":0.44650202989578247},{"id":"https://openalex.org/C152877465","wikidata":"https://www.wikidata.org/wiki/Q208042","display_name":"Regression analysis","level":2,"score":0.4446212947368622},{"id":"https://openalex.org/C83546350","wikidata":"https://www.wikidata.org/wiki/Q1139051","display_name":"Regression","level":2,"score":0.4280685484409332},{"id":"https://openalex.org/C163175372","wikidata":"https://www.wikidata.org/wiki/Q3339222","display_name":"Linear model","level":2,"score":0.4186221957206726},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.41056472063064575},{"id":"https://openalex.org/C124101348","wikidata":"https://www.wikidata.org/wiki/Q172491","display_name":"Data mining","level":1,"score":0.38054850697517395},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3467586040496826},{"id":"https://openalex.org/C33923547","wikidata":"https://www.wikidata.org/wiki/Q395","display_name":"Mathematics","level":0,"score":0.2966604232788086},{"id":"https://openalex.org/C162324750","wikidata":"https://www.wikidata.org/wiki/Q8134","display_name":"Economics","level":0,"score":0.0},{"id":"https://openalex.org/C21547014","wikidata":"https://www.wikidata.org/wiki/Q1423657","display_name":"Operations management","level":1,"score":0.0},{"id":"https://openalex.org/C134306372","wikidata":"https://www.wikidata.org/wiki/Q7754","display_name":"Mathematical analysis","level":1,"score":0.0}],"mesh":[],"locations_count":4,"locations":[{"id":"doi:10.1186/s12919-016-0021-1","doi":"https://doi.org/10.1186/s12919-016-0021-1","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s12919-016-0021-1","pdf_url":"https://bmcproc.biomedcentral.com/track/pdf/10.1186/s12919-016-0021-1","source":{"id":"https://openalex.org/S49206733","display_name":"BMC Proceedings","issn_l":"1753-6561","issn":["1753-6561"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","jufo-1","norway-1","poland-40","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Proceedings","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:4094330","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/5133476","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmid:27980627","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/27980627","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC proceedings","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:5133476","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC5133476/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Proc","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1186/s12919-016-0021-1","doi":"https://doi.org/10.1186/s12919-016-0021-1","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s12919-016-0021-1","pdf_url":"https://bmcproc.biomedcentral.com/track/pdf/10.1186/s12919-016-0021-1","source":{"id":"https://openalex.org/S49206733","display_name":"BMC Proceedings","issn_l":"1753-6561","issn":["1753-6561"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","jufo-1","norway-1","poland-40","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Proceedings","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.4043000042438507}],"study_designs":[],"awards":[{"id":"https://openalex.org/G3204657967","display_name":null,"funder_award_id":"HHSN268201200008I","funder_id":"https://openalex.org/F4320310145","funder_display_name":"Johns Hopkins University"},{"id":"https://openalex.org/G3226771441","display_name":null,"funder_award_id":"HHSN268201200008I","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G4407350458","display_name":null,"funder_award_id":"HHSN268201200008C","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G6862617662","display_name":null,"funder_award_id":"HHSN268201200008I","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G736005061","display_name":"Genetic Analysis of Common Diseases: An Evaluation","funder_award_id":"R01GM031575","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"}],"funders":[{"id":"https://openalex.org/F4320310145","display_name":"Johns Hopkins University","ror":"https://ror.org/00za53h95"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337338","display_name":"National Heart, Lung, and Blood Institute","ror":"https://ror.org/012pb6c26"},{"id":"https://openalex.org/F4320337348","display_name":"National Human Genome Research Institute","ror":"https://ror.org/00baak391"},{"id":"https://openalex.org/F4320337354","display_name":"National Institute of General Medical Sciences","ror":"https://ror.org/04q48ey07"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2550123383.pdf","grobid_xml":"https://content.openalex.org/works/W2550123383.grobid-xml"},"referenced_works_count":9,"referenced_works":["https://openalex.org/W1980991473","https://openalex.org/W2070230130","https://openalex.org/W2103581045","https://openalex.org/W2116868464","https://openalex.org/W2128207034","https://openalex.org/W2252976504","https://openalex.org/W2550899360","https://openalex.org/W2911964244","https://openalex.org/W4256060553"],"related_works":["https://openalex.org/W2252976504","https://openalex.org/W2089797399","https://openalex.org/W7138065584","https://openalex.org/W2766438525","https://openalex.org/W1979279626","https://openalex.org/W2751886678","https://openalex.org/W7099173847","https://openalex.org/W4386318974","https://openalex.org/W4387184330","https://openalex.org/W4415087183"],"abstract_inverted_index":{"Current":[0],"findings":[1,173],"from":[2],"genetic":[3,25],"studies":[4],"of":[5,16,20,138,184],"complex":[6],"human":[7],"traits":[8,22],"often":[9],"do":[10],"not":[11],"explain":[12],"a":[13,99,109,154,159,181,190],"large":[14],"proportion":[15],"the":[17,89,102,119,132,136,196],"estimated":[18],"variation":[19],"these":[21,69],"due":[23,32],"to":[24,33,60,78,118,157,169],"factors.":[26],"This":[27],"could":[28],"be,":[29],"in":[30,38],"part,":[31],"overly":[34],"stringent":[35],"significance":[36,160],"thresholds":[37],"traditional":[39],"statistical":[40],"methods,":[41,50],"such":[42,51],"as":[43,52,131,178,189],"linear":[44,149,170],"and":[45,84,186],"logistic":[46],"regression.":[47,171],"Machine":[48],"learning":[49],"Random":[53],"Forests":[54],"(RF),":[55],"are":[56,97,174],"an":[57],"alternative":[58],"approach":[59],"identify":[61],"potentially":[62],"interesting":[63],"variants.":[64],"One":[65],"major":[66],"issue":[67],"with":[68,126,145],"methods":[70],"is":[71,74,201],"that":[72,152,165],"there":[73],"no":[75],"clear":[76],"way":[77],"distinguish":[79],"between":[80],"probable":[81],"true":[82],"hits":[83],"noise":[85],"variables":[86],"based":[87],"on":[88],"importance":[90,198],"metric":[91],"calculated.":[92],"To":[93],"this":[94],"end,":[95],"we":[96,115],"developing":[98],"method":[100],"called":[101],"Relative":[103],"Recurrency":[104],"Variable":[105],"Importance":[106],"Metric":[107],"(r2VIM),":[108],"RF-based":[110],"variable":[111],"selection":[112],"method.":[113],"Here,":[114],"apply":[116],"r2VIM":[117,144,166],"unrelated":[120],"Genetic":[121],"Analysis":[122],"Workshop":[123],"19":[124],"data":[125],"simulated":[127],"systolic":[128],"blood":[129],"pressure":[130],"phenotype.":[133],"We":[134],"compare":[135],"number":[137,183],"\"true\"":[139],"functional":[140,185],"variants":[141,188],"identified":[142,147],"by":[143,148],"those":[146],"regression":[150],"analyses":[151],"use":[153],"Bonferroni":[155],"correction":[156],"calculate":[158],"threshold.":[161],"Our":[162,172],"results":[163],"show":[164],"performed":[167],"comparably":[168],"proof-of-concept":[175],"for":[176],"r2VIM,":[177],"it":[179],"identifies":[180],"similar":[182],"nonfunctional":[187],"more":[191],"commonly":[192],"used":[193],"technique":[194],"when":[195],"optimal":[197],"score":[199],"threshold":[200],"used.":[202]},"counts_by_year":[{"year":2024,"cited_by_count":1},{"year":2021,"cited_by_count":2},{"year":2016,"cited_by_count":1}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2016-11-30T00:00:00"}
