{"id":"https://openalex.org/W2547257401","doi":"https://doi.org/10.1182/blood.v122.21.2257.2257","title":"Deferasirox\u2013Deferoxamine Combination Therapy Reduces Cardiac Iron With Rapid Liver Iron Removal In Patients With Severe Transfusional Iron Overload (HYPERION)","display_name":"Deferasirox\u2013Deferoxamine Combination Therapy Reduces Cardiac Iron With Rapid Liver Iron Removal In Patients With Severe Transfusional Iron Overload (HYPERION)","publication_year":2013,"publication_date":"2013-11-15","ids":{"openalex":"https://openalex.org/W2547257401","doi":"https://doi.org/10.1182/blood.v122.21.2257.2257","mag":"2547257401"},"language":"en","primary_location":{"id":"doi:10.1182/blood.v122.21.2257.2257","doi":"https://doi.org/10.1182/blood.v122.21.2257.2257","is_oa":false,"landing_page_url":"https://doi.org/10.1182/blood.v122.21.2257.2257","pdf_url":null,"source":{"id":"https://openalex.org/S200071133","display_name":"Blood","issn_l":"0006-4971","issn":["0006-4971","1528-0020"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Blood","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5030388617","display_name":"Ye\u015fim Ayd\u0131nok","orcid":"https://orcid.org/0000-0001-6194-6826","observed_orcids":["https://orcid.org/0000-0001-6194-6826"]},"institutions":[{"id":"https://openalex.org/I4210163725","display_name":"Ege \u00dcniversitesi T\u0131p Fak\u00fcltesi Hastanesi","ror":"https://ror.org/05xv0p989","country_code":"TR","type":"healthcare","lineage":["https://openalex.org/I4210163725"]}],"countries":["TR"],"is_corresponding":false,"raw_author_name":"Yesim Aydinok","raw_affiliation_strings":["Ege University Hospital, Izmir, Turkey,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Ege University Hospital, Izmir, Turkey,","institution_ids":["https://openalex.org/I4210163725"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5053053769","display_name":"Antonis Kattamis","orcid":"https://orcid.org/0000-0002-5178-0655","observed_orcids":["https://orcid.org/0000-0002-5178-0655"]},"institutions":[{"id":"https://openalex.org/I200777214","display_name":"National and Kapodistrian University of Athens","ror":"https://ror.org/04gnjpq42","country_code":"GR","type":"education","lineage":["https://openalex.org/I200777214"]}],"countries":["GR"],"is_corresponding":false,"raw_author_name":"Antonis Kattamis","raw_affiliation_strings":["First Department of Pediatrics, University of Athens, Athens, Greece,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"First Department of Pediatrics, University of Athens, Athens, Greece,","institution_ids":["https://openalex.org/I200777214"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5064506274","display_name":"Maria Domenica Cappellini","orcid":"https://orcid.org/0000-0001-8676-6864","observed_orcids":["https://orcid.org/0000-0001-8676-6864"]},"institutions":[{"id":"https://openalex.org/I189158943","display_name":"University of Milan","ror":"https://ror.org/00wjc7c48","country_code":"IT","type":"education","lineage":["https://openalex.org/I189158943"]},{"id":"https://openalex.org/I2803066834","display_name":"Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico","ror":"https://ror.org/016zn0y21","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I189158943","https://openalex.org/I2803066834","https://openalex.org/I4210153126"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"M Domenica Cappellini","raw_affiliation_strings":["Universit\u00e1 di Milano, Ca Granda Foundation IRCCS, Milan, Italy,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Universit\u00e1 di Milano, Ca Granda Foundation IRCCS, Milan, Italy,","institution_ids":["https://openalex.org/I189158943","https://openalex.org/I2803066834"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5069567664","display_name":"Amal M. El-Beshlawy","orcid":"https://orcid.org/0000-0003-3293-1806","observed_orcids":["https://orcid.org/0000-0003-3293-1806"]},"institutions":[{"id":"https://openalex.org/I145487455","display_name":"Cairo University","ror":"https://ror.org/03q21mh05","country_code":"EG","type":"education","lineage":["https://openalex.org/I145487455"]}],"countries":["EG"],"is_corresponding":false,"raw_author_name":"Amal El-Beshlawy","raw_affiliation_strings":["Cairo University, Cairo, Egypt,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cairo University, Cairo, Egypt,","institution_ids":["https://openalex.org/I145487455"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5009338104","display_name":"Raffaella Origa","orcid":"https://orcid.org/0000-0002-2346-9616","observed_orcids":["https://orcid.org/0000-0002-2346-9616"]},"institutions":[{"id":"https://openalex.org/I4210126296","display_name":"Ospedale Microcitemico","ror":"https://ror.org/03neybp41","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210126296"]}],"countries":["IT"],"is_corresponding":true,"raw_author_name":"Raffaella Origa","raw_affiliation_strings":["Ospedale Regionale per le Microcitemie, Ospedale Regionale per le Microcitemie, Cagliari, Italy,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Ospedale Regionale per le Microcitemie, Ospedale Regionale per le Microcitemie, Cagliari, Italy,","institution_ids":["https://openalex.org/I4210126296"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5030910487","display_name":"Mohsen Saleh Elalfy","orcid":"https://orcid.org/0000-0002-2809-1552","observed_orcids":["https://orcid.org/0000-0002-2809-1552"]},"institutions":[{"id":"https://openalex.org/I107720978","display_name":"Ain Shams University","ror":"https://ror.org/00cb9w016","country_code":"EG","type":"education","lineage":["https://openalex.org/I107720978"]}],"countries":["EG"],"is_corresponding":true,"raw_author_name":"Mohsen Elalfy","raw_affiliation_strings":["Ain Shams University, Cairo, Egypt,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Ain Shams University, Cairo, Egypt,","institution_ids":["https://openalex.org/I107720978"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5047560467","display_name":"Yurdanur K\u0131l\u0131n\u00e7","orcid":"https://orcid.org/0000-0003-3552-7008","observed_orcids":["https://orcid.org/0000-0003-3552-7008"]},"institutions":[{"id":"https://openalex.org/I55931168","display_name":"Cukurova University","ror":"https://ror.org/05wxkj555","country_code":"TR","type":"education","lineage":["https://openalex.org/I55931168"]}],"countries":["TR"],"is_corresponding":false,"raw_author_name":"Yurdanur Kilin\u00e7","raw_affiliation_strings":["Cukurova University, Medical Facility, Adana, Turkey,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cukurova University, Medical Facility, Adana, Turkey,","institution_ids":["https://openalex.org/I55931168"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5045945097","display_name":"Silverio Perrotta","orcid":"https://orcid.org/0000-0001-6149-6845","observed_orcids":["https://orcid.org/0000-0001-6149-6845"]},"institutions":[{"id":"https://openalex.org/I4210117450","display_name":"Federico II University Hospital","ror":"https://ror.org/02jr6tp70","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210117450","https://openalex.org/I71267560"]}],"countries":["IT"],"is_corresponding":true,"raw_author_name":"Silverio Perrotta","raw_affiliation_strings":["I\u00b0Policlinico II\u00b0Universit\u00e0 di Napoli, Naples, Italy,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"I\u00b0Policlinico II\u00b0Universit\u00e0 di Napoli, Naples, Italy,","institution_ids":["https://openalex.org/I4210117450"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5058130927","display_name":"Zeynep Karaka\u015f","orcid":"https://orcid.org/0000-0002-8835-3235","observed_orcids":["https://orcid.org/0000-0002-8835-3235"]},"institutions":[{"id":"https://openalex.org/I4210112471","display_name":"Istanbul University-Cerrahpa\u015fa","ror":"https://ror.org/01dzn5f42","country_code":"TR","type":"education","lineage":["https://openalex.org/I4210112471"]},{"id":"https://openalex.org/I67581229","display_name":"Istanbul University","ror":"https://ror.org/03a5qrr21","country_code":"TR","type":"education","lineage":["https://openalex.org/I67581229"]}],"countries":["TR"],"is_corresponding":true,"raw_author_name":"Zeynep Karakas","raw_affiliation_strings":["Department of Pediatric Hematology, Istanbul University, Istanbul Medical Faculty, Istanbul, Turkey,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pediatric Hematology, Istanbul University, Istanbul Medical Faculty, Istanbul, Turkey,","institution_ids":["https://openalex.org/I4210112471","https://openalex.org/I67581229"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5080150203","display_name":"Vip Viprakasit","orcid":"https://orcid.org/0000-0003-3162-1849","observed_orcids":["https://orcid.org/0000-0003-3162-1849"]},"institutions":[{"id":"https://openalex.org/I1332387789","display_name":"Siriraj Hospital","ror":"https://ror.org/0331zs648","country_code":"TH","type":"healthcare","lineage":["https://openalex.org/I1332387789"]},{"id":"https://openalex.org/I25399158","display_name":"Mahidol University","ror":"https://ror.org/01znkr924","country_code":"TH","type":"education","lineage":["https://openalex.org/I25399158"]}],"countries":["TH"],"is_corresponding":true,"raw_author_name":"Vip Viprakasit","raw_affiliation_strings":["Department of Pediatrics and Thalassemia Center, Siriraj Hospital, Mahidol University, Bangkok, Thailand,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pediatrics and Thalassemia Center, Siriraj Hospital, Mahidol University, Bangkok, Thailand,","institution_ids":["https://openalex.org/I1332387789","https://openalex.org/I25399158"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5030898208","display_name":"Dany Habr","orcid":"https://orcid.org/0000-0002-3361-6309","observed_orcids":["https://orcid.org/0000-0002-3361-6309"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Dany Habr","raw_affiliation_strings":["Novartis Pharmaceuticals, East Hanover, NJ, USA,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Novartis Pharmaceuticals, East Hanover, NJ, USA,","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5001997857","display_name":"Antje Wegener","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210092929","display_name":"Novartis (France)","ror":"https://ror.org/00geypp27","country_code":"FR","type":"company","lineage":["https://openalex.org/I1283582996","https://openalex.org/I4210092929"]}],"countries":["FR"],"is_corresponding":true,"raw_author_name":"Antje Wegener","raw_affiliation_strings":["Novartis Pharma SAS, Rueil-Malmaison, France,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Novartis Pharma SAS, Rueil-Malmaison, France,","institution_ids":["https://openalex.org/I4210092929"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113059947","display_name":"Junwu Shen","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Junwu Shen","raw_affiliation_strings":["Novartis Pharmaceuticals, East Hanover, NJ, USA,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Novartis Pharmaceuticals, East Hanover, NJ, USA,","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5049244658","display_name":"John B. Porter","orcid":"https://orcid.org/0000-0003-3000-9359","observed_orcids":["https://orcid.org/0000-0003-3000-9359"]},"institutions":[{"id":"https://openalex.org/I45129253","display_name":"University College London","ror":"https://ror.org/02jx3x895","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I45129253"]}],"countries":["GB"],"is_corresponding":true,"raw_author_name":"John B Porter","raw_affiliation_strings":["University College London, London, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University College London, London, United Kingdom","institution_ids":["https://openalex.org/I45129253"]}]}],"institutions":[],"countries_distinct_count":7,"institutions_distinct_count":15,"corresponding_author_ids":["https://openalex.org/A5001997857","https://openalex.org/A5009338104","https://openalex.org/A5030910487","https://openalex.org/A5045945097","https://openalex.org/A5049244658","https://openalex.org/A5058130927","https://openalex.org/A5080150203","https://openalex.org/A5113059947"],"corresponding_institution_ids":["https://openalex.org/I107720978","https://openalex.org/I1332387789","https://openalex.org/I25399158","https://openalex.org/I4210092929","https://openalex.org/I4210112471","https://openalex.org/I4210117450","https://openalex.org/I4210126296","https://openalex.org/I45129253","https://openalex.org/I67581229"],"apc_list":{"value":5500,"currency":"USD","value_usd":5500},"apc_paid":null,"fwci":1.6755,"has_fulltext":false,"cited_by_count":11,"citation_normalized_percentile":{"value":0.8423415,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"122","issue":"21","first_page":"2257","last_page":"2257"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10554","display_name":"Hemoglobinopathies and Related Disorders","score":0.9121000170707703,"subfield":{"id":"https://openalex.org/subfields/2716","display_name":"Genetics (clinical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10554","display_name":"Hemoglobinopathies and Related Disorders","score":0.9121000170707703,"subfield":{"id":"https://openalex.org/subfields/2716","display_name":"Genetics (clinical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10452","display_name":"Iron Metabolism and Disorders","score":0.07760000228881836,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10693","display_name":"Blood transfusion and management","score":0.0017999999690800905,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/deferasirox","display_name":"deferasirox","score":0.9819999933242798},{"id":"https://openalex.org/keywords/deferoxamine","display_name":"deferoxamine","score":0.9980000257492065},{"id":"https://openalex.org/keywords/transfusional-iron-overload","display_name":"transfusional iron overload","score":0.9179999828338623},{"id":"https://openalex.org/keywords/cardiac-siderosis","display_name":"cardiac siderosis","score":0.9829999804496765},{"id":"https://openalex.org/keywords/cardiac-t2","display_name":"cardiac T2*","score":0.9750000238418579},{"id":"https://openalex.org/keywords/liver-iron-concentration","display_name":"liver iron concentration","score":0.8479999899864197},{"id":"https://openalex.org/keywords/transfusion-dependent-patients","display_name":"transfusion-dependent patients","score":0.7099999785423279},{"id":"https://openalex.org/keywords/cardiac-mri","display_name":"cardiac MRI","score":0.40299999713897705},{"id":"https://openalex.org/keywords/liver-mri","display_name":"liver MRI","score":0.6010000109672546},{"id":"https://openalex.org/keywords/dose-adjustment","display_name":"dose adjustment","score":0.3700000047683716},{"id":"https://openalex.org/keywords/safety-and-tolerability","display_name":"safety and tolerability","score":0.6240000128746033}],"concepts":[{"id":"https://openalex.org/C2781053155","wikidata":"https://www.wikidata.org/wiki/Q5251502","display_name":"Deferasirox","level":3,"score":0.8938542008399963},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8307840824127197},{"id":"https://openalex.org/C2776672577","wikidata":"https://www.wikidata.org/wiki/Q419618","display_name":"Deferoxamine","level":2,"score":0.8105077743530273},{"id":"https://openalex.org/C2780883591","wikidata":"https://www.wikidata.org/wiki/Q1413860","display_name":"Siderosis","level":2,"score":0.7469605803489685},{"id":"https://openalex.org/C78085059","wikidata":"https://www.wikidata.org/wiki/Q641303","display_name":"Ejection fraction","level":3,"score":0.583052396774292},{"id":"https://openalex.org/C2776999253","wikidata":"https://www.wikidata.org/wiki/Q1304270","display_name":"Combination therapy","level":2,"score":0.5164235234260559},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.47073328495025635},{"id":"https://openalex.org/C90924648","wikidata":"https://www.wikidata.org/wiki/Q120569","display_name":"Gastroenterology","level":1,"score":0.3832990527153015},{"id":"https://openalex.org/C2778198053","wikidata":"https://www.wikidata.org/wiki/Q181754","display_name":"Heart failure","level":2,"score":0.35955366492271423},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.3434015214443207},{"id":"https://openalex.org/C2777799968","wikidata":"https://www.wikidata.org/wiki/Q185137","display_name":"Thalassemia","level":2,"score":0.23009172081947327}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.1182/blood.v122.21.2257.2257","doi":"https://doi.org/10.1182/blood.v122.21.2257.2257","is_oa":false,"landing_page_url":"https://doi.org/10.1182/blood.v122.21.2257.2257","pdf_url":null,"source":{"id":"https://openalex.org/S200071133","display_name":"Blood","issn_l":"0006-4971","issn":["0006-4971","1528-0020"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Blood","raw_type":"journal-article"},{"id":"pmh:oai:iris.unica.it:11584/184982","doi":null,"is_oa":false,"landing_page_url":"http://hdl.handle.net/11584/184982","pdf_url":null,"source":{"id":"https://openalex.org/S4377196293","display_name":"UNICA IRIS Institutional Research Information System (University of Cagliari)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I172446870","host_organization_name":"University of Cagliari","host_organization_lineage":["https://openalex.org/I172446870"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":1.0,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/clinical-trial","display_name":"Clinical Trial"}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2133733540","https://openalex.org/W2572268349","https://openalex.org/W2185955564","https://openalex.org/W4223463122","https://openalex.org/W2512262037","https://openalex.org/W2518546557","https://openalex.org/W2150888813","https://openalex.org/W2548976620","https://openalex.org/W2545545249","https://openalex.org/W2592320114"],"abstract_inverted_index":{"Abstract":[0],"Background":[1],"Transfusion-dependent":[2],"patients":[3,28,86,111,258,281,308,320,364,471,504,585,785,806],"with":[4,87,112,122,213,309,335,379,472,532,582,586,598,640,648,668,672,751,807],"severe":[5,88,113,336,587,752,808],"cardiac":[6,55,90,114,124,178,207,240,302,342,436,458,481,529,604,653,692,753,810],"siderosis":[7,115],"often":[8,765],"require":[9],"intensive":[10],"iron":[11,23,136,337,590,654,658,693,743,754,780,811],"chelation":[12],"therapy":[13,203,770],"for":[14,43,157,278,307,678,738,771],"a":[15,32,183,214,264,297,736,772,789],"limited":[16,773],"time":[17,193,774],"to":[18,29,37,53,165,199,210,395,408,465,487,494,535,746,775,786,788,804],"facilitate":[19,776],"rapid":[20,777],"removal":[21,655,659,778],"of":[22,63,76,187,217,257,292,503,567,580,630,664,684,703,717,741,760,779,797,800,850,869],"from":[24,31,189,219,268,461,513,562,781],"the":[25,60,255,283,428,682,739,782,798,870],"heart,":[26,783],"allowing":[27,784],"move":[30,787],"high-risk":[33],"(cardiac":[34],"T2*<10":[35],"ms)":[36,41],"lower":[38],"risk":[39,759],"(\u226510":[40],"status":[42],"heart":[44,761],"failure.":[45,530],"Oral":[46],"deferasirox":[47,801],"(DFX)":[48],"monotherapy":[49,84,108,670,737],"has":[50],"been":[51],"shown":[52],"improve":[54],"T2*,":[56],"but":[57,634],"data":[58,650],"on":[59,227,689,699,713,846,867],"combined":[61],"use":[62,796],"DFX":[64,83,107,146,160,200,413,614],"and":[65,74,167,173,182,229,263,272,295,299,313,381,419,440,476,491,501,509,518,525,564,691,730,763,802],"deferoxamine":[66,731,803],"(DFO)":[67],"are":[68,732,756,764],"limited.":[69],"Aim":[70],"To":[71],"evaluate":[72,681],"efficacy":[73,228,233],"safety":[75,230],"investigational":[77],"DFX\u2013DFO":[78,102,583,665,686],"in":[79,85,103,109,237,282,584,638,687],"combination":[80,104,688,769,799],"followed":[81,105],"by":[82,106,246,449,767],"transfusional":[89,588,809],"siderosis.":[91],"Methods":[92],"The":[93,612],"prospective,":[94],"Phase":[95],"II,":[96],"open-label,":[97],"multinational":[98],"HYPERION":[99,679,871],"study":[100,293,536],"evaluated":[101],"transfusion-dependent":[110],"(NCT01254227).":[116],"Patients":[117,176,750],"enrolled":[118,322],"were":[119,197,225,321,539,627,635],"\u226510":[120,180,261,507],"years":[121],"CMR-measured":[123],"T2*":[125,179,185,208,221,241,260,303,310,343,390,437,459,482,506,575,605,625],"5\u2013<10":[126],"ms,":[127,345,489,496],"left":[128],"ventricular":[129],"ejection":[130],"fraction":[131],"(LVEF)":[132],"\u226556%,":[133],"R2-MRI":[134],"liver":[135,657,690],"concentration":[137],"(LIC)":[138],"\u22657":[139],"mg":[140,351,478,644],"Fe/g":[141,352,479,645],"dw.":[142],"Starting":[143],"dose":[144,161,291,411,615],"was":[145,204,235,254,276,412,484,666],"20":[147,363],"mg/kg/d,":[148,154,424],"7":[149,417],"d/wk,":[150,418],"plus":[151],"DFO":[152,420],"40":[153,168],"5":[155,366,425],"d/wk":[156],"\u22658":[158],"hrs/d.":[159],"could":[162],"be":[163],"increased":[164,438,460,545,549,758],"30":[166],"mg/kg/d":[169],"after":[170,194,270,609,617],"Month":[171,243,314,516,618],"1":[172,326,400,555],"6,":[174],"respectively.":[175,498,520],"achieving":[177,259],"ms":[181,212,262,467,508],"relative":[184,215,266,511],"increase":[186,267,512,561],"\u226510%":[188,218,265,510],"baseline":[190],"(BL)":[191],"any":[192],"6":[195,271,517,610,619],"months":[196,579],"switched":[198],"monotherapy.":[201],"Combination":[202],"resumed":[205],"if":[206],"fell":[209],"<10":[211],"decrease":[216],"previous":[220,649],"value.":[222],"Dose":[223],"adjustments":[224],"based":[226],"parameters.":[231],"Primary":[232],"endpoint":[234],"change":[236],"geometric":[238],"mean":[239,329,340,346],"at":[242,248,311,463,515,569,757],"12":[244,273,315,578],"divided":[245],"that":[247,652],"BL.":[249],"A":[250],"key":[251],"secondary":[252],"objective":[253],"proportion":[256],"BL":[269,298,312,464,473,514,563,593,631,641],"months.":[274,611],"Efficacy":[275],"analyzed":[277],"all":[279],"evaluable":[280,429],"full":[284],"analysis":[285],"set":[286],"(FAS)":[287],"who":[288],"received":[289],"\u22651":[290],"drug":[294,377,537],"had":[296,528,557],"post-BL":[300],"assessment;":[301],"is":[304],"also":[305],"reported":[306],"(12-month":[316],"completers).":[317],"Results":[318],"60":[319],"(59":[323],"\u03b2-thalassemia":[324],"major,":[325],"Diamond\u2013Blackfan":[327],"anemia;":[328],"age":[330],"22.8":[331],"years;":[332],"46.7%":[333],"male)":[334],"overload":[338,744,755],"(geometric":[339],"[Gmean]":[341],"7.03":[344],"LIC":[347,441,474,594,602,632,642],"33.4":[348],"\u00b1":[349,415,422],"14.5":[350],"dw,":[353,480,646],"median":[354],"serum":[355,445,558],"ferritin":[356,446],"5551":[357],"ng/mL":[358,451],"[range":[359],"1163,":[360],"11,317]).":[361],"Overall,":[362,499,600],"discontinued;":[365],"consent":[367],"withdrawals,":[368],"4":[369,384,393],"adverse":[370],"events":[371],"(AEs:":[372],"pruritus,":[373],"arthritis,":[374],"abdominal":[375,540],"pain,":[376,541],"rash":[378],"eosinophilia":[380],"systemic":[382],"symptoms),":[383],"abnormal":[385],"test":[386],"procedure":[387],"results":[388],"(all":[389,553],"<5":[391],"ms),":[392],"lost":[394],"follow-up,":[396],"2":[397,570],"administrative":[398],"problems,":[399],"death":[401],"(central":[402],"nervous":[403],"system":[404],"infection,":[405],"suspected":[406,533],"relationship":[407,534],"DFO).":[409],"Mean":[410,521],"29.6":[414],"6.3,":[416],"37.4":[421],"5.8":[423],"d/wk.":[426],"In":[427,470],"FAS":[430],"(n=52,":[431],"last":[432],"observation":[433],"carried":[434],"forward)":[435],"9%":[439],"decreased":[442,448,596,603],"46%":[443],"(Fig);":[444],"levels":[447,595],"2174":[450],"(\u20136138,":[452],"1570).":[453],"Among":[454],"12-month":[455],"completers":[456],"(n=36),":[457],"7.24":[462],"8.24":[466],"(14%":[468],"improvement).":[469],"<30":[475,643],"\u226530":[477],"improvement":[483],"17%":[485],"(7.85":[486],"9.15":[488],"n=16)":[490],"6%":[492],"(6.69":[493],"7.11":[495],"n=36),":[497],"12.5":[500],"19.2%":[502],"achieved":[505],"12,":[519],"LVEF":[522],"remained":[523],"stable":[524],"no":[526,673],"patient":[527,556],"AEs":[531],"(\u22655%)":[538],"nausea":[542],"(both":[543],"6.7%);":[544],"blood":[546,748],"creatinine,":[547],"diarrhea,":[548],"urine":[550],"protein/creatinine":[551],"ratio":[552],"5.0%).":[554],"creatinine":[559],">33%":[560],">upper":[565],"limit":[566],"normal":[568],"consecutive":[571],"visits.":[572],"Discussion":[573],"Cardiac":[574,624],"improved":[576],"during":[577],"treatment":[581,740],"body":[589],"burden.":[591],"High":[592],"considerably":[597],"DFX\u2013DFO.":[599],"as":[601,735],"increased,":[606],"most":[607,636],"notably":[608],"higher":[613],"permitted":[616],"possibly":[620],"influenced":[621],"this":[622],"trend.":[623],"improvements":[626],"observed":[628],"irrespective":[629],"value,":[633],"marked":[637],"those":[639],"consistent":[647,667],"showing":[651],"follows":[656],"(Noetzli":[660],"Blood":[661],"2008).":[662],"Safety":[663],"established":[669],"profiles,":[671],"unexpected":[674],"findings.":[675],"2-year":[676],"follow-up":[677],"will":[680],"impact":[683],"longer-term":[685],"removal.":[694],"Disclosures:":[695],"Aydinok:":[696],"Shire:":[697,839],"Membership":[698,712,845],"an":[700,714,847],"entity\u2019s":[701,715,848],"Board":[702,716,849],"Directors":[704,718,851],"or":[705,719,852],"advisory":[706,720,853],"committees,":[707,721,854],"Research":[708,722,814,828,832,837,840,855,880],"Funding;":[709,838,841],"Novartis:":[710,823,842,877],"Honoraria,":[711,824,831,836,844,879],"Funding,":[723,815,856],"Speakers":[724,816,819,825,857],"Bureau.":[725,820,826,858],"Off":[726],"Label":[727],"Use:":[728],"Deferasirox":[729],"both":[733],"indicated":[734],"chronic":[742],"due":[745],"frequent":[747],"transfusions.":[749],"failure":[762],"treated":[766],"off-label":[768,795],"lower-risk":[790],"status.":[791],"This":[792],"abstract":[793],"describes":[794],"treat":[805],"overload.":[812],"Kattamis:Novartis:":[813],"Bureau;":[817],"ApoPharma:":[818],"Cappellini:Genzyme:":[821],"Honoraria;":[822,874],"Perrotta:Novartis:":[827],"Funding.":[829,833,881],"Karakas:Novartis:":[830],"Viprakasit:GPO,":[834],"Thailand:":[835],"Consultancy,":[843,873,878],"Habr:Novartis:":[859],"Employment.":[860,862,864],"Wegener:Novartis:":[861],"Shen:Novartis:":[863],"Porter,":[865],"MD":[866],"behalf":[868],"investigators:Shire:":[872],"Celgene:":[875],"Consultancy;":[876]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":1},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":2},{"year":2014,"cited_by_count":4}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-11-11T00:00:00"}