{"id":"https://openalex.org/W2542223944","doi":"https://doi.org/10.1111/liv.13288","title":"Efficacy and safety of sofosbuvir/simeprevir plus flat dose ribavirin in genotype 1 elderly cirrhotic patients: A real\u2010life study","display_name":"Efficacy and safety of sofosbuvir/simeprevir plus flat dose ribavirin in genotype 1 elderly cirrhotic patients: A real\u2010life study","publication_year":2016,"publication_date":"2016-12-15","ids":{"openalex":"https://openalex.org/W2542223944","doi":"https://doi.org/10.1111/liv.13288","mag":"2542223944","pmid":"https://pubmed.ncbi.nlm.nih.gov/27782373"},"language":"en","primary_location":{"id":"doi:10.1111/liv.13288","doi":"https://doi.org/10.1111/liv.13288","is_oa":false,"landing_page_url":"https://doi.org/10.1111/liv.13288","pdf_url":null,"source":{"id":"https://openalex.org/S206392846","display_name":"Liver International","issn_l":"0106-9543","issn":["0106-9543","1478-3223","1478-3231","1600-0676"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Liver International","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5013733969","display_name":"Adriano Maria Pellicelli","orcid":"https://orcid.org/0000-0001-5845-6703","observed_orcids":["https://orcid.org/0000-0001-5845-6703"]},"institutions":[{"id":"https://openalex.org/I4210095143","display_name":"Azienda Ospedaliera San Camillo-Forlanini","ror":"https://ror.org/00j707644","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210095143"]}],"countries":["IT"],"is_corresponding":true,"raw_author_name":"Adriano M. Pellicelli","raw_affiliation_strings":["Liver Disease Unit, Department of Liver Transplantation, San Camillo Forlanini Hospital, Rome, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Liver Disease Unit, Department of Liver Transplantation, San Camillo Forlanini Hospital, Rome, Italy","institution_ids":["https://openalex.org/I4210095143"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110905853","display_name":"Valeria Pace Palitti","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210147037","display_name":"Azienda USL di Pescara","ror":"https://ror.org/048ym4d69","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210147037"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Valeria Pace Palitti","raw_affiliation_strings":["Hepatology Department of Medicine, ASL Pescara, Pescara, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Hepatology Department of Medicine, ASL Pescara, Pescara, Italy","institution_ids":["https://openalex.org/I4210147037"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5048997593","display_name":"Pascal Vignally","orcid":"https://orcid.org/0000-0003-1021-1648","observed_orcids":["https://orcid.org/0000-0003-1021-1648"]},"institutions":[{"id":"https://openalex.org/I3018768319","display_name":"Ente Ospedaliero Ospedali Galliera","ror":"https://ror.org/05bs6ak67","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I3018768319","https://openalex.org/I4405264730"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Pascal Vignally","raw_affiliation_strings":["Emergency Department, Galliera Hospital, Genoa, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Emergency Department, Galliera Hospital, Genoa, Italy","institution_ids":["https://openalex.org/I3018768319"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5069733218","display_name":"Francesca Ceccherini\u2010Silberstein","orcid":"https://orcid.org/0000-0002-6024-5101","observed_orcids":["https://orcid.org/0000-0002-6024-5101"]},"institutions":[{"id":"https://openalex.org/I116067653","display_name":"University of Rome Tor Vergata","ror":"https://ror.org/02p77k626","country_code":"IT","type":"education","lineage":["https://openalex.org/I116067653"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Francesca Ceccherini\u2010Silberstein","raw_affiliation_strings":["Department of Experimental Medicine and Surgery, University of Tor Vergata, Rome, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Experimental Medicine and Surgery, University of Tor Vergata, Rome, Italy","institution_ids":["https://openalex.org/I116067653"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111864472","display_name":"Massimo Siciliano","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2802557943","display_name":"Agostino Gemelli University Polyclinic","ror":"https://ror.org/00rg70c39","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I2802557943"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Massimo Siciliano","raw_affiliation_strings":["Internal Medicine, Catholic University Policlinico Gemelli, Rome, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Internal Medicine, Catholic University Policlinico Gemelli, Rome, Italy","institution_ids":["https://openalex.org/I2802557943"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103139644","display_name":"Valerio Giannelli","orcid":"https://orcid.org/0000-0003-3392-3752","observed_orcids":["https://orcid.org/0000-0003-3392-3752"]},"institutions":[{"id":"https://openalex.org/I4210095143","display_name":"Azienda Ospedaliera San Camillo-Forlanini","ror":"https://ror.org/00j707644","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210095143"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Valerio Giannelli","raw_affiliation_strings":["Liver Disease Unit, Department of Liver Transplantation, San Camillo Forlanini Hospital, Rome, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Liver Disease Unit, Department of Liver Transplantation, San Camillo Forlanini Hospital, Rome, Italy","institution_ids":["https://openalex.org/I4210095143"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Alessandra Moretti","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210097502","display_name":"Ospedale San Filippo Neri","ror":"https://ror.org/00qt4k071","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210097502"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Alessandra Moretti","raw_affiliation_strings":["Gastroenterology, San Filippo Neri Hospital, Rome, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Gastroenterology, San Filippo Neri Hospital, Rome, Italy","institution_ids":["https://openalex.org/I4210097502"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5013428000","display_name":"Pierluigi Tarquini","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2799288026","display_name":"Infectious Diseases Society of America","ror":"https://ror.org/03f1p6998","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I2799288026"]},{"id":"https://openalex.org/I4210119124","display_name":"Terumo (Japan)","ror":"https://ror.org/02kbe5v55","country_code":"JP","type":"company","lineage":["https://openalex.org/I4210119124"]},{"id":"https://openalex.org/I4396570471","display_name":"Aziende Socio Sanitarie Territoriale Lodi","ror":"https://ror.org/054x2er76","country_code":"IT","type":"government","lineage":["https://openalex.org/I4396570471"]},{"id":"https://openalex.org/I4396570609","display_name":"Azienda Socio Sanitaria Territoriale di Cremona","ror":"https://ror.org/02h6t3w06","country_code":"IT","type":"government","lineage":["https://openalex.org/I4396570609"]}],"countries":["IT","JP","US"],"is_corresponding":false,"raw_author_name":"Pierluigi Tarquini","raw_affiliation_strings":["Infectious Disease, ASL Teramo, Teramo, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Infectious Disease, ASL Teramo, Teramo, Italy","institution_ids":["https://openalex.org/I2799288026","https://openalex.org/I4210119124","https://openalex.org/I4396570471","https://openalex.org/I4396570609"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110429781","display_name":"Gaetano Scifo","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Gaetano Scifo","raw_affiliation_strings":["Infectious Disease, Umberto I Hospital, Siracusa, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Infectious Disease, Umberto I Hospital, Siracusa, Italy","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5028304250","display_name":"Vincenzo Messina","orcid":"https://orcid.org/0000-0003-1323-5127","observed_orcids":["https://orcid.org/0000-0003-1323-5127"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Vincenzo Messina","raw_affiliation_strings":["Infectious Disease, Sant'Anna and San Sebastiano Hospital Caserta, Rome, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Infectious Disease, Sant'Anna and San Sebastiano Hospital Caserta, Rome, Italy","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5107961974","display_name":"Antonio Ascione","orcid":"https://orcid.org/0000-0003-2040-8380","observed_orcids":["https://orcid.org/0000-0003-2040-8380"]},"institutions":[{"id":"https://openalex.org/I4210108212","display_name":"Fatebenefratelli Hospital","ror":"https://ror.org/01x9zv505","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210108212","https://openalex.org/I4210153126"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Antonio Ascione","raw_affiliation_strings":["Center for Liver Disease, Fatebenefratelli Hospital, Napoli, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Liver Disease, Fatebenefratelli Hospital, Napoli, Italy","institution_ids":["https://openalex.org/I4210108212"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109397634","display_name":"Antonio Izzi","orcid":"https://orcid.org/0000-0001-6776-5655","observed_orcids":["https://orcid.org/0000-0001-6776-5655"]},"institutions":[{"id":"https://openalex.org/I4210149343","display_name":"Ospedale D. Cotugno","ror":"https://ror.org/04k078691","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210149343"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Antonio Izzi","raw_affiliation_strings":["Infectious Disease, Cotugno Hospital, Napoli, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Infectious Disease, Cotugno Hospital, Napoli, Italy","institution_ids":["https://openalex.org/I4210149343"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5049004748","display_name":"Massimo Marignani","orcid":"https://orcid.org/0000-0002-8912-9972","observed_orcids":["https://orcid.org/0000-0002-8912-9972"]},"institutions":[{"id":"https://openalex.org/I4210125574","display_name":"Azienda Ospedaliera Sant'Andrea","ror":"https://ror.org/032298f51","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210125574"]},{"id":"https://openalex.org/I861853513","display_name":"Sapienza University of Rome","ror":"https://ror.org/02be6w209","country_code":"IT","type":"education","lineage":["https://openalex.org/I861853513"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Massimo Marignani","raw_affiliation_strings":["Digestive and Liver Disease Unit, Faculty Medicine and Psychology, S. Andrea Hospital, Sapienza University of Rome, Rome, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Digestive and Liver Disease Unit, Faculty Medicine and Psychology, S. Andrea Hospital, Sapienza University of Rome, Rome, Italy","institution_ids":["https://openalex.org/I4210125574","https://openalex.org/I861853513"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5009586905","display_name":"Cecilia D\u2019Ambrosio","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210095143","display_name":"Azienda Ospedaliera San Camillo-Forlanini","ror":"https://ror.org/00j707644","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210095143"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Cecilia D'Ambrosio","raw_affiliation_strings":["Liver Disease Unit, Department of Liver Transplantation, San Camillo Forlanini Hospital, Rome, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Liver Disease Unit, Department of Liver Transplantation, San Camillo Forlanini Hospital, Rome, Italy","institution_ids":["https://openalex.org/I4210095143"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5038154316","display_name":"Lucia Fondacaro","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210095143","display_name":"Azienda Ospedaliera San Camillo-Forlanini","ror":"https://ror.org/00j707644","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210095143"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Lucia Fondacaro","raw_affiliation_strings":["Liver Disease Unit, Department of Liver Transplantation, San Camillo Forlanini Hospital, Rome, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Liver Disease Unit, Department of Liver Transplantation, San Camillo Forlanini Hospital, Rome, Italy","institution_ids":["https://openalex.org/I4210095143"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5079351397","display_name":"Giuseppe Maria Ettorre","orcid":"https://orcid.org/0000-0002-7501-5472","observed_orcids":["https://orcid.org/0000-0002-7501-5472"]},"institutions":[{"id":"https://openalex.org/I4210095143","display_name":"Azienda Ospedaliera San Camillo-Forlanini","ror":"https://ror.org/00j707644","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210095143"]},{"id":"https://openalex.org/I4210153088","display_name":"Carlo Forlanini Hospital","ror":"https://ror.org/04z5vy146","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210153088"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Giuseppe M. Ettorre","raw_affiliation_strings":["Division of General Surgery and Liver Transplantation, S. Camillo Forlanini Hospital, Rome, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of General Surgery and Liver Transplantation, S. Camillo Forlanini Hospital, Rome, Italy","institution_ids":["https://openalex.org/I4210095143","https://openalex.org/I4210153088"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103517708","display_name":"Pasquale Ialongo","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210095143","display_name":"Azienda Ospedaliera San Camillo-Forlanini","ror":"https://ror.org/00j707644","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210095143"]},{"id":"https://openalex.org/I4210153088","display_name":"Carlo Forlanini Hospital","ror":"https://ror.org/04z5vy146","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210153088"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Pasquale Ialongo","raw_affiliation_strings":["Radiology, Camillo Forlanini Hospital, Rome, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Radiology, Camillo Forlanini Hospital, Rome, Italy","institution_ids":["https://openalex.org/I4210095143","https://openalex.org/I4210153088"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5038697021","display_name":"Rodolfo Sacco","orcid":"https://orcid.org/0000-0002-9887-7315","observed_orcids":["https://orcid.org/0000-0002-9887-7315"]},"institutions":[{"id":"https://openalex.org/I4210165410","display_name":"Azienda Ospedaliera Universitaria Pisana","ror":"https://ror.org/05xrcj819","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210165410"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Rodolfo Sacco","raw_affiliation_strings":["Liver Unit, Azienda Universitaria Pisana, Pisa, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Liver Unit, Azienda Universitaria Pisana, Pisa, Italy","institution_ids":["https://openalex.org/I4210165410"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5091721224","display_name":"Carlo Federico Perno","orcid":"https://orcid.org/0000-0002-0825-5388","observed_orcids":["https://orcid.org/0000-0002-0825-5388"]},"institutions":[{"id":"https://openalex.org/I116067653","display_name":"University of Rome Tor Vergata","ror":"https://ror.org/02p77k626","country_code":"IT","type":"education","lineage":["https://openalex.org/I116067653"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Carlo F. Perno","raw_affiliation_strings":["Department of Experimental Medicine and Surgery, University of Tor Vergata, Rome, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Experimental Medicine and Surgery, University of Tor Vergata, Rome, Italy","institution_ids":["https://openalex.org/I116067653"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5054008179","display_name":"Giorgio Barbarini","orcid":"https://orcid.org/0000-0003-2712-0259","observed_orcids":["https://orcid.org/0000-0003-2712-0259"]},"institutions":[{"id":"https://openalex.org/I4210151645","display_name":"Policlinico San Matteo Fondazione","ror":"https://ror.org/05w1q1c88","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210151645","https://openalex.org/I4210153126"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Giorgio Barbarini","raw_affiliation_strings":["Infectious Disease, IRCCS San Matteo, Pavia, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Infectious Disease, IRCCS San Matteo, Pavia, Italy","institution_ids":["https://openalex.org/I4210151645"]}]},{"author_position":"last","author":{"id":null,"display_name":"the CLEO Group","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"the CLEO Group","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":3,"institutions_distinct_count":17,"corresponding_author_ids":["https://openalex.org/A5013733969"],"corresponding_institution_ids":["https://openalex.org/I4210095143"],"apc_list":{"value":4780,"currency":"USD","value_usd":4780},"apc_paid":null,"fwci":2.3149,"has_fulltext":false,"cited_by_count":13,"citation_normalized_percentile":{"value":0.88597961,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"37","issue":"5","first_page":"653","last_page":"661"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10151","display_name":"Hepatitis C virus research","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10151","display_name":"Hepatitis C virus research","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11495","display_name":"Animal Virus Infections Studies","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1103","display_name":"Animal Science and Zoology"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10276","display_name":"Helicobacter pylori-related gastroenterology studies","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2715","display_name":"Gastroenterology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/sofosbuvir","display_name":"sofosbuvir","score":0.8479999899864197},{"id":"https://openalex.org/keywords/simeprevir","display_name":"simeprevir","score":1.0},{"id":"https://openalex.org/keywords/ribavirin","display_name":"ribavirin","score":0.996999979019165},{"id":"https://openalex.org/keywords/hcv-genotype-1","display_name":"HCV genotype 1","score":0.828000009059906},{"id":"https://openalex.org/keywords/chronic-hepatitis-c","display_name":"chronic hepatitis C","score":0.8130000233650208},{"id":"https://openalex.org/keywords/elderly-patients","display_name":"elderly patients","score":0.8960000276565552},{"id":"https://openalex.org/keywords/compensated-cirrhosis","display_name":"compensated cirrhosis","score":0.8460000157356262},{"id":"https://openalex.org/keywords/sustained-virologic-response","display_name":"sustained virological response","score":0.9570000171661377},{"id":"https://openalex.org/keywords/antiviral-efficacy","display_name":"antiviral efficacy","score":0.6370000243186951},{"id":"https://openalex.org/keywords/adverse-events","display_name":"adverse events","score":0.703000009059906},{"id":"https://openalex.org/keywords/anemia","display_name":"anemia","score":0.9750000238418579},{"id":"https://openalex.org/keywords/diabetes-comorbidity","display_name":"diabetes comorbidity","score":0.8230000138282776},{"id":"https://openalex.org/keywords/real-world-effectiveness","display_name":"real-world effectiveness","score":0.6809999942779541}],"concepts":[{"id":"https://openalex.org/C2778390639","wikidata":"https://www.wikidata.org/wiki/Q2502747","display_name":"Sofosbuvir","level":5,"score":0.9501068592071533},{"id":"https://openalex.org/C2778986448","wikidata":"https://www.wikidata.org/wiki/Q7517689","display_name":"Simeprevir","level":5,"score":0.9268219470977783},{"id":"https://openalex.org/C2780040827","wikidata":"https://www.wikidata.org/wiki/Q421862","display_name":"Ribavirin","level":4,"score":0.8326486349105835},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.7221505641937256},{"id":"https://openalex.org/C135763542","wikidata":"https://www.wikidata.org/wiki/Q106016","display_name":"Genotype","level":3,"score":0.542352020740509},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5073034167289734},{"id":"https://openalex.org/C90924648","wikidata":"https://www.wikidata.org/wiki/Q120569","display_name":"Gastroenterology","level":1,"score":0.4413440227508545},{"id":"https://openalex.org/C159047783","wikidata":"https://www.wikidata.org/wiki/Q7215","display_name":"Virology","level":1,"score":0.4058154821395874},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.33427000045776367},{"id":"https://openalex.org/C2776408679","wikidata":"https://www.wikidata.org/wiki/Q708693","display_name":"Hepatitis C virus","level":3,"score":0.13670143485069275},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.08878317475318909},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0},{"id":"https://openalex.org/C2522874641","wikidata":"https://www.wikidata.org/wiki/Q808","display_name":"Virus","level":2,"score":0.0},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000069474","descriptor_name":"Sofosbuvir","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D000069474","descriptor_name":"Sofosbuvir","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D000069616","descriptor_name":"Simeprevir","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D000069616","descriptor_name":"Simeprevir","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D000072230","descriptor_name":"Sustained Virologic Response","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000369","descriptor_name":"Aged, 80 and over","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000740","descriptor_name":"Anemia","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":false},{"descriptor_ui":"D000998","descriptor_name":"Antiviral Agents","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D000998","descriptor_name":"Antiviral Agents","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D004334","descriptor_name":"Drug Administration Schedule","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004359","descriptor_name":"Drug Therapy, Combination","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007558","descriptor_name":"Italy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008103","descriptor_name":"Liver Cirrhosis","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D008103","descriptor_name":"Liver Cirrhosis","qualifier_ui":"Q000821","qualifier_name":"virology","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012189","descriptor_name":"Retrospective Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012254","descriptor_name":"Ribavirin","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D012254","descriptor_name":"Ribavirin","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D015999","descriptor_name":"Multivariate Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016015","descriptor_name":"Logistic Models","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016174","descriptor_name":"Hepacivirus","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D019698","descriptor_name":"Hepatitis C, Chronic","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true}],"locations_count":3,"locations":[{"id":"doi:10.1111/liv.13288","doi":"https://doi.org/10.1111/liv.13288","is_oa":false,"landing_page_url":"https://doi.org/10.1111/liv.13288","pdf_url":null,"source":{"id":"https://openalex.org/S206392846","display_name":"Liver International","issn_l":"0106-9543","issn":["0106-9543","1478-3223","1478-3231","1600-0676"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Liver International","raw_type":"journal-article"},{"id":"pmid:27782373","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/27782373","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Liver international : official journal of the International Association for the Study of the Liver","raw_type":"Journal Article"},{"id":"pmh:oai:art.torvergata.it:2108/173559","doi":null,"is_oa":false,"landing_page_url":"http://hdl.handle.net/2108/173559","pdf_url":null,"source":{"id":"https://openalex.org/S4306400993","display_name":"Cineca Institutional Research Information System (Tor Vergata University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I116067653","host_organization_name":"University of Rome Tor Vergata","host_organization_lineage":["https://openalex.org/I116067653"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":1.0,"display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":25,"referenced_works":["https://openalex.org/W971519378","https://openalex.org/W1566532311","https://openalex.org/W1826210767","https://openalex.org/W1881390415","https://openalex.org/W1984640269","https://openalex.org/W2026691012","https://openalex.org/W2041186969","https://openalex.org/W2053716682","https://openalex.org/W2085070297","https://openalex.org/W2092646281","https://openalex.org/W2123899610","https://openalex.org/W2130567133","https://openalex.org/W2135121500","https://openalex.org/W2138619940","https://openalex.org/W2145933460","https://openalex.org/W2151554611","https://openalex.org/W2164466220","https://openalex.org/W2258263090","https://openalex.org/W2335913920","https://openalex.org/W2419146391","https://openalex.org/W2467713285","https://openalex.org/W2522227711","https://openalex.org/W2523313196","https://openalex.org/W2523606310","https://openalex.org/W4211051574"],"related_works":["https://openalex.org/W2536951822","https://openalex.org/W2979239398","https://openalex.org/W2522394799","https://openalex.org/W3091768989","https://openalex.org/W2888328246","https://openalex.org/W2613871620","https://openalex.org/W2598167769","https://openalex.org/W1837435324","https://openalex.org/W2535863801","https://openalex.org/W2114228887"],"abstract_inverted_index":{"BACKGROUND":[0],"&":[1],"AIMS:":[2],"The":[3,145],"proportion":[4],"of":[5,22,35,38,48,69,74,101,115,123,170],"HCV-infected":[6],"patients":[7,55,81,88,134,140,153,186],"over":[8],"age":[9],"65":[10],"years":[11,100,119,136],"in":[12,53,77,90,133,151,182],"Western":[13],"countries":[14],"is":[15],"increasing.":[16],"This":[17],"growth":[18],"and":[19,33,41,120,180],"the":[20,28,30,36,86,129],"advent":[21],"new":[23],"antiviral":[24],"therapy":[25],"bring":[26],"into":[27],"question":[29],"real-world":[31],"efficacy":[32],"safety":[34],"combination":[37],"sofosbuvir":[39],"(SOF)":[40],"simeprevir":[42],"(SMV)":[43],"plus":[44,165],"a":[45,72,155,166],"flat":[46,168],"dose":[47,169],"800":[49,172],"mg/d":[50],"ribavirin":[51],"(RBV)":[52],"elderly":[54,152,185],"with":[56,82,93,187],"cirrhosis":[57],"compared":[58,137],"to":[59,138],"younger":[60,139],"patients.":[61],"METHODS:":[62],"Retrospective":[63],"observational":[64],"multicentre":[65],"real-life":[66],"investigation":[67],"study":[68],"SOF/SMV/RBV":[70],"for":[71,174],"duration":[73],"12":[75,107,175],"weeks":[76,108,176],"HCV":[78],"genotype":[79,183],"1-infected":[80],"cirrhosis.":[83,189],"RESULTS:":[84],"Of":[85],"270":[87],"enrolled":[89],"this":[91],"study,":[92],"compensated":[94,188],"cirrhosis,":[95],"133":[96],"(49.2%)":[97],"were":[98],"\u226565":[99,125,135],"age.":[102],"Sustained":[103],"virological":[104],"response":[105],"at":[106],"(SVR12)":[109],"was":[110,128,154,177],"achieved":[111],"by":[112],"94.2%":[113],"(129/137)":[114],"those":[116,124],"aged":[117],"<65":[118],"97.7%":[121],"(130/133)":[122],"years.":[126],"Diabetes":[127],"most":[130,146],"common":[131,147],"comorbidity":[132],"(26.3%":[141],"vs":[142,160],"12.4%":[143],"P<.003).":[144],"adverse":[148],"event":[149],"(AE)":[150],"grade":[156],"2":[157],"anaemia":[158],"(35.3%":[159],"19.9%":[161],"P<.004).":[162],"CONCLUSIONS:":[163],"Sofosbuvir/simeprevir":[164],"daily":[167],"RBV":[171],"mg":[173],"highly":[178],"effective":[179],"safe":[181],"1":[184]},"counts_by_year":[{"year":2022,"cited_by_count":1},{"year":2019,"cited_by_count":3},{"year":2018,"cited_by_count":3},{"year":2017,"cited_by_count":5},{"year":2016,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-11-04T00:00:00"}
