{"id":"https://openalex.org/W2549956294","doi":null,"title":"Systematic analysis of fHbp sequence coverage by antibodies against meningococcal GMMA from african group W strains","display_name":"Systematic analysis of fHbp sequence coverage by antibodies against meningococcal GMMA from african group W strains","publication_year":2016,"publication_date":"2016-03-31","ids":{"openalex":"https://openalex.org/W2549956294","mag":"2549956294"},"language":"en","primary_location":{"id":"mag:2549956294","doi":null,"is_oa":false,"landing_page_url":"http://www.fedoa.unina.it/10917/","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null},"volume":null,"type":"article","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5058256966","display_name":"Maria Grazia Aruta","orcid":"https://orcid.org/0000-0002-9248-9362","observed_orcids":["https://orcid.org/0000-0002-9248-9362"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Maria Grazia Aruta","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-9248-9362","affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5058256966"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10873","display_name":"Bacterial Infections and Vaccines","score":0.9970999956130981,"subfield":{"id":"https://openalex.org/subfields/2404","display_name":"Microbiology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10873","display_name":"Bacterial Infections and Vaccines","score":0.9970999956130981,"subfield":{"id":"https://openalex.org/subfields/2404","display_name":"Microbiology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10993","display_name":"Complement system in diseases","score":0.0017999999690800905,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10943","display_name":"Escherichia coli research studies","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2404","display_name":"Microbiology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/fhbp","display_name":"fHbp","score":0.8569999933242798},{"id":"https://openalex.org/keywords/neisseria-meningitidis","display_name":"Neisseria meningitidis","score":0.8130000233650208},{"id":"https://openalex.org/keywords/factor-h-binding-protein","display_name":"factor H binding protein","score":0.7580000162124634},{"id":"https://openalex.org/keywords/sequence-diversity","display_name":"sequence diversity","score":0.6639999747276306},{"id":"https://openalex.org/keywords/bactericidal-antibodies","display_name":"bactericidal antibodies","score":0.6460000276565552},{"id":"https://openalex.org/keywords/serum-bactericidal-assay","display_name":"serum bactericidal assay","score":0.7419999837875366},{"id":"https://openalex.org/keywords/isogenic-strains","display_name":"isogenic strains","score":0.7649999856948853},{"id":"https://openalex.org/keywords/meningococcal-serogroups","display_name":"meningococcal serogroups","score":0.6380000114440918},{"id":"https://openalex.org/keywords/sub-saharan-africa","display_name":"sub-Saharan Africa","score":0.8019999861717224},{"id":"https://openalex.org/keywords/vaccine-targets","display_name":"vaccine targets","score":0.3330000042915344},{"id":"https://openalex.org/keywords/complement-evasion","display_name":"complement evasion","score":0.36899998784065247}],"concepts":[{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.7667316198348999},{"id":"https://openalex.org/C2778112365","wikidata":"https://www.wikidata.org/wiki/Q3511065","display_name":"Sequence (biology)","level":2,"score":0.5604819655418396},{"id":"https://openalex.org/C2778458888","wikidata":"https://www.wikidata.org/wiki/Q154625","display_name":"Neisseria meningitidis","level":3,"score":0.5526733994483948},{"id":"https://openalex.org/C61053724","wikidata":"https://www.wikidata.org/wiki/Q1154615","display_name":"Sequence analysis","level":3,"score":0.5457143783569336},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.501004695892334},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.44428855180740356},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.40645885467529297},{"id":"https://openalex.org/C523546767","wikidata":"https://www.wikidata.org/wiki/Q10876","display_name":"Bacteria","level":2,"score":0.08519527316093445}],"mesh":[],"locations_count":1,"locations":[{"id":"mag:2549956294","doi":null,"is_oa":false,"landing_page_url":"http://www.fedoa.unina.it/10917/","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.8560000061988831}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":147,"referenced_works":["https://openalex.org/W113658176","https://openalex.org/W197174392","https://openalex.org/W1491837037","https://openalex.org/W1527004061","https://openalex.org/W1540741194","https://openalex.org/W1574987843","https://openalex.org/W1622088669","https://openalex.org/W1632409802","https://openalex.org/W1796313524","https://openalex.org/W1865591512","https://openalex.org/W1880623742","https://openalex.org/W1881058623","https://openalex.org/W1885106571","https://openalex.org/W1911834075","https://openalex.org/W1934293658","https://openalex.org/W1963552245","https://openalex.org/W1966959397","https://openalex.org/W1968806793","https://openalex.org/W1971269498","https://openalex.org/W1974897055","https://openalex.org/W1975355256","https://openalex.org/W1976480590","https://openalex.org/W1978223569","https://openalex.org/W1978881112","https://openalex.org/W1980927941","https://openalex.org/W1981537887","https://openalex.org/W1982086945","https://openalex.org/W1986528054","https://openalex.org/W1986897865","https://openalex.org/W1988963904","https://openalex.org/W1991564172","https://openalex.org/W1992548028","https://openalex.org/W1994159005","https://openalex.org/W1995386819","https://openalex.org/W1997286533","https://openalex.org/W1999149075","https://openalex.org/W1999647505","https://openalex.org/W2012406808","https://openalex.org/W2012763858","https://openalex.org/W2013735067","https://openalex.org/W2016150993","https://openalex.org/W2020972880","https://openalex.org/W2025502898","https://openalex.org/W2025900515","https://openalex.org/W2032580447","https://openalex.org/W2036208499","https://openalex.org/W2036301066","https://openalex.org/W2038255959","https://openalex.org/W2040626353","https://openalex.org/W2043697833","https://openalex.org/W2047441714","https://openalex.org/W2049628926","https://openalex.org/W2050277020","https://openalex.org/W2052663923","https://openalex.org/W2052668978","https://openalex.org/W2053240723","https://openalex.org/W2054836349","https://openalex.org/W2056410023","https://openalex.org/W2056777116","https://openalex.org/W2057124618","https://openalex.org/W2058088551","https://openalex.org/W2059296531","https://openalex.org/W2067544875","https://openalex.org/W2068521456","https://openalex.org/W2069805037","https://openalex.org/W2073533707","https://openalex.org/W2074496735","https://openalex.org/W2075583035","https://openalex.org/W2076119379","https://openalex.org/W2077486234","https://openalex.org/W2080885816","https://openalex.org/W2081441884","https://openalex.org/W2083398339","https://openalex.org/W2085296777","https://openalex.org/W2087469928","https://openalex.org/W2088292756","https://openalex.org/W2089589286","https://openalex.org/W2093142425","https://openalex.org/W2098304400","https://openalex.org/W2098814980","https://openalex.org/W2099155299","https://openalex.org/W2100080502","https://openalex.org/W2102107859","https://openalex.org/W2102186420","https://openalex.org/W2102537411","https://openalex.org/W2103525707","https://openalex.org/W2103672698","https://openalex.org/W2104511165","https://openalex.org/W2104823480","https://openalex.org/W2106289779","https://openalex.org/W2107179227","https://openalex.org/W2108177341","https://openalex.org/W2108462386","https://openalex.org/W2111872769","https://openalex.org/W2111951615","https://openalex.org/W2111963409","https://openalex.org/W2114473472","https://openalex.org/W2114942154","https://openalex.org/W2116680478","https://openalex.org/W2120556801","https://openalex.org/W2121283148","https://openalex.org/W2122058226","https://openalex.org/W2123486624","https://openalex.org/W2124672930","https://openalex.org/W2125691593","https://openalex.org/W2125712986","https://openalex.org/W2126043388","https://openalex.org/W2127157242","https://openalex.org/W2127335580","https://openalex.org/W2128161048","https://openalex.org/W2129920904","https://openalex.org/W2130671412","https://openalex.org/W2132214292","https://openalex.org/W2132568235","https://openalex.org/W2133410828","https://openalex.org/W2133700480","https://openalex.org/W2133899577","https://openalex.org/W2145985597","https://openalex.org/W2146373443","https://openalex.org/W2146600649","https://openalex.org/W2148376394","https://openalex.org/W2150453173","https://openalex.org/W2151309008","https://openalex.org/W2152872757","https://openalex.org/W2154202775","https://openalex.org/W2154892242","https://openalex.org/W2155493374","https://openalex.org/W2155812349","https://openalex.org/W2156945929","https://openalex.org/W2157076815","https://openalex.org/W2157845870","https://openalex.org/W2158211929","https://openalex.org/W2158400228","https://openalex.org/W2160879811","https://openalex.org/W2161397634","https://openalex.org/W2164319606","https://openalex.org/W2164450255","https://openalex.org/W2166663556","https://openalex.org/W2167427908","https://openalex.org/W2171363873","https://openalex.org/W2171991586","https://openalex.org/W2175142028","https://openalex.org/W2269583392","https://openalex.org/W2336324839","https://openalex.org/W2344268543","https://openalex.org/W2460511656","https://openalex.org/W3122998181"],"related_works":["https://openalex.org/W7095150233","https://openalex.org/W7096772125","https://openalex.org/W2736816967","https://openalex.org/W6958179661","https://openalex.org/W1976512499","https://openalex.org/W7221560071","https://openalex.org/W1999647505","https://openalex.org/W1985306230","https://openalex.org/W2122058226","https://openalex.org/W2157630713"],"abstract_inverted_index":{"FHbp":[0],"sequence":[1,39,45,134,403],"diversity":[2,404],"expressed":[3,172,203],"by":[4,50,396,476],"African":[5,71,185,443],"isolates":[6,446],"is":[7,76,440],"limited":[8],"among":[9,442],"currently":[10],"circulating":[11],"strains":[12,190,227,254,257,302,351,375],"in":[13,19,66,89,142,159,173,258,330,383,461],"sub-Saharan":[14],"Africa":[15],"but":[16,400],"could":[17],"change":[18],"the":[20,25,33,43,85,113,137,143,160,174,207,290,300,323,333,346,359,364,373,384,392,434,451,493,511],"future.\nThe":[21],"primary":[22],"aim":[23],"of":[24,37,42,54,59,84,110,112,136,148,157,183,206,214,222,266,289,299,325,348,391,410,415,458,468,472,490,510],"project":[26],"was":[27,48,200,447,474],"to":[28,121,127,167,192,218,231,262,322,353,362,389,394,412,432,495],"systematically":[29],"investigate":[30],"and":[31,35,57,99,186,239,243,252,479,508],"dissect":[32],"breadth":[34],"nature":[36],"fHbp":[38,44,64,101,119,149,168,211,215,236,245,278,312,339,356,366,378,398,424,436,459],"coverage":[40,414],"irrespective":[41],"prevalence.":[46],"This":[47],"obtained":[49,105],"using":[51],"a":[52,107,153,181,204,220,272,406,418,426],"combination":[53],"bioinformatic":[55],"tools":[56],"analysis":[58,83,478],"functional":[60,264],"antibody":[61],"raised":[62,268,305,329],"against":[63,269,286,297,306,332,345],"over-expressed":[65,277,338,423],"meningococcal":[67],"GMMA":[68,270,307,336,416,449,462,491],"from":[69,271,417,450,463,492,499],"an":[70,485],"group":[72,175,273,334,419,428,444],"W":[73,176,274,335,420,429,445],"strain.\nThe":[74],"work":[75],"divided":[77],"into":[78],"three":[79],"parts:\n1.":[80],"Comparative":[81],"structure/sequence":[82],"amino":[86],"acids":[87],"involved":[88],"factor":[90,114,138,161],"H":[91,115,139,162],"binding":[92,116,140,164,386],"including":[93,358],"more":[94],"than":[95,460],"700":[96],"individual":[97],"existing":[98,234,242],"published":[100,244],"sequences.":[102,212],"The":[103,249,370],"results":[104,371],"show":[106],"differential":[108],"degree":[109],"variability":[111],"site":[117,141,165,387],"between":[118],"belonging":[120,126],"variant":[122,128,169],"1":[123,170],"versus":[124],"those":[125],"2":[129],"or":[130,198],"3":[131],"with":[132,276,337,372,422],"greater":[133],"diversification":[135],"v.1":[144,237,279,340,425],"group.\n2.":[145],"Systematic":[146],"selection":[147,216],"sequences":[150,238,357,379],"based":[151],"on":[152],"gradually":[154],"different":[155],"number":[156],"differences":[158,382],"(fH)":[163],"compared":[166],"ID9":[171],"GMMA.":[177],"Applying":[178],"these":[179],"criteria":[180,217],"panel":[182,221,347],"11":[184,291],"non-African":[187],"wild":[188,250,293,464],"type":[189,251,294,465],"(belonging":[191],"serogroup":[193],"A,":[194],"C,":[195],"W,":[196],"Y":[197],"X)":[199],"selected":[201],"that":[202,228,308,316,381],"subset":[205],"identified":[208],"phylogenetically":[209],"diverse":[210,235,292,355,377],"Use":[213],"generate":[219],"eight":[223,349],"genetically":[224],"defined":[225],"isogenic":[226,253,350,374],"were":[229,313,513],"engineered":[230,352,361,431],"express":[232,354,363],"seven":[233],"one":[240],"naturally":[241],"v.1/2":[246,367],"hybrid":[247,368],"protein.":[248],"as":[255],"test":[256],"serum":[259],"bactericidal":[260,284,314,326,343],"assay":[261,483],"measure":[263],"activity":[265,285,344],"antibodies":[267,399],"strain":[275,360,421,430],"ID":[280],"9.\nThe":[281],"sera":[282,304,328],"had":[283,342,453],"10":[287],"out":[288],"strains.":[295],"However,":[296],"8":[298],"susceptible":[301],"also":[303,341,401],"did":[309],"not":[310],"contain":[311],"suggesting":[315],"other":[317],"yet":[318],"unknown":[319],"target(s)":[320],"contribute":[321,388],"generation":[324],"antibodies.The":[327],"mice":[331],"natural":[365],"sequence.":[369],"expressing":[376],"suggest":[380],"fH":[385],"susceptibility":[390],"isolate":[393],"killing":[395],"anti":[397],"overall":[402],"plays":[405],"role.\n3.":[407],"As":[408],"proof":[409],"principle":[411],"broaden":[413],"mutant":[427,452,494],"over-express":[433],"native":[435],"v.2":[437],"sequence,":[438],"which":[439],"predominant":[441],"generated.":[448],"approximately":[454,486],"10-fold":[455],"higher":[456],"amount":[457],"meningococcus;":[466],"penta-acylation":[467],"lipidA":[469],"after":[470],"inactivation":[471],"lpxL1":[473],"confirmed":[475],"MALDI-TOF":[477],"Monocyte-Activation":[480],"Test":[481],"(MAT)":[482],"showed":[484],"100-fold":[487],"decreases":[488],"ability":[489],"activate":[496],"cytokine":[497],"release":[498],"human":[500],"blood":[501],"cells.":[502],"By":[503],"HPLC-SEC":[504],"MALLS":[505],"integrity,":[506],"size":[507],"impurities":[509],"vesicles":[512],"characterized.":[514]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-11-30T00:00:00"}
