{"id":"https://openalex.org/W2539833489","doi":null,"title":"Avalia\u00e7\u00e3o da sensibilidade linfocit\u00e1ria aos glicocortic\u00f3ides e marcadores inflamat\u00f3rios em crian\u00e7as com asma","display_name":"Avalia\u00e7\u00e3o da sensibilidade linfocit\u00e1ria aos glicocortic\u00f3ides e marcadores inflamat\u00f3rios em crian\u00e7as com asma","publication_year":2009,"publication_date":"2009-03-31","ids":{"openalex":"https://openalex.org/W2539833489","mag":"2539833489"},"language":"pt","primary_location":{"id":"pmh:oai:tede2.pucrs.br:tede/5339","doi":null,"is_oa":true,"landing_page_url":"http://tede2.pucrs.br/tede2/handle/tede/5339","pdf_url":null,"source":{"id":"https://openalex.org/S4306402641","display_name":"LA Referencia (Red Federada de Repositorios Institucionales de Publicaciones Cient\u00edficas)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4383465926","host_organization_name":"LA Referencia","host_organization_lineage":["https://openalex.org/I4383465926"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"instacron:PUC_RS","raw_type":"info:eu-repo/semantics/masterThesis"},"volume":null,"type":"dissertation","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"http://tede2.pucrs.br/tede2/handle/tede/5339","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5103535091","display_name":"Guilherme Cerutti M\u00fcller","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Guilherme Cerutti M\u00fcller","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5103535091"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10051","display_name":"Asthma and respiratory diseases","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10051","display_name":"Asthma and respiratory diseases","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10143","display_name":"Chronic Obstructive Pulmonary Disease (COPD) Research","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12421","display_name":"Adrenal Hormones and Disorders","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/childhood-asthma","display_name":"childhood asthma","score":0.7519999742507935},{"id":"https://openalex.org/keywords/glucocorticoid-sensitivity","display_name":"glucocorticoid sensitivity","score":0.878000020980835},{"id":"https://openalex.org/keywords/glucocorticoid-resistance","display_name":"glucocorticoid resistance","score":0.9459999799728394},{"id":"https://openalex.org/keywords/dexamethasone","display_name":"dexamethasone","score":0.9359999895095825},{"id":"https://openalex.org/keywords/peripheral-blood-mononuclear-cells","display_name":"peripheral blood mononuclear cells","score":0.9179999828338623},{"id":"https://openalex.org/keywords/inflammatory-markers","display_name":"inflammatory markers","score":0.5789999961853027},{"id":"https://openalex.org/keywords/brain-derived-neurotrophic-factor","display_name":"brain-derived neurotrophic factor","score":0.9120000004768372},{"id":"https://openalex.org/keywords/plasma-chemokines","display_name":"plasma chemokines","score":0.7549999952316284},{"id":"https://openalex.org/keywords/asthma-severity","display_name":"asthma severity","score":0.734000027179718},{"id":"https://openalex.org/keywords/disease-progression","display_name":"disease progression","score":0.49399998784065247},{"id":"https://openalex.org/keywords/mitogen-induced-proliferation","display_name":"mitogen-induced proliferation","score":0.4779999852180481}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5504636764526367},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.3424798250198364},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.18286898732185364}],"mesh":[],"locations_count":3,"locations":[{"id":"pmh:oai:tede2.pucrs.br:tede/5339","doi":null,"is_oa":true,"landing_page_url":"http://tede2.pucrs.br/tede2/handle/tede/5339","pdf_url":null,"source":{"id":"https://openalex.org/S4306402641","display_name":"LA Referencia (Red Federada de Repositorios Institucionales de Publicaciones Cient\u00edficas)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4383465926","host_organization_name":"LA Referencia","host_organization_lineage":["https://openalex.org/I4383465926"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"instacron:PUC_RS","raw_type":"info:eu-repo/semantics/masterThesis"},{"id":"pmh:oai:americanae.aecid.es:1598333","doi":null,"is_oa":true,"landing_page_url":"http://americanae.aecid.es/americanae/es/registros/registro.do?tipoRegistro=MTD&idBib=1598333","pdf_url":null,"source":{"id":"https://openalex.org/S4306400786","display_name":"Americanae (AECID Library)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"reponame:Biblioteca Digital de Teses e Disserta\u00e7\u00f5es da PUC_RS","raw_type":"info:eu-repo/semantics/masterThesis"},{"id":"mag:2539833489","doi":null,"is_oa":false,"landing_page_url":"http://repositorio.pucrs.br:80/dspace/bitstream/10923/1270/1/000411286-Texto%2bCompleto-0.pdf","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":{"id":"pmh:oai:tede2.pucrs.br:tede/5339","doi":null,"is_oa":true,"landing_page_url":"http://tede2.pucrs.br/tede2/handle/tede/5339","pdf_url":null,"source":{"id":"https://openalex.org/S4306402641","display_name":"LA Referencia (Red Federada de Repositorios Institucionales de Publicaciones Cient\u00edficas)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4383465926","host_organization_name":"LA Referencia","host_organization_lineage":["https://openalex.org/I4383465926"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"instacron:PUC_RS","raw_type":"info:eu-repo/semantics/masterThesis"},"sustainable_development_goals":[{"score":1.0,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":141,"referenced_works":["https://openalex.org/W1522773084","https://openalex.org/W1523292317","https://openalex.org/W1561482026","https://openalex.org/W1717444875","https://openalex.org/W1844439101","https://openalex.org/W1942668068","https://openalex.org/W1964185860","https://openalex.org/W1964518559","https://openalex.org/W1964964540","https://openalex.org/W1965794762","https://openalex.org/W1971721309","https://openalex.org/W1971990400","https://openalex.org/W1972421312","https://openalex.org/W1973635766","https://openalex.org/W1974180886","https://openalex.org/W1974766672","https://openalex.org/W1975082506","https://openalex.org/W1976194871","https://openalex.org/W1978994261","https://openalex.org/W1981722357","https://openalex.org/W1986342313","https://openalex.org/W1988567136","https://openalex.org/W1989245810","https://openalex.org/W1990970244","https://openalex.org/W1991051577","https://openalex.org/W1991119065","https://openalex.org/W1991380818","https://openalex.org/W1991600170","https://openalex.org/W1993357286","https://openalex.org/W1994403951","https://openalex.org/W1994783575","https://openalex.org/W1997103341","https://openalex.org/W1997671476","https://openalex.org/W2001749920","https://openalex.org/W2004029740","https://openalex.org/W2004669380","https://openalex.org/W2006923280","https://openalex.org/W2007169317","https://openalex.org/W2011859994","https://openalex.org/W2013415415","https://openalex.org/W2015163934","https://openalex.org/W2016967110","https://openalex.org/W2021497228","https://openalex.org/W2023617467","https://openalex.org/W2024871695","https://openalex.org/W2027691580","https://openalex.org/W2029328864","https://openalex.org/W2030344604","https://openalex.org/W2030676726","https://openalex.org/W2036571489","https://openalex.org/W2036632318","https://openalex.org/W2039412763","https://openalex.org/W2040362798","https://openalex.org/W2043327727","https://openalex.org/W2047914284","https://openalex.org/W2049013312","https://openalex.org/W2053798956","https://openalex.org/W2053851172","https://openalex.org/W2054648707","https://openalex.org/W2055091610","https://openalex.org/W2055857629","https://openalex.org/W2056294485","https://openalex.org/W2057189159","https://openalex.org/W2057377879","https://openalex.org/W2059168447","https://openalex.org/W2059507666","https://openalex.org/W2061574596","https://openalex.org/W2062303321","https://openalex.org/W2063001043","https://openalex.org/W2063467177","https://openalex.org/W2065950502","https://openalex.org/W2066609350","https://openalex.org/W2067917639","https://openalex.org/W2068227599","https://openalex.org/W2071909694","https://openalex.org/W2073310243","https://openalex.org/W2081776165","https://openalex.org/W2084104390","https://openalex.org/W2085562312","https://openalex.org/W2086111173","https://openalex.org/W2088781708","https://openalex.org/W2090021858","https://openalex.org/W2090852662","https://openalex.org/W2092504379","https://openalex.org/W2092784687","https://openalex.org/W2092889728","https://openalex.org/W2093902949","https://openalex.org/W2094452595","https://openalex.org/W2098456495","https://openalex.org/W2098599635","https://openalex.org/W2099112674","https://openalex.org/W2099803817","https://openalex.org/W2100269363","https://openalex.org/W2100527993","https://openalex.org/W2101965993","https://openalex.org/W2102060609","https://openalex.org/W2106136830","https://openalex.org/W2108167738","https://openalex.org/W2110244387","https://openalex.org/W2112298823","https://openalex.org/W2113562144","https://openalex.org/W2114396413","https://openalex.org/W2118462450","https://openalex.org/W2121159340","https://openalex.org/W2124657474","https://openalex.org/W2124937865","https://openalex.org/W2127186884","https://openalex.org/W2127236650","https://openalex.org/W2128019577","https://openalex.org/W2130614990","https://openalex.org/W2130656441","https://openalex.org/W2131472260","https://openalex.org/W2131662651","https://openalex.org/W2132430858","https://openalex.org/W2133009975","https://openalex.org/W2133895139","https://openalex.org/W2136576396","https://openalex.org/W2136872400","https://openalex.org/W2138833640","https://openalex.org/W2142090085","https://openalex.org/W2144095366","https://openalex.org/W2147280137","https://openalex.org/W2147397196","https://openalex.org/W2147533486","https://openalex.org/W2152032793","https://openalex.org/W2153836121","https://openalex.org/W2158007469","https://openalex.org/W2158022351","https://openalex.org/W2163060254","https://openalex.org/W2166640187","https://openalex.org/W2167083884","https://openalex.org/W2169374892","https://openalex.org/W2170235243","https://openalex.org/W2172283099","https://openalex.org/W2308777632","https://openalex.org/W2315018741","https://openalex.org/W2417985358","https://openalex.org/W2436589462","https://openalex.org/W2467155909","https://openalex.org/W2472111703","https://openalex.org/W4294250616"],"related_works":["https://openalex.org/W2464783721","https://openalex.org/W7036249890","https://openalex.org/W2064056947","https://openalex.org/W6998912222","https://openalex.org/W2327456909","https://openalex.org/W2171589499","https://openalex.org/W6964350607","https://openalex.org/W2167083884","https://openalex.org/W6920572399","https://openalex.org/W3047828045"],"abstract_inverted_index":{"Introdu\u00e7\u00e3o:":[0],"A":[1,49],"asma":[2,27,75,81,154,164,184,202,235],"\u00e9":[3,29,53,213],"uma":[4,157],"doen\u00e7a":[5,220],"inflamat\u00f3ria":[6],"cr\u00f4nica":[7],"e":[8,91,93,102,133,139,166,186],"os":[9,181],"glicocortic\u00f3ides":[10],"(GCs)":[11],"s\u00e3o":[12,205],"a":[13,37,55,110,117,228],"terapia":[14],"mais":[15,173],"efetiva":[16],"para":[17,108],"o":[18,189],"controle":[19],"da":[20,39,217,219],"doen\u00e7a.":[21,47],"Um":[22],"subgrupo":[23],"de":[24,67,72,137,171,192,199],"paciente":[25],"com":[26,45,74,80,95,148,153,163,180,183,201,234],"severa":[28,167,203,236],"resistente":[30],"aos":[31,41,64,207,230],"GCs,":[32],"mas":[33],"n\u00e3o":[34,204],"h\u00e1":[35],"dados":[36],"respeito":[38],"sensibilidade":[40,56,118],"GCs":[42,65,208,231],"em":[43,86,104,221,232],"crian\u00e7as":[44,73,96,200,222],"essa":[46],"Objetivos:":[48],"inten\u00e7\u00e3o":[50],"deste":[51],"estudo":[52],"analisar":[54],"das":[57],"c\u00e9lulas":[58],"mononucleares":[59],"do":[60,123,143],"sangue":[61],"perif\u00e9rico":[62],"(PBMC)":[63],"al\u00e9m":[66],"marcadores":[68],"inflamat\u00f3rios":[69],"no":[70],"plasma":[71,124],"persistente.":[76],"M\u00e9todos:":[77],"Os":[78],"pacientes":[79,182],"persistente":[82],"(n=57)":[83],"foram":[84,100,146],"divididos":[85],"tr\u00eas":[87],"grupos":[88],"(severa,":[89],"moderada":[90,165],"leve),":[92],"comparados":[94,179],"saud\u00e1veis":[97],"(n=18).":[98],"PBMCs":[99,197],"isoladas":[101],"postas":[103],"cultura":[105],"in":[106,209],"vitro":[107],"testar":[109],"prolifera\u00e7\u00e3o":[111],"induzida":[112],"por":[113],"mit\u00f3geno":[114],"assim":[115],"como":[116],"celular":[119],"\u00e0":[120,160],"dexametasona.":[121,161],"Quimiocinas":[122],"(CCL2,":[125],"CCL3,":[126],"CCL5,":[127],"CCL11,":[128],"CCL22,":[129],"CCL24,":[130],"CXCL9,":[131],"CXCL10":[132],"IL-8),":[134],"receptores":[135],"sol\u00faveis":[136],"TNF":[138],"fator":[140],"neurotr\u00f3fico":[141],"derivado":[142],"c\u00e9rebro":[144],"(BDNF)":[145],"analisados":[147],"ELISA.":[149],"Principais":[150],"Resultados:":[151],"Pacientes":[152,162],"leve":[155,185],"apresentaram":[156],"relativa":[158],"resist\u00eancia":[159,229],"mostraram":[168],"ter":[169],"n\u00edveis":[170],"BDNF":[172,211],"elevados":[174],"(p":[175],"<":[176],"0.01)":[177],"quando":[178],"controles,":[187],"sendo":[188],"melhor":[190],"marcador":[191,216],"severidade":[193],"neste":[194],"estudo.":[195],"Conclus\u00f5es:":[196],"derivadas":[198],"resistentes":[206],"vitro.":[210],"Plasm\u00e1tica":[212],"um":[214,239],"potencial":[215],"progress\u00e3o":[218],"asm\u00e1ticas.":[223],"Nossos":[224],"achados":[225],"sugerem":[226],"que":[227],"adultos":[233],"possa":[237],"ser":[238],"processo":[240],"adquirido.":[241]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-11-04T00:00:00"}