{"id":"https://openalex.org/W2540176210","doi":"https://doi.org/10.3390/ijms17111805","title":"Peculiarities of the Super-Folder GFP Folding in a Crowded Milieu","display_name":"Peculiarities of the Super-Folder GFP Folding in a Crowded Milieu","publication_year":2016,"publication_date":"2016-10-28","ids":{"openalex":"https://openalex.org/W2540176210","doi":"https://doi.org/10.3390/ijms17111805","mag":"2540176210","pmid":"https://pubmed.ncbi.nlm.nih.gov/27801849","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/5133806"},"language":"en","primary_location":{"id":"doi:10.3390/ijms17111805","doi":"https://doi.org/10.3390/ijms17111805","is_oa":true,"landing_page_url":"https://doi.org/10.3390/ijms17111805","pdf_url":"https://www.mdpi.com/1422-0067/17/11/1805/pdf?version=1477654676","source":{"id":"https://openalex.org/S10623703","display_name":"International Journal of Molecular Sciences","issn_l":"1422-0067","issn":["1422-0067","1661-6596"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","medline","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Molecular Sciences","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.mdpi.com/1422-0067/17/11/1805/pdf?version=1477654676","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5103059840","display_name":"Olesya V. Stepanenko","orcid":"https://orcid.org/0000-0003-3779-6711","observed_orcids":["https://orcid.org/0000-0003-3779-6711"]},"institutions":[{"id":"https://openalex.org/I1313323035","display_name":"Russian Academy of Sciences","ror":"https://ror.org/05qrfxd25","country_code":"RU","type":"government","lineage":["https://openalex.org/I1313323035"]},{"id":"https://openalex.org/I4210104940","display_name":"Institute of Cytology","ror":"https://ror.org/01p3q4q56","country_code":"RU","type":"facility","lineage":["https://openalex.org/I1313323035","https://openalex.org/I4210104940","https://openalex.org/I4210129690"]}],"countries":["RU"],"is_corresponding":false,"raw_author_name":"Olesya Stepanenko","raw_affiliation_strings":["Laboratory of Structural Dynamics, Stability and Folding of Proteins, Institute of Cytology, Russian Academy of Sciences, 4 Tikhoretsky Ave., St. Petersburg 194064, Russia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Structural Dynamics, Stability and Folding of Proteins, Institute of Cytology, Russian Academy of Sciences, 4 Tikhoretsky Ave., St. Petersburg 194064, Russia","institution_ids":["https://openalex.org/I1313323035","https://openalex.org/I4210104940"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5056211468","display_name":"Olga V. Stepanenko","orcid":"https://orcid.org/0000-0002-9145-3480","observed_orcids":["https://orcid.org/0000-0002-9145-3480"]},"institutions":[{"id":"https://openalex.org/I1313323035","display_name":"Russian Academy of Sciences","ror":"https://ror.org/05qrfxd25","country_code":"RU","type":"government","lineage":["https://openalex.org/I1313323035"]},{"id":"https://openalex.org/I4210104940","display_name":"Institute of Cytology","ror":"https://ror.org/01p3q4q56","country_code":"RU","type":"facility","lineage":["https://openalex.org/I1313323035","https://openalex.org/I4210104940","https://openalex.org/I4210129690"]}],"countries":["RU"],"is_corresponding":false,"raw_author_name":"Olga Stepanenko","raw_affiliation_strings":["Laboratory of Structural Dynamics, Stability and Folding of Proteins, Institute of Cytology, Russian Academy of Sciences, 4 Tikhoretsky Ave., St. Petersburg 194064, Russia"],"raw_orcid":"https://orcid.org/0000-0002-9145-3480","affiliations":[{"raw_affiliation_string":"Laboratory of Structural Dynamics, Stability and Folding of Proteins, Institute of Cytology, Russian Academy of Sciences, 4 Tikhoretsky Ave., St. Petersburg 194064, Russia","institution_ids":["https://openalex.org/I1313323035","https://openalex.org/I4210104940"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5061683155","display_name":"Irina \u041c. Kuznetsova","orcid":"https://orcid.org/0000-0002-3336-4834","observed_orcids":["https://orcid.org/0000-0002-3336-4834"]},"institutions":[{"id":"https://openalex.org/I1313323035","display_name":"Russian Academy of Sciences","ror":"https://ror.org/05qrfxd25","country_code":"RU","type":"government","lineage":["https://openalex.org/I1313323035"]},{"id":"https://openalex.org/I4210104940","display_name":"Institute of Cytology","ror":"https://ror.org/01p3q4q56","country_code":"RU","type":"facility","lineage":["https://openalex.org/I1313323035","https://openalex.org/I4210104940","https://openalex.org/I4210129690"]}],"countries":["RU"],"is_corresponding":false,"raw_author_name":"Irina Kuznetsova","raw_affiliation_strings":["Laboratory of Structural Dynamics, Stability and Folding of Proteins, Institute of Cytology, Russian Academy of Sciences, 4 Tikhoretsky Ave., St. Petersburg 194064, Russia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Structural Dynamics, Stability and Folding of Proteins, Institute of Cytology, Russian Academy of Sciences, 4 Tikhoretsky Ave., St. Petersburg 194064, Russia","institution_ids":["https://openalex.org/I1313323035","https://openalex.org/I4210104940"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5083199032","display_name":"Vladimir Nikolaevich Uversky","orcid":"https://orcid.org/0000-0002-4037-5857","observed_orcids":["https://orcid.org/0000-0002-4037-5857"]},"institutions":[{"id":"https://openalex.org/I1313323035","display_name":"Russian Academy of Sciences","ror":"https://ror.org/05qrfxd25","country_code":"RU","type":"government","lineage":["https://openalex.org/I1313323035"]},{"id":"https://openalex.org/I2613432","display_name":"University of South Florida","ror":"https://ror.org/032db5x82","country_code":"US","type":"education","lineage":["https://openalex.org/I2613432"]},{"id":"https://openalex.org/I4210104940","display_name":"Institute of Cytology","ror":"https://ror.org/01p3q4q56","country_code":"RU","type":"facility","lineage":["https://openalex.org/I1313323035","https://openalex.org/I4210104940","https://openalex.org/I4210129690"]},{"id":"https://openalex.org/I4210140006","display_name":"USF Health Byrd Alzheimer's Institute","ror":"https://ror.org/048768v87","country_code":"US","type":"facility","lineage":["https://openalex.org/I4210140006"]}],"countries":["RU","US"],"is_corresponding":true,"raw_author_name":"Vladimir Uversky","raw_affiliation_strings":["Department of Molecular Medicine and USF Health Byrd Alzheimer\u2019s Research Institute, Morsani College of Medicine, University of South Florida, 12901 Bruce B. Downs Blvd. MDC07, Tampa, FL 33612, USA","Laboratory of Structural Dynamics, Stability and Folding of Proteins, Institute of Cytology, Russian Academy of Sciences, 4 Tikhoretsky Ave., St. Petersburg 194064, Russia"],"raw_orcid":"https://orcid.org/0000-0002-4037-5857","affiliations":[{"raw_affiliation_string":"Department of Molecular Medicine and USF Health Byrd Alzheimer\u2019s Research Institute, Morsani College of Medicine, University of South Florida, 12901 Bruce B. Downs Blvd. MDC07, Tampa, FL 33612, USA","institution_ids":["https://openalex.org/I2613432","https://openalex.org/I4210140006"]},{"raw_affiliation_string":"Laboratory of Structural Dynamics, Stability and Folding of Proteins, Institute of Cytology, Russian Academy of Sciences, 4 Tikhoretsky Ave., St. Petersburg 194064, Russia","institution_ids":["https://openalex.org/I1313323035","https://openalex.org/I4210104940"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5007445606","display_name":"\u0422\u0443\u0440\u043e\u0432\u0435\u0440\u043e\u0432 \u041a\u043e\u043d\u0441\u0442\u0430\u043d\u0442\u0438\u043d \u041a\u043e\u043d\u0441\u0442\u0430\u043d\u0442\u0438\u043d\u043e\u0432\u0438\u0447","orcid":"https://orcid.org/0000-0002-6977-1896","observed_orcids":["https://orcid.org/0000-0002-6977-1896","https://orcid.org/0000-0002-3336-4834"]},"institutions":[{"id":"https://openalex.org/I1313323035","display_name":"Russian Academy of Sciences","ror":"https://ror.org/05qrfxd25","country_code":"RU","type":"government","lineage":["https://openalex.org/I1313323035"]},{"id":"https://openalex.org/I212220629","display_name":"Peter the Great St. Petersburg Polytechnic University","ror":"https://ror.org/02x91aj62","country_code":"RU","type":"education","lineage":["https://openalex.org/I212220629"]},{"id":"https://openalex.org/I4210104940","display_name":"Institute of Cytology","ror":"https://ror.org/01p3q4q56","country_code":"RU","type":"facility","lineage":["https://openalex.org/I1313323035","https://openalex.org/I4210104940","https://openalex.org/I4210129690"]}],"countries":["RU"],"is_corresponding":true,"raw_author_name":"Konstantin Turoverov","raw_affiliation_strings":["Institute of Physics, Nanotechnology and Telecommunications, Peter the Great St. Petersburg State Polytechnic University, 29 Polytechnicheskaya st., St. Petersburg 195251, Russia","Laboratory of Structural Dynamics, Stability and Folding of Proteins, Institute of Cytology, Russian Academy of Sciences, 4 Tikhoretsky Ave., St. Petersburg 194064, Russia"],"raw_orcid":"https://orcid.org/0000-0002-6977-1896","affiliations":[{"raw_affiliation_string":"Institute of Physics, Nanotechnology and Telecommunications, Peter the Great St. Petersburg State Polytechnic University, 29 Polytechnicheskaya st., St. Petersburg 195251, Russia","institution_ids":["https://openalex.org/I212220629"]},{"raw_affiliation_string":"Laboratory of Structural Dynamics, Stability and Folding of Proteins, Institute of Cytology, Russian Academy of Sciences, 4 Tikhoretsky Ave., St. Petersburg 194064, Russia","institution_ids":["https://openalex.org/I1313323035","https://openalex.org/I4210104940"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":5,"corresponding_author_ids":["https://openalex.org/A5007445606","https://openalex.org/A5083199032"],"corresponding_institution_ids":["https://openalex.org/I1313323035","https://openalex.org/I212220629","https://openalex.org/I2613432","https://openalex.org/I4210104940","https://openalex.org/I4210140006"],"apc_list":{"value":2900,"currency":"CHF","value_usd":3499},"apc_paid":{"value":2900,"currency":"CHF","value_usd":3499},"fwci":0.3368,"has_fulltext":true,"cited_by_count":16,"citation_normalized_percentile":{"value":0.5347302,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"17","issue":"11","first_page":"1805","last_page":"1805"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10044","display_name":"Protein Structure and Dynamics","score":0.9916999936103821,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10044","display_name":"Protein Structure and Dynamics","score":0.9916999936103821,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11124","display_name":"Protein purification and stability","score":0.002099999925121665,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10540","display_name":"Advanced Fluorescence Microscopy Techniques","score":0.0007999999797903001,"subfield":{"id":"https://openalex.org/subfields/1304","display_name":"Biophysics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/macromolecular-crowding","display_name":"macromolecular crowding","score":0.9309999942779541},{"id":"https://openalex.org/keywords/sfgfp","display_name":"sfGFP","score":0.8930000066757202},{"id":"https://openalex.org/keywords/protein-folding","display_name":"protein folding","score":0.8999999761581421},{"id":"https://openalex.org/keywords/excluded-volume","display_name":"excluded volume","score":0.8309999704360962},{"id":"https://openalex.org/keywords/polyethylene-glycol","display_name":"polyethylene glycol","score":0.6660000085830688},{"id":"https://openalex.org/keywords/dextran","display_name":"dextran","score":0.9139999747276306},{"id":"https://openalex.org/keywords/ficoll","display_name":"Ficoll","score":0.9670000076293945},{"id":"https://openalex.org/keywords/protein-unfolding","display_name":"protein unfolding","score":0.5799999833106995},{"id":"https://openalex.org/keywords/refolding","display_name":"refolding","score":0.699999988079071},{"id":"https://openalex.org/keywords/solvent-properties","display_name":"solvent properties","score":0.7369999885559082},{"id":"https://openalex.org/keywords/hydrodynamic-diameter","display_name":"hydrodynamic diameter","score":0.6320000290870667},{"id":"https://openalex.org/keywords/conformational-stability","display_name":"conformational stability","score":0.734000027179718}],"concepts":[{"id":"https://openalex.org/C142613039","wikidata":"https://www.wikidata.org/wiki/Q272983","display_name":"Green fluorescent protein","level":3,"score":0.6886813044548035},{"id":"https://openalex.org/C2776545253","wikidata":"https://www.wikidata.org/wiki/Q5464292","display_name":"Folding (DSP implementation)","level":2,"score":0.553022563457489},{"id":"https://openalex.org/C204328495","wikidata":"https://www.wikidata.org/wiki/Q847556","display_name":"Protein folding","level":2,"score":0.45033955574035645},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.44425418972969055},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.403203547000885},{"id":"https://openalex.org/C12554922","wikidata":"https://www.wikidata.org/wiki/Q7100","display_name":"Biophysics","level":1,"score":0.37462446093559265},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3250964879989624},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.31922006607055664},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.16412252187728882},{"id":"https://openalex.org/C127413603","wikidata":"https://www.wikidata.org/wiki/Q11023","display_name":"Engineering","level":0,"score":0.12209716439247131},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0},{"id":"https://openalex.org/C119599485","wikidata":"https://www.wikidata.org/wiki/Q43035","display_name":"Electrical engineering","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D008970","descriptor_name":"Molecular Weight","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011092","descriptor_name":"Polyethylene Glycols","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D011108","descriptor_name":"Polymers","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D011487","descriptor_name":"Protein Conformation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D012996","descriptor_name":"Solutions","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D012997","descriptor_name":"Solvents","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D014867","descriptor_name":"Water","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D017510","descriptor_name":"Protein Folding","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D049452","descriptor_name":"Green Fluorescent Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D049452","descriptor_name":"Green Fluorescent Proteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D060833","descriptor_name":"Cellular Microenvironment","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true}],"locations_count":5,"locations":[{"id":"doi:10.3390/ijms17111805","doi":"https://doi.org/10.3390/ijms17111805","is_oa":true,"landing_page_url":"https://doi.org/10.3390/ijms17111805","pdf_url":"https://www.mdpi.com/1422-0067/17/11/1805/pdf?version=1477654676","source":{"id":"https://openalex.org/S10623703","display_name":"International Journal of Molecular Sciences","issn_l":"1422-0067","issn":["1422-0067","1661-6596"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","medline","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Molecular Sciences","raw_type":"journal-article"},{"id":"pmid:27801849","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/27801849","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International journal of molecular sciences","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:5133806","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC5133806/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Int J Mol Sci","raw_type":"Text"},{"id":"pmh:oai:digitalcommons.usf.edu:mme_facpub-1828","doi":null,"is_oa":true,"landing_page_url":"https://digitalcommons.usf.edu/mme_facpub/875","pdf_url":null,"source":{"id":"https://openalex.org/S4377196272","display_name":"Digital Commons - University of South Florida (University of South Florida)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2613432","host_organization_name":"University of South Florida","host_organization_lineage":["https://openalex.org/I2613432"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Molecular Medicine Faculty Publications","raw_type":"text"},{"id":"pmh:oai:doaj.org/article:c52b7e7091c84d83b31facd070fdce84","doi":null,"is_oa":false,"landing_page_url":"https://doaj.org/article/c52b7e7091c84d83b31facd070fdce84","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"International Journal of Molecular Sciences, Vol 17, Iss 11, p 1805 (2016)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.3390/ijms17111805","doi":"https://doi.org/10.3390/ijms17111805","is_oa":true,"landing_page_url":"https://doi.org/10.3390/ijms17111805","pdf_url":"https://www.mdpi.com/1422-0067/17/11/1805/pdf?version=1477654676","source":{"id":"https://openalex.org/S10623703","display_name":"International Journal of Molecular Sciences","issn_l":"1422-0067","issn":["1422-0067","1661-6596"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","medline","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Molecular Sciences","raw_type":"journal-article"},"sustainable_development_goals":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G1146341600","display_name":null,"funder_award_id":"RSCF \u2116 14-24-00131","funder_id":"https://openalex.org/F4320324099","funder_display_name":"Russian Science Foundation"},{"id":"https://openalex.org/G4351622268","display_name":null,"funder_award_id":"14\u201024\u201000131","funder_id":"https://openalex.org/F4320324099","funder_display_name":"Russian Science Foundation"}],"funders":[{"id":"https://openalex.org/F4320324099","display_name":"Russian Science Foundation","ror":"https://ror.org/03y2gwe85"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2540176210.pdf","grobid_xml":"https://content.openalex.org/works/W2540176210.grobid-xml"},"referenced_works_count":56,"referenced_works":["https://openalex.org/W756242970","https://openalex.org/W1720678970","https://openalex.org/W1815218188","https://openalex.org/W1828400526","https://openalex.org/W1974243596","https://openalex.org/W1976488701","https://openalex.org/W2005634257","https://openalex.org/W2006512709","https://openalex.org/W2007328099","https://openalex.org/W2010772236","https://openalex.org/W2012500478","https://openalex.org/W2017118016","https://openalex.org/W2018289835","https://openalex.org/W2020506568","https://openalex.org/W2028014512","https://openalex.org/W2030693318","https://openalex.org/W2033212454","https://openalex.org/W2041804296","https://openalex.org/W2054130762","https://openalex.org/W2058132292","https://openalex.org/W2059136988","https://openalex.org/W2059172969","https://openalex.org/W2060872711","https://openalex.org/W2062819146","https://openalex.org/W2077045286","https://openalex.org/W2085216961","https://openalex.org/W2085519055","https://openalex.org/W2088858313","https://openalex.org/W2095107717","https://openalex.org/W2098004479","https://openalex.org/W2098103683","https://openalex.org/W2100837269","https://openalex.org/W2112616344","https://openalex.org/W2113816719","https://openalex.org/W2114218621","https://openalex.org/W2124341702","https://openalex.org/W2127068865","https://openalex.org/W2132892857","https://openalex.org/W2133486297","https://openalex.org/W2139414608","https://openalex.org/W2140319977","https://openalex.org/W2143466947","https://openalex.org/W2146731001","https://openalex.org/W2151431758","https://openalex.org/W2151637473","https://openalex.org/W2152229434","https://openalex.org/W2161996750","https://openalex.org/W2164564852","https://openalex.org/W2165360511","https://openalex.org/W2169505354","https://openalex.org/W2169515696","https://openalex.org/W2169926151","https://openalex.org/W2171551525","https://openalex.org/W2179280478","https://openalex.org/W2189803368","https://openalex.org/W2223442391"],"related_works":["https://openalex.org/W2189803368","https://openalex.org/W2485048396","https://openalex.org/W4253051038","https://openalex.org/W2989700053","https://openalex.org/W2587069644","https://openalex.org/W2059172969","https://openalex.org/W4414564049","https://openalex.org/W4414550047","https://openalex.org/W2008935619","https://openalex.org/W2060222676"],"abstract_inverted_index":{"The":[0],"natural":[1],"cellular":[2,39],"milieu":[3],"is":[4,16,41,65,80,108,219],"crowded":[5,73],"by":[6,18,44,67,139,222],"large":[7],"quantities":[8],"of":[9,22,27,51,54,70,78,88,100,103,115,132,145,163,184,191,209],"various":[10,89,192],"biological":[11],"macromolecules.":[12],"This":[13],"complex":[14],"environment":[15,40],"characterized":[17],"a":[19,36,52,71,76,83,116,133,164,170],"limited":[20,25],"amount":[21],"unoccupied":[23],"space,":[24],"amounts":[26],"free":[28],"water,":[29],"and":[30,143,197,200,206],"changed":[31],"solvent":[32,241],"properties.":[33,178,242],"Obviously,":[34],"such":[35,104],"tightly":[37],"packed":[38],"poorly":[42],"mimicked":[43],"traditional":[45],"physiological":[46],"conditions,":[47],"where":[48,75],"low":[49],"concentrations":[50,87],"protein":[53,77,118,135,214],"interest":[55,79],"are":[56,236],"analyzed":[57],"in":[58,82,172,227,239],"slightly":[59],"salted":[60],"aqueous":[61],"solutions.":[62],"An":[63,97],"alternative":[64],"given":[66],"the":[68,101,121,130,140,157,160,182,203,210,230,240],"use":[69],"model":[72,94],"milieu,":[74],"immersed":[81],"solution":[84],"containing":[85],"high":[86],"polymers":[90],"that":[91,152],"serve":[92],"as":[93],"crowding":[95,106,186],"agents.":[96],"expected":[98,231],"outcome":[99],"presence":[102],"macromolecular":[105,165],"agents":[107,187],"their":[109],"ability":[110,174],"to":[111,120,175,229],"increase":[112],"conformational":[113,177],"stability":[114],"globular":[117],"due":[119],"excluded":[122,232],"volume":[123,233],"effects.":[124],"In":[125,179],"line":[126],"with":[127,156],"this":[128,180],"hypothesis,":[129],"behavior":[131],"query":[134],"should":[136,167],"be":[137],"affected":[138,221],"hydrodynamic":[141],"size":[142],"concentration":[144],"an":[146,150],"inert":[147],"crowder":[148,166],"(i.e.,":[149],"agent":[151],"does":[153],"not":[154,168],"interact":[155],"protein),":[158],"whereas":[159],"chemical":[161],"nature":[162],"play":[169],"role":[171],"its":[173],"modulate":[176],"study,":[181],"effects":[183],"different":[185,223],"(polyethylene":[188],"glycols":[189],"(PEGs)":[190],"molecular":[193],"masses":[194],"(PEG-600,":[195],"PEG-8000,":[196],"PEG-12000),":[198],"Dextran-70,":[199],"Ficoll-70)":[201],"on":[202],"spectral":[204],"properties":[205],"unfolding-refolding":[207],"processes":[208],"super-folder":[211],"green":[212],"fluorescent":[213],"(sfGFP)":[215],"were":[216],"investigated.":[217],"sfGFP":[218],"differently":[220],"crowders,":[224],"suggesting":[225],"that,":[226],"addition":[228],"effects,":[234],"there":[235],"some":[237],"changes":[238]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2023,"cited_by_count":3},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":7},{"year":2019,"cited_by_count":2},{"year":2018,"cited_by_count":1}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2016-11-04T00:00:00"}