{"id":"https://openalex.org/W2546924501","doi":"https://doi.org/10.1016/j.cardfail.2016.09.010","title":"The Targeting Acute Congestion with Tolvaptan in Congestive Heart Failure Study: A Randomized, Double blind, Placebo-Controlled Trial in Acute Heart Failure","display_name":"The Targeting Acute Congestion with Tolvaptan in Congestive Heart Failure Study: A Randomized, Double blind, Placebo-Controlled Trial in Acute Heart Failure","publication_year":2016,"publication_date":"2016-11-01","ids":{"openalex":"https://openalex.org/W2546924501","doi":"https://doi.org/10.1016/j.cardfail.2016.09.010","mag":"2546924501"},"language":"en","primary_location":{"id":"doi:10.1016/j.cardfail.2016.09.010","doi":"https://doi.org/10.1016/j.cardfail.2016.09.010","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.cardfail.2016.09.010","pdf_url":null,"source":{"id":"https://openalex.org/S67869649","display_name":"Journal of Cardiac Failure","issn_l":"1071-9164","issn":["1071-9164","1532-8414"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Cardiac Failure","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5068642565","display_name":"Robert John Mentz","orcid":"https://orcid.org/0000-0002-3222-1719","observed_orcids":["https://orcid.org/0000-0002-3222-1719"]},"institutions":[{"id":"https://openalex.org/I4210126298","display_name":"Duke Medical Center","ror":"https://ror.org/03njmea73","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210126298","https://openalex.org/I4210144876"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Robert J. Mentz","raw_affiliation_strings":["Duke University Medical Center"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Duke University Medical Center","institution_ids":["https://openalex.org/I4210126298"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5022076272","display_name":"Gary Michael Felker","orcid":"https://orcid.org/0000-0002-5931-1239","observed_orcids":["https://orcid.org/0000-0002-5931-1239"]},"institutions":[{"id":"https://openalex.org/I4210126298","display_name":"Duke Medical Center","ror":"https://ror.org/03njmea73","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210126298","https://openalex.org/I4210144876"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"G. Michael Felker","raw_affiliation_strings":["Duke University Medical Center"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Duke University Medical Center","institution_ids":["https://openalex.org/I4210126298"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111549304","display_name":"Robert M. Cole","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210126298","display_name":"Duke Medical Center","ror":"https://ror.org/03njmea73","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210126298","https://openalex.org/I4210144876"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Robert Cole","raw_affiliation_strings":["Duke University Medical Center"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Duke University Medical Center","institution_ids":["https://openalex.org/I4210126298"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5106668177","display_name":"Kirkwood F. Adams","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210126298","display_name":"Duke Medical Center","ror":"https://ror.org/03njmea73","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210126298","https://openalex.org/I4210144876"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kirkwood F. Adams","raw_affiliation_strings":["Duke University Medical Center"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Duke University Medical Center","institution_ids":["https://openalex.org/I4210126298"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5070155924","display_name":"Gregory F. Egnaczyk","orcid":"https://orcid.org/0000-0002-1909-2334","observed_orcids":["https://orcid.org/0000-0002-1909-2334"]},"institutions":[{"id":"https://openalex.org/I4210126298","display_name":"Duke Medical Center","ror":"https://ror.org/03njmea73","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210126298","https://openalex.org/I4210144876"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Gregory Egnaczyk","raw_affiliation_strings":["Duke University Medical Center"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Duke University Medical Center","institution_ids":["https://openalex.org/I4210126298"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5058444528","display_name":"Mona Fiuzat","orcid":"https://orcid.org/0000-0001-6863-5537","observed_orcids":["https://orcid.org/0000-0001-6863-5537"]},"institutions":[{"id":"https://openalex.org/I4210126298","display_name":"Duke Medical Center","ror":"https://ror.org/03njmea73","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210126298","https://openalex.org/I4210144876"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Mona Fiuzat","raw_affiliation_strings":["Duke University Medical Center"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Duke University Medical Center","institution_ids":["https://openalex.org/I4210126298"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102943316","display_name":"Chetan B. Patel","orcid":"https://orcid.org/0000-0002-3990-5689","observed_orcids":["https://orcid.org/0000-0002-3990-5689"]},"institutions":[{"id":"https://openalex.org/I4210126298","display_name":"Duke Medical Center","ror":"https://ror.org/03njmea73","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210126298","https://openalex.org/I4210144876"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Chetan B. Patel","raw_affiliation_strings":["Duke University Medical Center"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Duke University Medical Center","institution_ids":["https://openalex.org/I4210126298"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5046957208","display_name":"Melvin R. Echols","orcid":"https://orcid.org/0000-0001-6630-5761","observed_orcids":["https://orcid.org/0000-0001-6630-5761"]},"institutions":[{"id":"https://openalex.org/I4210126298","display_name":"Duke Medical Center","ror":"https://ror.org/03njmea73","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210126298","https://openalex.org/I4210144876"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Melvin Echols","raw_affiliation_strings":["Duke University Medical Center"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Duke University Medical Center","institution_ids":["https://openalex.org/I4210126298"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5036509904","display_name":"Michel Georges Khouri","orcid":"https://orcid.org/0009-0002-6235-5176","observed_orcids":["https://orcid.org/0009-0002-6235-5176"]},"institutions":[{"id":"https://openalex.org/I4210126298","display_name":"Duke Medical Center","ror":"https://ror.org/03njmea73","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210126298","https://openalex.org/I4210144876"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Michel Khouri","raw_affiliation_strings":["Duke University Medical Center"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Duke University Medical Center","institution_ids":["https://openalex.org/I4210126298"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5033898505","display_name":"James M. Tauras","orcid":"https://orcid.org/0000-0003-1192-392X","observed_orcids":["https://orcid.org/0000-0003-1192-392X"]},"institutions":[{"id":"https://openalex.org/I4210126298","display_name":"Duke Medical Center","ror":"https://ror.org/03njmea73","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210126298","https://openalex.org/I4210144876"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"James M. Tauras","raw_affiliation_strings":["Duke University Medical Center"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Duke University Medical Center","institution_ids":["https://openalex.org/I4210126298"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101684826","display_name":"Divya Myadam Gupta","orcid":"https://orcid.org/0009-0005-5173-3989","observed_orcids":["https://orcid.org/0009-0005-5173-3989"]},"institutions":[{"id":"https://openalex.org/I4210126298","display_name":"Duke Medical Center","ror":"https://ror.org/03njmea73","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210126298","https://openalex.org/I4210144876"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Divya Gupta","raw_affiliation_strings":["Duke University Medical Center"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Duke University Medical Center","institution_ids":["https://openalex.org/I4210126298"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5041547416","display_name":"Pamela Monds","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210126298","display_name":"Duke Medical Center","ror":"https://ror.org/03njmea73","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210126298","https://openalex.org/I4210144876"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Pamela Monds","raw_affiliation_strings":["Duke University Medical Center"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Duke University Medical Center","institution_ids":["https://openalex.org/I4210126298"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5011361266","display_name":"Rhonda Roberts","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210126298","display_name":"Duke Medical Center","ror":"https://ror.org/03njmea73","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210126298","https://openalex.org/I4210144876"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Rhonda Roberts","raw_affiliation_strings":["Duke University Medical Center"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Duke University Medical Center","institution_ids":["https://openalex.org/I4210126298"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5111584665","display_name":"Christopher M. O\u2019Connor","orcid":"https://orcid.org/0000-0002-1076-718X","observed_orcids":["https://orcid.org/0000-0002-1076-718X"]},"institutions":[{"id":"https://openalex.org/I4210126298","display_name":"Duke Medical Center","ror":"https://ror.org/03njmea73","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210126298","https://openalex.org/I4210144876"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Christopher M. O'Connor","raw_affiliation_strings":["Duke University Medical Center"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Duke University Medical Center","institution_ids":["https://openalex.org/I4210126298"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I4210126298"],"apc_list":{"value":3970,"currency":"USD","value_usd":3970},"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.17409537,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"22","issue":"11","first_page":"939","last_page":"939"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10198","display_name":"Heart Failure Treatment and Management","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10198","display_name":"Heart Failure Treatment and Management","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11967","display_name":"Electrolyte and hormonal disorders","score":0.0013000000035390258,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10821","display_name":"Cardiovascular Function and Risk Factors","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/tolvaptan","display_name":"tolvaptan","score":0.9909999966621399},{"id":"https://openalex.org/keywords/acute-heart-failure","display_name":"acute heart failure","score":0.9139999747276306},{"id":"https://openalex.org/keywords/congestion","display_name":"congestion","score":0.6470000147819519},{"id":"https://openalex.org/keywords/fluid-overload","display_name":"fluid overload","score":0.7509999871253967},{"id":"https://openalex.org/keywords/dyspnea-relief","display_name":"dyspnea relief","score":0.7960000038146973},{"id":"https://openalex.org/keywords/aquaresis","display_name":"aquaresis","score":0.7649999856948853},{"id":"https://openalex.org/keywords/furosemide","display_name":"furosemide","score":0.8209999799728394},{"id":"https://openalex.org/keywords/renal-function","display_name":"renal function","score":0.7699999809265137},{"id":"https://openalex.org/keywords/fluid-loss","display_name":"fluid loss","score":0.4169999957084656},{"id":"https://openalex.org/keywords/weight-loss","display_name":"weight loss","score":0.5989999771118164},{"id":"https://openalex.org/keywords/salvage-therapy","display_name":"salvage therapy","score":0.6740000247955322},{"id":"https://openalex.org/keywords/ejection-fraction","display_name":"ejection fraction","score":0.5759999752044678},{"id":"https://openalex.org/keywords/diuretic-therapy","display_name":"diuretic therapy","score":0.4580000042915344}],"concepts":[{"id":"https://openalex.org/C2780615674","wikidata":"https://www.wikidata.org/wiki/Q426132","display_name":"Tolvaptan","level":3,"score":0.97203528881073},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9374765753746033},{"id":"https://openalex.org/C2778198053","wikidata":"https://www.wikidata.org/wiki/Q181754","display_name":"Heart failure","level":2,"score":0.8164666891098022},{"id":"https://openalex.org/C27081682","wikidata":"https://www.wikidata.org/wiki/Q269829","display_name":"Placebo","level":3,"score":0.671919584274292},{"id":"https://openalex.org/C78085059","wikidata":"https://www.wikidata.org/wiki/Q641303","display_name":"Ejection fraction","level":3,"score":0.6277446746826172},{"id":"https://openalex.org/C203092338","wikidata":"https://www.wikidata.org/wiki/Q1340863","display_name":"Clinical endpoint","level":3,"score":0.6206372976303101},{"id":"https://openalex.org/C168563851","wikidata":"https://www.wikidata.org/wiki/Q1436668","display_name":"Randomized controlled trial","level":2,"score":0.5356615781784058},{"id":"https://openalex.org/C2777955127","wikidata":"https://www.wikidata.org/wiki/Q388801","display_name":"Furosemide","level":2,"score":0.49395567178726196},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.48445653915405273},{"id":"https://openalex.org/C2781413609","wikidata":"https://www.wikidata.org/wiki/Q7308373","display_name":"Regimen","level":2,"score":0.4271330237388611},{"id":"https://openalex.org/C164705383","wikidata":"https://www.wikidata.org/wiki/Q10379","display_name":"Cardiology","level":1,"score":0.3804932236671448},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.0},{"id":"https://openalex.org/C204787440","wikidata":"https://www.wikidata.org/wiki/Q188504","display_name":"Alternative medicine","level":2,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1016/j.cardfail.2016.09.010","doi":"https://doi.org/10.1016/j.cardfail.2016.09.010","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.cardfail.2016.09.010","pdf_url":null,"source":{"id":"https://openalex.org/S67869649","display_name":"Journal of Cardiac Failure","issn_l":"1071-9164","issn":["1071-9164","1532-8414"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Cardiac Failure","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":1.0}],"study_designs":[{"id":"https://openalex.org/study-designs/randomized-controlled-trial","display_name":"Randomized Controlled Trial"},{"id":"https://openalex.org/study-designs/clinical-trial","display_name":"Clinical Trial"}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2519829957","https://openalex.org/W2257307533","https://openalex.org/W4245783928","https://openalex.org/W2210219061","https://openalex.org/W4310456553","https://openalex.org/W2342189688","https://openalex.org/W2596201728","https://openalex.org/W2580154307","https://openalex.org/W4386338729","https://openalex.org/W2141703599"],"abstract_inverted_index":null,"counts_by_year":[],"updated_date":"2026-09-27T08:07:27.782135","created_date":"2016-11-11T00:00:00"}