{"id":"https://openalex.org/W25467197","doi":null,"title":"\u00c9tude du zinc et des ATPases de type P dans l'interaction entre Mycobacterium tuberculosis et les cellules h\u00f4tes","display_name":"\u00c9tude du zinc et des ATPases de type P dans l'interaction entre Mycobacterium tuberculosis et les cellules h\u00f4tes","publication_year":2011,"publication_date":"2011-01-01","ids":{"openalex":"https://openalex.org/W25467197","mag":"25467197"},"language":"fr","primary_location":{"id":"pmh:oai:thesesups.ups-tlse.fr:1386","doi":null,"is_oa":true,"landing_page_url":"http://thesesups.ups-tlse.fr/1386/1/2011TOU30172.pdf","pdf_url":"http://thesesups.ups-tlse.fr/1386/1/2011TOU30172.pdf","source":{"id":"https://openalex.org/S4306400942","display_name":"Th\u00e8ses en ligne de l'Universit\u00e9 Toulouse III (Universit\u00e9 Toulouse III)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I134560555","host_organization_name":"Universit\u00e9 Toulouse III - Paul Sabatier","host_organization_lineage":["https://openalex.org/I134560555"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"","raw_type":"PhD Thesis"},"volume":null,"type":"dissertation","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"http://thesesups.ups-tlse.fr/1386/1/2011TOU30172.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5052922096","display_name":"H\u00e9l\u00e8ne Botella","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"H\u00e9l\u00e8ne Botella","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5052922096"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10038","display_name":"Tuberculosis Research and Epidemiology","score":0.9926999807357788,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10038","display_name":"Tuberculosis Research and Epidemiology","score":0.9926999807357788,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10120","display_name":"Bacterial Genetics and Biotechnology","score":0.0008999999845400453,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10915","display_name":"Trace Elements in Health","score":0.000699999975040555,"subfield":{"id":"https://openalex.org/subfields/2916","display_name":"Nutrition and Dietetics"},"field":{"id":"https://openalex.org/fields/29","display_name":"Nursing"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/mycobacterium-tuberculosis","display_name":"Mycobacterium tuberculosis","score":1.0},{"id":"https://openalex.org/keywords/zinc","display_name":"zinc","score":0.4970000088214874},{"id":"https://openalex.org/keywords/p-type-atpase","display_name":"P-type ATPase","score":0.9340000152587891},{"id":"https://openalex.org/keywords/znta","display_name":"ZntA","score":0.9259999990463257},{"id":"https://openalex.org/keywords/phagosome","display_name":"phagosome","score":0.796999990940094},{"id":"https://openalex.org/keywords/macrophages","display_name":"macrophages","score":0.906000018119812},{"id":"https://openalex.org/keywords/dendritic-cells","display_name":"dendritic cells","score":0.9879999756813049},{"id":"https://openalex.org/keywords/host-pathogen-interaction","display_name":"host-pathogen interaction","score":0.7850000262260437},{"id":"https://openalex.org/keywords/zinc-efflux","display_name":"zinc efflux","score":0.7020000219345093},{"id":"https://openalex.org/keywords/metal-transporters","display_name":"metal transporters","score":0.5669999718666077},{"id":"https://openalex.org/keywords/innate-immunity","display_name":"innate immunity","score":0.8420000076293945},{"id":"https://openalex.org/keywords/antimicrobial-immunity","display_name":"antimicrobial immunity","score":0.6620000004768372},{"id":"https://openalex.org/keywords/zinc-homeostasis","display_name":"zinc homeostasis","score":0.703000009059906}],"concepts":[{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.7777847051620483},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.477062851190567},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.47582486271858215},{"id":"https://openalex.org/C2777975735","wikidata":"https://www.wikidata.org/wiki/Q130971","display_name":"Mycobacterium tuberculosis","level":3,"score":0.4704165756702423},{"id":"https://openalex.org/C2781069245","wikidata":"https://www.wikidata.org/wiki/Q12204","display_name":"Tuberculosis","level":2,"score":0.13599413633346558},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.0},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.0}],"mesh":[],"locations_count":3,"locations":[{"id":"pmh:oai:thesesups.ups-tlse.fr:1386","doi":null,"is_oa":true,"landing_page_url":"http://thesesups.ups-tlse.fr/1386/1/2011TOU30172.pdf","pdf_url":"http://thesesups.ups-tlse.fr/1386/1/2011TOU30172.pdf","source":{"id":"https://openalex.org/S4306400942","display_name":"Th\u00e8ses en ligne de l'Universit\u00e9 Toulouse III (Universit\u00e9 Toulouse III)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I134560555","host_organization_name":"Universit\u00e9 Toulouse III - Paul Sabatier","host_organization_lineage":["https://openalex.org/I134560555"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"","raw_type":"PhD Thesis"},{"id":"pmh:hdl:10068/874130","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/10068/874130","pdf_url":null,"source":{"id":"https://openalex.org/S4377196900","display_name":"OpenGrey (Institut de l'Information Scientifique et Technique)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1295345811","host_organization_name":"Institut de l'Information Scientifique et Technique","host_organization_lineage":["https://openalex.org/I1295345811"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"U - Thesis"},{"id":"mag:25467197","doi":null,"is_oa":false,"landing_page_url":"http://thesesups.ups-tlse.fr/1386/","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":{"id":"pmh:oai:thesesups.ups-tlse.fr:1386","doi":null,"is_oa":true,"landing_page_url":"http://thesesups.ups-tlse.fr/1386/1/2011TOU30172.pdf","pdf_url":"http://thesesups.ups-tlse.fr/1386/1/2011TOU30172.pdf","source":{"id":"https://openalex.org/S4306400942","display_name":"Th\u00e8ses en ligne de l'Universit\u00e9 Toulouse III (Universit\u00e9 Toulouse III)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I134560555","host_organization_name":"Universit\u00e9 Toulouse III - Paul Sabatier","host_organization_lineage":["https://openalex.org/I134560555"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"","raw_type":"PhD Thesis"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.6240000128746033}],"study_designs":[],"awards":[{"id":"https://openalex.org/G4265943381","display_name":null,"funder_award_id":"11105121","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G8888806789","display_name":"Discovery and preclinical development of new generation tuberculosis vaccines","funder_award_id":"241745","funder_id":"https://openalex.org/F4320320300","funder_display_name":"European Commission"}],"funders":[{"id":"https://openalex.org/F4320311904","display_name":"Wellcome Trust","ror":"https://ror.org/029chgv08"},{"id":"https://openalex.org/F4320320300","display_name":"European Commission","ror":"https://ror.org/00k4n6c32"},{"id":"https://openalex.org/F4320320883","display_name":"Agence Nationale de la Recherche","ror":"https://ror.org/00rbzpz17"},{"id":"https://openalex.org/F4320320893","display_name":"Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale","ror":"https://ror.org/02vjkv261"},{"id":"https://openalex.org/F4320321001","display_name":"National Natural Science Foundation of China","ror":"https://ror.org/01h0zpd94"},{"id":"https://openalex.org/F4320322892","display_name":"Centre National de la Recherche Scientifique","ror":"https://ror.org/02feahw73"},{"id":"https://openalex.org/F4320334911","display_name":"St. George's, University of London","ror":"https://ror.org/040f08y74"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W25467197.pdf","grobid_xml":"https://content.openalex.org/works/W25467197.grobid-xml"},"referenced_works_count":1,"referenced_works":["https://openalex.org/W2047330514"],"related_works":["https://openalex.org/W2128702173","https://openalex.org/W7015401193","https://openalex.org/W7149309657","https://openalex.org/W4394800149","https://openalex.org/W7164038911","https://openalex.org/W7166103677","https://openalex.org/W2767933358","https://openalex.org/W2034435585","https://openalex.org/W2942307102","https://openalex.org/W3209683187"],"abstract_inverted_index":{"Apr\u00e8s":[0],"infection":[1,132],"d'une":[2,63],"cellule":[3],"h\u00f4te,":[4],"telle":[5],"qu'un":[6],"macrophage,":[7,146],"Mycobacterium":[8],"tuberculosis":[9,52,135],"(M.":[10],"tuberculosis)":[11],"r\u00e9side":[12],"\u00e0":[13,24,82,143,200],"l'int\u00e9rieur":[14,144],"d'un":[15],"phagosome":[16],"et":[17,29,53,58,90,147,189,194,216],"est":[18,195,251],"soumis":[19],"aux":[20],"actions":[21],"cellulaires":[22,111],"visant":[23],"l'\u00e9liminer.":[25],"Afin":[26],"de":[27,65,72,87,96,109,124,141,150,162,174,205,226,231,255],"survivre":[28],"se":[30,136],"multiplier,":[31],"le":[32,155,164,184,221],"bacille":[33,165],"a":[34,60,117,208],"d\u00e9velopp\u00e9":[35],"des":[36,78,85,94],"strat\u00e9gies":[37],"pour":[38,77,92,187,224,247],"combattre":[39],"ou":[40,102],"contourner":[41],"ces":[42,125,206],"m\u00e9canismes":[43],"bact\u00e9ricides.":[44],"Une":[45],"\u00e9tude":[46],"portant":[47],"sur":[48],"l'interaction":[49],"entre":[50],"M.":[51,134],"les":[54,167,202,244,249],"cellules-h\u00f4tes,":[55],"cellules":[56,245],"dendritiques":[57],"macrophages,":[59],"r\u00e9v\u00e9l\u00e9":[61],"l'existence":[62],"famille":[64,84],"g\u00e8nes":[66,75,110],"mycobact\u00e9riens":[67],"fortement":[68],"exprim\u00e9s":[69],"au":[70,192],"cours":[71],"l'infection.":[73],"Ces":[74],"codent":[76],"Ctp,":[79],"prot\u00e9ines":[80],"appartenant":[81],"la":[83,107],"ATPases":[86],"type":[88,175,227],"PIB":[89],"pr\u00e9dites":[91],"transporter":[93],"m\u00e9taux":[95],"transition":[97],"tels":[98],"que":[99,239],"Zn2+,":[100],"Cd2+":[101],"Cu+.":[103],"De":[104],"fa\u00e7on":[105],"compl\u00e9mentaire,":[106],"modulation":[108],"impliqu\u00e9s":[112],"dans":[113,154,183,197,220],"l'hom\u00e9ostasie":[114],"du":[115,145,170,233,241],"zinc":[116,142,152,193,234,242],"\u00e9t\u00e9":[118],"mise":[119],"en":[120],"\u00e9vidence.":[121],"A":[122],"partir":[123],"r\u00e9sultats,":[126],"nous":[127],"avons":[128],"pu":[129,209],"montrer":[130],"qu'apr\u00e8s":[131],"par":[133,243],"produit":[137],"une":[138,213],"lib\u00e9ration":[139],"massive":[140],"qu'une":[148],"partie":[149],"ce":[151],"s'accumule":[153],"phagosome.":[156],"En":[157,178],"r\u00e9action":[158],"cet":[159],"afflux":[160],"massif":[161],"zinc,":[163],"active":[166],"syst\u00e8mes":[168],"d'export":[169],"m\u00e9tal,":[171],"dont":[172],"l'ATPase":[173,225],"P":[176,228],"CtpC.":[177],"effet,":[179],"un":[180,217,252],"mutant":[181,218],"inactiv\u00e9":[182,219],"g\u00e8ne":[185,222],"codant":[186,223],"CtpC":[188],"tr\u00e8s":[190],"sensible":[191],"att\u00e9nu\u00e9":[196],"sa":[198],"capacit\u00e9":[199],"parasiter":[201],"macrophages.":[203],"L'ensemble":[204],"r\u00e9sultats":[207],"\u00eatre":[210],"reproduit":[211],"avec":[212],"souche":[214],"sauvage":[215],"ZntA":[229],"responsable":[230],"l'efflux":[232],"chez":[235],"Escherichia":[236],"coli,":[237],"sugg\u00e9rant":[238],"l'utilisation":[240],"immunitaires":[246],"empoisonner":[248],"microorganismes":[250],"m\u00e9canisme":[253],"g\u00e9n\u00e9ral":[254],"l'immunit\u00e9":[256],"inn\u00e9e":[257],"antimicrobienne.":[258]},"counts_by_year":[],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-06-24T00:00:00"}
