{"id":"https://openalex.org/W2549566502","doi":null,"title":"Original Article Immunotherapy with immunomodulatory antibody for hepatocellular carcinoma","display_name":"Original Article Immunotherapy with immunomodulatory antibody for hepatocellular carcinoma","publication_year":2015,"publication_date":"2015-01-01","ids":{"openalex":"https://openalex.org/W2549566502","mag":"2549566502"},"language":"en","primary_location":{"id":"mag:2549566502","doi":null,"is_oa":false,"landing_page_url":"http://www.ajdd.us/files/ajdd0015964.pdf","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null},"volume":null,"type":"article","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5101700506","display_name":"Liang Huang","orcid":"https://orcid.org/0000-0003-4850-6732","observed_orcids":["https://orcid.org/0000-0003-4850-6732"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Liang Huang","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0003-4850-6732","affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5101700506"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10158","display_name":"Cancer Immunotherapy and Biomarkers","score":0.61080002784729,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10158","display_name":"Cancer Immunotherapy and Biomarkers","score":0.61080002784729,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10073","display_name":"Hepatocellular Carcinoma Treatment and Prognosis","score":0.38670000433921814,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10340","display_name":"Hepatitis B Virus Studies","score":0.00039999998989515007,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/hepatocellular-carcinoma","display_name":"hepatocellular carcinoma","score":0.9929999709129333},{"id":"https://openalex.org/keywords/immunotherapy","display_name":"immunotherapy","score":0.8389999866485596},{"id":"https://openalex.org/keywords/immunomodulatory-antibodies","display_name":"immunomodulatory antibodies","score":0.8989999890327454},{"id":"https://openalex.org/keywords/immune-checkpoint-inhibitors","display_name":"immune checkpoint inhibitors","score":0.9010000228881836},{"id":"https://openalex.org/keywords/costimulatory-molecules","display_name":"costimulatory molecules","score":0.859000027179718},{"id":"https://openalex.org/keywords/t-cells","display_name":"T cells","score":0.7110000252723694},{"id":"https://openalex.org/keywords/antitumor-immunity","display_name":"antitumor immunity","score":0.8370000123977661},{"id":"https://openalex.org/keywords/pd-1-pathway","display_name":"PD-1 pathway","score":0.7799999713897705},{"id":"https://openalex.org/keywords/ipilimumab","display_name":"ipilimumab","score":0.8420000076293945},{"id":"https://openalex.org/keywords/clinical-trials","display_name":"clinical trials","score":0.7620000243186951}],"concepts":[{"id":"https://openalex.org/C2781433595","wikidata":"https://www.wikidata.org/wiki/Q2459042","display_name":"Ipilimumab","level":4,"score":0.8356142044067383},{"id":"https://openalex.org/C2777701055","wikidata":"https://www.wikidata.org/wiki/Q1427096","display_name":"Immunotherapy","level":3,"score":0.8174076080322266},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.6943277716636658},{"id":"https://openalex.org/C2778019345","wikidata":"https://www.wikidata.org/wiki/Q1148337","display_name":"Hepatocellular carcinoma","level":2,"score":0.6879674792289734},{"id":"https://openalex.org/C2780851360","wikidata":"https://www.wikidata.org/wiki/Q21686041","display_name":"Immune checkpoint","level":4,"score":0.6163616180419922},{"id":"https://openalex.org/C2780030458","wikidata":"https://www.wikidata.org/wiki/Q7041828","display_name":"Nivolumab","level":4,"score":0.5712780356407166},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.5148707628250122},{"id":"https://openalex.org/C159654299","wikidata":"https://www.wikidata.org/wiki/Q79460","display_name":"Antibody","level":2,"score":0.5132296085357666},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.5086596608161926},{"id":"https://openalex.org/C21705690","wikidata":"https://www.wikidata.org/wiki/Q2907609","display_name":"CTLA-4","level":4,"score":0.4334115982055664},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.38103872537612915},{"id":"https://openalex.org/C2776090121","wikidata":"https://www.wikidata.org/wiki/Q193529","display_name":"T cell","level":3,"score":0.1911080777645111}],"mesh":[],"locations_count":1,"locations":[{"id":"mag:2549566502","doi":null,"is_oa":false,"landing_page_url":"http://www.ajdd.us/files/ajdd0015964.pdf","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9763000011444092}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":104,"referenced_works":["https://openalex.org/W1181378967","https://openalex.org/W1492810762","https://openalex.org/W1522145177","https://openalex.org/W1523489331","https://openalex.org/W1534756886","https://openalex.org/W1601495799","https://openalex.org/W1757407923","https://openalex.org/W1769186443","https://openalex.org/W1913163130","https://openalex.org/W1929386821","https://openalex.org/W1961598420","https://openalex.org/W1964923494","https://openalex.org/W1969033642","https://openalex.org/W1969383383","https://openalex.org/W1971890973","https://openalex.org/W1977402753","https://openalex.org/W1985199927","https://openalex.org/W1986696487","https://openalex.org/W1988424227","https://openalex.org/W1988702078","https://openalex.org/W1990225108","https://openalex.org/W1993211204","https://openalex.org/W1995109981","https://openalex.org/W1996882335","https://openalex.org/W1997250936","https://openalex.org/W2003210438","https://openalex.org/W2004630197","https://openalex.org/W2005484337","https://openalex.org/W2010121426","https://openalex.org/W2011458181","https://openalex.org/W2013043293","https://openalex.org/W2014024036","https://openalex.org/W2015898002","https://openalex.org/W2017371347","https://openalex.org/W2023369016","https://openalex.org/W2025252557","https://openalex.org/W2026208522","https://openalex.org/W2029180341","https://openalex.org/W2033558602","https://openalex.org/W2034678662","https://openalex.org/W2035013975","https://openalex.org/W2036574174","https://openalex.org/W2036617944","https://openalex.org/W2039248453","https://openalex.org/W2044422127","https://openalex.org/W2044835625","https://openalex.org/W2045899029","https://openalex.org/W2046568352","https://openalex.org/W2046828081","https://openalex.org/W2047900254","https://openalex.org/W2049010867","https://openalex.org/W2050269012","https://openalex.org/W2052730188","https://openalex.org/W2059688175","https://openalex.org/W2068640002","https://openalex.org/W2069668308","https://openalex.org/W2070631889","https://openalex.org/W2070715664","https://openalex.org/W2071065868","https://openalex.org/W2073389228","https://openalex.org/W2077940506","https://openalex.org/W2079018735","https://openalex.org/W2082751482","https://openalex.org/W2082930742","https://openalex.org/W2083672604","https://openalex.org/W2084274600","https://openalex.org/W2088373848","https://openalex.org/W2090407934","https://openalex.org/W2091383142","https://openalex.org/W2094991897","https://openalex.org/W2095699174","https://openalex.org/W2097995306","https://openalex.org/W2099417164","https://openalex.org/W2102754583","https://openalex.org/W2103876938","https://openalex.org/W2103950437","https://openalex.org/W2107564997","https://openalex.org/W2110381465","https://openalex.org/W2116690744","https://openalex.org/W2126043960","https://openalex.org/W2128227067","https://openalex.org/W2131129763","https://openalex.org/W2134644618","https://openalex.org/W2137969636","https://openalex.org/W2139187785","https://openalex.org/W2142943268","https://openalex.org/W2147117254","https://openalex.org/W2147907637","https://openalex.org/W2150753841","https://openalex.org/W2152155935","https://openalex.org/W2153267053","https://openalex.org/W2153519961","https://openalex.org/W2158925892","https://openalex.org/W2162667703","https://openalex.org/W2164457267","https://openalex.org/W2168231169","https://openalex.org/W2168489055","https://openalex.org/W2172000034","https://openalex.org/W2172183947","https://openalex.org/W2326276411","https://openalex.org/W2601572279","https://openalex.org/W2908228626","https://openalex.org/W3139763557","https://openalex.org/W3151603452"],"related_works":["https://openalex.org/W4391253339","https://openalex.org/W2561612336","https://openalex.org/W2904923617","https://openalex.org/W3146723294","https://openalex.org/W1992450231","https://openalex.org/W2754580992","https://openalex.org/W2890430492","https://openalex.org/W2968827358","https://openalex.org/W3041930942","https://openalex.org/W2015897371"],"abstract_inverted_index":{"Investigators":[0],"have":[1,79],"been":[2],"interested":[3],"in":[4,29],"immunotherapy":[5,65],"for":[6,9,17,92,116],"hepatocellular":[7,18,93],"carcinoma":[8],"decades.":[10],"Immunotherapy":[11],"represents":[12],"a":[13,127],"new":[14],"effective":[15],"treatment":[16,90],"carcinoma.":[19,94],"Its":[20],"recent":[21],"breakthrough":[22],"is":[23],"largely":[24],"attributable":[25],"to":[26,53,100],"the":[27,42,54,62,81,104],"advances":[28],"understanding":[30],"of":[31,37,44,64,83,109],"anti-tumor":[32],"immune":[33,40,110,130],"responses,":[34],"tolerance,":[35],"regulation":[36],"anti-":[38],"tumor":[39],"and":[41,50,69,75,102,107,113],"advent":[43],"newer":[45],"therapies,":[46],"including":[47],"checkpoint":[48,111,131],"antibodies":[49,52],"agonist":[51],"co-":[55],"stimulatory":[56],"molecules":[57,115],"targeting":[58],"T":[59,117],"cells.":[60,118],"With":[61],"success":[63],"such":[66],"as":[67,87],"ipilimumab":[68],"programmed":[70],"death-1":[71],"pathway-targeted":[72],"agents,":[73],"more":[74,76],"preclinical":[77],"data":[78],"offered":[80],"basis":[82],"immunomodulatory":[84],"antibody":[85],"therapy":[86,112],"an":[88],"important":[89],"option":[91],"In":[95],"this":[96],"article,":[97],"I":[98,119],"attempted":[99],"review":[101],"summarize":[103],"mechanisms,":[105],"implication":[106],"future":[108],"costimulatory":[114],"also":[120],"discussed":[121],"some":[122],"ongoing":[123],"clinical":[124],"trials":[125],"with":[126],"focus":[128],"on":[129],"antibody.":[132]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-11-30T00:00:00"}