{"id":"https://openalex.org/W2547397680","doi":"https://doi.org/10.1093/neuonc/nov225.23","title":"NIMG-23A CONNECTOMIC PHENOTYPE OF 1p/19q LOSS OF HETEROZYGOSITY IN LOW-GRADE GLIOMA","display_name":"NIMG-23A CONNECTOMIC PHENOTYPE OF 1p/19q LOSS OF HETEROZYGOSITY IN LOW-GRADE GLIOMA","publication_year":2015,"publication_date":"2015-11-01","ids":{"openalex":"https://openalex.org/W2547397680","doi":"https://doi.org/10.1093/neuonc/nov225.23","mag":"2547397680"},"language":"en","primary_location":{"id":"doi:10.1093/neuonc/nov225.23","doi":"https://doi.org/10.1093/neuonc/nov225.23","is_oa":false,"landing_page_url":"https://doi.org/10.1093/neuonc/nov225.23","pdf_url":null,"source":{"id":"https://openalex.org/S106908163","display_name":"Neuro-Oncology","issn_l":"1522-8517","issn":["1522-8517","1523-5866"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Neuro-Oncology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4639046","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5090414948","display_name":"Linda Douw","orcid":"https://orcid.org/0000-0001-7058-4062","observed_orcids":["https://orcid.org/0000-0001-7058-4062"]},"institutions":[{"id":"https://openalex.org/I4210127055","display_name":"Athinoula A. Martinos Center for Biomedical Imaging","ror":"https://ror.org/032q5ym94","country_code":"US","type":"facility","lineage":["https://openalex.org/I136199984","https://openalex.org/I4210087915","https://openalex.org/I4210127055","https://openalex.org/I48633490","https://openalex.org/I63966007"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Linda Douw","raw_affiliation_strings":["Athinoula A. Martinos Center for Biomedical Imaging, Charlestown, MA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Athinoula A. Martinos Center for Biomedical Imaging, Charlestown, MA, USA","institution_ids":["https://openalex.org/I4210127055"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5014127051","display_name":"Julie J. Miller","orcid":"https://orcid.org/0000-0002-1288-593X","observed_orcids":["https://orcid.org/0000-0002-1288-593X"]},"institutions":[{"id":"https://openalex.org/I4210087915","display_name":"Massachusetts General Hospital","ror":"https://ror.org/002pd6e78","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087915","https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Julie Miller","raw_affiliation_strings":["Massachusetts General Hospital, Boston, MA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Massachusetts General Hospital, Boston, MA, USA","institution_ids":["https://openalex.org/I4210087915"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5082835319","display_name":"Elizabeth Robins Gerstner","orcid":"https://orcid.org/0000-0003-2382-3838","observed_orcids":["https://orcid.org/0000-0003-2382-3838"]},"institutions":[{"id":"https://openalex.org/I4210087915","display_name":"Massachusetts General Hospital","ror":"https://ror.org/002pd6e78","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087915","https://openalex.org/I48633490"]},{"id":"https://openalex.org/I4210127055","display_name":"Athinoula A. Martinos Center for Biomedical Imaging","ror":"https://ror.org/032q5ym94","country_code":"US","type":"facility","lineage":["https://openalex.org/I136199984","https://openalex.org/I4210087915","https://openalex.org/I4210127055","https://openalex.org/I48633490","https://openalex.org/I63966007"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Elizabeth Gerstner","raw_affiliation_strings":["Athinoula A. Martinos Center for Biomedical Imaging, Charlestown, MA, USA","Massachusetts General Hospital, Boston, MA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Athinoula A. Martinos Center for Biomedical Imaging, Charlestown, MA, USA","institution_ids":["https://openalex.org/I4210127055"]},{"raw_affiliation_string":"Massachusetts General Hospital, Boston, MA, USA","institution_ids":["https://openalex.org/I4210087915"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":5132,"currency":"USD","value_usd":5132},"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.26743367,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"17","issue":"suppl 5","first_page":"v158.3","last_page":"v158"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11304","display_name":"Advanced Neuroimaging Techniques and Applications","score":0.9595000147819519,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11304","display_name":"Advanced Neuroimaging Techniques and Applications","score":0.9595000147819519,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10241","display_name":"Functional Brain Connectivity Studies","score":0.03020000085234642,"subfield":{"id":"https://openalex.org/subfields/2805","display_name":"Cognitive Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10129","display_name":"Glioma Diagnosis and Treatment","score":0.007600000128149986,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/1p-19q-codeletion","display_name":"1p/19q codeletion","score":0.9240000247955322},{"id":"https://openalex.org/keywords/loss-of-heterozygosity","display_name":"loss of heterozygosity","score":0.9900000095367432},{"id":"https://openalex.org/keywords/low-grade-glioma","display_name":"low-grade glioma","score":0.9919999837875366},{"id":"https://openalex.org/keywords/brain-connectome","display_name":"brain connectome","score":0.8539999723434448},{"id":"https://openalex.org/keywords/path-length","display_name":"path length","score":0.6809999942779541},{"id":"https://openalex.org/keywords/diffusion-tensor-imaging","display_name":"diffusion tensor imaging","score":0.6679999828338623},{"id":"https://openalex.org/keywords/probabilistic-tractography","display_name":"probabilistic tractography","score":0.8489999771118164},{"id":"https://openalex.org/keywords/contralateral-hemisphere","display_name":"contralateral hemisphere","score":0.7680000066757202},{"id":"https://openalex.org/keywords/prognosis","display_name":"prognosis","score":0.6819999814033508}],"concepts":[{"id":"https://openalex.org/C45715564","wikidata":"https://www.wikidata.org/wiki/Q1292103","display_name":"Connectome","level":3,"score":0.6471878886222839},{"id":"https://openalex.org/C149550507","wikidata":"https://www.wikidata.org/wiki/Q899360","display_name":"Diffusion MRI","level":3,"score":0.637218177318573},{"id":"https://openalex.org/C2778227246","wikidata":"https://www.wikidata.org/wiki/Q1365309","display_name":"Glioma","level":2,"score":0.5950729846954346},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5126494765281677},{"id":"https://openalex.org/C84787856","wikidata":"https://www.wikidata.org/wiki/Q3076659","display_name":"Tractography","level":4,"score":0.48688188195228577},{"id":"https://openalex.org/C206041023","wikidata":"https://www.wikidata.org/wiki/Q1751970","display_name":"Wilcoxon signed-rank test","level":3,"score":0.41816943883895874},{"id":"https://openalex.org/C143589142","wikidata":"https://www.wikidata.org/wiki/Q2617554","display_name":"Loss of heterozygosity","level":4,"score":0.4175497889518738},{"id":"https://openalex.org/C2989005","wikidata":"https://www.wikidata.org/wiki/Q214963","display_name":"Nuclear medicine","level":1,"score":0.3934057354927063},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.3377613425254822},{"id":"https://openalex.org/C143409427","wikidata":"https://www.wikidata.org/wiki/Q161238","display_name":"Magnetic resonance imaging","level":2,"score":0.3310006260871887},{"id":"https://openalex.org/C12868164","wikidata":"https://www.wikidata.org/wiki/Q1424533","display_name":"Mann\u2013Whitney U test","level":2,"score":0.3258393406867981},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.28755444288253784},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.27603331208229065},{"id":"https://openalex.org/C126838900","wikidata":"https://www.wikidata.org/wiki/Q77604","display_name":"Radiology","level":1,"score":0.27107739448547363},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.25168079137802124},{"id":"https://openalex.org/C3018011982","wikidata":"https://www.wikidata.org/wiki/Q7316120","display_name":"Functional connectivity","level":2,"score":0.23125645518302917},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.16171401739120483},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0},{"id":"https://openalex.org/C180754005","wikidata":"https://www.wikidata.org/wiki/Q80726","display_name":"Allele","level":3,"score":0.0},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.0}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.1093/neuonc/nov225.23","doi":"https://doi.org/10.1093/neuonc/nov225.23","is_oa":false,"landing_page_url":"https://doi.org/10.1093/neuonc/nov225.23","pdf_url":null,"source":{"id":"https://openalex.org/S106908163","display_name":"Neuro-Oncology","issn_l":"1522-8517","issn":["1522-8517","1523-5866"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Neuro-Oncology","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:4639046","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4639046","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Neuro Oncol","raw_type":"Text"}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:4639046","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4639046","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Neuro Oncol","raw_type":"Text"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9763000011444092,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2153718867","https://openalex.org/W2107120959","https://openalex.org/W2123155935","https://openalex.org/W2607751237","https://openalex.org/W2047731362","https://openalex.org/W2719071932","https://openalex.org/W7132827906","https://openalex.org/W4391400965","https://openalex.org/W4220712896","https://openalex.org/W4284888137"],"abstract_inverted_index":{"The":[0,43],"efficiency":[1,25,266],"of":[2,30,49,84,110,116,140,276],"a":[3,35,97,216,284,302],"healthy":[4,99],"brain":[5,119],"network":[6,24,78,114],"(the":[7,106],"\u2018connectome\u2019)":[8],"is":[9,102,281,300],"positively":[10],"related":[11,27],"to":[12,19,28,124,129],"physical":[13],"and":[14,76,120,143,196,211,247,294,308],"cognitive":[15],"function.":[16],"We":[17],"sought":[18],"determine":[20],"whether":[21],"changes":[22],"in":[23,39,268,296],"were":[26,62,127,146,159],"loss":[29],"heterozygosity":[31],"(LOH)":[32],"at":[33,60],"1p/19q,":[34],"favorable":[36,291],"prognostic":[37],"marker":[38],"low-grade":[40],"glioma":[41],"(LGG).":[42],"presurgical":[44,244],"diffusion":[45],"tensor":[46],"imaging":[47],"(DTI)":[48],"LGG":[50,262],"patients":[51,141,153,176,183,260],"(WHO":[52],"grade":[53],"II)":[54],"with":[55,68,74,142,154,221,261,283],"known":[56],"1p/19q":[57,279],"status":[58,249,293],"treated":[59],"MGH":[61],"retrospectively":[63],"analyzed.":[64],"Processing":[65],"included":[66,160],"co-registration":[67],"anatomical":[69],"3D":[70],"images,":[71],"probabilistic":[72],"tractography":[73],"FSL,":[75],"binary":[77],"construction":[79],"based":[80],"on":[81],"the":[82,90,117,121,125,130,180,208,269,273,289],"number":[83,109],"streamlines":[85],"connecting":[86],"each":[87,113],"parcel":[88],"from":[89],"Automated":[91],"Anatomical":[92],"Labeling":[93],"atlas":[94],"for":[95,306,311],"which":[96],"benchmark":[98],"connectome":[100,265],"(HC)":[101],"available.":[103],"Path":[104,138],"length":[105,188,199,227],"average":[107],"shortest":[108],"steps":[111],"between":[112,157],"region)":[115],"whole":[118],"hemisphere":[122],"contralateral":[123,197,225,270],"tumor":[126,245],"compared":[128,147],"HC":[131,209],"by":[132],"one-sample":[133],"Wilcoxon":[134],"signed":[135],"rank":[136],"tests.":[137,151],"lengths":[139],"without":[144,230],"LOH":[145,222,280],"using":[148],"Mann-Whitney":[149],"U":[150],"Thirteen":[152],"images":[155],"acquired":[156],"2008-2014":[158],"(8":[161],"male,":[162],"mean":[163],"age":[164],"42":[165],"\u00b1":[166,190,201,232,236],"14":[167],"years,":[168],"8":[169],"left-sided":[170],"tumors,":[171],"median":[172],"KPS":[173],"90).":[174],"Four":[175],"showed":[177],"LOH.":[178],"At":[179],"group":[181],"level,":[182],"had":[184,223],"longer":[185],"whole-brain":[186],"path":[187,198,226],"(2.5":[189,231],"0.3":[191,233],"steps,":[192,203,213,238],"p":[193,204,239],"=":[194,205,240],"0.023)":[195],"(2.0":[200],"0.2":[202],"0.033)":[206],"than":[207,228],"(2.3":[210],"1.9":[212],"resp.),":[214],"indicating":[215],"less":[217],"efficient":[218,286],"connectome.":[219],"Patients":[220],"shorter":[224],"those":[229],"versus":[234],"2.3":[235],"0.1":[237],"0.011).":[241],"Age,":[242],"gender,":[243],"volume,":[246],"performance":[248,292],"did":[250],"not":[251],"influence":[252],"these":[253,297],"results":[254,257],"significantly.":[255],"These":[256],"indicate":[258],"that":[259],"have":[263],"decreased":[264],"even":[267],"hemisphere,":[271],"highlighting":[272],"global":[274],"impact":[275],"local":[277],"tumors.":[278],"associated":[282],"more":[285,290],"connectome,":[287],"supporting":[288],"prognosis":[295,307],"patients.":[298],"Connectivity":[299],"therefore":[301],"promising":[303],"noninvasive":[304],"biomarker":[305],"holds":[309],"potential":[310],"treatment":[312],"monitoring.":[313]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-11-11T00:00:00"}