{"id":"https://openalex.org/W2549401663","doi":"https://doi.org/10.1182/blood.v114.22.6.6","title":"Improving the Treatment Outcome of Acute Promyelocytic Leukemia in Developing Countries through International Cooperative Network. Report On the International Consortium On Acute Promyelocytic Leukemia Study Group.","display_name":"Improving the Treatment Outcome of Acute Promyelocytic Leukemia in Developing Countries through International Cooperative Network. Report On the International Consortium On Acute Promyelocytic Leukemia Study Group.","publication_year":2009,"publication_date":"2009-11-20","ids":{"openalex":"https://openalex.org/W2549401663","doi":"https://doi.org/10.1182/blood.v114.22.6.6","mag":"2549401663"},"language":"en","primary_location":{"id":"doi:10.1182/blood.v114.22.6.6","doi":"https://doi.org/10.1182/blood.v114.22.6.6","is_oa":false,"landing_page_url":"https://doi.org/10.1182/blood.v114.22.6.6","pdf_url":null,"source":{"id":"https://openalex.org/S200071133","display_name":"Blood","issn_l":"0006-4971","issn":["0006-4971","1528-0020"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Blood","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5041497834","display_name":"Eduardo Magalh\u00e3es Rego","orcid":"https://orcid.org/0000-0003-1567-4086","observed_orcids":["https://orcid.org/0000-0003-1567-4086"]},"institutions":[{"id":"https://openalex.org/I17974374","display_name":"Universidade de S\u00e3o Paulo","ror":"https://ror.org/036rp1748","country_code":"BR","type":"education","lineage":["https://openalex.org/I17974374"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Eduardo M Rego","raw_affiliation_strings":["Hematology Service, Internal Medicine, Medical School of Ribeira\u0303o Preto, University of Sa\u0303o Paulo, Ribeira\u0303o Preto, Brazil,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Hematology Service, Internal Medicine, Medical School of Ribeira\u0303o Preto, University of Sa\u0303o Paulo, Ribeira\u0303o Preto, Brazil,","institution_ids":["https://openalex.org/I17974374"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5045479163","display_name":"Haesook T. Kim","orcid":"https://orcid.org/0000-0003-4889-6849","observed_orcids":["https://orcid.org/0000-0003-4889-6849"]},"institutions":[{"id":"https://openalex.org/I4210117453","display_name":"Dana-Farber Cancer Institute","ror":"https://ror.org/02jzgtq86","country_code":"US","type":"facility","lineage":["https://openalex.org/I4210117453"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Haesook T. Kim","raw_affiliation_strings":["Dana Farber Cancer Institute, Boston, MA, USA,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Dana Farber Cancer Institute, Boston, MA, USA,","institution_ids":["https://openalex.org/I4210117453"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5022592090","display_name":"Guillermo Jose Ruiz-Arg\u00fcelles","orcid":"https://orcid.org/0000-0002-9335-0653","observed_orcids":["https://orcid.org/0000-0002-9335-0653"]},"institutions":[{"id":"https://openalex.org/I4210161313","display_name":"Cl\u00ednica Ruiz","ror":"https://ror.org/05xr0q537","country_code":"MX","type":"healthcare","lineage":["https://openalex.org/I4210161313"]}],"countries":["MX"],"is_corresponding":false,"raw_author_name":"Guillermo J. Ruiz-Arguelles","raw_affiliation_strings":["Clinica Ruiz de Puebla, Puebla, Mexico,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Clinica Ruiz de Puebla, Puebla, Mexico,","institution_ids":["https://openalex.org/I4210161313"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5007469088","display_name":"Rosario Uriarte","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Rosario Uriarte","raw_affiliation_strings":["Asociacion Espanola Primera de Socorros Mutuos, Montevideo, Uruguay,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Asociacion Espanola Primera de Socorros Mutuos, Montevideo, Uruguay,","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5074453675","display_name":"Rafael Henriques J\u00e1como","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I17974374","display_name":"Universidade de S\u00e3o Paulo","ror":"https://ror.org/036rp1748","country_code":"BR","type":"education","lineage":["https://openalex.org/I17974374"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Rafael H Jacomo","raw_affiliation_strings":["Internal Medicine, Medical School of Ribeira\u0303o Preto, University of Sa\u0303o Paulo, Ribeira\u0303o Preto, Brazil,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Internal Medicine, Medical School of Ribeira\u0303o Preto, University of Sa\u0303o Paulo, Ribeira\u0303o Preto, Brazil,","institution_ids":["https://openalex.org/I17974374"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5083338848","display_name":"Cesar Homero Guti\u00e9rrez\u2010Aguirre","orcid":"https://orcid.org/0000-0002-9876-3633","observed_orcids":["https://orcid.org/0000-0002-9876-3633"]},"institutions":[{"id":"https://openalex.org/I4210132044","display_name":"Hospital Universitario Dr Jos\u00e9 Eleuterio Gonzalez","ror":"https://ror.org/030ms0x66","country_code":"MX","type":"healthcare","lineage":["https://openalex.org/I4210132044"]}],"countries":["MX"],"is_corresponding":true,"raw_author_name":"Homero Gutie\u0301rrez-Aguirre","raw_affiliation_strings":["Hematology, Hospital Universitario, Monterrey, Mexico,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Hematology, Hospital Universitario, Monterrey, Mexico,","institution_ids":["https://openalex.org/I4210132044"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102248899","display_name":"Raul AM Melo","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Raul AM Melo","raw_affiliation_strings":["HEMOPE, Recife, Brazil,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"HEMOPE, Recife, Brazil,","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5049870109","display_name":"Rosane Bittencourt","orcid":"https://orcid.org/0000-0002-3173-4141","observed_orcids":["https://orcid.org/0000-0002-3173-4141","https://orcid.org/0000-0003-3071-7443"]},"institutions":[{"id":"https://openalex.org/I130442723","display_name":"Universidade Federal do Rio Grande do Sul","ror":"https://ror.org/041yk2d64","country_code":"BR","type":"education","lineage":["https://openalex.org/I130442723"]}],"countries":["BR"],"is_corresponding":true,"raw_author_name":"Rosane Bittencourt","raw_affiliation_strings":["Hematology and BMT, Universidade Federal do Rio Grande do Sul, Porto Alegre, Brazil,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Hematology and BMT, Universidade Federal do Rio Grande do Sul, Porto Alegre, Brazil,","institution_ids":["https://openalex.org/I130442723"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5086618764","display_name":"Ricardo Pasq\u00fcini","orcid":"https://orcid.org/0000-0002-9272-1061","observed_orcids":["https://orcid.org/0000-0002-9272-1061"]},"institutions":[{"id":"https://openalex.org/I52418104","display_name":"Universidade Federal do Paran\u00e1","ror":"https://ror.org/05syd6y78","country_code":"BR","type":"education","lineage":["https://openalex.org/I52418104"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Ricardo Pasquini","raw_affiliation_strings":["Federal Univeristy of Parana, Curitiba, Brazil,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Federal Univeristy of Parana, Curitiba, Brazil,","institution_ids":["https://openalex.org/I52418104"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5048799203","display_name":"K\u00e1tia B\u00f3rgia Barbosa Pagnano","orcid":"https://orcid.org/0000-0001-7975-0805","observed_orcids":["https://orcid.org/0000-0001-7975-0805"]},"institutions":[{"id":"https://openalex.org/I181391015","display_name":"Universidade Estadual de Campinas (UNICAMP)","ror":"https://ror.org/04wffgt70","country_code":"BR","type":"education","lineage":["https://openalex.org/I181391015"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Katia BB Pagnano","raw_affiliation_strings":["Internal Medicine-Hematology, UNICAMP, Campinas, Brazil,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Internal Medicine-Hematology, UNICAMP, Campinas, Brazil,","institution_ids":["https://openalex.org/I181391015"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5091595358","display_name":"Evandro Maranh\u00e3o Fagundes","orcid":"https://orcid.org/0000-0001-5191-9779","observed_orcids":["https://orcid.org/0000-0001-5191-9779"]},"institutions":[{"id":"https://openalex.org/I110200422","display_name":"Universidade Federal de Minas Gerais","ror":"https://ror.org/0176yjw32","country_code":"BR","type":"education","lineage":["https://openalex.org/I110200422"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Evandro M Fagundes","raw_affiliation_strings":["Hematology, Federal University of Minas Gerais, Belo Horizonte, Brazil,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Hematology, Federal University of Minas Gerais, Belo Horizonte, Brazil,","institution_ids":["https://openalex.org/I110200422"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5048779959","display_name":"Maria LF Chauffaille de Lourdes","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I88273585","display_name":"Universidade Federal de S\u00e3o Paulo","ror":"https://ror.org/02k5swt12","country_code":"BR","type":"education","lineage":["https://openalex.org/I88273585"]}],"countries":["BR"],"is_corresponding":true,"raw_author_name":"Maria LF Chauffaille de Lourdes","raw_affiliation_strings":["Hematology and Transfusion Medicine, Federal University of Sao Paulo, Sao Paulo, Brazil,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Hematology and Transfusion Medicine, Federal University of Sao Paulo, Sao Paulo, Brazil,","institution_ids":["https://openalex.org/I88273585"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5006007579","display_name":"CARLOS S\u00c9RGIO CHIATTONE","orcid":"https://orcid.org/0000-0002-4639-2578","observed_orcids":["https://orcid.org/0000-0002-4639-2578"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Carlos Chiattone","raw_affiliation_strings":["Hematology/Oncology, Santa Casa Medical School, Sao Paulo, Brazil,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Hematology/Oncology, Santa Casa Medical School, Sao Paulo, Brazil,","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5016980940","display_name":"Lem Mart\u00ednez","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Lem Martinez","raw_affiliation_strings":["Asociacion Espanola Primera de Socorros Mutuos, Montevideo, Uruguay,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Asociacion Espanola Primera de Socorros Mutuos, Montevideo, Uruguay,","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5008888432","display_name":"Luis Antonio Meillon","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210120064","display_name":"Centro Medico Nacional Siglo XXI","ror":"https://ror.org/02vz80y09","country_code":"MX","type":"healthcare","lineage":["https://openalex.org/I164915025","https://openalex.org/I4210120064"]}],"countries":["MX"],"is_corresponding":false,"raw_author_name":"Luis A Meillon","raw_affiliation_strings":["Centro Me\u0301dico Nacional Siglo XXI, Mexico, Mexico,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centro Me\u0301dico Nacional Siglo XXI, Mexico, Mexico,","institution_ids":["https://openalex.org/I4210120064"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5000360404","display_name":"David G\u00f3mez\u2010Almaguer","orcid":"https://orcid.org/0000-0002-0460-6427","observed_orcids":["https://orcid.org/0000-0002-0460-6427"]},"institutions":[{"id":"https://openalex.org/I4210132044","display_name":"Hospital Universitario Dr Jos\u00e9 Eleuterio Gonzalez","ror":"https://ror.org/030ms0x66","country_code":"MX","type":"healthcare","lineage":["https://openalex.org/I4210132044"]}],"countries":["MX"],"is_corresponding":false,"raw_author_name":"David Gomez-Almaguer","raw_affiliation_strings":["Hematology, Hospital Universitario, Monterrey, Mexico,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Hematology, Hospital Universitario, Monterrey, Mexico,","institution_ids":["https://openalex.org/I4210132044"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5063490330","display_name":"Hau C. Kwaan","orcid":"https://orcid.org/0000-0002-5733-6248","observed_orcids":["https://orcid.org/0000-0002-5733-6248"]},"institutions":[{"id":"https://openalex.org/I111979921","display_name":"Northwestern University","ror":"https://ror.org/000e0be47","country_code":"US","type":"education","lineage":["https://openalex.org/I111979921"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Hau C. Kwaan","raw_affiliation_strings":["Northwestern University, Chicago, IL, USA,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Northwestern University, Chicago, IL, USA,","institution_ids":["https://openalex.org/I111979921"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5046563419","display_name":"Javier Garc\u00e9s\u2010Eisele","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210161313","display_name":"Cl\u00ednica Ruiz","ror":"https://ror.org/05xr0q537","country_code":"MX","type":"healthcare","lineage":["https://openalex.org/I4210161313"]}],"countries":["MX"],"is_corresponding":true,"raw_author_name":"Javier Garces-Eisele","raw_affiliation_strings":["Clinica Ruiz de Puebla, Puebla, Mexico,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Clinica Ruiz de Puebla, Puebla, Mexico,","institution_ids":["https://openalex.org/I4210161313"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5040340688","display_name":"Robert E. Gallagher","orcid":"https://orcid.org/0000-0002-1476-8833","observed_orcids":["https://orcid.org/0000-0002-1476-8833"]},"institutions":[{"id":"https://openalex.org/I129975664","display_name":"Albert Einstein College of Medicine","ror":"https://ror.org/05cf8a891","country_code":"US","type":"education","lineage":["https://openalex.org/I129975664","https://openalex.org/I4210112371"]},{"id":"https://openalex.org/I4390039242","display_name":"Montefiore Einstein Comprehensive Cancer Center","ror":"https://ror.org/00cea8r21","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I129975664","https://openalex.org/I4210112371","https://openalex.org/I4390039242"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Robert E Gallagher","raw_affiliation_strings":["Medicine and Oncology, Albert Einstein Cancer Center, Bronx, NY, USA,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Medicine and Oncology, Albert Einstein Cancer Center, Bronx, NY, USA,","institution_ids":["https://openalex.org/I129975664","https://openalex.org/I4390039242"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5107499170","display_name":"Charlotte Marie Niemeyer","orcid":"https://orcid.org/0000-0003-3856-7937","observed_orcids":["https://orcid.org/0000-0003-3856-7937"]},"institutions":[{"id":"https://openalex.org/I161046081","display_name":"University of Freiburg","ror":"https://ror.org/0245cg223","country_code":"DE","type":"education","lineage":["https://openalex.org/I161046081"]},{"id":"https://openalex.org/I2801240073","display_name":"University Medical Center Freiburg","ror":"https://ror.org/03vzbgh69","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I2801240073"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Charlotte M Niemeyer","raw_affiliation_strings":["Dept. of Pediatrics and Adolescent Medicine, University Medical Center, Freiburg, Germany,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Dept. of Pediatrics and Adolescent Medicine, University Medical Center, Freiburg, Germany,","institution_ids":["https://openalex.org/I161046081","https://openalex.org/I2801240073"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5046775582","display_name":"Bob L\u00f6wenberg","orcid":"https://orcid.org/0000-0001-8982-5217","observed_orcids":["https://orcid.org/0000-0001-8982-5217"]},"institutions":[{"id":"https://openalex.org/I2801952686","display_name":"Erasmus MC","ror":"https://ror.org/018906e22","country_code":"NL","type":"healthcare","lineage":["https://openalex.org/I2801952686"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Bob Lowenberg","raw_affiliation_strings":["Hematology, Erasmus University Medical Center, Rotterdam, Netherlands,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Hematology, Erasmus University Medical Center, Rotterdam, Netherlands,","institution_ids":["https://openalex.org/I2801952686"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5086250633","display_name":"Raul Correa Ribeiro","orcid":"https://orcid.org/0000-0002-9956-5647","observed_orcids":["https://orcid.org/0000-0002-9956-5647"]},"institutions":[{"id":"https://openalex.org/I1313298211","display_name":"St. Jude Children's Research Hospital","ror":"https://ror.org/02r3e0967","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1313298211","https://openalex.org/I2802152183"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Raul C Ribeiro","raw_affiliation_strings":["St. Jude Children's Rsch. Hosp., Memphis, TN, USA,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"St. Jude Children's Rsch. Hosp., Memphis, TN, USA,","institution_ids":["https://openalex.org/I1313298211"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5063111161","display_name":"Francesco Lo\u2010Coco","orcid":"https://orcid.org/0000-0002-9499-8005","observed_orcids":["https://orcid.org/0000-0002-9499-8005"]},"institutions":[{"id":"https://openalex.org/I116067653","display_name":"University of Rome Tor Vergata","ror":"https://ror.org/02p77k626","country_code":"IT","type":"education","lineage":["https://openalex.org/I116067653"]}],"countries":["IT"],"is_corresponding":true,"raw_author_name":"Francesco Lo-Coco","raw_affiliation_strings":["University of Tor Vergata, Rome, Italy,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Tor Vergata, Rome, Italy,","institution_ids":["https://openalex.org/I116067653"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5017341923","display_name":"Miguel \u00c1ngel Sanz","orcid":"https://orcid.org/0000-0003-1489-1177","observed_orcids":["https://orcid.org/0000-0003-1489-1177"]},"institutions":[{"id":"https://openalex.org/I3019010403","display_name":"Hospital Universitari i Polit\u00e8cnic La Fe","ror":"https://ror.org/01ar2v535","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I3019010403","https://openalex.org/I4210166036"]}],"countries":["ES"],"is_corresponding":true,"raw_author_name":"Miguel A Sanz","raw_affiliation_strings":["Hospital Universitario La Fe, Valencia, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Hospital Universitario La Fe, Valencia, Spain","institution_ids":["https://openalex.org/I3019010403"]}]}],"institutions":[],"countries_distinct_count":7,"institutions_distinct_count":19,"corresponding_author_ids":["https://openalex.org/A5007469088","https://openalex.org/A5016980940","https://openalex.org/A5017341923","https://openalex.org/A5045479163","https://openalex.org/A5046563419","https://openalex.org/A5048779959","https://openalex.org/A5049870109","https://openalex.org/A5063111161","https://openalex.org/A5083338848","https://openalex.org/A5102248899"],"corresponding_institution_ids":["https://openalex.org/I116067653","https://openalex.org/I130442723","https://openalex.org/I3019010403","https://openalex.org/I4210117453","https://openalex.org/I4210132044","https://openalex.org/I4210161313","https://openalex.org/I88273585"],"apc_list":{"value":5500,"currency":"USD","value_usd":5500},"apc_paid":null,"fwci":1.1102,"has_fulltext":false,"cited_by_count":18,"citation_normalized_percentile":{"value":0.75340074,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":98},"biblio":{"volume":"114","issue":"22","first_page":"6","last_page":"6"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11559","display_name":"Retinoids in leukemia and cellular processes","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11559","display_name":"Retinoids in leukemia and cellular processes","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10950","display_name":"Acute Lymphoblastic Leukemia research","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10309","display_name":"Acute Myeloid Leukemia Research","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/acute-promyelocytic-leukemia","display_name":"acute promyelocytic leukemia","score":1.0},{"id":"https://openalex.org/keywords/all-trans-retinoic-acid","display_name":"all-trans retinoic acid","score":0.9509999752044678},{"id":"https://openalex.org/keywords/daunorubicin","display_name":"daunorubicin","score":0.8560000061988831},{"id":"https://openalex.org/keywords/anthracycline-based-chemotherapy","display_name":"anthracycline chemotherapy","score":0.6819999814033508},{"id":"https://openalex.org/keywords/developing-countries","display_name":"developing countries","score":0.7300000190734863},{"id":"https://openalex.org/keywords/treatment-outcomes","display_name":"treatment outcomes","score":0.6140000224113464},{"id":"https://openalex.org/keywords/overall-survival","display_name":"overall survival","score":0.722000002861023},{"id":"https://openalex.org/keywords/supportive-care","display_name":"supportive care","score":0.5360000133514404},{"id":"https://openalex.org/keywords/treatment-related-toxicity","display_name":"treatment toxicity","score":0.3709999918937683},{"id":"https://openalex.org/keywords/mexico","display_name":"Mexico","score":0.9919999837875366},{"id":"https://openalex.org/keywords/uruguay","display_name":"Uruguay","score":0.9990000128746033}],"concepts":[{"id":"https://openalex.org/C2776601000","wikidata":"https://www.wikidata.org/wiki/Q612108","display_name":"Acute promyelocytic leukemia","level":4,"score":0.9485398530960083},{"id":"https://openalex.org/C2779117419","wikidata":"https://www.wikidata.org/wiki/Q1063862","display_name":"Idarubicin","level":4,"score":0.7127459645271301},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.6953396797180176},{"id":"https://openalex.org/C2776863199","wikidata":"https://www.wikidata.org/wiki/Q976388","display_name":"Acute leukemia","level":3,"score":0.5397184491157532},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5214564204216003},{"id":"https://openalex.org/C2778461978","wikidata":"https://www.wikidata.org/wiki/Q29496","display_name":"Leukemia","level":2,"score":0.42828524112701416},{"id":"https://openalex.org/C2781121885","wikidata":"https://www.wikidata.org/wiki/Q425517","display_name":"Retinoic acid","level":3,"score":0.22530058026313782},{"id":"https://openalex.org/C2778041864","wikidata":"https://www.wikidata.org/wiki/Q180983","display_name":"Cytarabine","level":3,"score":0.22043141722679138},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.08037570118904114},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1182/blood.v114.22.6.6","doi":"https://doi.org/10.1182/blood.v114.22.6.6","is_oa":false,"landing_page_url":"https://doi.org/10.1182/blood.v114.22.6.6","pdf_url":null,"source":{"id":"https://openalex.org/S200071133","display_name":"Blood","issn_l":"0006-4971","issn":["0006-4971","1528-0020"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Blood","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":1.0},{"id":"https://metadata.un.org/sdg/17","display_name":"Partnerships for the goals","score":0.75}],"study_designs":[{"id":"https://openalex.org/study-designs/clinical-trial","display_name":"Clinical Trial"}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2090796175","https://openalex.org/W2058194952","https://openalex.org/W2799554876","https://openalex.org/W2119732947","https://openalex.org/W2073338096","https://openalex.org/W4399072532","https://openalex.org/W568633045","https://openalex.org/W2980834313","https://openalex.org/W2522163042","https://openalex.org/W4402635614"],"abstract_inverted_index":{"Abstract":[0,1],"6":[2],"Acute":[3,72],"promyelocytic":[4],"leukemia":[5],"(APL)":[6],"is":[7,48,76],"a":[8,62,112,129,161,316,397,438,513],"curable":[9],"disease,":[10],"and":[11,87,107,151,185,202,268,294,311,323,338,345,348,377,457,469,521],"contemporary":[12],"treatment":[13,39],"based":[14],"on":[15,71,120,540],"the":[16,38,80,85,88,96,137,143,155,165,170,251,282,324,349,374,381,402,410,478,505,508,524],"combination":[17],"of":[18,31,41,59,66,79,84,98,115,136,142,154,172,210,250,275,307,326,383,399,507,515,523,544],"all-trans":[19],"retinoic":[20],"acid":[21],"(ATRA)":[22],"with":[23,43,61,111,232,490],"anthracyclines":[24],"results":[25],"in":[26,45,104,160,285,415,512,518,532],"overall":[27,352,421],"survival":[28,353,379,422],"(OS)":[29],"rates":[30,342],"around":[32],"90%":[33],"at":[34,179,242,255,303,443],"five":[35],"years.":[36],"Unfortunately,":[37],"outcome":[40,403,525],"patients":[42,110,157,221,291,314,370,395],"APL":[44,116,220,278],"developing":[46],"countries":[47],"significantly":[49,488],"less.":[50],"A":[51],"recent":[52],"Brazilian":[53],"study":[54],"had":[55],"reported":[56,284,408,531],"an":[57,77,541],"OS":[58,376,436,461,491],"53%":[60],"first":[63],"5-days":[64],"mortality":[65,341,520],"13.4%.":[67],"The":[68,224,248,273,336,357,459],"International":[69,81],"Consortium":[70],"Promyelocytic":[73],"Leukemia":[74],"(IC-APL)":[75],"initiative":[78],"Members":[82],"Committee":[83],"ASH":[86],"project":[89],"aims":[90],"to":[91,128,164,258,406,486,526,529],"reduce":[92],"this":[93],"gap":[94],"through":[95,200],"establishment":[97,506],"international":[99,205],"network,":[100],"which":[101],"was":[102,139,147,227,244,261,354,363,385,404,462],"launched":[103],"Brazil,":[105,215],"Me\u0301xico":[106],"Uruguay.":[108],"All":[109],"suspected":[113],"diagnosis":[114,138,256],"were":[117,126,158,195,207,222,343,423,437],"immediately":[118],"started":[119],"ATRA,":[121],"while":[122],"bone":[123],"marrow":[124],"samples":[125],"shipped":[127],"national":[130],"central":[131],"lab":[132],"where":[133],"genetic":[134],"verification":[135],"performed.":[140],"Results":[141],"immunofluorescence":[144],"for":[145,169,420,448,451,454,464,467,471,474,494,501],"PML":[146],"obtained":[148],"within":[149],"hours":[150],"upon":[152],"confirmation":[153],"diagnosis,":[156],"enrolled":[159],"protocol":[162,414],"identical":[163],"PETHEMA-LPA":[166,412],"2005,":[167],"except":[168],"replacement":[171],"idarubicin":[173],"by":[174,409],"daunorubicin.":[175],"Supportive":[176],"care":[177],"aimed":[178],"maintaining":[180],"platelet":[181],"counts":[182,240],"above":[183,188],"30,000/\u03bcl":[184],"fibrinogen":[186],"levels":[187,527],"150":[189],"mg/dl.":[190],"In":[191,477,503],"each":[192],"country,":[193],"cases":[194],"discussed":[196],"every":[197],"other":[198],"week":[199],"internet":[201],"whenever":[203],"needed":[204],"experts":[206],"involved.":[208],"As":[209],"June":[211],"2009,":[212],"102":[213],"(70":[214],"25":[216],"Mexico,":[217],"7":[218,337],"Uruguay)":[219],"enrolled.":[223],"median":[225,236,358],"age":[226],"34":[228,269],"y":[229],"(range:":[230,366],"9\u201372y)":[231],"55":[233],"males":[234],"(54%).The":[235],"white":[237],"blood":[238],"cell":[239],"(WBC)":[241],"baseline":[243,444],"3.6\u00d7109":[245],"/L(range:":[246],"0.2\u2013149.7).":[247],"distribution":[249],"relapse":[252,440,496],"risk":[253,277,441,497],"score":[254,442],"according":[257],"PETHEMA-GIMEMA":[259],"criteria":[260],"14":[262,364],"low":[263,276],"(14%),":[264],"54":[265],"intermediate":[266],"(53%)":[267],"high":[270,439,495],"risk(33%)":[271],"respectively.":[272],"incidence":[274],"appeared":[279],"lower":[280],"than":[281],"values":[283],"developed":[286,533],"countries.":[287,534],"Of":[288,298],"102,":[289],"97":[290],"have":[292],"toxicity":[293],"response":[295],"data":[296],"available.":[297],"these":[299,481],"97,":[300],"12":[301],"(12.3%)experienced":[302],"least":[304],"three":[305],"symptoms/signs":[306],"differentiation":[308],"syndrome":[309],"(DS)":[310],"77":[312,369],"(79%)":[313],"achieved":[315,372],"complete":[317],"remission":[318],"(CR).":[319],"Twenty-three":[320],"deaths":[321,327],"occurred":[322],"cause":[325],"included":[328],"9":[329],"hemorrhage,":[330],"8":[331],"infection,":[332],"2":[333],"DS":[334],".":[335],"30":[339,400],"day":[340],"8%":[344],"19.6%,":[346],"respectively,":[347],"one-":[350],"year":[351],"75%":[355],"(95%CI:68%\u201384%).":[356],"follow-up":[359],"time":[360],"among":[361],"survivors":[362],"months":[365],"1.3\u201335).":[367],"Among":[368],"who":[371],"CR,":[373],"1-year":[375,460],"disease-free":[378],"from":[380],"date":[382],"CR":[384],"95%":[386],"(95%":[387],"CI:":[388],"89%\u2013100%).":[389],"Only":[390],"one":[391],"patient":[392],"relapsed.":[393],"For":[394],"surviving":[396],"minimum":[398],"days":[401],"similar":[405,528],"that":[407],"twin":[411],"2005":[413],"European":[416],"patients.":[417],"Prognostic":[418],"factors":[419,484],"examined":[424],"using":[425],"log-rank":[426],"test":[427],"as":[428,430],"well":[429],"multivariate":[431],"Cox":[432,479],"models.":[433],"Factors":[434],"predicting":[435],"(1-year":[445],"OS:":[446],"59%":[447],"high,":[449],"87%":[450],"intermediate,":[452],"91%":[453],"low,":[455],"p=0.0007)":[456],"age.":[458],"85%":[463],"age<25,":[465],"83%":[466],"25\u201340,":[468],"58%":[470],"age\u226540":[472,475],"(p=0.008":[473],"vs<40).":[476],"model,":[480],"two":[482],"prognostic":[483],"remain":[485],"be":[487],"associated":[489],"[HR=3.77,":[492],"p=0.004":[493],"score;":[498],"HR=2.4,":[499],"p=0.047":[500],"age\u226540].":[502],"conclusion,":[504],"IC-APL":[509],"network":[510],"resulted":[511],"decrease":[514],"about":[516],"40%":[517],"early":[519],"improvement":[522],"those":[530],"Disclosures:":[535],"Sanz:":[536],"Amgen":[537],"Inc.:":[538],"Membership":[539],"entity's":[542],"Board":[543],"Directors":[545],"or":[546],"advisory":[547],"committees,":[548],"Speakers":[549],"Bureau.":[550]},"counts_by_year":[{"year":2023,"cited_by_count":7},{"year":2018,"cited_by_count":1},{"year":2012,"cited_by_count":3}],"updated_date":"2026-10-27T15:51:10.671819","created_date":"2016-11-30T00:00:00"}
