{"id":"https://openalex.org/W2547166121","doi":null,"title":"The Yeast Mating Scaffold Ste5 Exhibits Evolutionary Specialization","display_name":"The Yeast Mating Scaffold Ste5 Exhibits Evolutionary Specialization","publication_year":2013,"publication_date":"2013-01-01","ids":{"openalex":"https://openalex.org/W2547166121","mag":"2547166121"},"language":"en","primary_location":{"id":"pmh:oai:commons.cu-portland.edu:theses-1098","doi":null,"is_oa":false,"landing_page_url":"https://commons.cu-portland.edu/theses/90","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Undergraduate Theses","raw_type":"text"},"volume":null,"type":"dissertation","indexed_in":[],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5010100856","display_name":"Jonathan A. Flores","orcid":"https://orcid.org/0000-0001-5008-2495","observed_orcids":["https://orcid.org/0000-0001-5008-2495"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Jonathan Flores","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0001-5008-2495","affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5010100856"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10497","display_name":"Fungal and yeast genetics research","score":0.9193999767303467,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10497","display_name":"Fungal and yeast genetics research","score":0.9193999767303467,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10169","display_name":"Protein Kinase Regulation and GTPase Signaling","score":0.03370000049471855,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10621","display_name":"Gene Regulatory Network Analysis","score":0.01549999974668026,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/ste5","display_name":"Ste5","score":0.8569999933242798},{"id":"https://openalex.org/keywords/scaffold-proteins","display_name":"scaffold proteins","score":0.9079999923706055},{"id":"https://openalex.org/keywords/mating-pathway","display_name":"mating pathway","score":0.6570000052452087},{"id":"https://openalex.org/keywords/fusca3","display_name":"FUS3","score":0.7350000143051147},{"id":"https://openalex.org/keywords/ste7","display_name":"Ste7","score":0.640999972820282},{"id":"https://openalex.org/keywords/saccharomyces-cerevisiae","display_name":"Saccharomyces cerevisiae","score":0.871999979019165},{"id":"https://openalex.org/keywords/kinase-cascade","display_name":"kinase cascade","score":0.5609999895095825},{"id":"https://openalex.org/keywords/phosphorylation-kinetics","display_name":"phosphorylation kinetics","score":0.4449999928474426}],"concepts":[{"id":"https://openalex.org/C89429830","wikidata":"https://www.wikidata.org/wiki/Q735710","display_name":"Scaffold","level":2,"score":0.5511292815208435},{"id":"https://openalex.org/C514575182","wikidata":"https://www.wikidata.org/wiki/Q228395","display_name":"Mating","level":2,"score":0.50813889503479},{"id":"https://openalex.org/C2779222958","wikidata":"https://www.wikidata.org/wiki/Q45422","display_name":"Yeast","level":2,"score":0.47100797295570374},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4526394307613373},{"id":"https://openalex.org/C78458016","wikidata":"https://www.wikidata.org/wiki/Q840400","display_name":"Evolutionary biology","level":1,"score":0.3755635619163513},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.23823696374893188},{"id":"https://openalex.org/C18903297","wikidata":"https://www.wikidata.org/wiki/Q7150","display_name":"Ecology","level":1,"score":0.15422403812408447},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.14908912777900696},{"id":"https://openalex.org/C77088390","wikidata":"https://www.wikidata.org/wiki/Q8513","display_name":"Database","level":1,"score":0.0}],"mesh":[],"locations_count":2,"locations":[{"id":"pmh:oai:commons.cu-portland.edu:theses-1098","doi":null,"is_oa":false,"landing_page_url":"https://commons.cu-portland.edu/theses/90","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Undergraduate Theses","raw_type":"text"},{"id":"mag:2547166121","doi":null,"is_oa":false,"landing_page_url":"https://digitalcommons.csp.edu/cup_commons_undergrad/201/","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[],"sustainable_development_goals_aurora":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W7100854032","https://openalex.org/W2163680039","https://openalex.org/W2084009754","https://openalex.org/W7095932859","https://openalex.org/W2113972438","https://openalex.org/W1990461008","https://openalex.org/W2110910553","https://openalex.org/W4237132544","https://openalex.org/W1972471009","https://openalex.org/W2028070789"],"abstract_inverted_index":{"Cells":[0],"use":[1],"scaffold":[2,21,41,75,277],"proteins":[3,42,225],"to":[4,51,56,120,186,237,264],"bind":[5],"and":[6,90,123,165,230,274],"organize":[7],"components":[8],"of":[9,68,80,97,138,161,202,249,268],"signaling":[10,14,32,59,282],"pathways.":[11],"A":[12],"customized":[13,58,281],"response":[15,33],"underlies":[16],"biological":[17],"adaptation.":[18],"Changes":[19],"in":[20,76,85,172,176,221,228,243,271],"protein":[22],"genes":[23],"may":[24,132],"be":[25,133,259],"a":[26,37,74,92,134,194],"mechanism":[27,131],"through":[28,34],"which":[29],"organisms":[30,50],"customize":[31],"evolution.":[35],"Such":[36],"hypothesis":[38],"has":[39],"emerged:":[40],"have":[43],"served":[44],"as":[45],"evolutionary":[46,66,266],"test":[47,218],"beds":[48],"for":[49,64,219],"elaborate":[52],"on":[53,116],"existing":[54],"pathways":[55],"generate":[57],"mechanisms.":[60],"However,":[61,111,241],"direct":[62,254],"evidence":[63],"the":[65,77,98,108,112,139,205,213,250],"diversification":[67],"scaffolds":[69],"is":[70,73,143,209],"lacking.":[71],"Ste5":[72,88,117,224,244,269],"mating":[78,109],"pathway":[79,127,170,239,255],"S.":[81,162,214,272],"cerevisiae":[82,163,215,273],"with":[83,285],"orthologues":[84,156,184],"related":[86,195],"species.":[87],"binds":[89,118],"organizes":[91],"kinase":[93,100,105],"cascade,":[94],"where":[95],"phosphorylation":[96,160,203],"terminal":[99],"(Fus3)":[101],"by":[102,204],"its":[103],"upstream":[104],"(Ste7)":[106],"activates":[107],"response.":[110],"Fus3-binding":[113],"domain":[114],"(FBD)":[115],"Fus3":[119,148,164,188],"stimulate":[121,159,187],"autophosphorylation":[122],"this":[124,167],"phospho-Fus3":[125],"inhibits":[126],"activation.":[128],"This":[129],"regulatory":[130],"recently":[135],"evolved":[136],"feature":[137],"scaffold,":[140],"since":[141],"little":[142],"known":[144],"about":[145],"FBD":[146,155,183,208],"or":[147],"orthologues.":[149],"Therefore,":[150],"we":[151,179],"hypothesized":[152],"that":[153,166,181,200,276],"selected":[154],"will":[157],"not":[158,258],"would":[168],"affect":[169],"output":[171,256],"vivo.":[173],"Using":[174],"an":[175,265],"vitro":[177],"system,":[178],"found":[180],"all":[182],"failed":[185],"phosphorylation,":[189],"except":[190],"one":[191],"V.":[192,206],"polyspora,":[193],"yeast.":[196],"Further":[197],"investigation":[198],"revealed":[199],"stimulation":[201],"polyspora":[207],"kinetically":[210],"distinct":[211],"from":[212],"FBD.":[216],"To":[217],"consequences":[220],"vivo,":[222],"chimeric":[223],"were":[226],"expressed":[227],"yeast":[229],"fluorescence-activated":[231],"cell":[232],"sorting":[233],"(FACS)":[234],"was":[235],"used":[236],"monitor":[238],"activity.":[240],"variability":[242],"expression":[245],"levels":[246],"confounded":[247],"interpretation":[248],"FACS":[251],"data.":[252],"Though":[253],"could":[257],"quantified,":[260],"our":[261],"data":[262],"point":[263],"expansion":[267],"function":[270],"imply":[275],"evolution":[278],"can":[279],"underlie":[280],"responses.\\nHonors:":[283],"Thesis":[284],"Distinction":[286],"Award":[287]},"counts_by_year":[],"updated_date":"2026-09-22T06:50:58.402377","created_date":"2016-11-11T00:00:00"}
