{"id":"https://openalex.org/W2546901302","doi":"https://doi.org/10.1002/adhm.201600684","title":"Culture on 3D Chitosan\u2010Hyaluronic Acid Scaffolds Enhances Stem Cell Marker Expression and Drug Resistance in Human Glioblastoma Cancer Stem Cells","display_name":"Culture on 3D Chitosan\u2010Hyaluronic Acid Scaffolds Enhances Stem Cell Marker Expression and Drug Resistance in Human Glioblastoma Cancer Stem Cells","publication_year":2016,"publication_date":"2016-11-02","ids":{"openalex":"https://openalex.org/W2546901302","doi":"https://doi.org/10.1002/adhm.201600684","mag":"2546901302","pmid":"https://pubmed.ncbi.nlm.nih.gov/27805789","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/5253135"},"language":"en","primary_location":{"id":"doi:10.1002/adhm.201600684","doi":"https://doi.org/10.1002/adhm.201600684","is_oa":false,"landing_page_url":"https://doi.org/10.1002/adhm.201600684","pdf_url":null,"source":{"id":"https://openalex.org/S2500736452","display_name":"Advanced Healthcare Materials","issn_l":"2192-2640","issn":["2192-2640","2192-2659"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","jufo-2","ki-jl-1","medline","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Advanced Healthcare Materials","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/5253135","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5100342676","display_name":"Kui Wang","orcid":"https://orcid.org/0000-0001-9984-3769","observed_orcids":["https://orcid.org/0000-0001-9984-3769"]},"institutions":[{"id":"https://openalex.org/I201448701","display_name":"University of Washington","ror":"https://ror.org/00cvxb145","country_code":"US","type":"education","lineage":["https://openalex.org/I201448701"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kui Wang","raw_affiliation_strings":["Department of Materials Science and Engineering, University of Washington, Seattle, WA, 98195 USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Materials Science and Engineering, University of Washington, Seattle, WA, 98195 USA","institution_ids":["https://openalex.org/I201448701"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5061782765","display_name":"Forrest M. Kievit","orcid":"https://orcid.org/0000-0002-9847-783X","observed_orcids":["https://orcid.org/0000-0002-9847-783X"]},"institutions":[{"id":"https://openalex.org/I201448701","display_name":"University of Washington","ror":"https://ror.org/00cvxb145","country_code":"US","type":"education","lineage":["https://openalex.org/I201448701"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Forrest M. Kievit","raw_affiliation_strings":["Department of Neurological Surgery, University of Washington, Seattle, WA, 98195 USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurological Surgery, University of Washington, Seattle, WA, 98195 USA","institution_ids":["https://openalex.org/I201448701"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5055927534","display_name":"Ariane E. Erickson","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I201448701","display_name":"University of Washington","ror":"https://ror.org/00cvxb145","country_code":"US","type":"education","lineage":["https://openalex.org/I201448701"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ariane E. Erickson","raw_affiliation_strings":["Department of Materials Science and Engineering, University of Washington, Seattle, WA, 98195 USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Materials Science and Engineering, University of Washington, Seattle, WA, 98195 USA","institution_ids":["https://openalex.org/I201448701"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5019976882","display_name":"John R. Silber","orcid":"https://orcid.org/0000-0001-9828-7190","observed_orcids":["https://orcid.org/0000-0001-9828-7190"]},"institutions":[{"id":"https://openalex.org/I201448701","display_name":"University of Washington","ror":"https://ror.org/00cvxb145","country_code":"US","type":"education","lineage":["https://openalex.org/I201448701"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"John R. Silber","raw_affiliation_strings":["Department of Neurological Surgery, University of Washington, Seattle, WA, 98195 USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurological Surgery, University of Washington, Seattle, WA, 98195 USA","institution_ids":["https://openalex.org/I201448701"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5011504343","display_name":"Richard G. Ellenbogen","orcid":"https://orcid.org/0000-0002-3463-1009","observed_orcids":["https://orcid.org/0000-0002-3463-1009"]},"institutions":[{"id":"https://openalex.org/I201448701","display_name":"University of Washington","ror":"https://ror.org/00cvxb145","country_code":"US","type":"education","lineage":["https://openalex.org/I201448701"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Richard G. Ellenbogen","raw_affiliation_strings":["Department of Neurological Surgery, University of Washington, Seattle, WA, 98195 USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurological Surgery, University of Washington, Seattle, WA, 98195 USA","institution_ids":["https://openalex.org/I201448701"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5082164835","display_name":"Miqin Zhang","orcid":"https://orcid.org/0000-0001-8974-1494","observed_orcids":["https://orcid.org/0000-0001-8974-1494"]},"institutions":[{"id":"https://openalex.org/I201448701","display_name":"University of Washington","ror":"https://ror.org/00cvxb145","country_code":"US","type":"education","lineage":["https://openalex.org/I201448701"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Miqin Zhang","raw_affiliation_strings":["Department of Materials Science and Engineering, University of Washington, Seattle, WA, 98195 USA","Department of Neurological Surgery, University of Washington, Seattle, WA, 98195 USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Materials Science and Engineering, University of Washington, Seattle, WA, 98195 USA","institution_ids":["https://openalex.org/I201448701"]},{"raw_affiliation_string":"Department of Neurological Surgery, University of Washington, Seattle, WA, 98195 USA","institution_ids":["https://openalex.org/I201448701"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5082164835"],"corresponding_institution_ids":["https://openalex.org/I201448701"],"apc_list":{"value":4880,"currency":"USD","value_usd":4880},"apc_paid":null,"fwci":5.5562,"has_fulltext":false,"cited_by_count":78,"citation_normalized_percentile":{"value":0.96261445,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":94,"max":100},"biblio":{"volume":"5","issue":"24","first_page":"3173","last_page":"3181"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10129","display_name":"Glioma Diagnosis and Treatment","score":0.7416999936103821,"subfield":{"id":"https://openalex.org/subfields/2716","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10129","display_name":"Glioma Diagnosis and Treatment","score":0.7416999936103821,"subfield":{"id":"https://openalex.org/subfields/2716","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10336","display_name":"Cancer Cells and Metastasis","score":0.08049999922513962,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10343","display_name":"Hydrogels: synthesis, properties, applications","score":0.05220000073313713,"subfield":{"id":"https://openalex.org/subfields/1313","display_name":"Molecular Medicine"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/glioblastoma","display_name":"glioblastoma","score":0.9390000104904175},{"id":"https://openalex.org/keywords/cancer-stem-cells","display_name":"cancer stem cells","score":0.8479999899864197},{"id":"https://openalex.org/keywords/3d-porous-scaffolds","display_name":"3D porous scaffolds","score":0.8920000195503235},{"id":"https://openalex.org/keywords/patient-derived-xenografts","display_name":"patient-derived xenografts","score":0.7889999747276306},{"id":"https://openalex.org/keywords/epithelial-mesenchymal-transition","display_name":"epithelial-mesenchymal transition","score":0.9160000085830688},{"id":"https://openalex.org/keywords/hypoxia-tolerance","display_name":"hypoxia tolerance","score":0.8220000267028809},{"id":"https://openalex.org/keywords/oxidative-stress","display_name":"oxidative stress","score":0.8270000219345093},{"id":"https://openalex.org/keywords/alkylating-agent-resistance","display_name":"alkylating agent resistance","score":0.9259999990463257},{"id":"https://openalex.org/keywords/stem-cell-marker-expression","display_name":"stem cell marker expression","score":0.828000009059906},{"id":"https://openalex.org/keywords/3d-cell-culture","display_name":"3D cell culture","score":0.6370000243186951}],"concepts":[{"id":"https://openalex.org/C2777529286","wikidata":"https://www.wikidata.org/wiki/Q337231","display_name":"Hyaluronic acid","level":2,"score":0.678428053855896},{"id":"https://openalex.org/C28328180","wikidata":"https://www.wikidata.org/wiki/Q48196","display_name":"Stem cell","level":2,"score":0.6437600255012512},{"id":"https://openalex.org/C198826908","wikidata":"https://www.wikidata.org/wiki/Q1922379","display_name":"Mesenchymal stem cell","level":2,"score":0.6431598663330078},{"id":"https://openalex.org/C55427017","wikidata":"https://www.wikidata.org/wiki/Q1638475","display_name":"Cancer stem cell","level":3,"score":0.6365002989768982},{"id":"https://openalex.org/C207001950","wikidata":"https://www.wikidata.org/wiki/Q141124","display_name":"In vivo","level":2,"score":0.6133975982666016},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.5110939145088196},{"id":"https://openalex.org/C89429830","wikidata":"https://www.wikidata.org/wiki/Q735710","display_name":"Scaffold","level":2,"score":0.479657918214798},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.4757632613182068},{"id":"https://openalex.org/C81885089","wikidata":"https://www.wikidata.org/wiki/Q189082","display_name":"Cell culture","level":2,"score":0.4688884913921356},{"id":"https://openalex.org/C96232424","wikidata":"https://www.wikidata.org/wiki/Q4118072","display_name":"Cancer cell","level":3,"score":0.460440993309021},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.4215664863586426},{"id":"https://openalex.org/C62112901","wikidata":"https://www.wikidata.org/wiki/Q189159","display_name":"Cell growth","level":2,"score":0.418398916721344},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3218744993209839},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.29793912172317505},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.2787604331970215},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.21081772446632385},{"id":"https://openalex.org/C136229726","wikidata":"https://www.wikidata.org/wiki/Q327092","display_name":"Biomedical engineering","level":1,"score":0.19977867603302002},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.11194023489952087},{"id":"https://openalex.org/C105702510","wikidata":"https://www.wikidata.org/wiki/Q514","display_name":"Anatomy","level":1,"score":0.0638459324836731},{"id":"https://openalex.org/C150903083","wikidata":"https://www.wikidata.org/wiki/Q7108","display_name":"Biotechnology","level":1,"score":0.06379497051239014},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D005909","descriptor_name":"Glioblastoma","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D005909","descriptor_name":"Glioblastoma","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006820","descriptor_name":"Hyaluronic Acid","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D006820","descriptor_name":"Hyaluronic Acid","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D010641","descriptor_name":"Phenotype","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014408","descriptor_name":"Biomarkers, Tumor","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D014411","descriptor_name":"Neoplastic Stem Cells","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D018929","descriptor_name":"Cell Culture Techniques","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D019008","descriptor_name":"Drug Resistance, Neoplasm","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D045744","descriptor_name":"Cell Line, Tumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D048271","descriptor_name":"Chitosan","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D048271","descriptor_name":"Chitosan","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D049109","descriptor_name":"Cell Proliferation","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D054457","descriptor_name":"Tissue Scaffolds","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D058750","descriptor_name":"Epithelial-Mesenchymal Transition","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D058750","descriptor_name":"Epithelial-Mesenchymal Transition","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1002/adhm.201600684","doi":"https://doi.org/10.1002/adhm.201600684","is_oa":false,"landing_page_url":"https://doi.org/10.1002/adhm.201600684","pdf_url":null,"source":{"id":"https://openalex.org/S2500736452","display_name":"Advanced Healthcare Materials","issn_l":"2192-2640","issn":["2192-2640","2192-2659"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","jufo-2","ki-jl-1","medline","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Advanced Healthcare Materials","raw_type":"journal-article"},{"id":"pmid:27805789","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/27805789","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Advanced healthcare materials","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:5253135","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/5253135","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Adv Healthc Mater","raw_type":"Text"}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:5253135","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/5253135","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Adv Healthc Mater","raw_type":"Text"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9391000270843506}],"study_designs":[],"awards":[{"id":"https://openalex.org/G3790572547","display_name":"New 3D tumor models to rapidly test drugs for brain cancer therapy","funder_award_id":"R01CA172455","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":53,"referenced_works":["https://openalex.org/W1544655463","https://openalex.org/W1545028983","https://openalex.org/W1560352621","https://openalex.org/W1577577364","https://openalex.org/W1902577542","https://openalex.org/W1964544761","https://openalex.org/W1964633780","https://openalex.org/W1976767579","https://openalex.org/W1981421409","https://openalex.org/W1985772559","https://openalex.org/W1987087659","https://openalex.org/W1990899278","https://openalex.org/W1997558986","https://openalex.org/W2013455696","https://openalex.org/W2018282169","https://openalex.org/W2018671779","https://openalex.org/W2019318549","https://openalex.org/W2021275669","https://openalex.org/W2029961990","https://openalex.org/W2035091931","https://openalex.org/W2047710431","https://openalex.org/W2056627178","https://openalex.org/W2056772956","https://openalex.org/W2060431203","https://openalex.org/W2086514756","https://openalex.org/W2094144162","https://openalex.org/W2097730243","https://openalex.org/W2109483601","https://openalex.org/W2113897909","https://openalex.org/W2119280418","https://openalex.org/W2123369892","https://openalex.org/W2126569401","https://openalex.org/W2132264180","https://openalex.org/W2134153240","https://openalex.org/W2134807618","https://openalex.org/W2147129352","https://openalex.org/W2154515817","https://openalex.org/W2168677667","https://openalex.org/W2168805837","https://openalex.org/W2204088283","https://openalex.org/W2219741073","https://openalex.org/W2224717864","https://openalex.org/W2236918265","https://openalex.org/W2238984538","https://openalex.org/W2251643549","https://openalex.org/W2295455218","https://openalex.org/W2331628193","https://openalex.org/W2344746583","https://openalex.org/W2345945788","https://openalex.org/W2417156317","https://openalex.org/W2419457711","https://openalex.org/W2432929366","https://openalex.org/W2507651434"],"related_works":["https://openalex.org/W1964633780","https://openalex.org/W2329381059","https://openalex.org/W2097730243","https://openalex.org/W2791466871","https://openalex.org/W2219741073","https://openalex.org/W2808629228","https://openalex.org/W2925746312","https://openalex.org/W2791205827","https://openalex.org/W2121684910","https://openalex.org/W2982899848"],"abstract_inverted_index":{"The":[0],"lack":[1],"of":[2,10,32,60,71,78,103,112,117,129,142,150],"in":[3,36,185],"vitro":[4],"models":[5,31],"that":[6,16,131,152,179],"support":[7],"the":[8,72,79],"growth":[9],"glioblastoma":[11],"(GBM)":[12],"stem":[13,74],"cells":[14,108,145,162],"(GSCs)":[15],"underlie":[17],"clinical":[18,189],"aggressiveness":[19],"hinders":[20],"developing":[21,195],"new,":[22],"effective":[23],"therapies":[24],"for":[25,194],"GBM.":[26],"While":[27,96],"orthotopic":[28],"patient-derived":[29],"xenograft":[30],"GBM":[33],"best":[34],"reflect":[35],"vivo":[37,186],"tumor":[38],"behavior,":[39],"establishing":[40],"xenografts":[41],"is":[42,66,94,124],"a":[43,55,137],"time":[44],"consuming,":[45],"costly,":[46],"and":[47,62,69,135,188,191],"frequently":[48],"unsuccessful":[49],"endeavor.":[50],"To":[51],"address":[52],"these":[53],"limitations,":[54],"3D":[56],"porous":[57],"scaffold":[58],"composed":[59],"chitosan":[61],"hyaluronic":[63],"acid":[64],"(CHA)":[65],"synthesized.":[67],"Growth":[68,121],"expression":[70,128,149],"cancer":[73],"cell":[75],"(CSC)":[76],"phenotype":[77],"GSC":[80],"GBM6":[81,107],"taken":[82],"directly":[83],"from":[84],"fresh":[85],"xenogratfs":[86],"grown":[87],"on":[88,122],"scaffolds":[89,114,123,182],"or":[90],"as":[91,101,115],"adherent":[92,98,174],"monolayers":[93,102],"compared.":[95],"2D":[97],"cultures":[99],"grow":[100],"flat":[104],"epitheliod":[105],"cells,":[106],"proliferate":[109],"within":[110],"pores":[111],"CHA":[113,181],"clusters":[116],"self-adherent":[118],"ovoid":[119],"cells.":[120,175],"accompanied":[125],"by":[126],"greater":[127,165],"genes":[130,151],"mediate":[132],"epithelial-mesenchymal":[133],"transition":[134],"maintain":[136],"primitive,":[138],"undifferentiated":[139],"phenotype,":[140],"hallmarks":[141],"CSCs.":[143],"Scaffold-grown":[144],"also":[146],"display":[147],"higher":[148],"promote":[153],"resistance":[154,166],"to":[155,167,173],"hypoxia-induced":[156],"oxidative":[157],"stress.":[158],"In":[159],"accord,":[160],"scaffold-grown":[161],"show":[163],"markedly":[164],"clinically":[168],"utilized":[169],"alkylating":[170],"agents":[171],"compared":[172],"These":[176],"findings":[177],"suggest":[178],"our":[180],"better":[183],"mimic":[184],"biological":[187],"behavior":[190],"provide":[192],"insights":[193],"novel":[196],"individualized":[197],"treatments.":[198]},"counts_by_year":[{"year":2026,"cited_by_count":3},{"year":2025,"cited_by_count":5},{"year":2024,"cited_by_count":5},{"year":2023,"cited_by_count":11},{"year":2022,"cited_by_count":10},{"year":2021,"cited_by_count":11},{"year":2020,"cited_by_count":10},{"year":2019,"cited_by_count":7},{"year":2018,"cited_by_count":14},{"year":2017,"cited_by_count":2}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-11-11T00:00:00"}
