{"id":"https://openalex.org/W2541664147","doi":"https://doi.org/10.1038/srep36179","title":"Global functional profiling of human ubiquitome identifies E3 ubiquitin ligase DCST1 as a novel negative regulator of Type-I interferon signaling","display_name":"Global functional profiling of human ubiquitome identifies E3 ubiquitin ligase DCST1 as a novel negative regulator of Type-I interferon signaling","publication_year":2016,"publication_date":"2016-10-26","ids":{"openalex":"https://openalex.org/W2541664147","doi":"https://doi.org/10.1038/srep36179","mag":"2541664147","pmid":"https://pubmed.ncbi.nlm.nih.gov/27782195","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/5080589"},"language":"en","primary_location":{"id":"doi:10.1038/srep36179","doi":"https://doi.org/10.1038/srep36179","is_oa":true,"landing_page_url":"https://doi.org/10.1038/srep36179","pdf_url":"https://www.nature.com/articles/srep36179.pdf","source":{"id":"https://openalex.org/S196734849","display_name":"Scientific Reports","issn_l":"2045-2322","issn":["2045-2322"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Scientific Reports","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.nature.com/articles/srep36179.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5012915269","display_name":"Sajith Nair","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210126319","display_name":"Duke-NUS Medical School","ror":"https://ror.org/02j1m6098","country_code":"SG","type":"education","lineage":["https://openalex.org/I165932596","https://openalex.org/I170897317","https://openalex.org/I4210126319"]}],"countries":["SG"],"is_corresponding":false,"raw_author_name":"Sajith Nair","raw_affiliation_strings":["Program in Emerging Infectious Diseases, Duke-NUS Medical School, 169857, Singapore"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Program in Emerging Infectious Diseases, Duke-NUS Medical School, 169857, Singapore","institution_ids":["https://openalex.org/I4210126319"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5034519667","display_name":"Pradeep Bist","orcid":"https://orcid.org/0000-0001-6163-9105","observed_orcids":["https://orcid.org/0000-0001-6163-9105","https://orcid.org/0000-0003-0662-4626"]},"institutions":[{"id":"https://openalex.org/I4210126319","display_name":"Duke-NUS Medical School","ror":"https://ror.org/02j1m6098","country_code":"SG","type":"education","lineage":["https://openalex.org/I165932596","https://openalex.org/I170897317","https://openalex.org/I4210126319"]}],"countries":["SG"],"is_corresponding":false,"raw_author_name":"Pradeep Bist","raw_affiliation_strings":["Program in Emerging Infectious Diseases, Duke-NUS Medical School, 169857, Singapore"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Program in Emerging Infectious Diseases, Duke-NUS Medical School, 169857, Singapore","institution_ids":["https://openalex.org/I4210126319"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5035280920","display_name":"Neha Dikshit","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210126319","display_name":"Duke-NUS Medical School","ror":"https://ror.org/02j1m6098","country_code":"SG","type":"education","lineage":["https://openalex.org/I165932596","https://openalex.org/I170897317","https://openalex.org/I4210126319"]}],"countries":["SG"],"is_corresponding":false,"raw_author_name":"Neha Dikshit","raw_affiliation_strings":["Program in Emerging Infectious Diseases, Duke-NUS Medical School, 169857, Singapore"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Program in Emerging Infectious Diseases, Duke-NUS Medical School, 169857, Singapore","institution_ids":["https://openalex.org/I4210126319"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5075664574","display_name":"Manoj N. Krishnan","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210126319","display_name":"Duke-NUS Medical School","ror":"https://ror.org/02j1m6098","country_code":"SG","type":"education","lineage":["https://openalex.org/I165932596","https://openalex.org/I170897317","https://openalex.org/I4210126319"]}],"countries":["SG"],"is_corresponding":true,"raw_author_name":"Manoj N Krishnan","raw_affiliation_strings":["Program in Emerging Infectious Diseases, Duke-NUS Medical School, 169857, Singapore"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Program in Emerging Infectious Diseases, Duke-NUS Medical School, 169857, Singapore","institution_ids":["https://openalex.org/I4210126319"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5075664574"],"corresponding_institution_ids":["https://openalex.org/I4210126319"],"apc_list":{"value":2690,"currency":"USD","value_usd":2690},"apc_paid":{"value":2690,"currency":"USD","value_usd":2690},"fwci":0.8212,"has_fulltext":true,"cited_by_count":24,"citation_normalized_percentile":{"value":0.7175725,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":98},"biblio":{"volume":"6","issue":"1","first_page":"36179","last_page":"36179"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11668","display_name":"interferon and immune responses","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11668","display_name":"interferon and immune responses","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11041","display_name":"Ubiquitin and proteasome pathways","score":0.0007999999797903001,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11503","display_name":"Cytokine Signaling Pathways and Interactions","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/e3-ubiquitin-ligase","display_name":"E3 ubiquitin ligase","score":0.9649999737739563},{"id":"https://openalex.org/keywords/type-i-interferon-signaling","display_name":"type I interferon signaling","score":0.8240000009536743},{"id":"https://openalex.org/keywords/interferon-beta","display_name":"interferon-beta","score":0.7919999957084656},{"id":"https://openalex.org/keywords/interferon-stimulated-genes","display_name":"interferon-stimulated genes","score":0.7549999952316284},{"id":"https://openalex.org/keywords/innate-immunity","display_name":"innate immunity","score":0.6150000095367432}],"concepts":[{"id":"https://openalex.org/C134459356","wikidata":"https://www.wikidata.org/wiki/Q4274835","display_name":"Ubiquitin ligase","level":4,"score":0.8332629799842834},{"id":"https://openalex.org/C2776178377","wikidata":"https://www.wikidata.org/wiki/Q188269","display_name":"Interferon","level":2,"score":0.7456453442573547},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.735466718673706},{"id":"https://openalex.org/C97037327","wikidata":"https://www.wikidata.org/wiki/Q5334291","display_name":"Ectopic expression","level":3,"score":0.7342483401298523},{"id":"https://openalex.org/C25602115","wikidata":"https://www.wikidata.org/wiki/Q407111","display_name":"Ubiquitin","level":3,"score":0.7244611978530884},{"id":"https://openalex.org/C2778278966","wikidata":"https://www.wikidata.org/wiki/Q6046488","display_name":"Interferon type I","level":3,"score":0.5090298652648926},{"id":"https://openalex.org/C9173399","wikidata":"https://www.wikidata.org/wiki/Q6046461","display_name":"Interferon regulatory factors","level":4,"score":0.4755798876285553},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.44363996386528015},{"id":"https://openalex.org/C119056186","wikidata":"https://www.wikidata.org/wiki/Q1431332","display_name":"Gene silencing","level":3,"score":0.43054574728012085},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.42922842502593994},{"id":"https://openalex.org/C161733203","wikidata":"https://www.wikidata.org/wiki/Q911828","display_name":"Reporter gene","level":4,"score":0.4243174195289612},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.40777093172073364},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.28154832124710083},{"id":"https://openalex.org/C86339819","wikidata":"https://www.wikidata.org/wiki/Q407384","display_name":"Transcription factor","level":3,"score":0.16144219040870667}],"mesh":[{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007370","descriptor_name":"Interferon Type I","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D014158","descriptor_name":"Transcription, Genetic","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016899","descriptor_name":"Interferon-beta","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D017930","descriptor_name":"Genes, Reporter","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D034622","descriptor_name":"RNA Interference","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D034741","descriptor_name":"RNA, Small Interfering","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D044767","descriptor_name":"Ubiquitin-Protein Ligases","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":false},{"descriptor_ui":"D044767","descriptor_name":"Ubiquitin-Protein Ligases","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D044767","descriptor_name":"Ubiquitin-Protein Ligases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D050795","descriptor_name":"STAT2 Transcription Factor","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D050835","descriptor_name":"Interferon Regulatory Factors","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D050835","descriptor_name":"Interferon Regulatory Factors","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D057149","descriptor_name":"Ubiquitinated Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D057149","descriptor_name":"Ubiquitinated Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D057809","descriptor_name":"HEK293 Cells","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":5,"locations":[{"id":"doi:10.1038/srep36179","doi":"https://doi.org/10.1038/srep36179","is_oa":true,"landing_page_url":"https://doi.org/10.1038/srep36179","pdf_url":"https://www.nature.com/articles/srep36179.pdf","source":{"id":"https://openalex.org/S196734849","display_name":"Scientific Reports","issn_l":"2045-2322","issn":["2045-2322"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Scientific Reports","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:4042552","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/5080589","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:5080589","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/5080589","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Sci Rep","raw_type":"Text"},{"id":"pmid:27782195","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/27782195","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Scientific reports","raw_type":"Journal Article"},{"id":"pmh:oai:scholarbank.nus.edu.sg:10635/174924","doi":null,"is_oa":false,"landing_page_url":"https://scholarbank.nus.edu.sg/handle/10635/174924","pdf_url":null,"source":{"id":"https://openalex.org/S7407052290","display_name":"National University of Singapore","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Unpaywall 20200831","raw_type":"Article"}],"best_oa_location":{"id":"doi:10.1038/srep36179","doi":"https://doi.org/10.1038/srep36179","is_oa":true,"landing_page_url":"https://doi.org/10.1038/srep36179","pdf_url":"https://www.nature.com/articles/srep36179.pdf","source":{"id":"https://openalex.org/S196734849","display_name":"Scientific Reports","issn_l":"2045-2322","issn":["2045-2322"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Scientific Reports","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.8371999859809875,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320320671","display_name":"National Research Foundation","ror":"https://ror.org/05s0g1g46"},{"id":"https://openalex.org/F4320320709","display_name":"National Research Foundation Singapore","ror":"https://ror.org/03cpyc314"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2541664147.pdf","grobid_xml":"https://content.openalex.org/works/W2541664147.grobid-xml"},"referenced_works_count":31,"referenced_works":["https://openalex.org/W1965398762","https://openalex.org/W1979448464","https://openalex.org/W1983630074","https://openalex.org/W1986838525","https://openalex.org/W1998041119","https://openalex.org/W2008123904","https://openalex.org/W2013279950","https://openalex.org/W2030739472","https://openalex.org/W2035129369","https://openalex.org/W2035509260","https://openalex.org/W2037216541","https://openalex.org/W2040665228","https://openalex.org/W2060418262","https://openalex.org/W2066691052","https://openalex.org/W2068294387","https://openalex.org/W2071829053","https://openalex.org/W2075256922","https://openalex.org/W2076425088","https://openalex.org/W2080587505","https://openalex.org/W2082429447","https://openalex.org/W2102555756","https://openalex.org/W2122974612","https://openalex.org/W2140700343","https://openalex.org/W2147511779","https://openalex.org/W2148690764","https://openalex.org/W2148810559","https://openalex.org/W2153859803","https://openalex.org/W2160258147","https://openalex.org/W2161759826","https://openalex.org/W2162638357","https://openalex.org/W2163158328"],"related_works":["https://openalex.org/W3097267158","https://openalex.org/W1997379466","https://openalex.org/W4376872226","https://openalex.org/W1771741017","https://openalex.org/W2161759826","https://openalex.org/W3205400438","https://openalex.org/W7071893990","https://openalex.org/W4401905262","https://openalex.org/W2536412587","https://openalex.org/W2596272607"],"abstract_inverted_index":{"Type":[0,154,192],"I":[1,155,193],"interferon":[2,16,41,95,121,136,156,194],"(IFN-I)":[3],"mediated":[4,42,92],"innate":[5],"immune":[6,26],"response":[7,98],"controls":[8],"virus":[9],"infections":[10],"by":[11,158],"inducing":[12],"the":[13,34,54,70,83,111,184],"expression":[14,58,139],"of":[15,33,36,53,56,59,76,94,110,120,143,165,170,186],"stimulated":[17,96],"genes":[18,80,109,190],"(ISGs).":[19],"Although":[20],"ubiquitination":[21,78,188],"plays":[22],"key":[23],"roles":[24],"in":[25,40,69,82,191],"signaling":[27,122,157],"regulation,":[28],"a":[29,50,129,179],"human":[30,71,84,112,187],"genome-wide":[31,51],"understanding":[32],"role":[35,185],"E3":[37,61,131],"ubiquitin":[38,62,132],"ligases":[39,63],"ISG":[43],"induction":[44,93],"is":[45],"lacking.":[46],"Here,":[47],"we":[48,125],"report":[49],"profiling":[52],"effect":[55],"ectopic":[57],"521":[60],"and":[64,107,117,140,147,161],"substrate":[65],"recognition":[66],"subunits":[67],"encoded":[68,81],"genome":[72],"(which":[73],"constitutes":[74],"84.4%":[75],"all":[77],"related":[79],"genome,":[85],"hereafter":[86],"termed":[87],"Human":[88],"Ubiquitome)":[89],"on":[90,183],"IFN\u03b2":[91],"DNA":[97],"element":[99],"(ISRE)":[100],"driven":[101],"reporter":[102,150],"activity.":[103,151],"We":[104],"identified":[105],"96":[106],"42":[108],"ubiquitome":[113],"as":[114,128],"novel":[115,130],"negative":[116],"positive":[118],"regulators":[119],"respectively.":[123],"Furthermore,":[124],"characterized":[126],"DCST1":[127,144,152],"ligase":[133],"negatively":[134],"regulating":[135],"response.":[137,195],"Ectopic":[138],"gene":[141,172],"silencing":[142],"respectively":[145],"attenuated":[146],"increased":[148],"ISRE":[149],"regulated":[153],"interacting":[159],"with":[160],"promoting":[162],"ubiquitination-mediated":[163],"degradation":[164],"STAT2,":[166],"an":[167],"essential":[168],"component":[169],"antiviral":[171],"induction.":[173],"In":[174],"summary,":[175],"this":[176],"study":[177],"provided":[178],"systems":[180],"level":[181],"view":[182],"associated":[189]},"counts_by_year":[{"year":2026,"cited_by_count":4},{"year":2025,"cited_by_count":3},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":3},{"year":2022,"cited_by_count":3},{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":3},{"year":2019,"cited_by_count":3},{"year":2018,"cited_by_count":2}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-11-04T00:00:00"}