{"id":"https://openalex.org/W2550103662","doi":"https://doi.org/10.1016/j.neulet.2016.11.014","title":"Circuit dysregulation and circuit-based treatments in posttraumatic stress disorder","display_name":"Circuit dysregulation and circuit-based treatments in posttraumatic stress disorder","publication_year":2016,"publication_date":"2016-11-11","ids":{"openalex":"https://openalex.org/W2550103662","doi":"https://doi.org/10.1016/j.neulet.2016.11.014","mag":"2550103662","pmid":"https://pubmed.ncbi.nlm.nih.gov/27845239","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/5422122"},"language":"en","primary_location":{"id":"doi:10.1016/j.neulet.2016.11.014","doi":"https://doi.org/10.1016/j.neulet.2016.11.014","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.neulet.2016.11.014","pdf_url":null,"source":{"id":"https://openalex.org/S203050076","display_name":"Neuroscience Letters","issn_l":"0304-3940","issn":["0304-3940","1872-7972"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-1","medline","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Neuroscience Letters","raw_type":"journal-article"},"volume":null,"type":"review","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://doi.org/10.1016/j.neulet.2016.11.014","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5039923105","display_name":"Jony Sheynin","orcid":"https://orcid.org/0000-0002-8463-2317","observed_orcids":["https://orcid.org/0000-0002-8463-2317"]},"institutions":[{"id":"https://openalex.org/I27837315","display_name":"University of Michigan","ror":"https://ror.org/00jmfr291","country_code":"US","type":"education","lineage":["https://openalex.org/I27837315"]},{"id":"https://openalex.org/I4210102099","display_name":"VA Ann Arbor Healthcare System","ror":"https://ror.org/018txrr13","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1322918889","https://openalex.org/I2799886695","https://openalex.org/I4210102099","https://openalex.org/I4210127612"]},{"id":"https://openalex.org/I4210114445","display_name":"Michigan Medicine","ror":"https://ror.org/01zcpa714","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210114445"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jony Sheynin","raw_affiliation_strings":["Veterans Affairs Ann Arbor Healthcare System and Department of Psychiatry, University of Michigan, Ann Arbor, MI, USA. Electronic address: jsheynin@med.umich.edu","Veterans Affairs Ann Arbor Healthcare System and Department of Psychiatry, University of Michigan, Ann Arbor, MI, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Veterans Affairs Ann Arbor Healthcare System and Department of Psychiatry, University of Michigan, Ann Arbor, MI, USA. Electronic address: jsheynin@med.umich.edu","institution_ids":["https://openalex.org/I27837315","https://openalex.org/I4210102099","https://openalex.org/I4210114445"]},{"raw_affiliation_string":"Veterans Affairs Ann Arbor Healthcare System and Department of Psychiatry, University of Michigan, Ann Arbor, MI, USA","institution_ids":["https://openalex.org/I27837315","https://openalex.org/I4210102099"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5075081932","display_name":"Israel Liberzon","orcid":"https://orcid.org/0000-0002-4990-556X","observed_orcids":["https://orcid.org/0000-0002-4990-556X"]},"institutions":[{"id":"https://openalex.org/I27837315","display_name":"University of Michigan","ror":"https://ror.org/00jmfr291","country_code":"US","type":"education","lineage":["https://openalex.org/I27837315"]},{"id":"https://openalex.org/I4210102099","display_name":"VA Ann Arbor Healthcare System","ror":"https://ror.org/018txrr13","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1322918889","https://openalex.org/I2799886695","https://openalex.org/I4210102099","https://openalex.org/I4210127612"]},{"id":"https://openalex.org/I4210114445","display_name":"Michigan Medicine","ror":"https://ror.org/01zcpa714","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210114445"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Israel Liberzon","raw_affiliation_strings":["Veterans Affairs Ann Arbor Healthcare System and Department of Psychiatry, University of Michigan, Ann Arbor, MI, USA. Electronic address: liberzon@med.umich.edu","Veterans Affairs Ann Arbor Healthcare System and Department of Psychiatry, University of Michigan, Ann Arbor, MI, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Veterans Affairs Ann Arbor Healthcare System and Department of Psychiatry, University of Michigan, Ann Arbor, MI, USA. Electronic address: liberzon@med.umich.edu","institution_ids":["https://openalex.org/I27837315","https://openalex.org/I4210102099","https://openalex.org/I4210114445"]},{"raw_affiliation_string":"Veterans Affairs Ann Arbor Healthcare System and Department of Psychiatry, University of Michigan, Ann Arbor, MI, USA","institution_ids":["https://openalex.org/I27837315","https://openalex.org/I4210102099"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5075081932"],"corresponding_institution_ids":["https://openalex.org/I27837315","https://openalex.org/I4210102099","https://openalex.org/I4210114445"],"apc_list":{"value":3430,"currency":"USD","value_usd":3430},"apc_paid":null,"fwci":1.3199,"has_fulltext":false,"cited_by_count":73,"citation_normalized_percentile":{"value":0.77910238,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":97,"max":99},"biblio":{"volume":"649","issue":null,"first_page":"133","last_page":"138"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10242","display_name":"Posttraumatic Stress Disorder Research","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/3203","display_name":"Clinical Psychology"},"field":{"id":"https://openalex.org/fields/32","display_name":"Psychology"},"domain":{"id":"https://openalex.org/domains/2","display_name":"Social Sciences"}},"topics":[{"id":"https://openalex.org/T10242","display_name":"Posttraumatic Stress Disorder Research","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/3203","display_name":"Clinical Psychology"},"field":{"id":"https://openalex.org/fields/32","display_name":"Psychology"},"domain":{"id":"https://openalex.org/domains/2","display_name":"Social Sciences"}},{"id":"https://openalex.org/T10448","display_name":"Memory and Neural Mechanisms","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2805","display_name":"Cognitive Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11132","display_name":"Psychoanalysis and Psychopathology Research","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/3203","display_name":"Clinical Psychology"},"field":{"id":"https://openalex.org/fields/32","display_name":"Psychology"},"domain":{"id":"https://openalex.org/domains/2","display_name":"Social Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/posttraumatic-stress-disorder","display_name":"post-traumatic stress disorder","score":1.0},{"id":"https://openalex.org/keywords/neural-circuits","display_name":"neural circuits","score":0.7329999804496765},{"id":"https://openalex.org/keywords/amygdala","display_name":"amygdala","score":0.8679999709129333},{"id":"https://openalex.org/keywords/dorsal-anterior-cingulate-cortex","display_name":"dorsal anterior cingulate cortex","score":0.8679999709129333},{"id":"https://openalex.org/keywords/insular-cortex","display_name":"insula","score":0.9879999756813049},{"id":"https://openalex.org/keywords/medial-prefrontal-cortex","display_name":"medial prefrontal cortex","score":0.996999979019165},{"id":"https://openalex.org/keywords/hippocampus","display_name":"hippocampus","score":0.9259999990463257},{"id":"https://openalex.org/keywords/fear-learning","display_name":"fear learning","score":0.9480000138282776},{"id":"https://openalex.org/keywords/threat-detection","display_name":"threat detection","score":0.9869999885559082},{"id":"https://openalex.org/keywords/context-processing","display_name":"context processing","score":0.9679999947547913},{"id":"https://openalex.org/keywords/emotion-regulation","display_name":"emotion regulation","score":0.8629999756813049},{"id":"https://openalex.org/keywords/exposure-therapy","display_name":"exposure therapy","score":0.8830000162124634},{"id":"https://openalex.org/keywords/drug-therapy","display_name":"pharmacotherapy","score":0.6589999794960022},{"id":"https://openalex.org/keywords/brain-stimulation","display_name":"brain stimulation","score":0.8849999904632568},{"id":"https://openalex.org/keywords/cognitive-therapy","display_name":"cognitive therapy","score":0.8410000205039978}],"concepts":[{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.7569763660430908},{"id":"https://openalex.org/C2779343474","wikidata":"https://www.wikidata.org/wiki/Q3109175","display_name":"Context (archaeology)","level":2,"score":0.6538844108581543},{"id":"https://openalex.org/C118403218","wikidata":"https://www.wikidata.org/wiki/Q43283","display_name":"Biological neural network","level":2,"score":0.6533586978912354},{"id":"https://openalex.org/C2779144063","wikidata":"https://www.wikidata.org/wiki/Q338924","display_name":"Amygdala","level":2,"score":0.6528304219245911},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.5737422704696655},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3217623233795166},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.08890950679779053},{"id":"https://openalex.org/C151730666","wikidata":"https://www.wikidata.org/wiki/Q7205","display_name":"Paleontology","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000679","descriptor_name":"Amygdala","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001921","descriptor_name":"Brain","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":true},{"descriptor_ui":"D003214","descriptor_name":"Conditioning, Classical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004644","descriptor_name":"Emotions","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D005239","descriptor_name":"Fear","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006624","descriptor_name":"Hippocampus","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009434","descriptor_name":"Neural Pathways","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D013313","descriptor_name":"Stress Disorders, Post-Traumatic","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":true},{"descriptor_ui":"D013313","descriptor_name":"Stress Disorders, Post-Traumatic","qualifier_ui":"Q000523","qualifier_name":"psychology","is_major_topic":false},{"descriptor_ui":"D013313","descriptor_name":"Stress Disorders, Post-Traumatic","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":true},{"descriptor_ui":"D017397","descriptor_name":"Prefrontal Cortex","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1016/j.neulet.2016.11.014","doi":"https://doi.org/10.1016/j.neulet.2016.11.014","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.neulet.2016.11.014","pdf_url":null,"source":{"id":"https://openalex.org/S203050076","display_name":"Neuroscience Letters","issn_l":"0304-3940","issn":["0304-3940","1872-7972"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-1","medline","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Neuroscience Letters","raw_type":"journal-article"},{"id":"pmid:27845239","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/27845239","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Neuroscience letters","raw_type":"Journal Article"},{"id":"pmh:oai:europepmc.org:4859321","doi":null,"is_oa":true,"landing_page_url":"http://europepmc.org/pmc/articles/PMC5422122","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"","raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:5422122","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/5422122","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Neurosci Lett","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1016/j.neulet.2016.11.014","doi":"https://doi.org/10.1016/j.neulet.2016.11.014","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.neulet.2016.11.014","pdf_url":null,"source":{"id":"https://openalex.org/S203050076","display_name":"Neuroscience Letters","issn_l":"0304-3940","issn":["0304-3940","1872-7972"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-1","medline","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Neuroscience Letters","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.98580002784729,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G3127553649","display_name":"IDENTIFYING MOLECULAR TARGETS FOR PTSD TREATMENT USING SINGLE PROLONGED STRESS","funder_award_id":"W81XWH1310377","funder_id":"https://openalex.org/F4320306078","funder_display_name":"U.S. Department of Defense"},{"id":"https://openalex.org/G5642536210","display_name":"Cognition-Emotion-HPA Interaction: Translation Network","funder_award_id":"R24MH075999","funder_id":"https://openalex.org/F4320337346","funder_display_name":"National Institute of Mental Health"}],"funders":[{"id":"https://openalex.org/F4320306078","display_name":"U.S. Department of Defense","ror":"https://ror.org/0447fe631"},{"id":"https://openalex.org/F4320337346","display_name":"National Institute of Mental Health","ror":"https://ror.org/04xeg9z08"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":83,"referenced_works":["https://openalex.org/W126997740","https://openalex.org/W834348615","https://openalex.org/W853579459","https://openalex.org/W1174009477","https://openalex.org/W1500773154","https://openalex.org/W1547865271","https://openalex.org/W1553183704","https://openalex.org/W1564331199","https://openalex.org/W1597129241","https://openalex.org/W1652584161","https://openalex.org/W1870410723","https://openalex.org/W1921511099","https://openalex.org/W1964851255","https://openalex.org/W1965978496","https://openalex.org/W1969678755","https://openalex.org/W1971421670","https://openalex.org/W1974348021","https://openalex.org/W1979172214","https://openalex.org/W1983067890","https://openalex.org/W1990137058","https://openalex.org/W1991878909","https://openalex.org/W1997603362","https://openalex.org/W1998512664","https://openalex.org/W1999197227","https://openalex.org/W2000064859","https://openalex.org/W2003344388","https://openalex.org/W2016117011","https://openalex.org/W2017238102","https://openalex.org/W2022797703","https://openalex.org/W2026268707","https://openalex.org/W2026836897","https://openalex.org/W2027181254","https://openalex.org/W2036537456","https://openalex.org/W2043256468","https://openalex.org/W2049423401","https://openalex.org/W2049812132","https://openalex.org/W2066525901","https://openalex.org/W2067808083","https://openalex.org/W2069861759","https://openalex.org/W2074794318","https://openalex.org/W2076246738","https://openalex.org/W2077083873","https://openalex.org/W2078696107","https://openalex.org/W2079538493","https://openalex.org/W2081763231","https://openalex.org/W2086721550","https://openalex.org/W2087082832","https://openalex.org/W2087755851","https://openalex.org/W2088069569","https://openalex.org/W2092220319","https://openalex.org/W2096423181","https://openalex.org/W2099574448","https://openalex.org/W2100035288","https://openalex.org/W2100561031","https://openalex.org/W2103881507","https://openalex.org/W2104061966","https://openalex.org/W2106557234","https://openalex.org/W2109167188","https://openalex.org/W2113485684","https://openalex.org/W2115274607","https://openalex.org/W2116658855","https://openalex.org/W2117693696","https://openalex.org/W2118371410","https://openalex.org/W2120055641","https://openalex.org/W2126043033","https://openalex.org/W2126520022","https://openalex.org/W2130135754","https://openalex.org/W2130838343","https://openalex.org/W2136449688","https://openalex.org/W2136536137","https://openalex.org/W2140201388","https://openalex.org/W2146256171","https://openalex.org/W2148011447","https://openalex.org/W2148239264","https://openalex.org/W2154459716","https://openalex.org/W2156900283","https://openalex.org/W2158749971","https://openalex.org/W2159812249","https://openalex.org/W2164876957","https://openalex.org/W2215327473","https://openalex.org/W2529186330","https://openalex.org/W2540952065","https://openalex.org/W4252170619"],"related_works":["https://openalex.org/W2529186330","https://openalex.org/W4389345348","https://openalex.org/W7213972090","https://openalex.org/W7148981438","https://openalex.org/W4244063943","https://openalex.org/W2884319195","https://openalex.org/W2801574273","https://openalex.org/W2003344388","https://openalex.org/W7128452331","https://openalex.org/W3153551522"],"abstract_inverted_index":null,"counts_by_year":[{"year":2025,"cited_by_count":5},{"year":2024,"cited_by_count":5},{"year":2023,"cited_by_count":5},{"year":2022,"cited_by_count":6},{"year":2021,"cited_by_count":10},{"year":2020,"cited_by_count":11},{"year":2019,"cited_by_count":9},{"year":2018,"cited_by_count":11},{"year":2017,"cited_by_count":11}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-11-30T00:00:00"}