{"id":"https://openalex.org/W2547042452","doi":"https://doi.org/10.1016/j.cardfail.2016.10.016","title":"Evaluating the Efficacy, Safety, and Tolerability of Serelaxin When Added to Standard Therapy in Asian Patients With Acute Heart Failure: Design and Rationale of RELAX-AHF-ASIA Trial","display_name":"Evaluating the Efficacy, Safety, and Tolerability of Serelaxin When Added to Standard Therapy in Asian Patients With Acute Heart Failure: Design and Rationale of RELAX-AHF-ASIA Trial","publication_year":2016,"publication_date":"2016-11-04","ids":{"openalex":"https://openalex.org/W2547042452","doi":"https://doi.org/10.1016/j.cardfail.2016.10.016","mag":"2547042452","pmid":"https://pubmed.ncbi.nlm.nih.gov/27825893"},"language":"en","primary_location":{"id":"doi:10.1016/j.cardfail.2016.10.016","doi":"https://doi.org/10.1016/j.cardfail.2016.10.016","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.cardfail.2016.10.016","pdf_url":null,"source":{"id":"https://openalex.org/S67869649","display_name":"Journal of Cardiac Failure","issn_l":"1071-9164","issn":["1071-9164","1532-8414"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Cardiac Failure","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://doi.org/10.1016/j.cardfail.2016.10.016","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5089083104","display_name":"Naoki Sato","orcid":"https://orcid.org/0000-0002-5550-0083","observed_orcids":["https://orcid.org/0000-0002-5550-0083"]},"institutions":[{"id":"https://openalex.org/I4210093346","display_name":"Nippon Medical School Musashi Kosugi Hospital","ror":"https://ror.org/00h5ck659","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210093346"]},{"id":"https://openalex.org/I80188885","display_name":"Nippon Medical School","ror":"https://ror.org/00krab219","country_code":"JP","type":"education","lineage":["https://openalex.org/I80188885"]}],"countries":["JP"],"is_corresponding":true,"raw_author_name":"Naoki Sato","raw_affiliation_strings":["Cardiology and Intensive Care Unit, Nippon Medical School, Musashi-Kosugi Hospital, Kawasaki, Japan. Electronic address: nms-ns@nms.ac.jp","Cardiology and Intensive Care Unit, Nippon Medical School, Musashi-Kosugi Hospital, Kawasaki, Japan"],"raw_orcid":"https://orcid.org/0000-0002-5550-0083","affiliations":[{"raw_affiliation_string":"Cardiology and Intensive Care Unit, Nippon Medical School, Musashi-Kosugi Hospital, Kawasaki, Japan. Electronic address: nms-ns@nms.ac.jp","institution_ids":["https://openalex.org/I4210093346"]},{"raw_affiliation_string":"Cardiology and Intensive Care Unit, Nippon Medical School, Musashi-Kosugi Hospital, Kawasaki, Japan","institution_ids":["https://openalex.org/I4210093346","https://openalex.org/I80188885"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5067422552","display_name":"Carolyn S.P. Lam","orcid":"https://orcid.org/0000-0003-1903-0018","observed_orcids":["https://orcid.org/0000-0003-1903-0018"]},"institutions":[{"id":"https://openalex.org/I165932596","display_name":"National University of Singapore","ror":"https://ror.org/01tgyzw49","country_code":"SG","type":"education","lineage":["https://openalex.org/I165932596"]},{"id":"https://openalex.org/I4210107866","display_name":"National University Heart Centre Singapore","ror":"https://ror.org/01vvdem88","country_code":"SG","type":"healthcare","lineage":["https://openalex.org/I4210107866"]},{"id":"https://openalex.org/I4210126319","display_name":"Duke-NUS Medical School","ror":"https://ror.org/02j1m6098","country_code":"SG","type":"education","lineage":["https://openalex.org/I165932596","https://openalex.org/I170897317","https://openalex.org/I4210126319"]},{"id":"https://openalex.org/I4210147238","display_name":"National Heart Centre Singapore","ror":"https://ror.org/04f8k9513","country_code":"SG","type":"healthcare","lineage":["https://openalex.org/I4210147238"]}],"countries":["SG"],"is_corresponding":false,"raw_author_name":"Carolyn S.P. Lam","raw_affiliation_strings":["National Heart Centre Singapore and Duke-NUS, Singapore"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"National Heart Centre Singapore and Duke-NUS, Singapore","institution_ids":["https://openalex.org/I165932596","https://openalex.org/I4210107866","https://openalex.org/I4210126319","https://openalex.org/I4210147238"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5017097200","display_name":"John R. Teerlink","orcid":"https://orcid.org/0000-0001-9527-0852","observed_orcids":["https://orcid.org/0000-0001-9527-0852"]},"institutions":[{"id":"https://openalex.org/I1315708478","display_name":"San Francisco VA Medical Center","ror":"https://ror.org/049peqw80","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1315708478","https://openalex.org/I1322918889","https://openalex.org/I2799886695","https://openalex.org/I4210125474","https://openalex.org/I4210143381"]},{"id":"https://openalex.org/I180670191","display_name":"University of California, San Francisco","ror":"https://ror.org/043mz5j54","country_code":"US","type":"education","lineage":["https://openalex.org/I180670191"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"John R. Teerlink","raw_affiliation_strings":["University of California, San Francisco, and San Francisco Veterans Affairs Medical Center, Los Angeles, California"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of California, San Francisco, and San Francisco Veterans Affairs Medical Center, Los Angeles, California","institution_ids":["https://openalex.org/I1315708478","https://openalex.org/I180670191"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5064906147","display_name":"Barry Greenberg","orcid":"https://orcid.org/0000-0002-6605-9385","observed_orcids":["https://orcid.org/0000-0002-6605-9385"]},"institutions":[{"id":"https://openalex.org/I36258959","display_name":"University of California San Diego","ror":"https://ror.org/0168r3w48","country_code":"US","type":"education","lineage":["https://openalex.org/I36258959"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Barry H. Greenberg","raw_affiliation_strings":["Division of Cardiology, University of California, San Diego, La Jolla, California"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Cardiology, University of California, San Diego, La Jolla, California","institution_ids":["https://openalex.org/I36258959"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5091849037","display_name":"Hiroyuki Tsutsui","orcid":"https://orcid.org/0000-0002-5291-2875","observed_orcids":["https://orcid.org/0000-0002-5291-2875"]},"institutions":[{"id":"https://openalex.org/I135598925","display_name":"Kyushu University","ror":"https://ror.org/00p4k0j84","country_code":"JP","type":"education","lineage":["https://openalex.org/I135598925"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Hiroyuki Tsutsui","raw_affiliation_strings":["Department of Cardiovascular Medicine, Faculty of Medical Sciences, Kyushu University, Fukuoka, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cardiovascular Medicine, Faculty of Medical Sciences, Kyushu University, Fukuoka, Japan","institution_ids":["https://openalex.org/I135598925"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5052064676","display_name":"Byung\u2010Hee Oh","orcid":"https://orcid.org/0000-0002-9945-4306","observed_orcids":["https://orcid.org/0000-0002-9945-4306"]},"institutions":[{"id":"https://openalex.org/I139264467","display_name":"Seoul National University","ror":"https://ror.org/04h9pn542","country_code":"KR","type":"education","lineage":["https://openalex.org/I139264467"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Byung-Hee Oh","raw_affiliation_strings":["Department of Internal Medicine, Seoul National University, College of Medicine, Seoul, South Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Internal Medicine, Seoul National University, College of Medicine, Seoul, South Korea","institution_ids":["https://openalex.org/I139264467"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100409969","display_name":"Jian Zhang","orcid":"https://orcid.org/0000-0002-5093-4325","observed_orcids":["https://orcid.org/0000-0002-5093-4325"]},"institutions":[{"id":"https://openalex.org/I200296433","display_name":"Chinese Academy of Medical Sciences & Peking Union Medical College","ror":"https://ror.org/02drdmm93","country_code":"CN","type":"education","lineage":["https://openalex.org/I200296433"]},{"id":"https://openalex.org/I4210161896","display_name":"Fu Wai Hospital","ror":"https://ror.org/0590dnz19","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210161896"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jian Zhang","raw_affiliation_strings":["Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, People's Republic of China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, People's Republic of China","institution_ids":["https://openalex.org/I200296433","https://openalex.org/I4210161896"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5080343259","display_name":"Martin P. Lefkowitz","orcid":"https://orcid.org/0000-0002-8830-6316","observed_orcids":["https://orcid.org/0000-0002-8830-6316"]},"institutions":[{"id":"https://openalex.org/I4210117619","display_name":"Novartis (United States)","ror":"https://ror.org/028fhxy95","country_code":"US","type":"company","lineage":["https://openalex.org/I1283582996","https://openalex.org/I4210117619"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Martin Lefkowitz","raw_affiliation_strings":["Novartis Pharmaceuticals Corporation, East Hanover, New Jersey"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Novartis Pharmaceuticals Corporation, East Hanover, New Jersey","institution_ids":["https://openalex.org/I4210117619"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108535618","display_name":"Tsushung A. Hua","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210117619","display_name":"Novartis (United States)","ror":"https://ror.org/028fhxy95","country_code":"US","type":"company","lineage":["https://openalex.org/I1283582996","https://openalex.org/I4210117619"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Tsushung A. Hua","raw_affiliation_strings":["Novartis Pharmaceuticals Corporation, East Hanover, New Jersey"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Novartis Pharmaceuticals Corporation, East Hanover, New Jersey","institution_ids":["https://openalex.org/I4210117619"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5039533464","display_name":"Thomas Holbro","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1283582996","display_name":"Novartis (Switzerland)","ror":"https://ror.org/02f9zrr09","country_code":"CH","type":"company","lineage":["https://openalex.org/I1283582996"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"Thomas Holbro","raw_affiliation_strings":["Novartis Pharma, Basel, Switzerland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Novartis Pharma, Basel, Switzerland","institution_ids":["https://openalex.org/I1283582996"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5046937124","display_name":"Miriam Marshood","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210117619","display_name":"Novartis (United States)","ror":"https://ror.org/028fhxy95","country_code":"US","type":"company","lineage":["https://openalex.org/I1283582996","https://openalex.org/I4210117619"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Miriam Marshood","raw_affiliation_strings":["Novartis Pharmaceuticals Corporation, East Hanover, New Jersey"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Novartis Pharmaceuticals Corporation, East Hanover, New Jersey","institution_ids":["https://openalex.org/I4210117619"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5071421730","display_name":"Xing Li Wang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210117619","display_name":"Novartis (United States)","ror":"https://ror.org/028fhxy95","country_code":"US","type":"company","lineage":["https://openalex.org/I1283582996","https://openalex.org/I4210117619"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Xing Li Wang","raw_affiliation_strings":["Novartis Pharmaceuticals Corporation, East Hanover, New Jersey"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Novartis Pharmaceuticals Corporation, East Hanover, New Jersey","institution_ids":["https://openalex.org/I4210117619"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5100758728","display_name":"Junbo Ge","orcid":"https://orcid.org/0000-0002-9360-7332","observed_orcids":["https://orcid.org/0000-0002-9360-7332"]},"institutions":[{"id":"https://openalex.org/I24943067","display_name":"Fudan University","ror":"https://ror.org/013q1eq08","country_code":"CN","type":"education","lineage":["https://openalex.org/I24943067"]},{"id":"https://openalex.org/I4210127074","display_name":"Zhongshan Hospital","ror":"https://ror.org/032x22645","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210127074"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Junbo Ge","raw_affiliation_strings":["Department of Cardiology, Zhongshan Hospital, Fudan University, Shanghai, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cardiology, Zhongshan Hospital, Fudan University, Shanghai, China","institution_ids":["https://openalex.org/I24943067","https://openalex.org/I4210127074"]}]}],"institutions":[],"countries_distinct_count":6,"institutions_distinct_count":17,"corresponding_author_ids":["https://openalex.org/A5089083104"],"corresponding_institution_ids":["https://openalex.org/I4210093346","https://openalex.org/I80188885"],"apc_list":{"value":3970,"currency":"USD","value_usd":3970},"apc_paid":{"value":3970,"currency":"USD","value_usd":3970},"fwci":5.4993,"has_fulltext":false,"cited_by_count":32,"citation_normalized_percentile":{"value":0.96389076,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":"23","issue":"1","first_page":"63","last_page":"71"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10198","display_name":"Heart Failure Treatment and Management","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10198","display_name":"Heart Failure Treatment and Management","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11962","display_name":"Cardiac Fibrosis and Remodeling","score":0.00039999998989515007,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10292","display_name":"Acute Myocardial Infarction Research","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/serelaxin","display_name":"serelaxin","score":0.9980000257492065},{"id":"https://openalex.org/keywords/acute-heart-failure","display_name":"acute heart failure","score":1.0},{"id":"https://openalex.org/keywords/asian-patients","display_name":"Asian patients","score":0.8009999990463257},{"id":"https://openalex.org/keywords/heart-failure-readmission","display_name":"heart failure readmission","score":0.8270000219345093},{"id":"https://openalex.org/keywords/all-cause-mortality","display_name":"all-cause mortality","score":0.7820000052452087},{"id":"https://openalex.org/keywords/cardiovascular-mortality","display_name":"cardiovascular mortality","score":0.9179999828338623},{"id":"https://openalex.org/keywords/dyspnea","display_name":"dyspnea","score":0.7820000052452087},{"id":"https://openalex.org/keywords/congestion","display_name":"congestion","score":0.3529999852180481},{"id":"https://openalex.org/keywords/mechanical-ventilation","display_name":"mechanical ventilation","score":0.421999990940094},{"id":"https://openalex.org/keywords/kidney-failure","display_name":"renal failure","score":0.5220000147819519},{"id":"https://openalex.org/keywords/phase-iii-trial-design","display_name":"phase III trial design","score":0.47099998593330383}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9616827964782715},{"id":"https://openalex.org/C2778198053","wikidata":"https://www.wikidata.org/wiki/Q181754","display_name":"Heart failure","level":2,"score":0.7852033972740173},{"id":"https://openalex.org/C2778375690","wikidata":"https://www.wikidata.org/wiki/Q7814214","display_name":"Tolerability","level":3,"score":0.6951183676719666},{"id":"https://openalex.org/C203092338","wikidata":"https://www.wikidata.org/wiki/Q1340863","display_name":"Clinical endpoint","level":3,"score":0.6608917713165283},{"id":"https://openalex.org/C168563851","wikidata":"https://www.wikidata.org/wiki/Q1436668","display_name":"Randomized controlled trial","level":2,"score":0.5824353694915771},{"id":"https://openalex.org/C2779295919","wikidata":"https://www.wikidata.org/wiki/Q4677930","display_name":"Acute decompensated heart failure","level":3,"score":0.4958213269710541},{"id":"https://openalex.org/C177713679","wikidata":"https://www.wikidata.org/wiki/Q679690","display_name":"Intensive care medicine","level":1,"score":0.4837527275085449},{"id":"https://openalex.org/C535046627","wikidata":"https://www.wikidata.org/wiki/Q30612","display_name":"Clinical trial","level":2,"score":0.4784805178642273},{"id":"https://openalex.org/C84393581","wikidata":"https://www.wikidata.org/wiki/Q82642","display_name":"Blood pressure","level":2,"score":0.4761604964733124},{"id":"https://openalex.org/C27081682","wikidata":"https://www.wikidata.org/wiki/Q269829","display_name":"Placebo","level":3,"score":0.45818012952804565},{"id":"https://openalex.org/C2776890885","wikidata":"https://www.wikidata.org/wiki/Q1067560","display_name":"Vital signs","level":2,"score":0.44612330198287964},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.3735865652561188},{"id":"https://openalex.org/C197934379","wikidata":"https://www.wikidata.org/wiki/Q2047938","display_name":"Adverse effect","level":2,"score":0.2911359667778015},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.1810324788093567},{"id":"https://openalex.org/C204787440","wikidata":"https://www.wikidata.org/wiki/Q188504","display_name":"Alternative medicine","level":2,"score":0.0},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000208","descriptor_name":"Acute Disease","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001208","descriptor_name":"Asia","qualifier_ui":"Q000453","qualifier_name":"epidemiology","is_major_topic":false},{"descriptor_ui":"D002317","descriptor_name":"Cardiovascular Agents","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D002423","descriptor_name":"Cause of Death","qualifier_ui":"Q000639","qualifier_name":"trends","is_major_topic":false},{"descriptor_ui":"D004305","descriptor_name":"Dose-Response Relationship, Drug","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004311","descriptor_name":"Double-Blind Method","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004359","descriptor_name":"Drug Therapy, Combination","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004361","descriptor_name":"Drug Tolerance","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006333","descriptor_name":"Heart Failure","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D006333","descriptor_name":"Heart Failure","qualifier_ui":"Q000453","qualifier_name":"epidemiology","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007262","descriptor_name":"Infusions, Intravenous","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011994","descriptor_name":"Recombinant Proteins","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D012065","descriptor_name":"Relaxin","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D015994","descriptor_name":"Incidence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015996","descriptor_name":"Survival Rate","qualifier_ui":"Q000639","qualifier_name":"trends","is_major_topic":false},{"descriptor_ui":"D016896","descriptor_name":"Treatment Outcome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1016/j.cardfail.2016.10.016","doi":"https://doi.org/10.1016/j.cardfail.2016.10.016","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.cardfail.2016.10.016","pdf_url":null,"source":{"id":"https://openalex.org/S67869649","display_name":"Journal of Cardiac Failure","issn_l":"1071-9164","issn":["1071-9164","1532-8414"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Cardiac Failure","raw_type":"journal-article"},{"id":"pmid:27825893","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/27825893","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of cardiac failure","raw_type":"Clinical Trial, Phase III"}],"best_oa_location":{"id":"doi:10.1016/j.cardfail.2016.10.016","doi":"https://doi.org/10.1016/j.cardfail.2016.10.016","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.cardfail.2016.10.016","pdf_url":null,"source":{"id":"https://openalex.org/S67869649","display_name":"Journal of Cardiac Failure","issn_l":"1071-9164","issn":["1071-9164","1532-8414"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Cardiac Failure","raw_type":"journal-article"},"sustainable_development_goals":[{"score":1.0,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"sustainable_development_goals_aurora":[{"score":0.8399999737739563,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/study-protocol","display_name":"Study Protocol"}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":47,"referenced_works":["https://openalex.org/W59066530","https://openalex.org/W178637483","https://openalex.org/W595989430","https://openalex.org/W1573768413","https://openalex.org/W1673222108","https://openalex.org/W1914379759","https://openalex.org/W1972388303","https://openalex.org/W1998846386","https://openalex.org/W2005042184","https://openalex.org/W2043596199","https://openalex.org/W2045962981","https://openalex.org/W2048936478","https://openalex.org/W2052166908","https://openalex.org/W2052953200","https://openalex.org/W2054965274","https://openalex.org/W2069722675","https://openalex.org/W2070841254","https://openalex.org/W2072345235","https://openalex.org/W2073742622","https://openalex.org/W2084419627","https://openalex.org/W2094825299","https://openalex.org/W2105095326","https://openalex.org/W2119340816","https://openalex.org/W2123336269","https://openalex.org/W2126557110","https://openalex.org/W2128616793","https://openalex.org/W2129176676","https://openalex.org/W2136332000","https://openalex.org/W2145732657","https://openalex.org/W2148910374","https://openalex.org/W2152189242","https://openalex.org/W2156076674","https://openalex.org/W2160489474","https://openalex.org/W2165668878","https://openalex.org/W2168017932","https://openalex.org/W2168576251","https://openalex.org/W2169560588","https://openalex.org/W2181350280","https://openalex.org/W2233304763","https://openalex.org/W2261222936","https://openalex.org/W2289284238","https://openalex.org/W2335312575","https://openalex.org/W2399100387","https://openalex.org/W2408948170","https://openalex.org/W2427094903","https://openalex.org/W3141887505","https://openalex.org/W6708114788"],"related_works":["https://openalex.org/W2902583368","https://openalex.org/W2609921509","https://openalex.org/W2160489474","https://openalex.org/W2136728517","https://openalex.org/W2513263127","https://openalex.org/W2907911327","https://openalex.org/W1971004259","https://openalex.org/W2105342327","https://openalex.org/W2069790052","https://openalex.org/W2340335125"],"abstract_inverted_index":{"BACKGROUND:":[0],"Acute":[1],"heart":[2,115],"failure":[3,107,116],"(AHF),":[4],"a":[5,42,176,187],"common":[6],"and":[7,20,59,97,138,154,156,182],"growing":[8],"health":[9],"concern":[10],"worldwide,":[11],"is":[12],"associated":[13],"with":[14,66],"high":[15],"risk":[16],"of":[17,28,54,69,100,110,114,120,189],"post-discharge":[18],"rehospitalization":[19,129],"mortality.":[21],"Existing":[22],"evidence":[23],"indicates":[24],"potential":[25,184],"therapeutic":[26],"benefits":[27],"serelaxin":[29,55,75],"in":[30,37,62,78,94,169],"Caucasian":[31],"AHF":[32,64,171,190],"patients,":[33,65],"but":[34],"corresponding":[35],"data":[36],"Asians":[38],"remain":[39],"scarce.":[40],"RELAX-AHF-ASIA,":[41,163],"multinational,":[43],"randomized,":[44],"double-blind,":[45],"placebo-controlled,":[46],"phase":[47],"III":[48],"trial,":[49],"will":[50],"evaluate":[51],"the":[52,67,164,183],"effects":[53],"on":[56,102],"symptom":[57],"relief":[58],"clinical":[60,167],"outcomes":[61],"Asian":[63,170],"use":[68],"novel":[70,177],"assessments.":[71],"METHODS":[72],"AND":[73],"RESULTS:":[74],"or":[76,124,133],"placebo":[77],"addition":[79],"to":[80,131,147,173,185],"standard":[81],"therapy.":[82],"The":[83],"composite":[84,178],"primary":[85,179],"end":[86,143,180],"point":[87,181],"includes:":[88],"(1)":[89],"treatment":[90,106],"success":[91],"(moderate/marked":[92],"improvement":[93],"patient-reported":[95],"dyspnea":[96],"physician-assessed":[98],"signs":[99,111],"congestion":[101],"day":[103,136,152,160],"2);":[104],"(2)":[105],"(in-hospital":[108],"worsening":[109,149],"and/or":[112],"symptoms":[113],"[HF]":[117],"requiring":[118],"intensification":[119],"intravenous":[121],"HF":[122,150],"therapy":[123],"mechanical":[125],"ventilation,":[126],"renal/circulatory":[127],"support,":[128],"due":[130],"HF/renal-failure,":[132],"death":[134],"through":[135,151,159],"5);":[137],"(3)":[139],"unchanged":[140],"status.":[141],"Secondary":[142],"points":[144],"include":[145],"time":[146],"in-hospital":[148],"5":[153],"all-cause":[155],"cardiovascular":[157],"deaths":[158],"180.":[161],"CONCLUSIONS:":[162],"largest":[165],"randomized":[166],"trial":[168],"patients":[172],"date,":[174],"has":[175],"become":[186],"hallmark":[188],"trials.":[191]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":5},{"year":2018,"cited_by_count":6},{"year":2017,"cited_by_count":4},{"year":2016,"cited_by_count":5},{"year":2015,"cited_by_count":3},{"year":2014,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-11-11T00:00:00"}
