{"id":"https://openalex.org/W2538540485","doi":null,"title":"Iron homeostasis and anemia in HIV and tuberculosis","display_name":"Iron homeostasis and anemia in HIV and tuberculosis","publication_year":2015,"publication_date":"2015-05-24","ids":{"openalex":"https://openalex.org/W2538540485","mag":"2538540485"},"language":"en","primary_location":{"id":"pmh:oai:ecommons.cornell.edu:1813/40696","doi":null,"is_oa":true,"landing_page_url":"https://hdl.handle.net/1813/40696","pdf_url":"https://ecommons.cornell.edu/bitstreams/670a8623-32c3-46ac-b397-2a7373a9af8b/download","source":{"id":"https://openalex.org/S4306400757","display_name":"eCommons (Cornell University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I205783295","host_organization_name":"Cornell University","host_organization_lineage":["https://openalex.org/I205783295"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"dissertation or thesis"},"volume":null,"type":"dissertation","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://ecommons.cornell.edu/bitstreams/670a8623-32c3-46ac-b397-2a7373a9af8b/download","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5036593044","display_name":"Peter A. Minchella","orcid":"https://orcid.org/0000-0002-6295-0998","observed_orcids":["https://orcid.org/0000-0002-6295-0998"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Peter A. Minchella","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-6295-0998","affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5036593044"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10452","display_name":"Iron Metabolism and Disorders","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10452","display_name":"Iron Metabolism and Disorders","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10038","display_name":"Tuberculosis Research and Epidemiology","score":0.0017000000225380063,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10915","display_name":"Trace Elements in Health","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2916","display_name":"Nutrition and Dietetics"},"field":{"id":"https://openalex.org/fields/29","display_name":"Nursing"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/iron-homeostasis","display_name":"iron homeostasis","score":1.0},{"id":"https://openalex.org/keywords/hepcidin","display_name":"hepcidin","score":0.9380000233650208},{"id":"https://openalex.org/keywords/anemia","display_name":"anemia","score":0.7929999828338623},{"id":"https://openalex.org/keywords/hiv","display_name":"HIV","score":0.7429999709129333},{"id":"https://openalex.org/keywords/tuberculosis","display_name":"tuberculosis","score":0.9980000257492065},{"id":"https://openalex.org/keywords/tuberculosis-progression","display_name":"tuberculosis progression","score":0.4690000116825104},{"id":"https://openalex.org/keywords/tuberculosis-contacts","display_name":"tuberculosis contacts","score":0.5149999856948853},{"id":"https://openalex.org/keywords/ferritin","display_name":"ferritin","score":0.6499999761581421},{"id":"https://openalex.org/keywords/anemia-of-chronic-disease","display_name":"anemia of chronic disease","score":0.8740000128746033},{"id":"https://openalex.org/keywords/iron-deficiency-anemia","display_name":"iron deficiency anemia","score":0.6389999985694885},{"id":"https://openalex.org/keywords/tuberculosis-treatment","display_name":"tuberculosis treatment","score":0.578000009059906},{"id":"https://openalex.org/keywords/mortality","display_name":"mortality","score":0.3720000088214874}],"concepts":[{"id":"https://openalex.org/C2911035656","wikidata":"https://www.wikidata.org/wiki/Q5925744","display_name":"Iron homeostasis","level":3,"score":0.7704823017120361},{"id":"https://openalex.org/C2781069245","wikidata":"https://www.wikidata.org/wiki/Q12204","display_name":"Tuberculosis","level":2,"score":0.6834341287612915},{"id":"https://openalex.org/C3013748606","wikidata":"https://www.wikidata.org/wiki/Q15787","display_name":"Human immunodeficiency virus (HIV)","level":2,"score":0.6711171865463257},{"id":"https://openalex.org/C2778248108","wikidata":"https://www.wikidata.org/wiki/Q5445","display_name":"Anemia","level":2,"score":0.5871164202690125},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5738939046859741},{"id":"https://openalex.org/C63645605","wikidata":"https://www.wikidata.org/wiki/Q103191","display_name":"Homeostasis","level":2,"score":0.46891674399375916},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.42133253812789917},{"id":"https://openalex.org/C159047783","wikidata":"https://www.wikidata.org/wiki/Q7215","display_name":"Virology","level":1,"score":0.3442173898220062},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.2309485375881195},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.13015177845954895},{"id":"https://openalex.org/C62231903","wikidata":"https://www.wikidata.org/wiki/Q1057","display_name":"Metabolism","level":2,"score":0.05042552947998047}],"mesh":[],"locations_count":2,"locations":[{"id":"pmh:oai:ecommons.cornell.edu:1813/40696","doi":null,"is_oa":true,"landing_page_url":"https://hdl.handle.net/1813/40696","pdf_url":"https://ecommons.cornell.edu/bitstreams/670a8623-32c3-46ac-b397-2a7373a9af8b/download","source":{"id":"https://openalex.org/S4306400757","display_name":"eCommons (Cornell University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I205783295","host_organization_name":"Cornell University","host_organization_lineage":["https://openalex.org/I205783295"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"dissertation or thesis"},{"id":"mag:2538540485","doi":null,"is_oa":false,"landing_page_url":"http://ecommons.cornell.edu/bitstream/1813/40696/1/pam295.pdf","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":{"id":"pmh:oai:ecommons.cornell.edu:1813/40696","doi":null,"is_oa":true,"landing_page_url":"https://hdl.handle.net/1813/40696","pdf_url":"https://ecommons.cornell.edu/bitstreams/670a8623-32c3-46ac-b397-2a7373a9af8b/download","source":{"id":"https://openalex.org/S4306400757","display_name":"eCommons (Cornell University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I205783295","host_organization_name":"Cornell University","host_organization_lineage":["https://openalex.org/I205783295"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"dissertation or thesis"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":1.0}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320334626","display_name":"Medical Research Council","ror":"https://ror.org/03x94j517"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2538540485.pdf","grobid_xml":"https://content.openalex.org/works/W2538540485.grobid-xml"},"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2270042728","https://openalex.org/W6959163405","https://openalex.org/W2012926193","https://openalex.org/W4367335978","https://openalex.org/W7095337761","https://openalex.org/W2160627401","https://openalex.org/W2129396727","https://openalex.org/W3120109813","https://openalex.org/W2115980353","https://openalex.org/W2082339691"],"abstract_inverted_index":{"Background:":[0],"Evidence":[1],"supports":[2],"a":[3,245,334],"role":[4],"for":[5,69,80,113,251,325,336],"iron":[6,16,23,26,31,51,63,92,152,269,306,328],"homeostasis":[7,64,93,153,270,307],"in":[8,74,84,97,132,161,208,268,279,316],"the":[9,135,144,180,301],"pathogenesis":[10],"of":[11,42,59,102,107,151,179,192,211,221,231,242,263,288,304,318],"HIV":[12,53,140,166,280],"and":[13,25,45,55,72,78,104,110,117,120,123,143,177,194,205,223,277,281,299],"tuberculosis.":[14],"The":[15,162],"regulatory":[17],"peptide,":[18],"hepcidin,":[19,37],"inhibits":[20],"both":[21],"dietary":[22],"absorption":[24],"efflux":[27],"leading":[28],"to":[29,82,99,217,283,296],"macrophage":[30],"retention.":[32],"Conditions":[33],"associated":[34,187,273,312],"with":[35,188,201,253,274,313,327],"elevated":[36],"which":[38],"include":[39],"altered":[40],"concentrations":[41,155,207,257],"ferritin,":[43],"transferrin":[44],"hemoglobin,":[46],"may":[47],"favor":[48],"Mycobacterium":[49],"tuberculosis":[50,173,193],"acquisition,":[52],"progression":[54,81,282],"anemia.":[56,114],"In":[57,88],"light":[58],"this,":[60],"we":[61,90],"investigated":[62],"biomarkers":[65,222,271],"as":[66,339,341],"risk":[67],"factors":[68],"incident":[70,172,275],"TB":[71,83,95,146,213,218,226,235,264,276,284,290,309,345],"mortality":[73,278],"an":[75,85],"HIVseropositive":[76],"cohort":[77,142],"also":[79],"HIV-seromixed":[86,209],"cohort.":[87],"addition,":[89],"characterized":[91],"during":[94,225],"therapy":[96,227,310],"order":[98],"identify":[100],"causes":[101],"anemia":[103,224,230,252,317,326],"inform":[105],"selection":[106],"safe,":[108],"effective":[109],"well-timed":[111],"treatments":[112],"Methods:":[115],"Clinical":[116,167],"demographic":[118],"data":[119],"archived":[121],"plasma":[122],"serum":[124],"samples":[125],"from":[126],"two":[127,342],"research":[128],"platforms":[129],"were":[130,175],"utilized":[131],"this":[133],"work:":[134],"Medical":[136],"Research":[137],"Council":[138],"(MRC)":[139],"clinical":[141,302],"MRC":[145,159],"case":[147],"contact":[148],"study.":[149],"Analysis":[150,220],"biomarker":[154],"was":[156,186,199,233,248],"conducted":[157],"at":[158],"laboratories":[160],"Gambia.":[163],"Results:":[164],"During":[165],"Cohort":[168],"follow":[169],"up,":[170],"32":[171],"cases":[174,214],"identified":[176],"64%":[178],"196":[181],"participants":[182],"died.":[183],"Greater":[184],"hepcidin":[185,206,332],"significantly":[189,238,258],"increased":[190],"likelihood":[191],"greater":[195],"all-cause":[196],"mortality.":[197],"This":[198],"consistent":[200],"observed":[202],"higher":[203],"ferritin":[204],"contacts":[210,287],"infectious":[212,289],"that":[215,229],"progressed":[216],"earlier.":[219],"revealed":[228],"inflammation":[232],"predominant":[234],"diagnosis,":[236],"declining":[237],"after":[239,260],"six":[240],"months":[241,262,343],"treatment;":[243],"however,":[244],"corresponding":[246],"reduction":[247],"not":[249],"evident":[250],"iron-responsive":[254],"components.":[255,330],"Hepcidin":[256],"declined":[259],"2":[261],"treatment.":[265,346],"Conclusions:":[266],"Changes":[267],"are":[272,294,323],"disease":[285],"among":[286],"cases.":[291],"Further":[292],"studies":[293],"needed":[295,324],"elucidate":[297],"mechanisms":[298],"determine":[300],"utility":[303],"monitoring":[305],"biomarkers.":[308],"is":[311],"significant":[314],"reductions":[315],"inflammation,":[319],"but":[320],"iron-based":[321],"interventions":[322],"responsive":[329],"Monitoring":[331],"reveals":[333],"window":[335],"intervention":[337],"opening":[338],"early":[340],"into":[344]},"counts_by_year":[],"updated_date":"2026-08-21T09:56:20.448147","created_date":"2016-10-28T00:00:00"}