{"id":"https://openalex.org/W2541387378","doi":null,"title":"Chronic Swim Stress Attenuates Endocrine Response and Improves Cardiac Function in Mice Lacking the Angiotensin II Type 1a Receptor","display_name":"Chronic Swim Stress Attenuates Endocrine Response and Improves Cardiac Function in Mice Lacking the Angiotensin II Type 1a Receptor","publication_year":2013,"publication_date":"2013-01-01","ids":{"openalex":"https://openalex.org/W2541387378","mag":"2541387378"},"language":"en","primary_location":{"id":"pmh:oai:etd.ohiolink.edu:wright1389108988","doi":null,"is_oa":true,"landing_page_url":"http://rave.ohiolink.edu/etdc/view?acc_num=wright1389108988","pdf_url":"https://etd.ohiolink.edu/acprod/odb_etd/ws/send_file/send?accession=wright1389108988&disposition=inline","source":{"id":"https://openalex.org/S4377196344","display_name":"OhioLink ETD Center (Ohio Library and Information Network)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210155183","host_organization_name":"Ohio Library and Information Network","host_organization_lineage":["https://openalex.org/I4210155183"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"http://rave.ohiolink.edu/etdc/view?acc_num=wright1389108988","raw_type":"text"},"volume":null,"type":"article","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://etd.ohiolink.edu/acprod/odb_etd/ws/send_file/send?accession=wright1389108988&disposition=inline","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5041380531","display_name":"Najat Khalifa Almahroug","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Najat Khalifa Almahroug","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5041380531"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11001","display_name":"Renin-Angiotensin System Studies","score":0.9810000061988831,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11001","display_name":"Renin-Angiotensin System Studies","score":0.9810000061988831,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11209","display_name":"Cardiovascular and exercise physiology","score":0.008299999870359898,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10529","display_name":"Stress Responses and Cortisol","score":0.0027000000700354576,"subfield":{"id":"https://openalex.org/subfields/2802","display_name":"Behavioral Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/angiotensin-ii-type-1a-receptor","display_name":"angiotensin II type 1a receptor","score":0.9470000267028809},{"id":"https://openalex.org/keywords/exercise-stress","display_name":"exercise stress","score":0.7710000276565552},{"id":"https://openalex.org/keywords/corticosterone","display_name":"corticosterone","score":0.8690000176429749},{"id":"https://openalex.org/keywords/adrenal-stress-response","display_name":"adrenal stress response","score":0.7860000133514404},{"id":"https://openalex.org/keywords/catecholamines","display_name":"catecholamines","score":0.972000002861023},{"id":"https://openalex.org/keywords/cardiac-function","display_name":"cardiac function","score":0.8140000104904175},{"id":"https://openalex.org/keywords/ejection-fraction","display_name":"ejection fraction","score":0.9129999876022339},{"id":"https://openalex.org/keywords/mitral-valve-function","display_name":"mitral valve function","score":0.8460000157356262},{"id":"https://openalex.org/keywords/cardiac-remodeling","display_name":"cardiac remodeling","score":0.8069999814033508},{"id":"https://openalex.org/keywords/norepinephrine","display_name":"norepinephrine","score":0.75},{"id":"https://openalex.org/keywords/epinephrine","display_name":"epinephrine","score":0.9959999918937683}],"concepts":[{"id":"https://openalex.org/C2908929049","wikidata":"https://www.wikidata.org/wiki/Q65963433","display_name":"Angiotensin II","level":3,"score":0.7354515194892883},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.5868896245956421},{"id":"https://openalex.org/C46699223","wikidata":"https://www.wikidata.org/wiki/Q11078","display_name":"Endocrine system","level":3,"score":0.5453883409500122},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5319621562957764},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.5215303897857666},{"id":"https://openalex.org/C198710026","wikidata":"https://www.wikidata.org/wiki/Q898218","display_name":"Renin\u2013angiotensin system","level":3,"score":0.44521716237068176},{"id":"https://openalex.org/C111566952","wikidata":"https://www.wikidata.org/wiki/Q1303462","display_name":"Cardiac function curve","level":3,"score":0.42324453592300415},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.41985538601875305},{"id":"https://openalex.org/C78604142","wikidata":"https://www.wikidata.org/wiki/Q1640582","display_name":"Fight-or-flight response","level":3,"score":0.4195810854434967},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.36868780851364136},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.35965535044670105},{"id":"https://openalex.org/C2778198053","wikidata":"https://www.wikidata.org/wiki/Q181754","display_name":"Heart failure","level":2,"score":0.1962416172027588},{"id":"https://openalex.org/C71315377","wikidata":"https://www.wikidata.org/wiki/Q11364","display_name":"Hormone","level":2,"score":0.19143584370613098},{"id":"https://openalex.org/C84393581","wikidata":"https://www.wikidata.org/wiki/Q82642","display_name":"Blood pressure","level":2,"score":0.08329391479492188},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.08095663785934448},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0}],"mesh":[],"locations_count":3,"locations":[{"id":"pmh:oai:etd.ohiolink.edu:wright1389108988","doi":null,"is_oa":true,"landing_page_url":"http://rave.ohiolink.edu/etdc/view?acc_num=wright1389108988","pdf_url":"https://etd.ohiolink.edu/acprod/odb_etd/ws/send_file/send?accession=wright1389108988&disposition=inline","source":{"id":"https://openalex.org/S4377196344","display_name":"OhioLink ETD Center (Ohio Library and Information Network)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210155183","host_organization_name":"Ohio Library and Information Network","host_organization_lineage":["https://openalex.org/I4210155183"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"http://rave.ohiolink.edu/etdc/view?acc_num=wright1389108988","raw_type":"text"},{"id":"pmh:oai:corescholar.libraries.wright.edu:etd_all-2297","doi":null,"is_oa":false,"landing_page_url":"https://corescholar.libraries.wright.edu/etd_all/1158","pdf_url":null,"source":{"id":"https://openalex.org/S2737205702","display_name":"Journal of Bioresource Management","issn_l":"2309-3854","issn":["2309-3854"],"is_oa":false,"is_in_doaj":true,"is_core":false,"listed_in":["doaj","erih-plus"],"host_organization":"https://openalex.org/P4310316536","host_organization_name":"Bioresource Research Center (BRC), Islamabad","host_organization_lineage":["https://openalex.org/P4310316536"],"host_organization_lineage_names":["Bioresource Research Center (BRC), Islamabad"],"type":"journal"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Browse all Theses and Dissertations","raw_type":"text"},{"id":"mag:2541387378","doi":null,"is_oa":false,"landing_page_url":"https://corescholar.libraries.wright.edu/cgi/viewcontent.cgi?article=2297&context=etd_all","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":{"id":"pmh:oai:etd.ohiolink.edu:wright1389108988","doi":null,"is_oa":true,"landing_page_url":"http://rave.ohiolink.edu/etdc/view?acc_num=wright1389108988","pdf_url":"https://etd.ohiolink.edu/acprod/odb_etd/ws/send_file/send?accession=wright1389108988&disposition=inline","source":{"id":"https://openalex.org/S4377196344","display_name":"OhioLink ETD Center (Ohio Library and Information Network)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210155183","host_organization_name":"Ohio Library and Information Network","host_organization_lineage":["https://openalex.org/I4210155183"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"http://rave.ohiolink.edu/etdc/view?acc_num=wright1389108988","raw_type":"text"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9391000270843506,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2541387378.pdf","grobid_xml":"https://content.openalex.org/works/W2541387378.grobid-xml"},"referenced_works_count":104,"referenced_works":["https://openalex.org/W23462658","https://openalex.org/W67673880","https://openalex.org/W143205812","https://openalex.org/W1492984283","https://openalex.org/W1508148070","https://openalex.org/W1527240164","https://openalex.org/W1555308783","https://openalex.org/W1558224624","https://openalex.org/W1560543947","https://openalex.org/W1590013808","https://openalex.org/W1677147117","https://openalex.org/W1760461988","https://openalex.org/W1844072728","https://openalex.org/W1951287031","https://openalex.org/W1965539898","https://openalex.org/W1968000956","https://openalex.org/W1968874083","https://openalex.org/W1969412681","https://openalex.org/W1970388701","https://openalex.org/W1976317014","https://openalex.org/W1977152294","https://openalex.org/W1978387124","https://openalex.org/W1979058873","https://openalex.org/W1980258438","https://openalex.org/W1980533762","https://openalex.org/W1981281207","https://openalex.org/W1984247780","https://openalex.org/W1985671788","https://openalex.org/W1986221824","https://openalex.org/W1990152014","https://openalex.org/W1996824977","https://openalex.org/W1997973024","https://openalex.org/W1998071719","https://openalex.org/W2005998322","https://openalex.org/W2007937331","https://openalex.org/W2010210915","https://openalex.org/W2011393212","https://openalex.org/W2011780678","https://openalex.org/W2015230257","https://openalex.org/W2015853734","https://openalex.org/W2016990929","https://openalex.org/W2028664377","https://openalex.org/W2032441070","https://openalex.org/W2038329905","https://openalex.org/W2041299165","https://openalex.org/W2044635352","https://openalex.org/W2045619262","https://openalex.org/W2055488359","https://openalex.org/W2058713776","https://openalex.org/W2059565963","https://openalex.org/W2064098156","https://openalex.org/W2064327398","https://openalex.org/W2074645772","https://openalex.org/W2076486455","https://openalex.org/W2077051208","https://openalex.org/W2079616283","https://openalex.org/W2081088335","https://openalex.org/W2085033522","https://openalex.org/W2085405463","https://openalex.org/W2086041680","https://openalex.org/W2090433981","https://openalex.org/W2091715626","https://openalex.org/W2092398829","https://openalex.org/W2093455663","https://openalex.org/W2095364526","https://openalex.org/W2096682768","https://openalex.org/W2097489256","https://openalex.org/W2098347568","https://openalex.org/W2098948935","https://openalex.org/W2100767767","https://openalex.org/W2102554866","https://openalex.org/W2104077271","https://openalex.org/W2113554954","https://openalex.org/W2113978616","https://openalex.org/W2115600048","https://openalex.org/W2117630260","https://openalex.org/W2118315968","https://openalex.org/W2121497015","https://openalex.org/W2126420467","https://openalex.org/W2131177152","https://openalex.org/W2132165603","https://openalex.org/W2134074925","https://openalex.org/W2134899427","https://openalex.org/W2137510773","https://openalex.org/W2144101679","https://openalex.org/W2145879452","https://openalex.org/W2151464048","https://openalex.org/W2153567878","https://openalex.org/W2153874499","https://openalex.org/W2161978326","https://openalex.org/W2166351086","https://openalex.org/W2168052680","https://openalex.org/W2168675611","https://openalex.org/W2180153357","https://openalex.org/W2209434885","https://openalex.org/W2210271034","https://openalex.org/W2223421358","https://openalex.org/W2228790936","https://openalex.org/W2334787351","https://openalex.org/W2399357669","https://openalex.org/W2418766746","https://openalex.org/W2472735866","https://openalex.org/W2531403977","https://openalex.org/W2623448807"],"related_works":["https://openalex.org/W3174414895","https://openalex.org/W2510373438","https://openalex.org/W4415262353","https://openalex.org/W3135757787","https://openalex.org/W2980974239","https://openalex.org/W2623448807","https://openalex.org/W4412016894","https://openalex.org/W2608456419","https://openalex.org/W2979108532","https://openalex.org/W7120465497"],"abstract_inverted_index":{"Chronic":[0],"Swim":[1],"Stress":[2],"Attenuates":[3],"Endocrine":[4],"Response":[5],"and":[6,32,64,116,127,143,147,150,161,194,260,266,268,313],"Improves":[7],"Cardiac":[8],"Function":[9],"in":[10,29,96,192,218,246,258,272,285,301],"Mice":[11],"Lacking":[12],"the":[13,40,81,106,210,223,228,244,247,264],"Angiotensin":[14],"AT1a":[15,124],"Receptor.Stress":[16],"is":[17,37,323],"a":[18,93,111,279,297],"stimulus":[19],"that":[20,44,187,233,252],"causes":[21],"an":[22,324],"often":[23],"abrupt":[24],"but":[25,90],"always":[26],"large":[27],"change":[28],"autonomic":[30],"activity":[31],"hormone":[33,78],"secretion.Angiotensin":[34],"II":[35],"(AngII)":[36],"one":[38],"of":[39,51,67,73,83,100,108,292,327],"main":[41],"neurohormonal":[42],"mediators":[43],"are":[45],"stimulated":[46],"by":[47,167,183],"stress.AngII":[48],"mediates":[49],"most":[50],"its":[52],"relevant":[53],"biological":[54],"effects":[55],"via":[56],"AngII":[57,68],"type1":[58],"receptor":[59,112],"(AT1R)":[60],"activation.Stress":[61],"increases":[62],"tissue":[63],"circulating":[65],"levels":[66],"which":[69],"contributes":[70],"to":[71,104,198,207,213,227,243,276,305,318],"stimulation":[72],"adrenal":[74,115,315],"AT1R,":[75],"mediating":[76],"stressinduced":[77],"release.AngII":[79],"through":[80],"activation":[82],"AT1R":[84],"not":[85],"only":[86],"elevates":[87],"blood":[88],"pressure":[89,174],"also":[91,231],"has":[92],"patho-physiological":[94],"relevance":[95],"cardiac":[97,117,311,330],"remodeling.The":[98],"goal":[99],"this":[101],"study":[102],"was":[103,153,181,190,205],"assess":[105],"influence":[107],"AT1":[109],"subtype":[110],"(AT1aR)":[113],"on":[114],"function":[118,180,295],"during":[119,332],"chronic":[120,319],"swim":[121],"stress.Adult":[122],"male":[123],"knockout":[125],"(KO)":[126],"wild":[128],"type":[129],"(WT)":[130],"mice":[131,308],"(n=":[132],"6":[133],"per":[134],"group)":[135],"were":[136,139,165,170,254],"used;":[137],"groups":[138,200],"exercise":[140,144,214,333],"KO":[141,149],"(KOEX)":[142],"WT":[145],"(WTEX)":[146],"control":[148,199],"WT.Exercise":[151],"paradigm":[152],"swimming,":[154],"1":[155],"hour":[156],"3d/wk":[157],"for":[158],"7":[159],"weeks.Urine":[160],"plasma":[162,188],"corticosterone":[163],"(CORT)":[164],"measured":[166,171],"radioimmunoassay.Urinary":[168],"catecholamines":[169,249],"using":[172],"high":[173],"liquid":[175],"chromatography":[176],"with":[177],"electrochemical":[178],"detection.Cardiac":[179],"assessed":[182],"echocardiography":[184],"(Echo).Results":[185],"showed":[186,232,278,296,309],"CORT":[189,204,216,238],"lower":[191,236],"KOEX":[193,219,234,265,273,286,302],"WTEX":[195,289],"as":[196,241,274,303],"compared":[197,226,242,275,304],"(3":[201],"fold":[202],"decreases).Urinary":[203],"used":[206],"iv":[208],"show":[209],"dynamic":[211],"response":[212,312,317],"stress.Urinary":[215],"decreased":[217],"after":[220],"2hour":[221],"from":[222],"swimming":[224],"session":[225],"WTEX.These":[229],"data":[230],"had":[235],"urinary":[237],"at":[239],"baseline":[240,245],"WTEX.Urinary":[248],"results":[250],"indicate":[251],"there":[253],"no":[255],"significant":[256],"differences":[257],"Norepinephrine":[259],"Epinephrine":[261],"responses":[262],"between":[263],"WTEX.Distance":[267],"Velocity":[269],"significantly":[270],"increased":[271],"WTEX.Echo":[277],"higher":[280,298],"ejection":[281],"fraction":[282],"(EF":[283],"%)":[284],"(75%)":[287],"vs.":[288],"(55":[290],"%).Assessment":[291],"mitral":[293],"valve":[294],"A-wave":[299],"velocity":[300],"WTEX.AT1a":[306],"deficient":[307],"improved":[310],"reduced":[314],"stress":[316,328],"exercise.In":[320],"conclusion,":[321],"AT1aR":[322],"important":[325],"mediator":[326],"induced":[329],"dysfunction":[331],"training.":[334]},"counts_by_year":[],"updated_date":"2026-11-06T12:05:46.655746","created_date":"2016-11-04T00:00:00"}
