{"id":"https://openalex.org/W2549831703","doi":"https://doi.org/10.3389/fphar.2016.00443","title":"Comparison of Liver Cell Models Using the Basel Phenotyping Cocktail","display_name":"Comparison of Liver Cell Models Using the Basel Phenotyping Cocktail","publication_year":2016,"publication_date":"2016-11-21","ids":{"openalex":"https://openalex.org/W2549831703","doi":"https://doi.org/10.3389/fphar.2016.00443","mag":"2549831703","pmid":"https://pubmed.ncbi.nlm.nih.gov/27917125"},"language":"en","primary_location":{"id":"doi:10.3389/fphar.2016.00443","doi":"https://doi.org/10.3389/fphar.2016.00443","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fphar.2016.00443","pdf_url":"https://www.frontiersin.org/articles/10.3389/fphar.2016.00443/pdf","source":{"id":"https://openalex.org/S132108250","display_name":"Frontiers in Pharmacology","issn_l":"1663-9812","issn":["1663-9812"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","ki-jl-1","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Pharmacology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.frontiersin.org/articles/10.3389/fphar.2016.00443/pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5077152954","display_name":"Benjamin Berger","orcid":"https://orcid.org/0000-0001-7777-5734","observed_orcids":["https://orcid.org/0000-0001-7777-5734"]},"institutions":[{"id":"https://openalex.org/I1850255","display_name":"University of Basel","ror":"https://ror.org/02s6k3f65","country_code":"CH","type":"education","lineage":["https://openalex.org/I1850255"]},{"id":"https://openalex.org/I2802542264","display_name":"University Hospital of Basel","ror":"https://ror.org/04k51q396","country_code":"CH","type":"healthcare","lineage":["https://openalex.org/I2802542264"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"Benjamin Berger","raw_affiliation_strings":["Division of Clinical Pharmacology and Toxicology, University Hospital BaselBasel, Switzerland; Department of Biomedicine, University of BaselBasel, Switzerland","Department of Biomedicine, University of Basel, Basel, Switzerland","Division of Clinical Pharmacology and Toxicology, University Hospital Basel, Basel, Switzerland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Clinical Pharmacology and Toxicology, University Hospital BaselBasel, Switzerland; Department of Biomedicine, University of BaselBasel, Switzerland","institution_ids":["https://openalex.org/I1850255","https://openalex.org/I2802542264"]},{"raw_affiliation_string":"Department of Biomedicine, University of Basel, Basel, Switzerland","institution_ids":["https://openalex.org/I1850255"]},{"raw_affiliation_string":"Division of Clinical Pharmacology and Toxicology, University Hospital Basel, Basel, Switzerland","institution_ids":["https://openalex.org/I2802542264"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5080326431","display_name":"Massimiliano Donzelli","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1850255","display_name":"University of Basel","ror":"https://ror.org/02s6k3f65","country_code":"CH","type":"education","lineage":["https://openalex.org/I1850255"]},{"id":"https://openalex.org/I2802542264","display_name":"University Hospital of Basel","ror":"https://ror.org/04k51q396","country_code":"CH","type":"healthcare","lineage":["https://openalex.org/I2802542264"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"Massimiliano Donzelli","raw_affiliation_strings":["Division of Clinical Pharmacology and Toxicology, University Hospital BaselBasel, Switzerland; Department of Biomedicine, University of BaselBasel, Switzerland","Department of Biomedicine, University of Basel, Basel, Switzerland","Division of Clinical Pharmacology and Toxicology, University Hospital Basel, Basel, Switzerland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Clinical Pharmacology and Toxicology, University Hospital BaselBasel, Switzerland; Department of Biomedicine, University of BaselBasel, Switzerland","institution_ids":["https://openalex.org/I1850255","https://openalex.org/I2802542264"]},{"raw_affiliation_string":"Department of Biomedicine, University of Basel, Basel, Switzerland","institution_ids":["https://openalex.org/I1850255"]},{"raw_affiliation_string":"Division of Clinical Pharmacology and Toxicology, University Hospital Basel, Basel, Switzerland","institution_ids":["https://openalex.org/I2802542264"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5020937327","display_name":"Swarna Maseneni","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1850255","display_name":"University of Basel","ror":"https://ror.org/02s6k3f65","country_code":"CH","type":"education","lineage":["https://openalex.org/I1850255"]},{"id":"https://openalex.org/I2802542264","display_name":"University Hospital of Basel","ror":"https://ror.org/04k51q396","country_code":"CH","type":"healthcare","lineage":["https://openalex.org/I2802542264"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"Swarna Maseneni","raw_affiliation_strings":["Division of Clinical Pharmacology and Toxicology, University Hospital BaselBasel, Switzerland; Department of Biomedicine, University of BaselBasel, Switzerland","Department of Biomedicine, University of Basel, Basel, Switzerland","Division of Clinical Pharmacology and Toxicology, University Hospital Basel, Basel, Switzerland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Clinical Pharmacology and Toxicology, University Hospital BaselBasel, Switzerland; Department of Biomedicine, University of BaselBasel, Switzerland","institution_ids":["https://openalex.org/I1850255","https://openalex.org/I2802542264"]},{"raw_affiliation_string":"Department of Biomedicine, University of Basel, Basel, Switzerland","institution_ids":["https://openalex.org/I1850255"]},{"raw_affiliation_string":"Division of Clinical Pharmacology and Toxicology, University Hospital Basel, Basel, Switzerland","institution_ids":["https://openalex.org/I2802542264"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5050962059","display_name":"Franziska Boess","orcid":"https://orcid.org/0000-0002-3886-8193","observed_orcids":["https://orcid.org/0000-0002-3886-8193"]},"institutions":[{"id":"https://openalex.org/I118019719","display_name":"F. Hoffmann-La Roche AG","ror":"https://ror.org/00by1q217","country_code":"CH","type":"company","lineage":["https://openalex.org/I118019719"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"Franziska Boess","raw_affiliation_strings":["Roche Innovation Center Basel, Pharmaceutical Sciences, Hoffmann-La Roche Ltd. Basel, Switzerland","Roche Innovation Center Basel, Pharmaceutical Sciences, Hoffmann-La Roche Ltd., Basel, Switzerland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Roche Innovation Center Basel, Pharmaceutical Sciences, Hoffmann-La Roche Ltd. Basel, Switzerland","institution_ids":["https://openalex.org/I118019719"]},{"raw_affiliation_string":"Roche Innovation Center Basel, Pharmaceutical Sciences, Hoffmann-La Roche Ltd., Basel, Switzerland","institution_ids":["https://openalex.org/I118019719"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5057418067","display_name":"Adrian B. Roth","orcid":"https://orcid.org/0000-0003-3164-3300","observed_orcids":["https://orcid.org/0000-0003-3164-3300"]},"institutions":[{"id":"https://openalex.org/I118019719","display_name":"F. Hoffmann-La Roche AG","ror":"https://ror.org/00by1q217","country_code":"CH","type":"company","lineage":["https://openalex.org/I118019719"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"Adrian Roth","raw_affiliation_strings":["Roche Innovation Center Basel, Pharmaceutical Sciences, Hoffmann-La Roche Ltd. Basel, Switzerland","Roche Innovation Center Basel, Pharmaceutical Sciences, Hoffmann-La Roche Ltd., Basel, Switzerland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Roche Innovation Center Basel, Pharmaceutical Sciences, Hoffmann-La Roche Ltd. Basel, Switzerland","institution_ids":["https://openalex.org/I118019719"]},{"raw_affiliation_string":"Roche Innovation Center Basel, Pharmaceutical Sciences, Hoffmann-La Roche Ltd., Basel, Switzerland","institution_ids":["https://openalex.org/I118019719"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5087882435","display_name":"Stephan Kr\u00e4henb\u00fchl","orcid":"https://orcid.org/0000-0001-8347-4145","observed_orcids":["https://orcid.org/0000-0001-8347-4145"]},"institutions":[{"id":"https://openalex.org/I1850255","display_name":"University of Basel","ror":"https://ror.org/02s6k3f65","country_code":"CH","type":"education","lineage":["https://openalex.org/I1850255"]},{"id":"https://openalex.org/I2802542264","display_name":"University Hospital of Basel","ror":"https://ror.org/04k51q396","country_code":"CH","type":"healthcare","lineage":["https://openalex.org/I2802542264"]},{"id":"https://openalex.org/I4391768042","display_name":"Swiss Centre for Applied Human Toxicology","ror":"https://ror.org/03wma5x57","country_code":null,"type":"facility","lineage":["https://openalex.org/I4391768042"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"Stephan Kr\u00e4henb\u00fchl","raw_affiliation_strings":["Division of Clinical Pharmacology and Toxicology, University Hospital BaselBasel, Switzerland; Department of Biomedicine, University of BaselBasel, Switzerland; Swiss Center for Applied Human ToxicologyBasel, Switzerland","Department of Biomedicine, University of Basel, Basel, Switzerland","Division of Clinical Pharmacology and Toxicology, University Hospital Basel, Basel, Switzerland","Swiss Center for Applied Human Toxicology, Basel, Switzerland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Clinical Pharmacology and Toxicology, University Hospital BaselBasel, Switzerland; Department of Biomedicine, University of BaselBasel, Switzerland; Swiss Center for Applied Human ToxicologyBasel, Switzerland","institution_ids":["https://openalex.org/I1850255","https://openalex.org/I2802542264"]},{"raw_affiliation_string":"Department of Biomedicine, University of Basel, Basel, Switzerland","institution_ids":["https://openalex.org/I1850255"]},{"raw_affiliation_string":"Division of Clinical Pharmacology and Toxicology, University Hospital Basel, Basel, Switzerland","institution_ids":["https://openalex.org/I2802542264"]},{"raw_affiliation_string":"Swiss Center for Applied Human Toxicology, Basel, Switzerland","institution_ids":["https://openalex.org/I4391768042"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5071531513","display_name":"Manuel Haschke","orcid":"https://orcid.org/0000-0003-1846-8640","observed_orcids":["https://orcid.org/0000-0003-1846-8640"]},"institutions":[{"id":"https://openalex.org/I1850255","display_name":"University of Basel","ror":"https://ror.org/02s6k3f65","country_code":"CH","type":"education","lineage":["https://openalex.org/I1850255"]},{"id":"https://openalex.org/I2802542264","display_name":"University Hospital of Basel","ror":"https://ror.org/04k51q396","country_code":"CH","type":"healthcare","lineage":["https://openalex.org/I2802542264"]}],"countries":["CH"],"is_corresponding":true,"raw_author_name":"Manuel Haschke","raw_affiliation_strings":["Division of Clinical Pharmacology and Toxicology, University Hospital BaselBasel, Switzerland; Department of Biomedicine, University of BaselBasel, Switzerland","Department of Biomedicine, University of Basel, Basel, Switzerland","Division of Clinical Pharmacology and Toxicology, University Hospital Basel, Basel, Switzerland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Clinical Pharmacology and Toxicology, University Hospital BaselBasel, Switzerland; Department of Biomedicine, University of BaselBasel, Switzerland","institution_ids":["https://openalex.org/I1850255","https://openalex.org/I2802542264"]},{"raw_affiliation_string":"Department of Biomedicine, University of Basel, Basel, Switzerland","institution_ids":["https://openalex.org/I1850255"]},{"raw_affiliation_string":"Division of Clinical Pharmacology and Toxicology, University Hospital Basel, Basel, Switzerland","institution_ids":["https://openalex.org/I2802542264"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5071531513"],"corresponding_institution_ids":["https://openalex.org/I1850255","https://openalex.org/I2802542264"],"apc_list":{"value":3150,"currency":"CHF","value_usd":3801},"apc_paid":{"value":3150,"currency":"CHF","value_usd":3801},"fwci":10.3603,"has_fulltext":true,"cited_by_count":92,"citation_normalized_percentile":{"value":0.98550073,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":98,"max":99},"biblio":{"volume":"7","issue":null,"first_page":"443","last_page":"443"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10375","display_name":"Pharmacogenetics and Drug Metabolism","score":0.9717000126838684,"subfield":{"id":"https://openalex.org/subfields/3004","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10375","display_name":"Pharmacogenetics and Drug Metabolism","score":0.9717000126838684,"subfield":{"id":"https://openalex.org/subfields/3004","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11465","display_name":"Drug-Induced Hepatotoxicity and Protection","score":0.015599999576807022,"subfield":{"id":"https://openalex.org/subfields/3004","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10570","display_name":"Drug Transport and Resistance Mechanisms","score":0.0044999998062849045,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/cytochrome-p450-induction","display_name":"cytochrome P450 induction","score":0.6169999837875366},{"id":"https://openalex.org/keywords/drug-metabolism","display_name":"drug metabolism","score":0.593999981880188},{"id":"https://openalex.org/keywords/primary-human-hepatocytes","display_name":"primary human hepatocytes","score":0.9240000247955322},{"id":"https://openalex.org/keywords/hepg2-cells","display_name":"HepG2 cells","score":0.8259999752044678},{"id":"https://openalex.org/keywords/heparg-cells","display_name":"HepaRG cells","score":0.9919999837875366},{"id":"https://openalex.org/keywords/cyp3a4","display_name":"CYP3A4","score":0.7649999856948853},{"id":"https://openalex.org/keywords/cyp2c19","display_name":"CYP2C19","score":0.875},{"id":"https://openalex.org/keywords/cyp2b6","display_name":"CYP2B6","score":0.8560000061988831},{"id":"https://openalex.org/keywords/cyp2d6","display_name":"CYP2D6","score":0.8700000047683716},{"id":"https://openalex.org/keywords/cyp1a2","display_name":"CYP1A2","score":0.890999972820282},{"id":"https://openalex.org/keywords/cyp2c9","display_name":"CYP2C9","score":0.9879999756813049},{"id":"https://openalex.org/keywords/rifampicin","display_name":"rifampicin","score":0.8610000014305115}],"concepts":[{"id":"https://openalex.org/C109650736","wikidata":"https://www.wikidata.org/wiki/Q424440","display_name":"CYP3A4","level":4,"score":0.7202752828598022},{"id":"https://openalex.org/C50605568","wikidata":"https://www.wikidata.org/wiki/Q14912267","display_name":"CYP2B6","level":5,"score":0.6924959421157837},{"id":"https://openalex.org/C207001950","wikidata":"https://www.wikidata.org/wiki/Q141124","display_name":"In vivo","level":2,"score":0.5672950744628906},{"id":"https://openalex.org/C2776200302","wikidata":"https://www.wikidata.org/wiki/Q827450","display_name":"Hepatocyte","level":3,"score":0.5459096431732178},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.5263763070106506},{"id":"https://openalex.org/C89311334","wikidata":"https://www.wikidata.org/wiki/Q1124842","display_name":"Drug metabolism","level":3,"score":0.5086387395858765},{"id":"https://openalex.org/C81885089","wikidata":"https://www.wikidata.org/wiki/Q189082","display_name":"Cell culture","level":2,"score":0.5003385543823242},{"id":"https://openalex.org/C526171541","wikidata":"https://www.wikidata.org/wiki/Q407693","display_name":"Cytochrome P450","level":3,"score":0.47684943675994873},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.4417877793312073},{"id":"https://openalex.org/C33664856","wikidata":"https://www.wikidata.org/wiki/Q3271142","display_name":"CYP2D6","level":4,"score":0.4397276043891907},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.3987998962402344},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3839437663555145},{"id":"https://openalex.org/C62231903","wikidata":"https://www.wikidata.org/wiki/Q1057","display_name":"Metabolism","level":2,"score":0.1947140395641327},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.18076398968696594},{"id":"https://openalex.org/C2780035454","wikidata":"https://www.wikidata.org/wiki/Q8386","display_name":"Drug","level":2,"score":0.1298830807209015},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0},{"id":"https://openalex.org/C150903083","wikidata":"https://www.wikidata.org/wiki/Q7108","display_name":"Biotechnology","level":1,"score":0.0}],"mesh":[],"locations_count":5,"locations":[{"id":"doi:10.3389/fphar.2016.00443","doi":"https://doi.org/10.3389/fphar.2016.00443","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fphar.2016.00443","pdf_url":"https://www.frontiersin.org/articles/10.3389/fphar.2016.00443/pdf","source":{"id":"https://openalex.org/S132108250","display_name":"Frontiers in Pharmacology","issn_l":"1663-9812","issn":["1663-9812"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","ki-jl-1","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Pharmacology","raw_type":"journal-article"},{"id":"pmid:27917125","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/27917125","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in pharmacology","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:5116554","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/5116554","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Front Pharmacol","raw_type":"Text"},{"id":"pmh:oai:doaj.org/article:d26b41a9ef8d4a8792f7f576e5048f28","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/d26b41a9ef8d4a8792f7f576e5048f28","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Frontiers in Pharmacology, Vol 7 (2016)","raw_type":"article"},{"id":"pmh:oai:edoc.unibas.ch:62291","doi":null,"is_oa":false,"landing_page_url":"https://edoc.unibas.ch/62291/","pdf_url":null,"source":{"id":"https://openalex.org/S4306401836","display_name":"edoc (University of Basel)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1850255","host_organization_name":"University of Basel","host_organization_lineage":["https://openalex.org/I1850255"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Article"}],"best_oa_location":{"id":"doi:10.3389/fphar.2016.00443","doi":"https://doi.org/10.3389/fphar.2016.00443","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fphar.2016.00443","pdf_url":"https://www.frontiersin.org/articles/10.3389/fphar.2016.00443/pdf","source":{"id":"https://openalex.org/S132108250","display_name":"Frontiers in Pharmacology","issn_l":"1663-9812","issn":["1663-9812"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","ki-jl-1","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Pharmacology","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9391000270843506,"id":"https://metadata.un.org/sdg/3"}],"sustainable_development_goals_aurora":[{"display_name":"Good health and well-being","score":0.550000011920929,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G4951541787","display_name":"Idiosyncratic drug-induced liver injury: hepatotoxicity of tyrosine kinase inhibitors and impairment of mitochondrial fatty acid metabolism","funder_award_id":"156270","funder_id":"https://openalex.org/F4320320924","funder_display_name":"Schweizerischer Nationalfonds zur F\u00f6rderung der Wissenschaftlichen Forschung"}],"funders":[{"id":"https://openalex.org/F4320306076","display_name":"National Science Foundation","ror":"https://ror.org/021nxhr62"},{"id":"https://openalex.org/F4320320924","display_name":"Schweizerischer Nationalfonds zur F\u00f6rderung der Wissenschaftlichen Forschung","ror":"https://ror.org/00yjd3n13"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2549831703.pdf","grobid_xml":"https://content.openalex.org/works/W2549831703.grobid-xml"},"referenced_works_count":36,"referenced_works":["https://openalex.org/W119374870","https://openalex.org/W787448140","https://openalex.org/W1508080975","https://openalex.org/W1822042631","https://openalex.org/W1964184380","https://openalex.org/W1967325600","https://openalex.org/W1971763588","https://openalex.org/W1974249349","https://openalex.org/W1980455299","https://openalex.org/W1981563176","https://openalex.org/W2001143171","https://openalex.org/W2006545737","https://openalex.org/W2012791491","https://openalex.org/W2026330543","https://openalex.org/W2027254129","https://openalex.org/W2028921444","https://openalex.org/W2031092738","https://openalex.org/W2035855164","https://openalex.org/W2041648785","https://openalex.org/W2043515466","https://openalex.org/W2044911368","https://openalex.org/W2051833837","https://openalex.org/W2059216445","https://openalex.org/W2072624946","https://openalex.org/W2075976888","https://openalex.org/W2077067141","https://openalex.org/W2078702135","https://openalex.org/W2080548859","https://openalex.org/W2084398087","https://openalex.org/W2094392052","https://openalex.org/W2100213712","https://openalex.org/W2107277218","https://openalex.org/W2115650781","https://openalex.org/W2134520937","https://openalex.org/W2169675397","https://openalex.org/W4238706709"],"related_works":["https://openalex.org/W2112546684","https://openalex.org/W2126277050","https://openalex.org/W2277368739","https://openalex.org/W1998541081","https://openalex.org/W2567759360","https://openalex.org/W2380178840","https://openalex.org/W2059551847","https://openalex.org/W2162873465","https://openalex.org/W2145492382","https://openalex.org/W2510816179"],"abstract_inverted_index":{"Currently":[0],"used":[1],"hepatocyte":[2,19,51],"cell":[3,14,52,132,226],"systems":[4,53,227],"for":[5,123,144,151,160,165,179,228,258],"in":[6,29,46,63,68,86,93,101,111,126,174,192,199,235,267],"vitro":[7,47],"assessment":[8,260],"of":[9,26,246,261],"drug":[10,230],"metabolism":[11,73,231],"include":[12],"hepatoma":[13],"lines":[15],"and":[16,48,58,74,91,95,97,99,113,149,153,157,162,186,194,219,232,249,264],"primary":[17,59],"human":[18,61],"(PHH)":[20],"cultures.":[21],"We":[22],"investigated":[23],"the":[24,27,130,202,211,247,259],"suit-ability":[25],"validated":[28],"vivo":[30,200],"Basel":[31,253],"phenotyping":[32,204,254],"cocktail":[33,255],"(caffeine":[34],"[CYP1A2],":[35],"efavirenz":[36],"[CYP2B6],":[37],"losartan":[38],"[CYP2C9],":[39],"omeprazole":[40],"[CYP2C19],":[41],"metoprolol":[42],"[CYP2D6],":[43],"midazolam":[44],"[CYP3A4])":[45],"characterized":[49],"four":[50],"(HepG2":[54],"cells,":[55,57],"HepaRG":[56,114,152,223],"cryopreserved":[60],"hepatocytes":[62],"2-dimensional":[64],"[2D]":[65],"culture":[66],"or":[67],"3D-spheroid":[69],"co-culture)":[70],"regarding":[71],"basal":[72],"CYP":[75,81,107,175,182,196,233,244,262],"inducibility.":[76],"Under":[77],"non-induced":[78,106],"conditions,":[79],"all":[80,124,145,180],"activities":[82,108],"could":[83],"be":[84],"determined":[85],"3D-PHH,":[87,154],"CYP2B6,":[88],"CYP2C19,":[89],"CYP2D6":[90],"CYP3A4":[92,100],"2D-PHH":[94,161,193],"HepaRG,":[96],"CYP2C19":[98],"HepG2":[102,237],"cells.":[103,115],"The":[104,252],"highest":[105],"were":[109],"observed":[110,178],"3D-PHH":[112,127,168,212,218],"mRNA":[116,139],"expression":[117],"was":[118,177,206],"at":[119,169],"least":[120,170],"4-fold":[121,155,163],"higher":[122],"CYPs":[125,146],"compared":[128],"to":[129,142,242],"other":[131],"systems.":[133],"After":[134],"treatment":[135],"with":[136],"20\u00b5M":[137],"rifampicin,":[138],"increased":[140],"3":[141],"50-fold":[143],"except":[147],"CYP1A2":[148,185],"2D6":[150],"(CYP2B6)":[156],"17-fold":[158],"(CYP3A4)":[159,164],"HepG2.":[166],"In":[167],"a":[171],"2-fold":[172],"in-crease":[173],"activity":[176,188,263],"inducible":[181],"isoforms":[183],"while":[184],"CYP2C9":[187],"did":[189],"not":[190],"increase":[191],"HepaRG.":[195],"inducibility":[197],"assessed":[198],"using":[201],"same":[203],"probes":[205],"also":[207,266],"best":[208],"reflected":[209],"by":[210],"model.":[213],"Our":[214],"studies":[215],"show":[216],"that":[217],"(with":[220],"some":[221],"limitations)":[222],"are":[224,239],"suitable":[225,257],"assessing":[229],"induction":[234,245,265],"vitro.":[236,268],"cells":[238],"less":[240],"suited":[241],"as-sess":[243],"2C":[248],"3A":[250],"family.":[251],"is":[256]},"counts_by_year":[{"year":2026,"cited_by_count":9},{"year":2025,"cited_by_count":6},{"year":2024,"cited_by_count":8},{"year":2023,"cited_by_count":8},{"year":2022,"cited_by_count":8},{"year":2021,"cited_by_count":11},{"year":2020,"cited_by_count":14},{"year":2019,"cited_by_count":8},{"year":2018,"cited_by_count":12},{"year":2017,"cited_by_count":8}],"updated_date":"2026-10-22T18:32:59.640997","created_date":"2025-10-10T00:00:00"}