{"id":"https://openalex.org/W2546482015","doi":"https://doi.org/10.3892/mmr.2016.5922","title":"Presence of multimeric isoforms of human C-reactive protein in tissues and blood","display_name":"Presence of multimeric isoforms of human C-reactive protein in tissues and blood","publication_year":2016,"publication_date":"2016-11-03","ids":{"openalex":"https://openalex.org/W2546482015","doi":"https://doi.org/10.3892/mmr.2016.5922","mag":"2546482015","pmid":"https://pubmed.ncbi.nlm.nih.gov/27840940","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/5355649"},"language":"en","primary_location":{"id":"doi:10.3892/mmr.2016.5922","doi":"https://doi.org/10.3892/mmr.2016.5922","is_oa":true,"landing_page_url":"https://doi.org/10.3892/mmr.2016.5922","pdf_url":"http://www.spandidos-publications.com/10.3892/mmr.2016.5922/download","source":{"id":"https://openalex.org/S95395365","display_name":"Molecular Medicine Reports","issn_l":"1791-2997","issn":["1791-2997","1791-3004"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-d","jufo-1","medline","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320412","host_organization_name":"Spandidos Publishing","host_organization_lineage":["https://openalex.org/P4310320412"],"host_organization_lineage_names":["Spandidos Publishing"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular Medicine Reports","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"http://www.spandidos-publications.com/10.3892/mmr.2016.5922/download","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5007309170","display_name":"Qiling Li","orcid":"https://orcid.org/0000-0003-3763-4456","observed_orcids":["https://orcid.org/0000-0003-3763-4456","https://orcid.org/0000-0001-9438-6765"]},"institutions":[{"id":"https://openalex.org/I4210121771","display_name":"First Affiliated Hospital of Xi'an Jiaotong University","ror":"https://ror.org/02tbvhh96","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210121771"]},{"id":"https://openalex.org/I87445476","display_name":"Xi'an Jiaotong University","ror":"https://ror.org/017zhmm22","country_code":"CN","type":"education","lineage":["https://openalex.org/I87445476"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Qiling Li","raw_affiliation_strings":["Department of Obstetrics and Gynecology, First Affiliated Hospital, Xi'an Jiaotong University, Xi'an, Shaanxi 710061, P.R. China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Obstetrics and Gynecology, First Affiliated Hospital, Xi'an Jiaotong University, Xi'an, Shaanxi 710061, P.R. China","institution_ids":["https://openalex.org/I4210121771","https://openalex.org/I87445476"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100700765","display_name":"Wei Xu","orcid":"https://orcid.org/0000-0001-6324-5759","observed_orcids":["https://orcid.org/0000-0001-6324-5759"]},"institutions":[{"id":"https://openalex.org/I6332465","display_name":"Morehouse School of Medicine","ror":"https://ror.org/01pbhra64","country_code":"US","type":"education","lineage":["https://openalex.org/I6332465"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Wei Xu","raw_affiliation_strings":["Cardiovascular Research Institute, Morehouse School of Medicine, Atlanta, GA 30310, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cardiovascular Research Institute, Morehouse School of Medicine, Atlanta, GA 30310, USA","institution_ids":["https://openalex.org/I6332465"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5006165243","display_name":"Xue Xue","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210121771","display_name":"First Affiliated Hospital of Xi'an Jiaotong University","ror":"https://ror.org/02tbvhh96","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210121771"]},{"id":"https://openalex.org/I87445476","display_name":"Xi'an Jiaotong University","ror":"https://ror.org/017zhmm22","country_code":"CN","type":"education","lineage":["https://openalex.org/I87445476"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xue Xue","raw_affiliation_strings":["Department of Obstetrics and Gynecology, First Affiliated Hospital, Xi'an Jiaotong University, Xi'an, Shaanxi 710061, P.R. China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Obstetrics and Gynecology, First Affiliated Hospital, Xi'an Jiaotong University, Xi'an, Shaanxi 710061, P.R. China","institution_ids":["https://openalex.org/I4210121771","https://openalex.org/I87445476"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Qi Wang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210121771","display_name":"First Affiliated Hospital of Xi'an Jiaotong University","ror":"https://ror.org/02tbvhh96","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210121771"]},{"id":"https://openalex.org/I87445476","display_name":"Xi'an Jiaotong University","ror":"https://ror.org/017zhmm22","country_code":"CN","type":"education","lineage":["https://openalex.org/I87445476"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Qi Wang","raw_affiliation_strings":["Department of Obstetrics and Gynecology, First Affiliated Hospital, Xi'an Jiaotong University, Xi'an, Shaanxi 710061, P.R. China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Obstetrics and Gynecology, First Affiliated Hospital, Xi'an Jiaotong University, Xi'an, Shaanxi 710061, P.R. China","institution_ids":["https://openalex.org/I4210121771","https://openalex.org/I87445476"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112973216","display_name":"Lu Han","orcid":"https://orcid.org/0000-0003-3119-4824","observed_orcids":["https://orcid.org/0000-0003-3119-4824"]},"institutions":[{"id":"https://openalex.org/I4210121771","display_name":"First Affiliated Hospital of Xi'an Jiaotong University","ror":"https://ror.org/02tbvhh96","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210121771"]},{"id":"https://openalex.org/I87445476","display_name":"Xi'an Jiaotong University","ror":"https://ror.org/017zhmm22","country_code":"CN","type":"education","lineage":["https://openalex.org/I87445476"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Lu Han","raw_affiliation_strings":["Department of Obstetrics and Gynecology, First Affiliated Hospital, Xi'an Jiaotong University, Xi'an, Shaanxi 710061, P.R. China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Obstetrics and Gynecology, First Affiliated Hospital, Xi'an Jiaotong University, Xi'an, Shaanxi 710061, P.R. China","institution_ids":["https://openalex.org/I4210121771","https://openalex.org/I87445476"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100327146","display_name":"Wenzhi Li","orcid":"https://orcid.org/0000-0002-5244-6333","observed_orcids":["https://orcid.org/0000-0002-5244-6333","https://orcid.org/0000-0002-6671-890X"]},"institutions":[{"id":"https://openalex.org/I6332465","display_name":"Morehouse School of Medicine","ror":"https://ror.org/01pbhra64","country_code":"US","type":"education","lineage":["https://openalex.org/I6332465"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Wenzhi Li","raw_affiliation_strings":["Cardiovascular Research Institute, Morehouse School of Medicine, Atlanta, GA 30310, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cardiovascular Research Institute, Morehouse School of Medicine, Atlanta, GA 30310, USA","institution_ids":["https://openalex.org/I6332465"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5114016697","display_name":"Shulan Lv","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210121771","display_name":"First Affiliated Hospital of Xi'an Jiaotong University","ror":"https://ror.org/02tbvhh96","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210121771"]},{"id":"https://openalex.org/I87445476","display_name":"Xi'an Jiaotong University","ror":"https://ror.org/017zhmm22","country_code":"CN","type":"education","lineage":["https://openalex.org/I87445476"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Shulan Lv","raw_affiliation_strings":["Department of Obstetrics and Gynecology, First Affiliated Hospital, Xi'an Jiaotong University, Xi'an, Shaanxi 710061, P.R. China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Obstetrics and Gynecology, First Affiliated Hospital, Xi'an Jiaotong University, Xi'an, Shaanxi 710061, P.R. China","institution_ids":["https://openalex.org/I4210121771","https://openalex.org/I87445476"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100407502","display_name":"Dong Liu","orcid":"https://orcid.org/0000-0002-9977-959X","observed_orcids":["https://orcid.org/0000-0002-9977-959X"]},"institutions":[{"id":"https://openalex.org/I4210121771","display_name":"First Affiliated Hospital of Xi'an Jiaotong University","ror":"https://ror.org/02tbvhh96","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210121771"]},{"id":"https://openalex.org/I87445476","display_name":"Xi'an Jiaotong University","ror":"https://ror.org/017zhmm22","country_code":"CN","type":"education","lineage":["https://openalex.org/I87445476"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Dong Liu","raw_affiliation_strings":["Department of Obstetrics and Gynecology, First Affiliated Hospital, Xi'an Jiaotong University, Xi'an, Shaanxi 710061, P.R. China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Obstetrics and Gynecology, First Affiliated Hospital, Xi'an Jiaotong University, Xi'an, Shaanxi 710061, P.R. China","institution_ids":["https://openalex.org/I4210121771","https://openalex.org/I87445476"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5040132248","display_name":"Jendai C. Richards","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I6332465","display_name":"Morehouse School of Medicine","ror":"https://ror.org/01pbhra64","country_code":"US","type":"education","lineage":["https://openalex.org/I6332465"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jendai Richards","raw_affiliation_strings":["Cardiovascular Research Institute, Morehouse School of Medicine, Atlanta, GA 30310, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cardiovascular Research Institute, Morehouse School of Medicine, Atlanta, GA 30310, USA","institution_ids":["https://openalex.org/I6332465"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5079530856","display_name":"Zhujun Shen","orcid":"https://orcid.org/0000-0003-0787-1303","observed_orcids":["https://orcid.org/0000-0003-0787-1303","https://orcid.org/0009-0005-7016-2675"]},"institutions":[{"id":"https://openalex.org/I200296433","display_name":"Chinese Academy of Medical Sciences & Peking Union Medical College","ror":"https://ror.org/02drdmm93","country_code":"CN","type":"education","lineage":["https://openalex.org/I200296433"]},{"id":"https://openalex.org/I2801228662","display_name":"Peking Union Medical College Hospital","ror":"https://ror.org/04jztag35","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I2801228662"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Zhujun Shen","raw_affiliation_strings":["Department of Cardiology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing 100730, P.R. China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cardiology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing 100730, P.R. China","institution_ids":["https://openalex.org/I200296433","https://openalex.org/I2801228662"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5091854106","display_name":"Li Ma","orcid":"https://orcid.org/0000-0001-5847-2375","observed_orcids":["https://orcid.org/0000-0001-5847-2375"]},"institutions":[{"id":"https://openalex.org/I6332465","display_name":"Morehouse School of Medicine","ror":"https://ror.org/01pbhra64","country_code":"US","type":"education","lineage":["https://openalex.org/I6332465"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Li Ma","raw_affiliation_strings":["Cardiovascular Research Institute, Morehouse School of Medicine, Atlanta, GA 30310, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cardiovascular Research Institute, Morehouse School of Medicine, Atlanta, GA 30310, USA","institution_ids":["https://openalex.org/I6332465"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5102787380","display_name":"Qing Song","orcid":"https://orcid.org/0000-0002-9773-1517","observed_orcids":["https://orcid.org/0000-0002-9773-1517"]},"institutions":[{"id":"https://openalex.org/I4210121771","display_name":"First Affiliated Hospital of Xi'an Jiaotong University","ror":"https://ror.org/02tbvhh96","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210121771"]},{"id":"https://openalex.org/I87445476","display_name":"Xi'an Jiaotong University","ror":"https://ror.org/017zhmm22","country_code":"CN","type":"education","lineage":["https://openalex.org/I87445476"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Qing Song","raw_affiliation_strings":["Department of Obstetrics and Gynecology, First Affiliated Hospital, Xi'an Jiaotong University, Xi'an, Shaanxi 710061, P.R. China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Obstetrics and Gynecology, First Affiliated Hospital, Xi'an Jiaotong University, Xi'an, Shaanxi 710061, P.R. China","institution_ids":["https://openalex.org/I4210121771","https://openalex.org/I87445476"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":5,"corresponding_author_ids":["https://openalex.org/A5007309170","https://openalex.org/A5102787380"],"corresponding_institution_ids":["https://openalex.org/I4210121771","https://openalex.org/I87445476"],"apc_list":null,"apc_paid":null,"fwci":0.2018,"has_fulltext":true,"cited_by_count":12,"citation_normalized_percentile":{"value":0.65037013,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":97},"biblio":{"volume":"14","issue":"6","first_page":"5461","last_page":"5466"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T14245","display_name":"Biomarkers in Disease Mechanisms","score":0.9976000189781189,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T14245","display_name":"Biomarkers in Disease Mechanisms","score":0.9976000189781189,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10528","display_name":"Adipokines, Inflammation, and Metabolic Diseases","score":0.0015999999595806003,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11503","display_name":"Cytokine Signaling Pathways and Interactions","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/c-reactive-protein","display_name":"C-reactive protein","score":1.0},{"id":"https://openalex.org/keywords/pentameric-crp","display_name":"pentameric CRP","score":0.8629999756813049},{"id":"https://openalex.org/keywords/transgenic-rats","display_name":"transgenic rats","score":0.8009999990463257}],"concepts":[{"id":"https://openalex.org/C53345823","wikidata":"https://www.wikidata.org/wiki/Q5531554","display_name":"Gene isoform","level":3,"score":0.7471955418586731},{"id":"https://openalex.org/C85265743","wikidata":"https://www.wikidata.org/wiki/Q885458","display_name":"Blot","level":3,"score":0.6126998662948608},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5351384878158569},{"id":"https://openalex.org/C2781195455","wikidata":"https://www.wikidata.org/wiki/Q422766","display_name":"C-reactive protein","level":3,"score":0.5234910249710083},{"id":"https://openalex.org/C141035611","wikidata":"https://www.wikidata.org/wiki/Q5532934","display_name":"Genetically modified mouse","level":4,"score":0.4103161692619324},{"id":"https://openalex.org/C102230213","wikidata":"https://www.wikidata.org/wiki/Q430117","display_name":"Transgene","level":3,"score":0.40249761939048767},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.40114474296569824},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.3848426342010498},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.3402220606803894},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.26514342427253723},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.2544988691806793},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.21836841106414795},{"id":"https://openalex.org/C2776914184","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammation","level":2,"score":0.1432894766330719},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.07346263527870178}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002097","descriptor_name":"C-Reactive Protein","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D002097","descriptor_name":"C-Reactive Protein","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D002097","descriptor_name":"C-Reactive Protein","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D004797","descriptor_name":"Enzyme-Linked Immunosorbent Assay","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006331","descriptor_name":"Heart Diseases","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D006331","descriptor_name":"Heart Diseases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015415","descriptor_name":"Biomarkers","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020033","descriptor_name":"Protein Isoforms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D030801","descriptor_name":"Animals, Genetically Modified","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D055503","descriptor_name":"Protein Multimerization","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":3,"locations":[{"id":"doi:10.3892/mmr.2016.5922","doi":"https://doi.org/10.3892/mmr.2016.5922","is_oa":true,"landing_page_url":"https://doi.org/10.3892/mmr.2016.5922","pdf_url":"http://www.spandidos-publications.com/10.3892/mmr.2016.5922/download","source":{"id":"https://openalex.org/S95395365","display_name":"Molecular Medicine Reports","issn_l":"1791-2997","issn":["1791-2997","1791-3004"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-d","jufo-1","medline","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320412","host_organization_name":"Spandidos Publishing","host_organization_lineage":["https://openalex.org/P4310320412"],"host_organization_lineage_names":["Spandidos Publishing"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular Medicine Reports","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:5355649","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/5355649","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Mol Med Rep","raw_type":"Text"},{"id":"pmid:27840940","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/27840940","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular medicine reports","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.3892/mmr.2016.5922","doi":"https://doi.org/10.3892/mmr.2016.5922","is_oa":true,"landing_page_url":"https://doi.org/10.3892/mmr.2016.5922","pdf_url":"http://www.spandidos-publications.com/10.3892/mmr.2016.5922/download","source":{"id":"https://openalex.org/S95395365","display_name":"Molecular Medicine Reports","issn_l":"1791-2997","issn":["1791-2997","1791-3004"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-d","jufo-1","medline","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320412","host_organization_name":"Spandidos Publishing","host_organization_lineage":["https://openalex.org/P4310320412"],"host_organization_lineage_names":["Spandidos Publishing"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular Medicine Reports","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9391000270843506,"id":"https://metadata.un.org/sdg/3"}],"sustainable_development_goals_aurora":[{"display_name":"Good health and well-being","score":0.8399999737739563,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2546482015.pdf","grobid_xml":"https://content.openalex.org/works/W2546482015.grobid-xml"},"referenced_works_count":37,"referenced_works":["https://openalex.org/W179846065","https://openalex.org/W1531003870","https://openalex.org/W1932537843","https://openalex.org/W1972554106","https://openalex.org/W1981315894","https://openalex.org/W1986553067","https://openalex.org/W2000718683","https://openalex.org/W2006037629","https://openalex.org/W2006547599","https://openalex.org/W2009682964","https://openalex.org/W2015158463","https://openalex.org/W2023298382","https://openalex.org/W2026281835","https://openalex.org/W2026771907","https://openalex.org/W2028427382","https://openalex.org/W2031018826","https://openalex.org/W2034346346","https://openalex.org/W2039404828","https://openalex.org/W2049234369","https://openalex.org/W2051471629","https://openalex.org/W2058449885","https://openalex.org/W2060028214","https://openalex.org/W2062637468","https://openalex.org/W2068666335","https://openalex.org/W2069758703","https://openalex.org/W2081737697","https://openalex.org/W2086898975","https://openalex.org/W2095002482","https://openalex.org/W2100857735","https://openalex.org/W2101848486","https://openalex.org/W2104196299","https://openalex.org/W2119510296","https://openalex.org/W2122378582","https://openalex.org/W2138333556","https://openalex.org/W2156837080","https://openalex.org/W2166626624","https://openalex.org/W2324558918"],"related_works":["https://openalex.org/W4386837301","https://openalex.org/W2028402934","https://openalex.org/W7096555631","https://openalex.org/W1972554106","https://openalex.org/W2068767059","https://openalex.org/W3173667908","https://openalex.org/W2060028214","https://openalex.org/W2806528949","https://openalex.org/W2049508838","https://openalex.org/W2940913353"],"abstract_inverted_index":{"The":[0,37,159],"baseline":[1],"concentration":[2],"of":[3,14,32,79,113,155,161,170,189],"C-reactive":[4],"protein":[5],"(CRP)":[6],"has":[7],"been":[8],"associated":[9],"with":[10],"a":[11,29,106],"wide":[12],"array":[13],"human":[15,58,83,88,114,171],"diseases.":[16],"In":[17,96],"epidemiological":[18,179],"studies":[19,180],"and":[20,67,77,82,108,120,134,153,178],"in":[21,48,87,110,125,150,167,195],"the":[22,49,61,75,99,111,151,168,187,190],"clinic,":[23],"CRP":[24,35,53,59,85,102,115,122,163,184,199],"is":[25],"typically":[26,181],"measured":[27],"as":[28,105,145],"pentamer,":[30],"composed":[31],"5":[33],"identical":[34],"subunits.":[36],"present":[38,47,191],"study":[39,192],"aimed":[40],"to":[41,98,142,197],"determine":[42],"whether":[43],"other":[44],"isoforms":[45,140,164],"were":[46,65,90,147],"blood":[50,76,89,112,152,169],"by":[51,92,173],"examining":[52],"conformations.":[54],"Transgenic":[55],"rats":[56,81],"expressing":[57],"under":[60],"mouse":[62],"albumin":[63],"promoter":[64],"generated":[66],"genotyped.":[68],"Non\u2011reducing":[69],"western":[70,175],"blotting":[71],"was":[72,103,123,165],"performed":[73],"using":[74],"tissues":[78,154],"transgenic":[80,116,157],"patients.":[84],"concentrations":[86],"examined":[91],"enzyme\u2011linked":[93],"immunosorbent":[94],"assay.":[95],"addition":[97,196],"pentameric":[100],"isoform,":[101],"detected":[104,148],"trimer":[107],"tetramer":[109],"rats.":[117,158],"Furthermore,":[118],"trimeric":[119],"tetrameric":[121],"observed":[124],"various":[126],"tissues,":[127],"including":[128],"aorta,":[129],"liver,":[130],"kidney,":[131],"pancreas,":[132],"heart":[133],"skeletal":[135],"muscle.":[136],"Notably,":[137],"these":[138],"two":[139],"appeared":[141],"be":[143],"age\u2011associated,":[144],"they":[146],"only":[149],"older":[156],"existence":[160],"additional":[162],"confirmed":[166],"patients":[172],"non\u2011reducing":[174],"blotting.":[176],"Clinical":[177],"focus":[182],"on":[183],"concentration.":[185],"However,":[186],"results":[188],"suggest":[193],"that,":[194],"concentration,":[198],"conformation":[200],"may":[201],"require":[202],"analysis.":[203]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":4},{"year":2019,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-11-11T00:00:00"}