{"id":"https://openalex.org/W2547765252","doi":"https://doi.org/10.1002/biot.201600104","title":"Systems biology for understanding and engineering of heterotrophic oleaginous microorganisms","display_name":"Systems biology for understanding and engineering of heterotrophic oleaginous microorganisms","publication_year":2016,"publication_date":"2016-11-03","ids":{"openalex":"https://openalex.org/W2547765252","doi":"https://doi.org/10.1002/biot.201600104","mag":"2547765252","pmid":"https://pubmed.ncbi.nlm.nih.gov/27809410"},"language":"en","primary_location":{"id":"doi:10.1002/biot.201600104","doi":"https://doi.org/10.1002/biot.201600104","is_oa":false,"landing_page_url":"https://doi.org/10.1002/biot.201600104","pdf_url":null,"source":{"id":"https://openalex.org/S31411064","display_name":"Biotechnology Journal","issn_l":"1860-6768","issn":["1860-6768","1860-7314"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biotechnology Journal","raw_type":"journal-article"},"volume":null,"type":"review","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5072386274","display_name":"Beom Gi Park","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I139264467","display_name":"Seoul National University","ror":"https://ror.org/04h9pn542","country_code":"KR","type":"education","lineage":["https://openalex.org/I139264467"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Beom Gi Park","raw_affiliation_strings":["School of Chemical and Biological Engineering, Institute of Molecular Biology and Genetics, and Bioengineering Institute, Seoul National University, Seoul, Republic of Korea","These authors contributed equally to the work"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Chemical and Biological Engineering, Institute of Molecular Biology and Genetics, and Bioengineering Institute, Seoul National University, Seoul, Republic of Korea","institution_ids":["https://openalex.org/I139264467"]},{"raw_affiliation_string":"These authors contributed equally to the work","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100786199","display_name":"Minsuk Kim","orcid":"https://orcid.org/0000-0001-9958-0380","observed_orcids":["https://orcid.org/0000-0001-9958-0380"]},"institutions":[{"id":"https://openalex.org/I139264467","display_name":"Seoul National University","ror":"https://ror.org/04h9pn542","country_code":"KR","type":"education","lineage":["https://openalex.org/I139264467"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Minsuk Kim","raw_affiliation_strings":["School of Chemical and Biological Engineering, Institute of Molecular Biology and Genetics, and Bioengineering Institute, Seoul National University, Seoul, Republic of Korea","These authors contributed equally to the work"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Chemical and Biological Engineering, Institute of Molecular Biology and Genetics, and Bioengineering Institute, Seoul National University, Seoul, Republic of Korea","institution_ids":["https://openalex.org/I139264467"]},{"raw_affiliation_string":"These authors contributed equally to the work","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103096536","display_name":"Joonwon Kim","orcid":"https://orcid.org/0000-0001-9964-0777","observed_orcids":["https://orcid.org/0000-0001-9964-0777"]},"institutions":[{"id":"https://openalex.org/I139264467","display_name":"Seoul National University","ror":"https://ror.org/04h9pn542","country_code":"KR","type":"education","lineage":["https://openalex.org/I139264467"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Joonwon Kim","raw_affiliation_strings":["School of Chemical and Biological Engineering, Institute of Molecular Biology and Genetics, and Bioengineering Institute, Seoul National University, Seoul, Republic of Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Chemical and Biological Engineering, Institute of Molecular Biology and Genetics, and Bioengineering Institute, Seoul National University, Seoul, Republic of Korea","institution_ids":["https://openalex.org/I139264467"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5007171294","display_name":"Hee\u2010Wang Yoo","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I139264467","display_name":"Seoul National University","ror":"https://ror.org/04h9pn542","country_code":"KR","type":"education","lineage":["https://openalex.org/I139264467"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Heewang Yoo","raw_affiliation_strings":["Interdisciplinary Program for Biochemical Engineering and Biotechnology, Seoul National University, Seoul, Republic of Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Interdisciplinary Program for Biochemical Engineering and Biotechnology, Seoul National University, Seoul, Republic of Korea","institution_ids":["https://openalex.org/I139264467"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5052315121","display_name":"Byung\u2010Gee Kim","orcid":"https://orcid.org/0000-0002-3776-1001","observed_orcids":["https://orcid.org/0000-0002-3776-1001"]},"institutions":[{"id":"https://openalex.org/I139264467","display_name":"Seoul National University","ror":"https://ror.org/04h9pn542","country_code":"KR","type":"education","lineage":["https://openalex.org/I139264467"]}],"countries":["KR"],"is_corresponding":true,"raw_author_name":"Byung\u2010Gee Kim","raw_affiliation_strings":["Interdisciplinary Program for Biochemical Engineering and Biotechnology, Seoul National University, Seoul, Republic of Korea","School of Chemical and Biological Engineering, Institute of Molecular Biology and Genetics, and Bioengineering Institute, Seoul National University, Seoul, Republic of Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Interdisciplinary Program for Biochemical Engineering and Biotechnology, Seoul National University, Seoul, Republic of Korea","institution_ids":["https://openalex.org/I139264467"]},{"raw_affiliation_string":"School of Chemical and Biological Engineering, Institute of Molecular Biology and Genetics, and Bioengineering Institute, Seoul National University, Seoul, Republic of Korea","institution_ids":["https://openalex.org/I139264467"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5052315121"],"corresponding_institution_ids":["https://openalex.org/I139264467"],"apc_list":{"value":4780,"currency":"USD","value_usd":4780},"apc_paid":null,"fwci":0.231,"has_fulltext":false,"cited_by_count":21,"citation_normalized_percentile":{"value":0.17214069,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"12","issue":"1","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10932","display_name":"Microbial Metabolic Engineering and Bioproduction","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10932","display_name":"Microbial Metabolic Engineering and Bioproduction","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11844","display_name":"Lipid metabolism and biosynthesis","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/1303","display_name":"Biochemistry"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10476","display_name":"Algal biology and biofuel production","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2105","display_name":"Renewable Energy, Sustainability and the Environment"},"field":{"id":"https://openalex.org/fields/21","display_name":"Energy"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/lipid-accumulation","display_name":"lipid accumulation","score":0.8199999928474426},{"id":"https://openalex.org/keywords/nitrogen-limitation","display_name":"nitrogen limitation","score":0.9670000076293945},{"id":"https://openalex.org/keywords/metabolic-engineering","display_name":"metabolic engineering","score":0.8090000152587891},{"id":"https://openalex.org/keywords/metabolic-switch","display_name":"metabolic switch","score":0.652999997138977},{"id":"https://openalex.org/keywords/systems-biology","display_name":"systems biology","score":0.6169999837875366},{"id":"https://openalex.org/keywords/metabolic-modeling","display_name":"metabolic modeling","score":0.6079999804496765},{"id":"https://openalex.org/keywords/omics","display_name":"omics","score":0.6439999938011169},{"id":"https://openalex.org/keywords/biofuels","display_name":"biofuels","score":0.8510000109672546},{"id":"https://openalex.org/keywords/oleochemicals","display_name":"oleochemicals","score":0.8989999890327454},{"id":"https://openalex.org/keywords/strain-improvement","display_name":"strain improvement","score":0.6639999747276306}],"concepts":[{"id":"https://openalex.org/C6350086","wikidata":"https://www.wikidata.org/wiki/Q6822347","display_name":"Metabolic engineering","level":3,"score":0.7656807899475098},{"id":"https://openalex.org/C175605896","wikidata":"https://www.wikidata.org/wiki/Q39833","display_name":"Microorganism","level":3,"score":0.7295553684234619},{"id":"https://openalex.org/C183696295","wikidata":"https://www.wikidata.org/wiki/Q2487696","display_name":"Biochemical engineering","level":1,"score":0.6311135292053223},{"id":"https://openalex.org/C152662350","wikidata":"https://www.wikidata.org/wiki/Q815297","display_name":"Systems biology","level":2,"score":0.5774232149124146},{"id":"https://openalex.org/C35195898","wikidata":"https://www.wikidata.org/wiki/Q159344","display_name":"Heterotroph","level":3,"score":0.5450336337089539},{"id":"https://openalex.org/C191908910","wikidata":"https://www.wikidata.org/wiki/Q862838","display_name":"Synthetic biology","level":2,"score":0.5082902312278748},{"id":"https://openalex.org/C53991642","wikidata":"https://www.wikidata.org/wiki/Q128991","display_name":"Biofuel","level":2,"score":0.48950278759002686},{"id":"https://openalex.org/C206139338","wikidata":"https://www.wikidata.org/wiki/Q192355","display_name":"Raw material","level":2,"score":0.4722922444343567},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.42177626490592957},{"id":"https://openalex.org/C2778348673","wikidata":"https://www.wikidata.org/wiki/Q739302","display_name":"Production (economics)","level":2,"score":0.412627249956131},{"id":"https://openalex.org/C150903083","wikidata":"https://www.wikidata.org/wiki/Q7108","display_name":"Biotechnology","level":1,"score":0.4109017252922058},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.22668716311454773},{"id":"https://openalex.org/C18903297","wikidata":"https://www.wikidata.org/wiki/Q7150","display_name":"Ecology","level":1,"score":0.18246719241142273},{"id":"https://openalex.org/C523546767","wikidata":"https://www.wikidata.org/wiki/Q10876","display_name":"Bacteria","level":2,"score":0.1595475971698761},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.15415748953819275},{"id":"https://openalex.org/C127413603","wikidata":"https://www.wikidata.org/wiki/Q11023","display_name":"Engineering","level":0,"score":0.12066546082496643},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.057260602712631226},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0},{"id":"https://openalex.org/C139719470","wikidata":"https://www.wikidata.org/wiki/Q39680","display_name":"Macroeconomics","level":1,"score":0.0},{"id":"https://openalex.org/C162324750","wikidata":"https://www.wikidata.org/wiki/Q8134","display_name":"Economics","level":0,"score":0.0}],"mesh":[{"descriptor_ui":"D001419","descriptor_name":"Bacteria","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D001419","descriptor_name":"Bacteria","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D005658","descriptor_name":"Fungi","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D005658","descriptor_name":"Fungi","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008828","descriptor_name":"Microbiological Techniques","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008962","descriptor_name":"Models, Theoretical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D049490","descriptor_name":"Systems Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D050356","descriptor_name":"Lipid Metabolism","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D052836","descriptor_name":"Heterotrophic Processes","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D060847","descriptor_name":"Metabolic Engineering","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true}],"locations_count":3,"locations":[{"id":"doi:10.1002/biot.201600104","doi":"https://doi.org/10.1002/biot.201600104","is_oa":false,"landing_page_url":"https://doi.org/10.1002/biot.201600104","pdf_url":null,"source":{"id":"https://openalex.org/S31411064","display_name":"Biotechnology Journal","issn_l":"1860-6768","issn":["1860-6768","1860-7314"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biotechnology Journal","raw_type":"journal-article"},{"id":"pmid:27809410","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/27809410","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biotechnology journal","raw_type":"Journal Article"},{"id":"pmh:oai:s-space.snu.ac.kr:10371/232304","doi":null,"is_oa":false,"landing_page_url":"https://hdl.handle.net/10371/232304","pdf_url":null,"source":{"id":"https://openalex.org/S4306401345","display_name":"Seoul National University Open Repository (Seoul National University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I139264467","host_organization_name":"Seoul National University","host_organization_lineage":["https://openalex.org/I139264467"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Review"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/2","score":0.40450000762939453,"display_name":"Zero hunger"},{"id":"https://metadata.un.org/sdg/7","score":0.4000000059604645,"display_name":"Affordable and clean energy"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G3840262505","display_name":null,"funder_award_id":"NRF\u20102012H1A2A1001956","funder_id":"https://openalex.org/F4320322120","funder_display_name":"National Research Foundation of Korea"},{"id":"https://openalex.org/G3856665864","display_name":null,"funder_award_id":"NRF\u20102014K1A3A1A20034749","funder_id":"https://openalex.org/F4320322120","funder_display_name":"National Research Foundation of Korea"},{"id":"https://openalex.org/G6533254133","display_name":null,"funder_award_id":"HN12C0055","funder_id":"https://openalex.org/F4320322120","funder_display_name":"National Research Foundation of Korea"}],"funders":[{"id":"https://openalex.org/F4320322120","display_name":"National Research Foundation of Korea","ror":"https://ror.org/013aysd81"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":70,"referenced_works":["https://openalex.org/W617905279","https://openalex.org/W1136334226","https://openalex.org/W1156627145","https://openalex.org/W1821513802","https://openalex.org/W1910730933","https://openalex.org/W1917798260","https://openalex.org/W1937944396","https://openalex.org/W1979287129","https://openalex.org/W1981238279","https://openalex.org/W1982896844","https://openalex.org/W1988418243","https://openalex.org/W1993141629","https://openalex.org/W1994421370","https://openalex.org/W1996355791","https://openalex.org/W1996575561","https://openalex.org/W2000206290","https://openalex.org/W2000952896","https://openalex.org/W2001484723","https://openalex.org/W2003029675","https://openalex.org/W2012746361","https://openalex.org/W2014390233","https://openalex.org/W2019457244","https://openalex.org/W2035360701","https://openalex.org/W2038812526","https://openalex.org/W2042206503","https://openalex.org/W2043814117","https://openalex.org/W2044935306","https://openalex.org/W2046026069","https://openalex.org/W2054506883","https://openalex.org/W2056522438","https://openalex.org/W2061084055","https://openalex.org/W2066089342","https://openalex.org/W2071166796","https://openalex.org/W2076262841","https://openalex.org/W2076830784","https://openalex.org/W2078355959","https://openalex.org/W2079137794","https://openalex.org/W2082382448","https://openalex.org/W2084143870","https://openalex.org/W2086592553","https://openalex.org/W2093941784","https://openalex.org/W2099735525","https://openalex.org/W2102164505","https://openalex.org/W2102289265","https://openalex.org/W2111943920","https://openalex.org/W2114535505","https://openalex.org/W2116775961","https://openalex.org/W2116875566","https://openalex.org/W2128836283","https://openalex.org/W2129292461","https://openalex.org/W2135941702","https://openalex.org/W2146183772","https://openalex.org/W2147146088","https://openalex.org/W2148044817","https://openalex.org/W2150706111","https://openalex.org/W2154767435","https://openalex.org/W2159408188","https://openalex.org/W2169756968","https://openalex.org/W2174873063","https://openalex.org/W2187650526","https://openalex.org/W2220644831","https://openalex.org/W2266748163","https://openalex.org/W2274010545","https://openalex.org/W2281403128","https://openalex.org/W2285229206","https://openalex.org/W2292710945","https://openalex.org/W2329815048","https://openalex.org/W2333535089","https://openalex.org/W2344329402","https://openalex.org/W2469961646"],"related_works":["https://openalex.org/W2046026069","https://openalex.org/W3141342802","https://openalex.org/W127896444","https://openalex.org/W4200114413","https://openalex.org/W4409002419","https://openalex.org/W3027792681","https://openalex.org/W4396558213","https://openalex.org/W1148722567","https://openalex.org/W4406268187","https://openalex.org/W2468941095"],"abstract_inverted_index":{"Heterotrophic":[0],"oleaginous":[1,104],"microorganisms":[2,105],"continue":[3],"to":[4,35,112],"draw":[5],"interest":[6],"as":[7],"they":[8],"can":[9],"accumulate":[10],"a":[11,18,61],"large":[12],"amount":[13],"of":[14,24,47,67],"lipids":[15],"which":[16],"is":[17,33,74],"promising":[19],"feedstock":[20],"for":[21,60],"the":[22,38,45,51,54,84,102],"production":[23,40,56],"biofuels":[25],"and":[26,70,95],"oleochemicals.":[27],"Nutrient":[28],"limitation,":[29,32],"especially":[30],"nitrogen":[31],"known":[34],"effectively":[36],"trigger":[37],"lipid":[39,55],"in":[41],"these":[42],"microorganisms.":[43],"For":[44],"aim":[46],"developing":[48],"improved":[49],"strains,":[50],"mechanisms":[52],"behind":[53],"have":[57],"been":[58],"studied":[59],"long":[62],"time.":[63],"Nowadays,":[64],"system-level":[65],"understanding":[66],"their":[68],"metabolism":[69],"associated":[71],"metabolic":[72,113],"switches":[73],"attainable":[75],"with":[76,106],"modern":[77],"systems":[78,85],"biology":[79,86],"tools.":[80],"This":[81],"work":[82],"reviews":[83],"studies,":[87],"based":[88],"on":[89,101,109],"(i)":[90],"top-down,":[91],"large-scale":[92],"'omics'":[93],"tools,":[94],"(ii)":[96],"bottom-up,":[97],"mathematical":[98],"modeling":[99],"methods,":[100],"heterotrophic":[103],"an":[107],"emphasis":[108],"further":[110],"application":[111],"engineering.":[114]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":3},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":5},{"year":2020,"cited_by_count":2},{"year":2019,"cited_by_count":2},{"year":2018,"cited_by_count":4},{"year":2017,"cited_by_count":2}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-11-11T00:00:00"}
