{"id":"https://openalex.org/W2537597095","doi":"https://doi.org/10.1158/1538-7445.tme16-a07","title":"Abstract A07: Plinabulin: Evidence for an immune-mediated mechanism of action","display_name":"Abstract A07: Plinabulin: Evidence for an immune-mediated mechanism of action","publication_year":2016,"publication_date":"2016-07-28","ids":{"openalex":"https://openalex.org/W2537597095","doi":"https://doi.org/10.1158/1538-7445.tme16-a07","mag":"2537597095"},"language":"en","primary_location":{"id":"doi:10.1158/1538-7445.tme16-a07","doi":"https://doi.org/10.1158/1538-7445.tme16-a07","is_oa":false,"landing_page_url":"https://doi.org/10.1158/1538-7445.tme16-a07","pdf_url":null,"source":{"id":"https://openalex.org/S168522863","display_name":"Cancer Research","issn_l":"0008-5472","issn":["0008-5472","1538-7445"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Research","raw_type":"journal-article"},"volume":null,"type":"conference-abstract","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5110212659","display_name":"George Kenneth Lloyd","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210155797","display_name":"M\u00e9decins Sans Fronti\u00e8res","ror":"https://ror.org/05g6deb76","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I4210128224","https://openalex.org/I4210155797"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"George Kenneth Lloyd","raw_affiliation_strings":["1BeyondSpring Pharmaceuticals, New York, NY,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1BeyondSpring Pharmaceuticals, New York, NY,","institution_ids":["https://openalex.org/I4210155797"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111106734","display_name":"Philipp Mueller","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2802542264","display_name":"University Hospital of Basel","ror":"https://ror.org/04k51q396","country_code":"CH","type":"healthcare","lineage":["https://openalex.org/I2802542264"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"Philipp Mueller","raw_affiliation_strings":["2University Hospital, Basel, Switzerland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"2University Hospital, Basel, Switzerland","institution_ids":["https://openalex.org/I2802542264"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5068350308","display_name":"Alfred Zippelius","orcid":"https://orcid.org/0000-0003-1933-8178","observed_orcids":["https://orcid.org/0000-0003-1933-8178"]},"institutions":[{"id":"https://openalex.org/I2802542264","display_name":"University Hospital of Basel","ror":"https://ror.org/04k51q396","country_code":"CH","type":"healthcare","lineage":["https://openalex.org/I2802542264"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"ALfred Zippelius","raw_affiliation_strings":["2University Hospital, Basel, Switzerland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"2University Hospital, Basel, Switzerland","institution_ids":["https://openalex.org/I2802542264"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5070754234","display_name":"Lan Huang","orcid":"https://orcid.org/0000-0002-3140-4687","observed_orcids":["https://orcid.org/0000-0002-3140-4687"]},"institutions":[{"id":"https://openalex.org/I4210155797","display_name":"M\u00e9decins Sans Fronti\u00e8res","ror":"https://ror.org/05g6deb76","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I4210128224","https://openalex.org/I4210155797"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Lan Huang","raw_affiliation_strings":["1BeyondSpring Pharmaceuticals, New York, NY,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1BeyondSpring Pharmaceuticals, New York, NY,","institution_ids":["https://openalex.org/I4210155797"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":4,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"76","issue":"15_Supplement","first_page":"A07","last_page":"A07"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10158","display_name":"Cancer Immunotherapy and Biomarkers","score":0.9214000105857849,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10158","display_name":"Cancer Immunotherapy and Biomarkers","score":0.9214000105857849,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10580","display_name":"Immunotherapy and Immune Responses","score":0.07660000026226044,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T14072","display_name":"Immunotoxicology and immune responses","score":0.00039999998989515007,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/plinabulin","display_name":"plinabulin","score":1.0},{"id":"https://openalex.org/keywords/tubulin-polymerization-inhibitors","display_name":"tubulin polymerization inhibitors","score":0.796999990940094},{"id":"https://openalex.org/keywords/dendritic-cell-maturation","display_name":"dendritic cell maturation","score":0.9459999799728394},{"id":"https://openalex.org/keywords/antitumor-immunity","display_name":"antitumor immunity","score":0.8140000104904175},{"id":"https://openalex.org/keywords/anti-pd-1-therapy","display_name":"anti-PD-1 therapy","score":0.8370000123977661},{"id":"https://openalex.org/keywords/ctla-4-inhibition","display_name":"CTLA-4 inhibition","score":0.9850000143051147},{"id":"https://openalex.org/keywords/immune-checkpoint-inhibitors","display_name":"immune checkpoint inhibitors","score":0.6890000104904175},{"id":"https://openalex.org/keywords/pro-inflammatory-cytokines","display_name":"inflammatory cytokines","score":0.6330000162124634},{"id":"https://openalex.org/keywords/non-small-cell-lung-cancer","display_name":"non-small cell lung cancer","score":0.8640000224113464},{"id":"https://openalex.org/keywords/nivolumab","display_name":"nivolumab","score":0.7990000247955322},{"id":"https://openalex.org/keywords/combination-therapy","display_name":"combination therapy","score":0.3779999911785126}],"concepts":[{"id":"https://openalex.org/C2777292972","wikidata":"https://www.wikidata.org/wiki/Q423762","display_name":"Paclitaxel","level":3,"score":0.6612714529037476},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.5670387148857117},{"id":"https://openalex.org/C207001950","wikidata":"https://www.wikidata.org/wiki/Q141124","display_name":"In vivo","level":2,"score":0.564671516418457},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.540799081325531},{"id":"https://openalex.org/C2781190966","wikidata":"https://www.wikidata.org/wiki/Q420436","display_name":"Docetaxel","level":3,"score":0.5310913324356079},{"id":"https://openalex.org/C2781101188","wikidata":"https://www.wikidata.org/wiki/Q5009846","display_name":"CD86","level":4,"score":0.507440984249115},{"id":"https://openalex.org/C2780394083","wikidata":"https://www.wikidata.org/wiki/Q539568","display_name":"Angiogenesis","level":2,"score":0.4829646646976471},{"id":"https://openalex.org/C2776120743","wikidata":"https://www.wikidata.org/wiki/Q3271540","display_name":"Mechanism of action","level":3,"score":0.4788905680179596},{"id":"https://openalex.org/C2909009945","wikidata":"https://www.wikidata.org/wiki/Q189933","display_name":"Microtubule polymerization","level":4,"score":0.45630592107772827},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.42784908413887024},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.4224255383014679},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.42112842202186584},{"id":"https://openalex.org/C190283241","wikidata":"https://www.wikidata.org/wiki/Q14599311","display_name":"Apoptosis","level":2,"score":0.41707485914230347},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.38997888565063477},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.34293484687805176},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.29315030574798584},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.27424317598342896},{"id":"https://openalex.org/C84425145","wikidata":"https://www.wikidata.org/wiki/Q422492","display_name":"Tubulin","level":3,"score":0.2515983283519745},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.22848784923553467},{"id":"https://openalex.org/C2776090121","wikidata":"https://www.wikidata.org/wiki/Q193529","display_name":"T cell","level":3,"score":0.2220650315284729},{"id":"https://openalex.org/C20418707","wikidata":"https://www.wikidata.org/wiki/Q189933","display_name":"Microtubule","level":2,"score":0.21465346217155457},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.1459258794784546},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.09906098246574402},{"id":"https://openalex.org/C150903083","wikidata":"https://www.wikidata.org/wiki/Q7108","display_name":"Biotechnology","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1158/1538-7445.tme16-a07","doi":"https://doi.org/10.1158/1538-7445.tme16-a07","is_oa":false,"landing_page_url":"https://doi.org/10.1158/1538-7445.tme16-a07","pdf_url":null,"source":{"id":"https://openalex.org/S168522863","display_name":"Cancer Research","issn_l":"0008-5472","issn":["0008-5472","1538-7445"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Research","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9763000011444092,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W4411731224","https://openalex.org/W4415900347","https://openalex.org/W4388042545","https://openalex.org/W3168416271","https://openalex.org/W4379878640","https://openalex.org/W4395043992","https://openalex.org/W2912532602","https://openalex.org/W2897073478","https://openalex.org/W3197380096","https://openalex.org/W3013994074"],"abstract_inverted_index":{"Abstract":[0],"The":[1,63],"purpose":[2],"of":[3,15,30,110,120,168,185,199,280,282,293,324,329,335],"this":[4,210],"study":[5],"was":[6,190],"to":[7,133],"investigate":[8],"the":[9,46,66,118,147,154,165,197,255,286,296,330],"evidence":[10,212],"for":[11,17,23,59,65,288,320],"an":[12,28,276,321],"immune-mediated":[13,322],"mechanism":[14,279,323],"action":[16,281],"plinabulin.":[18],"Plinabulin,":[19],"a":[20,176,290],"novel":[21],"compound":[22],"use":[24],"in":[25,55,67,70,89,143,153,248,251,300,338],"oncology,":[26],"is":[27,54],"inhibitor":[29],"tubulin":[31,221],"polymerization,":[32],"induces":[33],"direct":[34],"tumor":[35,151,173,188],"cell":[36,103,241],"apoptosis":[37],"(Nicholson":[38],"et":[39,50,78,83,266,270,304],"al,":[40,51,267,271,305],"2006),":[41],"inhibits":[42],"angiogenesis":[43],"and":[44,53,69,81,114,116,127,139,203,243,250,284],"activates":[45],"JNK":[47],"pathway":[48],"(Singh":[49],"2011)":[52],"Phase":[56],"3":[57],"trials":[58],"NSCLC":[60,302],"(Bazhenova,":[61],"2015).":[62,306],"methods":[64],"vitro":[68,90,249],"vivo":[71],"studies":[72,91],"performed":[73],"are":[74],"described":[75],"by":[76,107,239],"Martin":[77],"al":[79,84],"(2014)":[80],"M\u00fcller":[82,269],"(2014).":[85],"Recent":[86],"data":[87,274],"from":[88],"demonstrate":[92],"that":[93,216],"plinabulin":[94,158,194,283,294],"enhances":[95],"immune":[96,262,277],"responses":[97],"as":[98,105,124,237],"(1)":[99],"it":[100],"increases":[101,130],"dendritic":[102,240],"maturation":[104,242],"evidenced":[106],"elevated":[108],"levels":[109],"CD40,":[111],"MHCII,":[112],"CD80":[113],"CD86":[115],"(2)":[117],"release":[119],"pro-inflammatory":[121],"cytokines":[122],"such":[123],"IL-1beta,":[125],"IL-6":[126],"IL12p40.":[128],"These":[129,273],"were":[131,141],"similar":[132],"those":[134],"observed":[135],"with":[136,175,220,261,295],"LPS.":[137],"Paclitaxel":[138],"etoposide":[140],"inactive":[142],"these":[144],"assays.":[145],"In":[146,209,253],"MC-38":[148],"syngeneic":[149],"colon":[150],"model":[152],"C57BL/6":[155],"immunocompetent":[156],"mouse,":[157],"(7.5":[159],"mg/kg,":[160],"IP,":[161],"BIW)":[162],"significantly":[163,195],"enhanced":[164,196,244],"therapeutic":[166],"effect":[167,178,198],"combined":[169,204],"PD-1/CTLA-4":[170],"inhibition":[171,202],"on":[172],"volume,":[174],"maximal":[177],"occurring":[179],"between":[180],"days":[181],"13-20":[182],"after":[183],"initiation":[184],"treatment.":[186],"When":[187],"weight":[189],"measured":[191],"at":[192],"necropsy,":[193],"both":[200,247],"PD-1":[201,205,297],"+":[206],"CTLA-4":[207],"inhibition.":[208],"regard,":[211],"has":[213],"been":[214],"provided":[215],"agents":[217,230,258],"which":[218],"interfere":[219],"polymerization":[222],"(e.g.":[223,231],"ansamytocin-P3,":[224],"dolastatin-10),":[225],"but":[226],"not":[227],"microtubule":[228,256],"stabilizing":[229],"docetaxel,":[232],"paclitaxel)":[233],"promote":[234],"anti-tumor":[235],"immunity":[236],"demonstrated":[238],"T-cell":[245],"activation":[246],"vivo.":[252],"addition,":[254],"depolymerizing":[257],"act":[259],"synergistically":[260],"checkpoint":[263],"inhibitors":[264],"(Martin":[265],"2014,":[268],"2014).":[272],"indicate":[275],"mediated":[278],"provide":[285],"basis":[287],"initiating":[289],"clinical":[291],"trial":[292],"mAb":[298],"Nivolumab":[299],"metastatic":[301],"(Yeh":[303],"Citation":[307],"Format:":[308],"George":[309],"Kenneth":[310],"Lloyd,":[311],"Philipp":[312],"Mueller,":[313],"ALfred":[314],"Zippelius,":[315],"Lan":[316],"Huang.":[317],"Plinabulin:":[318],"Evidence":[319],"action.":[325],"[abstract].":[326],"In:":[327],"Proceedings":[328],"AACR":[331],"Special":[332],"Conference:":[333],"Function":[334],"Tumor":[336],"Microenvironment":[337],"Cancer":[339,350],"Progression;":[340],"2016":[341],"Jan":[342],"7\u201310;":[343],"San":[344],"Diego,":[345],"CA.":[346],"Philadelphia":[347],"(PA):":[348],"AACR;":[349],"Res":[351],"2016;76(15":[352],"Suppl):Abstract":[353],"nr":[354],"A07.":[355]},"counts_by_year":[{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":1},{"year":2017,"cited_by_count":1}],"updated_date":"2026-10-02T10:15:12.560889","created_date":"2016-10-28T00:00:00"}