{"id":"https://openalex.org/W25413856","doi":null,"title":"Monophosphoryl lipid A as a prophylactic for sepsis and septic shock.","display_name":"Monophosphoryl lipid A as a prophylactic for sepsis and septic shock.","publication_year":1995,"publication_date":"1995-01-01","ids":{"openalex":"https://openalex.org/W25413856","mag":"25413856","pmid":"https://pubmed.ncbi.nlm.nih.gov/8524964"},"language":"en","primary_location":{"id":"pmid:8524964","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/8524964","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Progress in clinical and biological research","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5071105971","display_name":"G L Gustafson","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"G L Gustafson","raw_affiliation_strings":["Ribi ImmunoChem Research, Inc., Hamilton, MT 59840, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Ribi ImmunoChem Research, Inc., Hamilton, MT 59840, USA","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108556044","display_name":"Michael J. Rhodes","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"M J Rhodes","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5058356369","display_name":"T Hegel","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"T Hegel","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":1.3397,"has_fulltext":false,"cited_by_count":29,"citation_normalized_percentile":{"value":0.79524398,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":93},"biblio":{"volume":"392","issue":null,"first_page":"567","last_page":"79"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10218","display_name":"Sepsis Diagnosis and Treatment","score":0.6660000085830688,"subfield":{"id":"https://openalex.org/subfields/2706","display_name":"Critical Care and Intensive Care Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10218","display_name":"Sepsis Diagnosis and Treatment","score":0.6660000085830688,"subfield":{"id":"https://openalex.org/subfields/2706","display_name":"Critical Care and Intensive Care Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10371","display_name":"Immune Response and Inflammation","score":0.32420000433921814,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T13410","display_name":"Immune responses and vaccinations","score":0.0017999999690800905,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/monophosphoryl-lipid-a","display_name":"monophosphoryl lipid A","score":1.0},{"id":"https://openalex.org/keywords/sepsis","display_name":"sepsis","score":0.7850000262260437},{"id":"https://openalex.org/keywords/septic-shock","display_name":"septic shock","score":0.9959999918937683},{"id":"https://openalex.org/keywords/endotoxin-tolerance","display_name":"endotoxin tolerance","score":0.9020000100135803},{"id":"https://openalex.org/keywords/tnf-alpha","display_name":"TNF-\u03b1","score":0.7870000004768372},{"id":"https://openalex.org/keywords/interferon-gamma","display_name":"interferon-gamma","score":0.9679999947547913},{"id":"https://openalex.org/keywords/nitric-oxide","display_name":"nitric oxide","score":0.7789999842643738},{"id":"https://openalex.org/keywords/macrophages","display_name":"macrophages","score":0.6159999966621399},{"id":"https://openalex.org/keywords/hepatocytes","display_name":"hepatocytes","score":0.6859999895095825},{"id":"https://openalex.org/keywords/immunostimulants","display_name":"immunostimulants","score":0.6370000243186951},{"id":"https://openalex.org/keywords/cytokine-response","display_name":"cytokine response","score":0.3709999918937683},{"id":"https://openalex.org/keywords/gram-negative-bacteria","display_name":"Gram-negative bacteria","score":0.531000018119812},{"id":"https://openalex.org/keywords/gram-positive-bacteria","display_name":"Gram-positive bacteria","score":0.9160000085830688}],"concepts":[{"id":"https://openalex.org/C144464004","wikidata":"https://www.wikidata.org/wiki/Q3077338","display_name":"Lipid A","level":3,"score":0.6522399187088013},{"id":"https://openalex.org/C2778384902","wikidata":"https://www.wikidata.org/wiki/Q183134","display_name":"Sepsis","level":2,"score":0.6051292419433594},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.6021435856819153},{"id":"https://openalex.org/C2781264782","wikidata":"https://www.wikidata.org/wiki/Q901656","display_name":"Immunostimulant","level":3,"score":0.6013123989105225},{"id":"https://openalex.org/C2777628635","wikidata":"https://www.wikidata.org/wiki/Q1765564","display_name":"Septic shock","level":3,"score":0.5679609775543213},{"id":"https://openalex.org/C2778754761","wikidata":"https://www.wikidata.org/wiki/Q421804","display_name":"Lipopolysaccharide","level":2,"score":0.5469101667404175},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.503065288066864},{"id":"https://openalex.org/C17991360","wikidata":"https://www.wikidata.org/wiki/Q21173843","display_name":"Tumor necrosis factor alpha","level":2,"score":0.47841840982437134},{"id":"https://openalex.org/C519581460","wikidata":"https://www.wikidata.org/wiki/Q207843","display_name":"Nitric oxide","level":2,"score":0.4531087279319763},{"id":"https://openalex.org/C2778690821","wikidata":"https://www.wikidata.org/wiki/Q212354","display_name":"Cytokine","level":2,"score":0.41460278630256653},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.4121731221675873},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.38878142833709717},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.1409488320350647}],"mesh":[{"descriptor_ui":"D000276","descriptor_name":"Adjuvants, Immunologic","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004195","descriptor_name":"Disease Models, Animal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007371","descriptor_name":"Interferon-gamma","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D008050","descriptor_name":"Lipid A","qualifier_ui":"Q000031","qualifier_name":"analogs & derivatives","is_major_topic":true},{"descriptor_ui":"D008050","descriptor_name":"Lipid A","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D008070","descriptor_name":"Lipopolysaccharides","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":false},{"descriptor_ui":"D008070","descriptor_name":"Lipopolysaccharides","qualifier_ui":"Q000633","qualifier_name":"toxicity","is_major_topic":false},{"descriptor_ui":"D008099","descriptor_name":"Liver","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D008099","descriptor_name":"Liver","qualifier_ui":"Q000293","qualifier_name":"injuries","is_major_topic":false},{"descriptor_ui":"D008813","descriptor_name":"Mice, Inbred ICR","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012772","descriptor_name":"Shock, Septic","qualifier_ui":"Q000517","qualifier_name":"prevention & control","is_major_topic":true},{"descriptor_ui":"D014409","descriptor_name":"Tumor Necrosis Factor-alpha","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D017737","descriptor_name":"Macrophages, Peritoneal","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D017737","descriptor_name":"Macrophages, Peritoneal","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D017942","descriptor_name":"Nitric Acid","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D018805","descriptor_name":"Sepsis","qualifier_ui":"Q000517","qualifier_name":"prevention & control","is_major_topic":true},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"pmid:8524964","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/8524964","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Progress in clinical and biological research","raw_type":"Journal Article"},{"id":"mag:25413856","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/8524964","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.98580002784729,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":51,"referenced_works":["https://openalex.org/W1967804852","https://openalex.org/W2044290191","https://openalex.org/W2031333737","https://openalex.org/W1975912702","https://openalex.org/W2090237658","https://openalex.org/W1996585845","https://openalex.org/W1969457012","https://openalex.org/W2099481084","https://openalex.org/W2127205378","https://openalex.org/W2115187947","https://openalex.org/W2335507038","https://openalex.org/W2155750393","https://openalex.org/W2951174548","https://openalex.org/W2080819340","https://openalex.org/W2004584323","https://openalex.org/W2128372719","https://openalex.org/W2031016462","https://openalex.org/W2142609481","https://openalex.org/W2044676806","https://openalex.org/W2101979321","https://openalex.org/W1989886111","https://openalex.org/W2036729665","https://openalex.org/W2012625165","https://openalex.org/W2012958102","https://openalex.org/W2042925728","https://openalex.org/W2055464117","https://openalex.org/W1970690412","https://openalex.org/W2028984344","https://openalex.org/W2159098538","https://openalex.org/W2141934093","https://openalex.org/W2033503179","https://openalex.org/W2033116451","https://openalex.org/W2155480339","https://openalex.org/W2088532287","https://openalex.org/W2016132243","https://openalex.org/W2116878814","https://openalex.org/W2022623358","https://openalex.org/W2013771731","https://openalex.org/W1996221065","https://openalex.org/W2164372703","https://openalex.org/W2005718551","https://openalex.org/W2150146274","https://openalex.org/W2077246501","https://openalex.org/W2117013761","https://openalex.org/W2001762874","https://openalex.org/W2079784321","https://openalex.org/W2131536155","https://openalex.org/W2040544673","https://openalex.org/W2170292869","https://openalex.org/W1973436374","https://openalex.org/W2001018320"],"related_works":["https://openalex.org/W1998065992","https://openalex.org/W2428992214","https://openalex.org/W2415296859","https://openalex.org/W2379837657","https://openalex.org/W2068116832","https://openalex.org/W2038465120","https://openalex.org/W2073677792","https://openalex.org/W2466500078","https://openalex.org/W2467855941","https://openalex.org/W2159193147"],"abstract_inverted_index":{"The":[0,103],"ability":[1,46],"of":[2,20,25,31,47,52,59,72,85,141,149,151,171,175,194,200],"monophosphoryl":[3],"lipid":[4],"A":[5],"(MLA)":[6],"to":[7,44,49,94,109,122,153,186],"provide":[8],"prophylactic":[9],"protection":[10],"against":[11,99,113],"septic":[12],"shock":[13],"was":[14],"evaluated":[15],"in":[16,56,68,74,188],"a":[17,65],"mouse":[18],"model":[19],"induced":[21],"endotoxin":[22,34,123,142,187],"hypersensitivity.":[23],"Treatments":[24],"hypersensitized":[26],"animals":[27,152],"with":[28,131,156],"low":[29],"doses":[30],"MLA":[32,48,61,80,104,145,176,181],"attenuated":[33],"lethality":[35],"and":[36,54,87,97,198],"endotoxin-mediated":[37,100],"liver":[38,101],"damage.":[39,102],"These":[40],"effects":[41],"were":[42],"related":[43],"the":[45,57,70,75,139,147,172,192],"suppress":[50,83],"accumulation":[51,71,197],"TNF-alpha":[53],"IFN-gamma":[55],"bloodstream":[58],"animals.":[60],"treatments":[62,105],"had":[63,126],"only":[64],"modest":[66],"effect":[67],"suppressing":[69],"nitrate":[73],"bloodstream.":[76],"This":[77],"implied":[78],"that":[79,92,138,180],"did":[81,106],"not":[82,107],"induction":[84,140,148],"macrophage":[86],"hepatocyte":[88],"nitric":[89],"oxide":[90],"synthetases":[91],"contribute":[93],"antimicrobial":[95],"defense":[96],"protect":[98],"appear":[108],"compromise":[110],"inflammatory":[111],"defenses":[112],"local":[114],"infection":[115],"since":[116],"locally":[117],"recruited":[118],"leukocytes":[119],"remained":[120],"responsive":[121],"after":[124],"hypersensitivity":[125],"been":[127],"attenuated.":[128],"In":[129],"agreement":[130],"these":[132],"findings,":[133],"other":[134],"studies":[135],"have":[136,178],"shown":[137],"tolerance":[143],"by":[144],"parallels":[146],"resistance":[150],"lethal":[154],"challenges":[155],"either":[157],"Gram":[158,161],"negative":[159],"or":[160],"positive":[162],"bacteria.":[163],"As":[164],"predicted":[165],"from":[166],"preclinical":[167],"studies,":[168],"human":[169],"trials":[170],"clinical":[173],"form":[174],"(MPL-immunostimulant)":[177],"confirmed":[179],"could":[182],"attenuate":[183],"systemic":[184],"responses":[185],"normal":[189],"volunteers,":[190],"including":[191],"attenuation":[193,199],"blood":[195],"cytokine":[196],"symptomatic":[201],"responses.":[202]},"counts_by_year":[{"year":2024,"cited_by_count":1},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":1},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":1},{"year":2012,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
