{"id":"https://openalex.org/W2544533469","doi":null,"title":"THE EFFECTS OF MITOCHONDRIAL DYSFUNCTION ON OSTEOBLAST FUNCTION IN THE PATHOGENESIS OF OSTEOPOROSIS","display_name":"THE EFFECTS OF MITOCHONDRIAL DYSFUNCTION ON OSTEOBLAST FUNCTION IN THE PATHOGENESIS OF OSTEOPOROSIS","publication_year":2018,"publication_date":"2018-02-21","ids":{"openalex":"https://openalex.org/W2544533469","mag":"2544533469"},"language":"en","primary_location":{"id":"mag:2800100664","doi":null,"is_oa":false,"landing_page_url":"https://online.boneandjoint.org.uk/doi/10.1302/1358-992X.98BSUPP_16.BORS2016-048","pdf_url":null,"source":{"id":"https://openalex.org/S4387287184","display_name":"Orthopaedic Proceedings","issn_l":"1358-992X","issn":["1358-992X","2049-4416"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"Orthopaedic Proceedings","raw_type":null},"volume":null,"type":"article","indexed_in":[],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5033371473","display_name":"Philip F. Dobson","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210138563","display_name":"Wellcome Centre for Mitochondrial Research","ror":"https://ror.org/03myjph80","country_code":"GB","type":"facility","lineage":["https://openalex.org/I4210138563","https://openalex.org/I84884186","https://openalex.org/I87048295"]},{"id":"https://openalex.org/I84884186","display_name":"Newcastle University","ror":"https://ror.org/01kj2bm70","country_code":"GB","type":"education","lineage":["https://openalex.org/I84884186"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Philip F. Dobson","raw_affiliation_strings":["Wellcome Trust Centre for Mitochondrial Research, Institute for Neuroscience, Medical School, Newcastle University, Newcastle upon Tyne NE2 4HH, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Wellcome Trust Centre for Mitochondrial Research, Institute for Neuroscience, Medical School, Newcastle University, Newcastle upon Tyne NE2 4HH, UK","institution_ids":["https://openalex.org/I4210138563","https://openalex.org/I84884186"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5008579548","display_name":"Laura C. Greaves","orcid":"https://orcid.org/0000-0002-8071-5916","observed_orcids":["https://orcid.org/0000-0002-8071-5916"]},"institutions":[{"id":"https://openalex.org/I4210138563","display_name":"Wellcome Centre for Mitochondrial Research","ror":"https://ror.org/03myjph80","country_code":"GB","type":"facility","lineage":["https://openalex.org/I4210138563","https://openalex.org/I84884186","https://openalex.org/I87048295"]},{"id":"https://openalex.org/I84884186","display_name":"Newcastle University","ror":"https://ror.org/01kj2bm70","country_code":"GB","type":"education","lineage":["https://openalex.org/I84884186"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Laura C. Greaves","raw_affiliation_strings":["Wellcome Trust Centre for Mitochondrial Research, Institute for Neuroscience, Medical School, Newcastle University, Newcastle upon Tyne NE2 4HH, UK"],"raw_orcid":"https://orcid.org/0000-0002-8071-5916","affiliations":[{"raw_affiliation_string":"Wellcome Trust Centre for Mitochondrial Research, Institute for Neuroscience, Medical School, Newcastle University, Newcastle upon Tyne NE2 4HH, UK","institution_ids":["https://openalex.org/I4210138563","https://openalex.org/I84884186"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5007355607","display_name":"David John Deehan","orcid":"https://orcid.org/0000-0001-5780-8818","observed_orcids":["https://orcid.org/0000-0001-5780-8818"]},"institutions":[{"id":"https://openalex.org/I4210138563","display_name":"Wellcome Centre for Mitochondrial Research","ror":"https://ror.org/03myjph80","country_code":"GB","type":"facility","lineage":["https://openalex.org/I4210138563","https://openalex.org/I84884186","https://openalex.org/I87048295"]},{"id":"https://openalex.org/I84884186","display_name":"Newcastle University","ror":"https://ror.org/01kj2bm70","country_code":"GB","type":"education","lineage":["https://openalex.org/I84884186"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"David J. Deehan","raw_affiliation_strings":["Wellcome Trust Centre for Mitochondrial Research, Institute for Neuroscience, Medical School, Newcastle University, Newcastle upon Tyne NE2 4HH, UK"],"raw_orcid":"https://orcid.org/0000-0001-5780-8818","affiliations":[{"raw_affiliation_string":"Wellcome Trust Centre for Mitochondrial Research, Institute for Neuroscience, Medical School, Newcastle University, Newcastle upon Tyne NE2 4HH, UK","institution_ids":["https://openalex.org/I4210138563","https://openalex.org/I84884186"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5050697713","display_name":"Douglass M. Turnbull","orcid":"https://orcid.org/0000-0002-8878-9901","observed_orcids":["https://orcid.org/0000-0002-8878-9901"]},"institutions":[{"id":"https://openalex.org/I4210138563","display_name":"Wellcome Centre for Mitochondrial Research","ror":"https://ror.org/03myjph80","country_code":"GB","type":"facility","lineage":["https://openalex.org/I4210138563","https://openalex.org/I84884186","https://openalex.org/I87048295"]},{"id":"https://openalex.org/I84884186","display_name":"Newcastle University","ror":"https://ror.org/01kj2bm70","country_code":"GB","type":"education","lineage":["https://openalex.org/I84884186"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Douglass M. Turnbull","raw_affiliation_strings":["Wellcome Trust Centre for Mitochondrial Research, Institute for Neuroscience, Medical School, Newcastle University, Newcastle upon Tyne NE2 4HH, UK"],"raw_orcid":"https://orcid.org/0000-0002-8878-9901","affiliations":[{"raw_affiliation_string":"Wellcome Trust Centre for Mitochondrial Research, Institute for Neuroscience, Medical School, Newcastle University, Newcastle upon Tyne NE2 4HH, UK","institution_ids":["https://openalex.org/I4210138563","https://openalex.org/I84884186"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.00140815,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11219","display_name":"Bone Metabolism and Diseases","score":0.8511000275611877,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11219","display_name":"Bone Metabolism and Diseases","score":0.8511000275611877,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10301","display_name":"Mitochondrial Function and Pathology","score":0.09229999780654907,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10071","display_name":"Bone health and osteoporosis research","score":0.047200001776218414,"subfield":{"id":"https://openalex.org/subfields/2732","display_name":"Orthopedics and Sports Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/mitochondrial-dysfunction","display_name":"mitochondrial dysfunction","score":0.9409999847412109},{"id":"https://openalex.org/keywords/osteoporosis","display_name":"osteoporosis","score":0.8090000152587891},{"id":"https://openalex.org/keywords/osteoblasts","display_name":"osteoblasts","score":0.9350000023841858},{"id":"https://openalex.org/keywords/mtdna-mutations","display_name":"mitochondrial DNA mutations","score":0.9549999833106995},{"id":"https://openalex.org/keywords/bone-mineral-density","display_name":"bone mineral density","score":0.8659999966621399},{"id":"https://openalex.org/keywords/bone-homeostasis","display_name":"bone homeostasis","score":0.8930000066757202},{"id":"https://openalex.org/keywords/aging","display_name":"aging","score":0.6179999709129333},{"id":"https://openalex.org/keywords/respiratory-chain-deficiency","display_name":"respiratory chain deficiency","score":0.8410000205039978},{"id":"https://openalex.org/keywords/immunofluorescence-assay","display_name":"immunofluorescence assay","score":0.7910000085830688}],"concepts":[{"id":"https://openalex.org/C24586158","wikidata":"https://www.wikidata.org/wiki/Q27075","display_name":"Mitochondrial DNA","level":3,"score":0.7207582592964172},{"id":"https://openalex.org/C2776541429","wikidata":"https://www.wikidata.org/wiki/Q165328","display_name":"Osteoporosis","level":2,"score":0.7083926796913147},{"id":"https://openalex.org/C2780942790","wikidata":"https://www.wikidata.org/wiki/Q372016","display_name":"Pathogenesis","level":2,"score":0.571071982383728},{"id":"https://openalex.org/C134305767","wikidata":"https://www.wikidata.org/wiki/Q725508","display_name":"Somatic cell","level":3,"score":0.5598233342170715},{"id":"https://openalex.org/C28859421","wikidata":"https://www.wikidata.org/wiki/Q39572","display_name":"Mitochondrion","level":2,"score":0.5173220634460449},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.49522367119789124},{"id":"https://openalex.org/C2778260815","wikidata":"https://www.wikidata.org/wiki/Q917177","display_name":"Osteoblast","level":3,"score":0.4675627648830414},{"id":"https://openalex.org/C501734568","wikidata":"https://www.wikidata.org/wiki/Q42918","display_name":"Mutation","level":3,"score":0.44756829738616943},{"id":"https://openalex.org/C2776886416","wikidata":"https://www.wikidata.org/wiki/Q4941567","display_name":"Bone mineral","level":3,"score":0.4378000497817993},{"id":"https://openalex.org/C93304396","wikidata":"https://www.wikidata.org/wiki/Q14763008","display_name":"Mitosis","level":2,"score":0.4359617829322815},{"id":"https://openalex.org/C500499127","wikidata":"https://www.wikidata.org/wiki/Q332154","display_name":"Ageing","level":2,"score":0.42880210280418396},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.3973847031593323},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.3667082190513611},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.35766327381134033},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.340914249420166},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.3289642333984375},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.20782890915870667},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.16833093762397766}],"mesh":[],"locations_count":1,"locations":[{"id":"mag:2800100664","doi":null,"is_oa":false,"landing_page_url":"https://online.boneandjoint.org.uk/doi/10.1302/1358-992X.98BSUPP_16.BORS2016-048","pdf_url":null,"source":{"id":"https://openalex.org/S4387287184","display_name":"Orthopaedic Proceedings","issn_l":"1358-992X","issn":["1358-992X","2049-4416"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"Orthopaedic Proceedings","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9537000060081482,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"sustainable_development_goals_aurora":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W3043814793","https://openalex.org/W7221075773","https://openalex.org/W4385606890","https://openalex.org/W6891520972","https://openalex.org/W4391484381","https://openalex.org/W2605105084","https://openalex.org/W4318457136","https://openalex.org/W2972028793","https://openalex.org/W4405611390","https://openalex.org/W4213239476"],"abstract_inverted_index":{"The":[0],"pathogenesis":[1],"of":[2,12,25,50,127,149],"falling":[3,131],"bone":[4,128],"mineral":[5],"density":[6],"(BMD)":[7],"as":[8,188],"a":[9,54,137,173,189],"universal":[10],"feature":[11],"advancing":[13],"age":[14],"is":[15,29],"poorly":[16],"understood":[17],"1":[18],".":[19,63,88,111],"Frequently":[20],"culminating":[21],"in":[22,40,77,91,186,193],"the":[23,27,41,59,107,116,125,147],"development":[24],"osteoporosis,":[26],"process":[28,109],"attributable":[30],"to":[31,58,70,106,124,160,167,178,198],"more":[32],"than":[33],"500,000":[34],"fragility":[35],"fractures":[36],"occurring":[37],"every":[38],"year":[39],"UK":[42],"Such":[43],"injuries":[44],"are":[45,68,104,165],"associated":[46],"with":[47],"great":[48],"levels":[49],"morbidity,":[51],"mortality":[52],"and":[53,79,83,130,154],"\u00a33.5":[55],"billion":[56],"cost":[57],"healthcare":[60],"economy":[61],"2":[62],"With":[65],"age,":[66],"humans":[67],"known":[69],"accumulate":[71],"somatic":[72],"mitochondrial":[73,120,181],"DNA":[74],"(mtDNA)":[75],"mutations":[76,103,143],"mitotic":[78,81],"post":[80],"tissue,":[82],"stem":[84],"cell":[85,201],"precursors":[86],"3":[87],"Compelling":[89],"evidence":[90,114],"recent":[92],"years,":[93],"particularly":[94],"that":[95,101,119,140,163,180],"provided":[96],"by":[97],"animal":[98],"models":[99],"suggests":[100],"these":[102],"intrinsic":[105],"ageing":[108,153],"4\u20136":[110],"We":[112,134,170],"provide":[113],"for":[115],"first":[117],"time":[118],"dysfunction":[121,184],"contributes":[122],"significantly":[123],"failure":[126],"homeostasis":[129],"BMD.":[132],"have":[135,171],"utilised":[136],"mouse":[138],"model":[139],"accumulates":[141],"mtDNA":[142,168],"at":[144],"3\u20135":[145],"times":[146],"rate":[148],"normal":[150],"mice,":[151],"consequently":[152],"developing":[155],"osteoporosis":[156],"prematurely":[157],"7":[158],",":[159],"clearly":[161],"demonstrate":[162],"osteoblasts":[164,187],"vulnerable":[166],"mutations.":[169],"developed":[172],"new":[174],"quadruple":[175],"immunofluorescent":[176],"assay":[177],"show":[179],"respiratory":[182],"chain":[183],"occurs":[185],"consequence":[190],"(p":[191,203],"vitro":[194],"when":[196],"compared":[197],"wild":[199],"type":[200],"lines":[202]},"counts_by_year":[],"updated_date":"2026-09-22T06:50:58.402377","created_date":"2025-10-10T00:00:00"}
