{"id":"https://openalex.org/W2547415730","doi":null,"title":"Telomeres and telomerase and their functional applications in myeloproliferative neoplasms and acute myeloid leukemia","display_name":"Telomeres and telomerase and their functional applications in myeloproliferative neoplasms and acute myeloid leukemia","publication_year":2016,"publication_date":"2016-10-25","ids":{"openalex":"https://openalex.org/W2547415730","mag":"2547415730"},"language":"en","primary_location":{"id":"pmh:oai:figshare.com:article/26920942","doi":null,"is_oa":false,"landing_page_url":"https://figshare.com/articles/thesis/Telomeres_and_telomerase_and_their_functional_applications_in_myeloproliferative_neoplasms_and_acute_myeloid_leukemia/26920942","pdf_url":null,"source":{"id":"https://openalex.org/S4377196282","display_name":"Figshare","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210132348","host_organization_name":"Figshare (United Kingdom)","host_organization_lineage":["https://openalex.org/I4210132348"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Thesis"},"volume":null,"type":"dissertation","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"http://hdl.handle.net/10616/45328","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5046871078","display_name":"Jenny Dahlstr\u00f6m","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Jenny Dahlstr\u00f6m","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5046871078"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10937","display_name":"Telomeres, Telomerase, and Senescence","score":0.79830002784729,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10937","display_name":"Telomeres, Telomerase, and Senescence","score":0.79830002784729,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11628","display_name":"Myeloproliferative Neoplasms: Diagnosis and Treatment","score":0.19460000097751617,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10309","display_name":"Acute Myeloid Leukemia Research","score":0.0020000000949949026,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/myeloproliferative-neoplasms","display_name":"myeloproliferative neoplasms","score":0.9639999866485596},{"id":"https://openalex.org/keywords/acute-myeloid-leukemia","display_name":"acute myeloid leukemia","score":0.9520000219345093},{"id":"https://openalex.org/keywords/telomeres","display_name":"telomeres","score":0.9710000157356262},{"id":"https://openalex.org/keywords/telomerase","display_name":"telomerase","score":0.8560000061988831},{"id":"https://openalex.org/keywords/telomere-length","display_name":"telomere length","score":0.8820000290870667},{"id":"https://openalex.org/keywords/tert","display_name":"telomerase reverse transcriptase","score":0.7789999842643738},{"id":"https://openalex.org/keywords/genetic-susceptibility","display_name":"genetic susceptibility","score":0.7509999871253967},{"id":"https://openalex.org/keywords/jak-stat-signaling","display_name":"JAK/STAT signaling","score":0.8690000176429749},{"id":"https://openalex.org/keywords/polycythemia-vera","display_name":"polycythemia vera","score":0.7860000133514404},{"id":"https://openalex.org/keywords/essential-thrombocythemia","display_name":"essential thrombocythemia","score":0.9739999771118164},{"id":"https://openalex.org/keywords/primary-myelofibrosis","display_name":"primary myelofibrosis","score":0.9909999966621399},{"id":"https://openalex.org/keywords/telomere-binding-proteins","display_name":"telomere-binding proteins","score":0.7580000162124634},{"id":"https://openalex.org/keywords/granulocytes","display_name":"granulocytes","score":0.6000000238418579}],"concepts":[{"id":"https://openalex.org/C94581717","wikidata":"https://www.wikidata.org/wiki/Q331839","display_name":"Telomerase","level":3,"score":0.8008251190185547},{"id":"https://openalex.org/C177336024","wikidata":"https://www.wikidata.org/wiki/Q14872779","display_name":"Telomere","level":3,"score":0.8002016544342041},{"id":"https://openalex.org/C2778729363","wikidata":"https://www.wikidata.org/wiki/Q11688946","display_name":"Myeloid leukemia","level":2,"score":0.7340602874755859},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5158306956291199},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.4941425621509552},{"id":"https://openalex.org/C2778461978","wikidata":"https://www.wikidata.org/wiki/Q29496","display_name":"Leukemia","level":2,"score":0.4446733295917511},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3515225648880005},{"id":"https://openalex.org/C552990157","wikidata":"https://www.wikidata.org/wiki/Q7430","display_name":"DNA","level":2,"score":0.2504769563674927},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.22875308990478516},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.21503636240959167},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.10116058588027954}],"mesh":[],"locations_count":3,"locations":[{"id":"pmh:oai:figshare.com:article/26920942","doi":null,"is_oa":false,"landing_page_url":"https://figshare.com/articles/thesis/Telomeres_and_telomerase_and_their_functional_applications_in_myeloproliferative_neoplasms_and_acute_myeloid_leukemia/26920942","pdf_url":null,"source":{"id":"https://openalex.org/S4377196282","display_name":"Figshare","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210132348","host_organization_name":"Figshare (United Kingdom)","host_organization_lineage":["https://openalex.org/I4210132348"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Thesis"},{"id":"pmh:oai:openarchive.ki.se:10616/45328","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/10616/45328","pdf_url":null,"source":{"id":"https://openalex.org/S4306400147","display_name":"Open Archive (Karolinska Institutet)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I28166907","host_organization_name":"Karolinska Institutet","host_organization_lineage":["https://openalex.org/I28166907"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"info:eu-repo/semantics/doctoralThesis"},{"id":"mag:2547415730","doi":null,"is_oa":false,"landing_page_url":"https://openarchive.ki.se/xmlui/handle/10616/45328","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":{"id":"pmh:oai:openarchive.ki.se:10616/45328","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/10616/45328","pdf_url":null,"source":{"id":"https://openalex.org/S4306400147","display_name":"Open Archive (Karolinska Institutet)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I28166907","host_organization_name":"Karolinska Institutet","host_organization_lineage":["https://openalex.org/I28166907"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"info:eu-repo/semantics/doctoralThesis"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9940000176429749}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":115,"referenced_works":["https://openalex.org/W19215287","https://openalex.org/W1521209045","https://openalex.org/W1545398558","https://openalex.org/W1574658543","https://openalex.org/W1653629301","https://openalex.org/W1695470093","https://openalex.org/W1761773172","https://openalex.org/W1773479024","https://openalex.org/W1806091569","https://openalex.org/W1863677123","https://openalex.org/W1918141746","https://openalex.org/W1952219440","https://openalex.org/W1970553871","https://openalex.org/W1972999102","https://openalex.org/W1976021029","https://openalex.org/W1976479449","https://openalex.org/W1978463385","https://openalex.org/W1980568348","https://openalex.org/W1980878206","https://openalex.org/W1981730769","https://openalex.org/W1982199027","https://openalex.org/W1983673827","https://openalex.org/W1985177017","https://openalex.org/W1991495650","https://openalex.org/W1991802905","https://openalex.org/W1993793998","https://openalex.org/W1995369623","https://openalex.org/W1995370367","https://openalex.org/W1996338414","https://openalex.org/W1998371493","https://openalex.org/W1998393353","https://openalex.org/W1999701140","https://openalex.org/W2004023747","https://openalex.org/W2007567598","https://openalex.org/W2010157893","https://openalex.org/W2010872865","https://openalex.org/W2013073993","https://openalex.org/W2017410022","https://openalex.org/W2019523681","https://openalex.org/W2025791374","https://openalex.org/W2026588020","https://openalex.org/W2027613124","https://openalex.org/W2028148743","https://openalex.org/W2028320710","https://openalex.org/W2028489949","https://openalex.org/W2030209169","https://openalex.org/W2030976397","https://openalex.org/W2035551570","https://openalex.org/W2039101448","https://openalex.org/W2039709545","https://openalex.org/W2041607731","https://openalex.org/W2042897772","https://openalex.org/W2047079894","https://openalex.org/W2049145190","https://openalex.org/W2051090019","https://openalex.org/W2051608147","https://openalex.org/W2053584669","https://openalex.org/W2053997093","https://openalex.org/W2054383392","https://openalex.org/W2055521085","https://openalex.org/W2055902044","https://openalex.org/W2056777053","https://openalex.org/W2057360098","https://openalex.org/W2057838630","https://openalex.org/W2058188142","https://openalex.org/W2058357883","https://openalex.org/W2060955969","https://openalex.org/W2062395030","https://openalex.org/W2065817684","https://openalex.org/W2066039361","https://openalex.org/W2070405344","https://openalex.org/W2075214128","https://openalex.org/W2076426515","https://openalex.org/W2076578191","https://openalex.org/W2077087852","https://openalex.org/W2078532650","https://openalex.org/W2080032853","https://openalex.org/W2090426240","https://openalex.org/W2092712702","https://openalex.org/W2095501262","https://openalex.org/W2096638244","https://openalex.org/W2108234281","https://openalex.org/W2108482850","https://openalex.org/W2115400483","https://openalex.org/W2121410166","https://openalex.org/W2125987139","https://openalex.org/W2129559773","https://openalex.org/W2130910832","https://openalex.org/W2133777490","https://openalex.org/W2135835093","https://openalex.org/W2136536098","https://openalex.org/W2138709799","https://openalex.org/W2138741508","https://openalex.org/W2142047303","https://openalex.org/W2143004103","https://openalex.org/W2148101855","https://openalex.org/W2150443333","https://openalex.org/W2153170459","https://openalex.org/W2154837214","https://openalex.org/W2157694607","https://openalex.org/W2159659449","https://openalex.org/W2160219845","https://openalex.org/W2161925081","https://openalex.org/W2163229747","https://openalex.org/W2164427458","https://openalex.org/W2165460647","https://openalex.org/W2170044093","https://openalex.org/W2176681260","https://openalex.org/W2253288561","https://openalex.org/W2265314871","https://openalex.org/W2315165120","https://openalex.org/W2317624320","https://openalex.org/W2342233937","https://openalex.org/W2461476252","https://openalex.org/W2550438126"],"related_works":["https://openalex.org/W2053997093","https://openalex.org/W2979489582","https://openalex.org/W3081785837","https://openalex.org/W2051608147","https://openalex.org/W2095501262","https://openalex.org/W2101746711","https://openalex.org/W850284460","https://openalex.org/W7017771591","https://openalex.org/W2519053332","https://openalex.org/W2263540771"],"abstract_inverted_index":{"Myeloproliferative":[0],"neoplasms":[1,761],"(MPNs)":[2],"are":[3,46,63,77,103,112,272,754],"a":[4,92,123,154,352,422,425,434,440,444,481,562,581,590,658,666,680,814,818],"group":[5],"of":[6,15,23,35,51,57,67,73,131,139,157,175,203,228,232,239,243,253,296,325,333,340,368,415,436,459,484,568,597,601,612,630,637,683,692,709,759,770,803,809],"diseases":[7],"characterized":[8],"by":[9,627,851],"hyperproliferation":[10],"in":[11,48,54,128,143,163,179,197,219,247,264,268,274,299,328,345,387,392,421,465,470,527,532,549,573,580,670,689,716,762,813,838],"the":[12,16,58,71,89,101,106,129,136,140,167,210,237,260,269,288,294,315,334,360,369,382,396,400,437,460,471,476,491,497,512,541,566,569,576,602,610,616,631,676,804,852],"myeloid":[13],"lineages":[14],"bone":[17],"marrow,":[18],"leading":[19],"to":[20,115,147,201,209,259,276,374,381,390,410,431],"increased":[21,323,338,609],"levels":[22],"circulating":[24],"mature":[25],"blood":[26],"cells":[27,90,107,598,614,640,841],"from":[28,308],"one":[29],"or":[30,443],"more":[31,113,408],"lineages.":[32],"MPNs":[33,132,183,193,298,341],"consist":[34],"polycythemia":[36],"vera,":[37],"essential":[38],"thrombocythemia":[39],"and":[40,83,111,133,135,159,173,184,224,236,278,293,305,310,312,449,468,500,518,530,595,653,661,764,807],"primary":[41],"myelofibrosis.":[42],"Several":[43],"recurrent":[44],"mutations":[45,469],"seen":[47,263,344,386,643],"MPNs,":[49,164],"most":[50,478],"them":[52,407],"resulting":[53],"an":[55,285,322,337,416,505,621,628,848],"activation":[56],"JAK/STAT":[59,684],"signaling":[60,685],"pathway.":[61],"Telomeres":[62],"non-coding":[64],"repetitive":[65],"sequences":[66],"DNA":[68],"located":[69],"at":[70],"end":[72],"chromosomes.":[74],"The":[75,226,251,331,413,587],"telomeres":[76,102,158,196],"shortened":[78],"with":[79,182,192,249,321,336,395,424,534,554,558,575,606,713,756,817],"every":[80],"cell":[81,585,618],"division":[82],"when":[84,511],"they":[85,537],"become":[86,108],"critically":[87],"short,":[88,105],"enter":[91],"permanent":[93],"growth":[94],"arrest":[95],"state":[96],"called":[97],"replicative":[98],"senescence.":[99],"When":[100],"very":[104,426,819],"genetically":[109],"unstable":[110],"susceptible":[114,409],"genetic":[116,466,520],"aberrations.":[117,521],"There":[118,215],"is":[119,319,548],"accumulating":[120],"evidence":[121],"for":[122,125,552],"role":[124],"telomere":[126,160,168,176,254,261,687,714],"dysregulation":[127,156,252],"pathogenesis":[130],"AML,":[134],"overall":[137],"aim":[138],"studies":[141],"included":[142],"this":[144,150],"thesis":[145],"was":[146,216,234,245,342,429,624,641],"better":[148],"define":[149],"role.":[151],"To":[152],"clarify":[153],"potential":[155,667],"associated":[161,177,320,755],"proteins":[162,178,256],"we":[165,473],"studied":[166,430,565],"length":[169],"(TL),":[170],"TERT":[171,220,270,290,316,370,397,402,751],"expression":[172,174,221,227,238],"81":[180],"patients":[181,191,223,248,304,533],"43":[185],"healthy":[186,204,306,362],"controls.":[187,225],"We":[188,302,488,564],"found":[189,313],"that":[190,202,314,391,475,490,623,650,662],"have":[194,351,524,657],"shorter":[195],"their":[198,375],"granulocytes":[199],"compared":[200,208,373,389],"controls,":[205],"but":[206,463,536,557],"also":[207,283],"patients\u2019":[211],"own":[212],"lymphoid":[213],"cells.":[214],"no":[217],"difference":[218],"between":[222,287,433],"two":[229,240],"positive":[230,639,844],"regulators":[231,242],"TL":[233,244],"lower,":[235],"negative":[241,719],"higher":[246],"MPNs.":[250,265,412,671,690],"binding":[255],"may":[257,379,405,656,664],"contribute":[258,380],"shortening":[262,715],"Genetic":[266],"variants":[267],"locus":[271],"implicated":[273],"susceptibility":[275],"cancer":[277],"other":[279,519],"diseases.":[280],"Recent":[281],"reports":[282],"revealed":[284],"association":[286,332],"SNP":[289],"rs2736100_CC":[291,398],"genotype":[292],"risk":[295,324,339,758],"developing":[297],"Caucasian":[300],"populations.":[301,330,768],"genotyped":[303],"controls":[307],"Sweden":[309],"China":[311,388],"rs2736100_C":[317,371],"allele":[318,372],"MPN":[326,347,357,384],"development":[327],"both":[329],"C-allele":[335],"only":[343],"male":[346,766],"patients,":[348],"who":[349],"generally":[350],"worse":[353],"outcome":[354],"than":[355,599],"female":[356],"patients.":[358],"Moreover,":[359],"Chinese":[361,765],"population":[363],"had":[364,399,589],"significantly":[365],"lower":[366,383],"frequency":[367],"Swedish":[376,763],"counterpart,":[377],"which":[378,404],"incidence":[385],"Europe.":[393],"Patients":[394],"highest":[401],"expression,":[403],"make":[406],"develop":[411,503],"evolution":[414,808],"acute":[417,810],"promyelocytic":[418,811],"leukemia":[419,812,840],"(APL)-clone":[420],"patient":[423,477,767,816],"late":[427,820],"relapse":[428,435,483],"distinguish":[432],"first":[438],"APL,":[439,448],"secondary":[441],"APL":[442,506],"second":[445],"de":[446],"novo":[447],"thereby":[450],"guide":[451],"future":[452],"treatment":[453],"decisions.":[454],"Based":[455],"on":[456,593,686],"identical":[457],"breakpoints":[458],"PML-RAR\u03b1":[461],"gene,":[462],"differences":[464],"aberrations":[467],"FLT3-gene,":[472],"conclude":[474],"likely":[479],"suffered":[480],"true":[482],"her":[485],"initial":[486,498],"APL.":[487],"hypothesize":[489],"PML-RAR\u03b1-":[492],"bearing":[493],"pre-leukemic":[494],"clone":[495,513],"survived":[496],"chemotherapy":[499],"did":[501],"not":[502,539,642],"into":[504],"until":[507],"seventeen":[508],"years":[509],"later,":[510],"acquired":[514],"another":[515],"FLT3":[516],"mutation":[517],"JAK2":[522,570,673,836],"inhibitors":[523],"proven":[525],"effective":[526],"reducing":[528],"symptoms":[529],"splenomegaly":[531],"myelofibrosis,":[535],"do":[538],"eliminate":[540],"disease":[542],"initiating":[543],"clones.":[544],"A":[545],"telomerase":[546,577,654,677,853],"inhibitor":[547,571,578,854],"clinical":[550],"trials":[551],"MF":[553],"promising":[555],"results,":[556],"severe":[559],"myelosuppression":[560],"as":[561],"side-effect.":[563],"effect":[567,592,622,682,849],"LY2784544":[572,607],"combination":[574,588],"GRN163L":[579],"JAK2V617F":[582],"\u2013bearing":[583],"erythroleukemia":[584],"line.":[586],"larger":[591],"viability":[594],"number":[596],"either":[600],"drugs":[603],"alone.":[604],"Treatment":[605],"alone":[608],"fraction":[611],"HEL":[613],"expressing":[615],"stem":[617,846],"marker":[619],"CD34,":[620],"partially":[625],"mediated":[626],"up-regulation":[629],"transcription":[632],"factor":[633],"KLF4.":[634],"Importantly,":[635],"accumulation":[636],"CD34":[638,843],"after":[644],"combined":[645],"LY2784544/GRN163":[646],"treatment.":[647],"This":[648],"suggests":[649],"combining":[651],"JAK2-":[652],"inhibition":[655,674,837],"therapeutic":[659,668],"benefit,":[660],"KLF4":[663],"be":[665],"target":[669],"Furthermore,":[672],"reduced":[675],"activity,":[678],"indicating":[679],"direct":[681],"regulation":[688],"List":[691],"scientific":[693],"papers":[694],"I.":[695],"Dahlstro\u0308m":[696,728,781,830],"J,":[697,729,782,794,831],"Zhang":[698,777,779],"X,":[699,733,778],"Ghaderi":[700,736,789],"M,":[701,703,705,737,748,790,833],"Hultcrantz":[702],"Bjo\u0308rkholm":[704,747,799,832],"Xu":[706,749,797,834],"D.":[707,750,835],"Dysregulation":[708],"shelterin":[710],"factors":[711],"coupled":[712],"Philadelphia":[717],"chromosome":[718],"myeloproliferative":[720,760],"neoplasms.":[721],"Haematologica.":[722],"2015;":[723],"100,":[724],"e402-e405.":[725],"https://doi.org/10.3324/haematol.2015.125765":[726],"II.":[727],"Liu":[730],"T,":[731],"Yuan":[732],"Saft":[734],"L,":[735],"Wei":[738],"Y":[739],"B,":[740,786],"Lavebratt":[741],"C,":[742,746],"Li":[743],"P,":[744],"Zheng":[745],"rs2736100":[752],"genotypes":[753],"differential":[757],"Annals":[769],"Hematology.":[771],"2016;":[772],"95,":[773],"1825\u20131832.":[774],"https://doi.org/10.1007/s00277-016-2787-7":[775],"III.":[776],"Q,":[780],"Tran":[783],"A-N,":[784],"Yang":[785],"Gu":[787],"Z,":[788],"Porwit":[791],"A,":[792],"Jia":[793],"Derolf":[795],"A\u030a,":[796],"D,":[798],"M.":[800],"Genomic":[801],"analysis":[802],"clonal":[805],"origin":[806],"unique":[815],"(17":[821],"years)":[822],"relapse.":[823],"Leukemia.":[824],"2014;":[825],"28,":[826],"1751\u20131754.":[827],"https://doi.org/10.1038/leu.2014.113":[828],"IV.":[829],"JAK2V617F-bearing":[839],"enriches":[842],"leukemic":[845],"cells,":[847],"abolished":[850],"GRN163L.":[855],"[Manuscript]":[856]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-11-11T00:00:00"}