{"id":"https://openalex.org/W2539976587","doi":"https://doi.org/10.1002/psp4.12126","title":"Assessing the Impact of Tissue Target Concentration Data on Uncertainty in In Vivo Target Coverage Predictions","display_name":"Assessing the Impact of Tissue Target Concentration Data on Uncertainty in In Vivo Target Coverage Predictions","publication_year":2016,"publication_date":"2016-10-01","ids":{"openalex":"https://openalex.org/W2539976587","doi":"https://doi.org/10.1002/psp4.12126","mag":"2539976587","pmid":"https://pubmed.ncbi.nlm.nih.gov/27770597","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/5080652"},"language":"en","primary_location":{"id":"doi:10.1002/psp4.12126","doi":"https://doi.org/10.1002/psp4.12126","is_oa":true,"landing_page_url":"https://doi.org/10.1002/psp4.12126","pdf_url":"https://ascpt.onlinelibrary.wiley.com/doi/pdfdirect/10.1002/psp4.12126","source":{"id":"https://openalex.org/S4210231731","display_name":"CPT Pharmacometrics & Systems Pharmacology","issn_l":"2163-8306","issn":["2163-8306"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-70","russia-white-list-1"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"CPT: Pharmacometrics &amp; Systems Pharmacology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://ascpt.onlinelibrary.wiley.com/doi/pdfdirect/10.1002/psp4.12126","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":null,"display_name":"A Tiwari","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I180857899","display_name":"Pfizer (United States)","ror":"https://ror.org/01xdqrp08","country_code":"US","type":"company","lineage":["https://openalex.org/I180857899"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"A Tiwari","raw_affiliation_strings":["Department of Pharmacokinetics, Dynamics, and Metabolism, Pfizer Worldwide R&D, Cambridge, Massachusetts, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacokinetics, Dynamics, and Metabolism, Pfizer Worldwide R&D, Cambridge, Massachusetts, USA","institution_ids":["https://openalex.org/I180857899"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5076437039","display_name":"Haobin Luo","orcid":"https://orcid.org/0000-0002-6497-0159","observed_orcids":["https://orcid.org/0000-0002-6497-0159"]},"institutions":[{"id":"https://openalex.org/I4210137149","display_name":"Renewable Energy Systems (United States)","ror":"https://ror.org/036gc1b60","country_code":"US","type":"company","lineage":["https://openalex.org/I4210090535","https://openalex.org/I4210137149"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"H Luo","raw_affiliation_strings":["RES Group, Needham, Massachusetts, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"RES Group, Needham, Massachusetts, USA","institution_ids":["https://openalex.org/I4210137149"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5048218216","display_name":"X Chen","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I180857899","display_name":"Pfizer (United States)","ror":"https://ror.org/01xdqrp08","country_code":"US","type":"company","lineage":["https://openalex.org/I180857899"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"X Chen","raw_affiliation_strings":["Department of Pharmacokinetics, Dynamics, and Metabolism, Pfizer Worldwide R&D, Cambridge, Massachusetts, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacokinetics, Dynamics, and Metabolism, Pfizer Worldwide R&D, Cambridge, Massachusetts, USA","institution_ids":["https://openalex.org/I180857899"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5070248454","display_name":"Pratap Singh","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I180857899","display_name":"Pfizer (United States)","ror":"https://ror.org/01xdqrp08","country_code":"US","type":"company","lineage":["https://openalex.org/I180857899"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"P Singh","raw_affiliation_strings":["Department of Pharmacokinetics, Dynamics, and Metabolism, Pfizer Worldwide R&D, Cambridge, Massachusetts, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacokinetics, Dynamics, and Metabolism, Pfizer Worldwide R&D, Cambridge, Massachusetts, USA","institution_ids":["https://openalex.org/I180857899"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101620095","display_name":"Indranil Bhattacharya","orcid":"https://orcid.org/0000-0001-9268-6844","observed_orcids":["https://orcid.org/0000-0001-9268-6844"]},"institutions":[{"id":"https://openalex.org/I180857899","display_name":"Pfizer (United States)","ror":"https://ror.org/01xdqrp08","country_code":"US","type":"company","lineage":["https://openalex.org/I180857899"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"I Bhattacharya","raw_affiliation_strings":["Quantitative Clinical Sciences, PharmaTherapeutics R&D, Pfizer Inc.Cambridge Massachusetts USA;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Quantitative Clinical Sciences, PharmaTherapeutics R&D, Pfizer Inc.Cambridge Massachusetts USA;","institution_ids":["https://openalex.org/I180857899"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5059392154","display_name":"Paul Jasper","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210137149","display_name":"Renewable Energy Systems (United States)","ror":"https://ror.org/036gc1b60","country_code":"US","type":"company","lineage":["https://openalex.org/I4210090535","https://openalex.org/I4210137149"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"P Jasper","raw_affiliation_strings":["RES Group, Needham, Massachusetts, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"RES Group, Needham, Massachusetts, USA","institution_ids":["https://openalex.org/I4210137149"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5010406019","display_name":"JE Tolsma","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210137149","display_name":"Renewable Energy Systems (United States)","ror":"https://ror.org/036gc1b60","country_code":"US","type":"company","lineage":["https://openalex.org/I4210090535","https://openalex.org/I4210137149"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"JE Tolsma","raw_affiliation_strings":["RES Group, Needham, Massachusetts, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"RES Group, Needham, Massachusetts, USA","institution_ids":["https://openalex.org/I4210137149"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108441684","display_name":"HM Jones","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I180857899","display_name":"Pfizer (United States)","ror":"https://ror.org/01xdqrp08","country_code":"US","type":"company","lineage":["https://openalex.org/I180857899"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"HM Jones","raw_affiliation_strings":["Department of Pharmacokinetics, Dynamics, and Metabolism, Pfizer Worldwide R&D, Cambridge, Massachusetts, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacokinetics, Dynamics, and Metabolism, Pfizer Worldwide R&D, Cambridge, Massachusetts, USA","institution_ids":["https://openalex.org/I180857899"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5038722539","display_name":"Anup Zutshi","orcid":"https://orcid.org/0009-0004-1721-1557","observed_orcids":["https://orcid.org/0009-0004-1721-1557"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"A Zutshi","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5073097686","display_name":"Anson K. Abraham","orcid":"https://orcid.org/0000-0002-9579-7483","observed_orcids":["https://orcid.org/0000-0002-9579-7483"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"AK Abraham","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I180857899"],"apc_list":{"value":4140,"currency":"USD","value_usd":4140},"apc_paid":{"value":4140,"currency":"USD","value_usd":4140},"fwci":0.43,"has_fulltext":false,"cited_by_count":11,"citation_normalized_percentile":{"value":0.58373791,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":96},"biblio":{"volume":"5","issue":"10","first_page":"565","last_page":"574"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11016","display_name":"Monoclonal and Polyclonal Antibodies Research","score":0.7407000064849854,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11016","display_name":"Monoclonal and Polyclonal Antibodies Research","score":0.7407000064849854,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11235","display_name":"Statistical Methods in Clinical Trials","score":0.09589999914169312,"subfield":{"id":"https://openalex.org/subfields/2613","display_name":"Statistics and Probability"},"field":{"id":"https://openalex.org/fields/26","display_name":"Mathematics"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10211","display_name":"Computational Drug Discovery Methods","score":0.08110000193119049,"subfield":{"id":"https://openalex.org/subfields/3002","display_name":"Drug Discovery"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/uncertainty-quantification","display_name":"uncertainty quantification","score":0.6990000009536743},{"id":"https://openalex.org/keywords/global-sensitivity-analysis","display_name":"global sensitivity analysis","score":0.7929999828338623},{"id":"https://openalex.org/keywords/drug-development","display_name":"drug development","score":0.32100000977516174}],"concepts":[{"id":"https://openalex.org/C12725497","wikidata":"https://www.wikidata.org/wiki/Q810247","display_name":"Baseline (sea)","level":2,"score":0.6332147121429443},{"id":"https://openalex.org/C44249647","wikidata":"https://www.wikidata.org/wiki/Q208498","display_name":"Confidence interval","level":2,"score":0.5457857847213745},{"id":"https://openalex.org/C21200559","wikidata":"https://www.wikidata.org/wiki/Q7451068","display_name":"Sensitivity (control systems)","level":2,"score":0.4864756762981415},{"id":"https://openalex.org/C207001950","wikidata":"https://www.wikidata.org/wiki/Q141124","display_name":"In vivo","level":2,"score":0.4575246572494507},{"id":"https://openalex.org/C55037315","wikidata":"https://www.wikidata.org/wiki/Q5421151","display_name":"Experimental data","level":2,"score":0.44220998883247375},{"id":"https://openalex.org/C105795698","wikidata":"https://www.wikidata.org/wiki/Q12483","display_name":"Statistics","level":1,"score":0.37225979566574097},{"id":"https://openalex.org/C186060115","wikidata":"https://www.wikidata.org/wiki/Q30336093","display_name":"Biological system","level":1,"score":0.3669002652168274},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.3638155460357666},{"id":"https://openalex.org/C33923547","wikidata":"https://www.wikidata.org/wiki/Q395","display_name":"Mathematics","level":0,"score":0.21533674001693726},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.16776111721992493},{"id":"https://openalex.org/C127413603","wikidata":"https://www.wikidata.org/wiki/Q11023","display_name":"Engineering","level":0,"score":0.09401333332061768},{"id":"https://openalex.org/C150903083","wikidata":"https://www.wikidata.org/wiki/Q7108","display_name":"Biotechnology","level":1,"score":0.0881814956665039},{"id":"https://openalex.org/C505870484","wikidata":"https://www.wikidata.org/wiki/Q180538","display_name":"Fishery","level":1,"score":0.0},{"id":"https://openalex.org/C24326235","wikidata":"https://www.wikidata.org/wiki/Q126095","display_name":"Electronic engineering","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000906","descriptor_name":"Antibodies","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D000906","descriptor_name":"Antibodies","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004305","descriptor_name":"Dose-Response Relationship, Drug","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006207","descriptor_name":"Half-Life","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008962","descriptor_name":"Models, Theoretical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014018","descriptor_name":"Tissue Distribution","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016013","descriptor_name":"Likelihood Functions","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D035501","descriptor_name":"Uncertainty","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D055808","descriptor_name":"Drug Discovery","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1002/psp4.12126","doi":"https://doi.org/10.1002/psp4.12126","is_oa":true,"landing_page_url":"https://doi.org/10.1002/psp4.12126","pdf_url":"https://ascpt.onlinelibrary.wiley.com/doi/pdfdirect/10.1002/psp4.12126","source":{"id":"https://openalex.org/S4210231731","display_name":"CPT Pharmacometrics & Systems Pharmacology","issn_l":"2163-8306","issn":["2163-8306"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-70","russia-white-list-1"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"CPT: Pharmacometrics &amp; Systems Pharmacology","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:4042598","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/5080652","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmid:27770597","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/27770597","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"CPT: pharmacometrics & systems pharmacology","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:5080652","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC5080652/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"CPT Pharmacometrics Syst Pharmacol","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1002/psp4.12126","doi":"https://doi.org/10.1002/psp4.12126","is_oa":true,"landing_page_url":"https://doi.org/10.1002/psp4.12126","pdf_url":"https://ascpt.onlinelibrary.wiley.com/doi/pdfdirect/10.1002/psp4.12126","source":{"id":"https://openalex.org/S4210231731","display_name":"CPT Pharmacometrics & Systems Pharmacology","issn_l":"2163-8306","issn":["2163-8306"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-70","russia-white-list-1"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"CPT: Pharmacometrics &amp; Systems Pharmacology","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.6240000128746033,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320307765","display_name":"Pfizer","ror":"https://ror.org/01xdqrp08"}],"has_content":{"pdf":true,"grobid_xml":false},"content_urls":{"pdf":"https://content.openalex.org/works/W2539976587.pdf"},"referenced_works_count":40,"referenced_works":["https://openalex.org/W28215347","https://openalex.org/W79463722","https://openalex.org/W163753916","https://openalex.org/W1596845942","https://openalex.org/W1763034166","https://openalex.org/W1898884874","https://openalex.org/W1928409188","https://openalex.org/W1966821331","https://openalex.org/W1967416910","https://openalex.org/W1979364075","https://openalex.org/W1979669311","https://openalex.org/W1984763603","https://openalex.org/W1985763670","https://openalex.org/W1985770955","https://openalex.org/W1989473468","https://openalex.org/W1997299931","https://openalex.org/W1998532042","https://openalex.org/W2002067498","https://openalex.org/W2006216497","https://openalex.org/W2008735674","https://openalex.org/W2027143209","https://openalex.org/W2054739927","https://openalex.org/W2056439160","https://openalex.org/W2059685386","https://openalex.org/W2067933166","https://openalex.org/W2081306620","https://openalex.org/W2097735053","https://openalex.org/W2110348886","https://openalex.org/W2152803686","https://openalex.org/W2154160510","https://openalex.org/W2155702314","https://openalex.org/W2158946016","https://openalex.org/W2161304688","https://openalex.org/W2162729310","https://openalex.org/W2164977460","https://openalex.org/W2165655699","https://openalex.org/W2171612134","https://openalex.org/W2319777633","https://openalex.org/W2321759714","https://openalex.org/W2481213349"],"related_works":["https://openalex.org/W4392463812","https://openalex.org/W7204847087","https://openalex.org/W4316013558","https://openalex.org/W2625487214","https://openalex.org/W2140412742","https://openalex.org/W1563165141","https://openalex.org/W2010128825","https://openalex.org/W2808151376","https://openalex.org/W2040762948","https://openalex.org/W2082982490"],"abstract_inverted_index":{"Understanding":[0],"pharmacological":[1],"target":[2,35,103,108,129],"coverage":[3,45,73,93,117,135,147],"is":[4,94],"fundamental":[5],"in":[6,43,71,78,105,116,134,146],"drug":[7],"discovery":[8],"and":[9,67,107,111,137],"development":[10],"as":[11,101],"it":[12],"helps":[13],"establish":[14],"a":[15,48,87],"sequence":[16],"of":[17,33,41,50,63,126],"research":[18],"activities,":[19],"from":[20],"laboratory":[21],"objectives":[22],"to":[23,60,96],"clinical":[24],"doses.":[25],"To":[26],"this":[27],"end,":[28],"we":[29,75],"evaluated":[30],"the":[31,39,58,69,132,144],"impact":[32,143],"tissue":[34,44,65,84,128],"concentration":[36,104,130],"data":[37,66],"on":[38],"level":[40],"confidence":[42,145],"predictions":[46,136],"using":[47],"site":[49],"action":[51],"(SoA)":[52],"model":[53,59],"for":[54],"antibodies.":[55],"By":[56],"fitting":[57],"increasing":[61],"amounts":[62],"synthetic":[64],"comparing":[68],"uncertainty":[70,80,115,133],"SoA":[72],"predictions,":[74],"confirmed":[76],"that,":[77],"general,":[79],"decreases":[81],"with":[82],"longitudinal":[83],"data.":[85],"Furthermore,":[86],"global":[88],"sensitivity":[89],"analysis":[90,122],"showed":[91],"that":[92,124,141],"sensitive":[95],"experimentally":[97],"identifiable":[98],"parameters,":[99],"such":[100],"baseline":[102,127],"plasma":[106],"turnover":[109],"half-life":[110],"fixing":[112],"them":[113],"reduces":[114,131],"predictions.":[118,148],"Overall,":[119],"our":[120],"computational":[121],"indicates":[123],"measurement":[125],"identifies":[138],"target-related":[139],"parameters":[140],"greatly":[142]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":1},{"year":2022,"cited_by_count":3},{"year":2021,"cited_by_count":2},{"year":2019,"cited_by_count":1},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":1}],"updated_date":"2026-11-12T12:28:57.059296","created_date":"2016-11-04T00:00:00"}
