{"id":"https://openalex.org/W2536799296","doi":null,"title":"Exendin-4 protects A\u03b2(1-42) oligomer-induced PC12 cell apoptosis.","display_name":"Exendin-4 protects A\u03b2(1-42) oligomer-induced PC12 cell apoptosis.","publication_year":2016,"publication_date":"2016-01-01","ids":{"openalex":"https://openalex.org/W2536799296","mag":"2536799296","pmid":"https://pubmed.ncbi.nlm.nih.gov/27648144","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/5009406"},"language":"en","primary_location":{"id":"pmh:oai:europepmc.org:3984384","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/5009406","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/5009406","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":null,"display_name":"Chen Qiu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I118783713","display_name":"Fujian University of Traditional Chinese Medicine","ror":"https://ror.org/05n0qbd70","country_code":"CN","type":"education","lineage":["https://openalex.org/I118783713"]},{"id":"https://openalex.org/I129708740","display_name":"Fujian Medical University","ror":"https://ror.org/050s6ns64","country_code":"CN","type":"education","lineage":["https://openalex.org/I129708740"]},{"id":"https://openalex.org/I4210163933","display_name":"Union Hospital","ror":"https://ror.org/055gkcy74","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210163933"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Chen Qiu","raw_affiliation_strings":["Fujian Institute of Endocrinology, Fujian Medical University Union HospitalFuzhou 350001, Fujian, China; Department of Endocrinology, People's Hospital Affiliated to Fujian University of Traditional Chinese MedicineFuzhou 350004, Fujian, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Fujian Institute of Endocrinology, Fujian Medical University Union HospitalFuzhou 350001, Fujian, China; Department of Endocrinology, People's Hospital Affiliated to Fujian University of Traditional Chinese MedicineFuzhou 350004, Fujian, China","institution_ids":["https://openalex.org/I118783713","https://openalex.org/I129708740","https://openalex.org/I4210163933"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Yan-Ping Wang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I129708740","display_name":"Fujian Medical University","ror":"https://ror.org/050s6ns64","country_code":"CN","type":"education","lineage":["https://openalex.org/I129708740"]},{"id":"https://openalex.org/I4210163933","display_name":"Union Hospital","ror":"https://ror.org/055gkcy74","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210163933"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yan-Ping Wang","raw_affiliation_strings":["Fujian Institute of Endocrinology, Fujian Medical University Union HospitalFuzhou 350001, Fujian, China; Department of Endocrinology, Fujian Medical University Union HospitalFuzhou 350001, Fujian, China; Department of Geriatrics, Fujian Medical University Union HospitalFuzhou 350001, Fujian, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Fujian Institute of Endocrinology, Fujian Medical University Union HospitalFuzhou 350001, Fujian, China; Department of Endocrinology, Fujian Medical University Union HospitalFuzhou 350001, Fujian, China; Department of Geriatrics, Fujian Medical University Union HospitalFuzhou 350001, Fujian, China","institution_ids":["https://openalex.org/I129708740","https://openalex.org/I4210163933"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5067409432","display_name":"Xiaodong Pan","orcid":"https://orcid.org/0000-0001-9511-6986","observed_orcids":["https://orcid.org/0000-0001-9511-6986"]},"institutions":[{"id":"https://openalex.org/I4210163933","display_name":"Union Hospital","ror":"https://ror.org/055gkcy74","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210163933"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xiao-Dong Pan","raw_affiliation_strings":["Department of Neurology, Fujian Medical University Union Hospital Fuzhou 350001, Fujian, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurology, Fujian Medical University Union Hospital Fuzhou 350001, Fujian, China","institution_ids":["https://openalex.org/I4210163933"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100394435","display_name":"Xiaoying Liu","orcid":"https://orcid.org/0000-0002-0597-685X","observed_orcids":["https://orcid.org/0000-0002-0597-685X"]},"institutions":[{"id":"https://openalex.org/I129708740","display_name":"Fujian Medical University","ror":"https://ror.org/050s6ns64","country_code":"CN","type":"education","lineage":["https://openalex.org/I129708740"]},{"id":"https://openalex.org/I4210163933","display_name":"Union Hospital","ror":"https://ror.org/055gkcy74","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210163933"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xiao-Ying Liu","raw_affiliation_strings":["Fujian Institute of Endocrinology, Fujian Medical University Union Hospital Fuzhou 350001, Fujian, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Fujian Institute of Endocrinology, Fujian Medical University Union Hospital Fuzhou 350001, Fujian, China","institution_ids":["https://openalex.org/I129708740","https://openalex.org/I4210163933"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102578865","display_name":"Zhou Chen","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I129708740","display_name":"Fujian Medical University","ror":"https://ror.org/050s6ns64","country_code":"CN","type":"education","lineage":["https://openalex.org/I129708740"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Zhou Chen","raw_affiliation_strings":["College of Pharmacy, Fujian Medical University Fuzhou 350108, Fujian, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"College of Pharmacy, Fujian Medical University Fuzhou 350108, Fujian, China","institution_ids":["https://openalex.org/I129708740"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5100644187","display_name":"Libin Liu","orcid":"https://orcid.org/0000-0002-0352-3865","observed_orcids":["https://orcid.org/0000-0002-0352-3865","https://orcid.org/0000-0002-4558-5167"]},"institutions":[{"id":"https://openalex.org/I129708740","display_name":"Fujian Medical University","ror":"https://ror.org/050s6ns64","country_code":"CN","type":"education","lineage":["https://openalex.org/I129708740"]},{"id":"https://openalex.org/I4210163933","display_name":"Union Hospital","ror":"https://ror.org/055gkcy74","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210163933"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Li-Bin Liu","raw_affiliation_strings":["Fujian Institute of Endocrinology, Fujian Medical University Union HospitalFuzhou 350001, Fujian, China; Institute of Geriatric Health Science, Fujian Medical UniversityFuzhou 350001, Fujian, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Fujian Institute of Endocrinology, Fujian Medical University Union HospitalFuzhou 350001, Fujian, China; Institute of Geriatric Health Science, Fujian Medical UniversityFuzhou 350001, Fujian, China","institution_ids":["https://openalex.org/I129708740","https://openalex.org/I4210163933"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.9496,"has_fulltext":false,"cited_by_count":25,"citation_normalized_percentile":{"value":0.71064324,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":98},"biblio":{"volume":"8","issue":"8","first_page":"3540","last_page":"8"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10086","display_name":"Alzheimer's disease research and treatments","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10086","display_name":"Alzheimer's disease research and treatments","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11266","display_name":"Neuroinflammation and Neurodegeneration Mechanisms","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2808","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10401","display_name":"Diabetes Treatment and Management","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/exendin-4","display_name":"exendin-4","score":1.0},{"id":"https://openalex.org/keywords/apoptosis","display_name":"apoptosis","score":0.6899999976158142},{"id":"https://openalex.org/keywords/pc12-cells","display_name":"PC12 cells","score":0.8600000143051147},{"id":"https://openalex.org/keywords/neuroprotection","display_name":"neuroprotection","score":0.9110000133514404},{"id":"https://openalex.org/keywords/glp-1-receptor-agonists","display_name":"GLP-1 receptor agonists","score":0.8679999709129333},{"id":"https://openalex.org/keywords/alzheimer-s-disease","display_name":"Alzheimer's disease","score":0.875},{"id":"https://openalex.org/keywords/type-2-diabetes","display_name":"type 2 diabetes","score":0.9279999732971191},{"id":"https://openalex.org/keywords/caspase-3","display_name":"caspase-3","score":0.9900000095367432},{"id":"https://openalex.org/keywords/bcl-2","display_name":"Bcl-2","score":1.0},{"id":"https://openalex.org/keywords/akt-phosphorylation","display_name":"Akt phosphorylation","score":0.8790000081062317},{"id":"https://openalex.org/keywords/creb-phosphorylation","display_name":"CREB phosphorylation","score":0.9670000076293945}],"concepts":[{"id":"https://openalex.org/C25498285","wikidata":"https://www.wikidata.org/wiki/Q1981368","display_name":"Neuroprotection","level":2,"score":0.7990071177482605},{"id":"https://openalex.org/C190283241","wikidata":"https://www.wikidata.org/wiki/Q14599311","display_name":"Apoptosis","level":2,"score":0.6211394667625427},{"id":"https://openalex.org/C2777633098","wikidata":"https://www.wikidata.org/wiki/Q2736051","display_name":"Amyloid (mycology)","level":2,"score":0.49978160858154297},{"id":"https://openalex.org/C88634738","wikidata":"https://www.wikidata.org/wiki/Q24769543","display_name":"Annexin","level":3,"score":0.4896593689918518},{"id":"https://openalex.org/C1629964","wikidata":"https://www.wikidata.org/wiki/Q106950729","display_name":"CREB","level":4,"score":0.48668938875198364},{"id":"https://openalex.org/C75217442","wikidata":"https://www.wikidata.org/wiki/Q423650","display_name":"Protein kinase B","level":3,"score":0.4813188314437866},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.47115007042884827},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.45419058203697205},{"id":"https://openalex.org/C53227056","wikidata":"https://www.wikidata.org/wiki/Q189152","display_name":"Viability assay","level":3,"score":0.4438440799713135},{"id":"https://openalex.org/C2780783641","wikidata":"https://www.wikidata.org/wiki/Q738686","display_name":"MTT assay","level":3,"score":0.42663508653640747},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.3750620484352112},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.2934640049934387},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.29143381118774414},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.22395235300064087},{"id":"https://openalex.org/C179104552","wikidata":"https://www.wikidata.org/wiki/Q11165","display_name":"Inorganic chemistry","level":1,"score":0.0},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0},{"id":"https://openalex.org/C86339819","wikidata":"https://www.wikidata.org/wiki/Q407384","display_name":"Transcription factor","level":3,"score":0.0}],"mesh":[],"locations_count":4,"locations":[{"id":"pmh:oai:europepmc.org:3984384","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/5009406","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:5009406","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/5009406","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Am J Transl Res","raw_type":"Text"},{"id":"pmid:27648144","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/27648144","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"American journal of translational research","raw_type":"Journal Article"},{"id":"mag:2536799296","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/27648144","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":{"id":"pmh:oai:europepmc.org:3984384","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/5009406","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":1.0}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":22,"referenced_works":["https://openalex.org/W1546941007","https://openalex.org/W1979656222","https://openalex.org/W1983703572","https://openalex.org/W2000202490","https://openalex.org/W2002287054","https://openalex.org/W2005944734","https://openalex.org/W2011284760","https://openalex.org/W2021375788","https://openalex.org/W2022847635","https://openalex.org/W2030198351","https://openalex.org/W2031173385","https://openalex.org/W2032605307","https://openalex.org/W2038523007","https://openalex.org/W2078613171","https://openalex.org/W2081089804","https://openalex.org/W2091598446","https://openalex.org/W2093534363","https://openalex.org/W2094411486","https://openalex.org/W2094880658","https://openalex.org/W2097140255","https://openalex.org/W2399549279","https://openalex.org/W2411459535"],"related_works":["https://openalex.org/W1983703572","https://openalex.org/W2152355721","https://openalex.org/W2301862958","https://openalex.org/W2235909882","https://openalex.org/W4289939749","https://openalex.org/W2094880658","https://openalex.org/W1985305554","https://openalex.org/W2777129864","https://openalex.org/W2050622919","https://openalex.org/W2106339546"],"abstract_inverted_index":{"BACKGROUND:":[0],"Type":[1],"2":[2],"diabetes":[3],"mellitus":[4],"(T2DM)":[5],"increases":[6],"the":[7,44,72,102,141,157,171,187,213,216,236],"risk":[8],"of":[9,46,74,148,159,173,190,215,239],"developing":[10],"Alzheimer's":[11],"disease.":[12],"Most":[13],"recently,":[14],"GLP-1":[15,50,199],"analogs":[16],"have":[17,21],"been":[18],"shown":[19],"to":[20,86],"a":[22,49,59,79,119,203,227],"significant":[23],"neuroprotective":[24,204],"role":[25],"in":[26,58,78,118,121,129,235],"several":[27],"neurodegenerative":[28],"diseases.":[29],"However,":[30],"few":[31],"are":[32],"known":[33],"on":[34,53],"its":[35],"potential":[36,228],"mechanism.":[37],"OBJECTIVE:":[38],"In":[39,183],"this":[40,149],"study,":[41],"we":[42],"report":[43],"effect":[45,91,205],"exendin-4":[47],"(Ex-4),":[48],"receptor":[51],"agonist,":[52],"amyloid-\u03b2(1-42)":[54,87,107,113,135],"peptide":[55],"oligomer-induced":[56],"apoptosis":[57,142,210],"PC12":[60,75,103,208],"neuronal":[61,138,217],"cell":[62,209],"model.":[63],"METHODS:":[64],"MTT,":[65],"DAPI":[66],"and":[67,81,123,161,177,192],"Annexin-V/PI":[68],"assays":[69],"revealed":[70,151],"that":[71,134,152,198,224],"viability":[73],"cells":[76,104,139],"decreased":[77,156],"dose-":[80],"time-dependent":[82],"manner":[83],"after":[84],"exposure":[85],"oligomers.":[88],"This":[89,221],"apoptotic":[90],"could":[92],"be":[93],"attenuated":[94],"by":[95],"Ex-4":[96,167,185,201,225,240],"(100-300":[97],"nM)":[98,169],"pre-treatment,":[99],"compared":[100],"with":[101,106,112,166,247],"treated":[105],"oligomers":[108,114,136,154],"alone.":[109],"Moreover,":[110],"treatment":[111],"(10":[115],"\u03bcM)":[116],"resulted":[117],"decrease":[120],"active-":[122],"pro-caspase-3":[124],"expression,":[125],"as":[126,128],"well":[127],"Bcl-2":[130,176],"protein":[131,175],"expression;":[132],"suggesting":[133],"impaired":[137],"via":[140],"signaling":[143,219],"pathway.":[144,220],"A":[145],"further":[146],"study":[147],"mechanism":[150],"amyloid-\u03b2":[153],"(A\u03b2Os)":[155],"phosphorylation":[158,188],"Akt":[160,191],"CREB.":[162,193],"As":[163],"expected,":[164],"pre-treatment":[165],"(300":[168],"increased":[170],"expression":[172,181],"anti-apoptotic":[174],"reduced":[178],"active":[179],"caspase-3":[180],"levels.":[182],"addition,":[184],"upregulated":[186],"levels":[189],"CONCLUSIONS:":[194],"These":[195],"findings":[196],"indicate":[197],"analogue":[200],"has":[202],"against":[206],"A\u03b2O-induced":[207,233],"through":[211],"reversing":[212],"impairment":[214],"survival":[218],"strongly":[222],"suggests":[223],"is":[226],"therapeutic":[229],"option":[230],"for":[231,241],"ameliorating":[232],"neurotoxicity":[234],"clinical":[237],"application":[238],"AD":[242],"treatment,":[243],"particularly":[244],"when":[245],"associated":[246],"diabetes.":[248]},"counts_by_year":[{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":4},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":6},{"year":2020,"cited_by_count":3},{"year":2019,"cited_by_count":4},{"year":2018,"cited_by_count":2},{"year":2017,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-10-28T00:00:00"}
