{"id":"https://openalex.org/W2536633292","doi":"https://doi.org/10.1126/scisignal.aaj2227","title":"Leveraging unique structural characteristics of WNK kinases to achieve therapeutic inhibition","display_name":"Leveraging unique structural characteristics of WNK kinases to achieve therapeutic inhibition","publication_year":2016,"publication_date":"2016-10-18","ids":{"openalex":"https://openalex.org/W2536633292","doi":"https://doi.org/10.1126/scisignal.aaj2227","mag":"2536633292","pmid":"https://pubmed.ncbi.nlm.nih.gov/27811182"},"language":"en","primary_location":{"id":"doi:10.1126/scisignal.aaj2227","doi":"https://doi.org/10.1126/scisignal.aaj2227","is_oa":false,"landing_page_url":"https://doi.org/10.1126/scisignal.aaj2227","pdf_url":null,"source":{"id":"https://openalex.org/S155937366","display_name":"Science Signaling","issn_l":"1937-9145","issn":["1937-9145","1945-0877"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310315823","host_organization_name":"American Association for the Advancement of Science","host_organization_lineage":["https://openalex.org/P4310315823"],"host_organization_lineage_names":["American Association for the Advancement of Science"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Science Signaling","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://discovery.dundee.ac.uk/ws/files/10795485/author_accepted_manuscript.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5100392703","display_name":"Jinwei Zhang","orcid":"https://orcid.org/0000-0001-8683-509X","observed_orcids":["https://orcid.org/0000-0001-8683-509X","https://orcid.org/0000-0003-1992-4636"]},"institutions":[{"id":"https://openalex.org/I177639307","display_name":"University of Dundee","ror":"https://ror.org/03h2bxq36","country_code":"GB","type":"education","lineage":["https://openalex.org/I177639307"]},{"id":"https://openalex.org/I4210110201","display_name":"MRC Protein Phosphorylation and Ubiquitylation Unit","ror":"https://ror.org/01zg1tt02","country_code":"GB","type":"facility","lineage":["https://openalex.org/I177639307","https://openalex.org/I4210087105","https://openalex.org/I4210110201","https://openalex.org/I90344618"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Jinwei Zhang","raw_affiliation_strings":["MRC Protein Phosphorylation and Ubiquitylation Unit, College of Life Sciences, University of Dundee, Dundee DD1 5EH, Scotland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"MRC Protein Phosphorylation and Ubiquitylation Unit, College of Life Sciences, University of Dundee, Dundee DD1 5EH, Scotland","institution_ids":["https://openalex.org/I177639307","https://openalex.org/I4210110201"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5013649577","display_name":"Xianming Deng","orcid":"https://orcid.org/0000-0002-9354-5864","observed_orcids":["https://orcid.org/0000-0002-9354-5864"]},"institutions":[{"id":"https://openalex.org/I191208505","display_name":"Xiamen University","ror":"https://ror.org/00mcjh785","country_code":"CN","type":"education","lineage":["https://openalex.org/I191208505"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xianming Deng","raw_affiliation_strings":["State Key Laboratory of Cellular Stress Biology, Innovation Center for Cell Signaling Network, School of Life Sciences, Xiamen University, Xiamen, Fujian 361102, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"State Key Laboratory of Cellular Stress Biology, Innovation Center for Cell Signaling Network, School of Life Sciences, Xiamen University, Xiamen, Fujian 361102, China","institution_ids":["https://openalex.org/I191208505"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5058936141","display_name":"Kristopher Thomas Kahle","orcid":"https://orcid.org/0000-0002-5922-7547","observed_orcids":["https://orcid.org/0000-0002-5922-7547"]},"institutions":[{"id":"https://openalex.org/I32971472","display_name":"Yale University","ror":"https://ror.org/03v76x132","country_code":"US","type":"education","lineage":["https://openalex.org/I32971472"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Kristopher T. Kahle","raw_affiliation_strings":["Department of Cellular and Molecular Physiology and Centers for Mendelian Genomics, Yale School of Medicine, New Haven, CT 06510, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cellular and Molecular Physiology and Centers for Mendelian Genomics, Yale School of Medicine, New Haven, CT 06510, USA","institution_ids":["https://openalex.org/I32971472"]}]}],"institutions":[],"countries_distinct_count":3,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5058936141"],"corresponding_institution_ids":["https://openalex.org/I32971472"],"apc_list":null,"apc_paid":null,"fwci":1.3855,"has_fulltext":true,"cited_by_count":24,"citation_normalized_percentile":{"value":0.81625338,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":90,"max":98},"biblio":{"volume":"9","issue":"450","first_page":"e3","last_page":"e3"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10724","display_name":"Ion Transport and Channel Regulation","score":0.6137999892234802,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10724","display_name":"Ion Transport and Channel Regulation","score":0.6137999892234802,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10169","display_name":"Protein Kinase Regulation and GTPase Signaling","score":0.09430000185966492,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10211","display_name":"Computational Drug Discovery Methods","score":0.052799999713897705,"subfield":{"id":"https://openalex.org/subfields/1703","display_name":"Computational Theory and Mathematics"},"field":{"id":"https://openalex.org/fields/17","display_name":"Computer Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/wnk-kinases","display_name":"WNK kinases","score":0.9980000257492065},{"id":"https://openalex.org/keywords/kinase-inhibitors","display_name":"kinase inhibitors","score":0.8299999833106995},{"id":"https://openalex.org/keywords/kinase-inhibitor-selectivity","display_name":"kinase selectivity","score":0.734000027179718},{"id":"https://openalex.org/keywords/renal-sodium-transport","display_name":"renal sodium transport","score":0.593999981880188},{"id":"https://openalex.org/keywords/oral-bioavailability","display_name":"oral bioavailability","score":0.5989999771118164},{"id":"https://openalex.org/keywords/in-vivo-pharmacology","display_name":"in vivo pharmacology","score":0.7279999852180481}],"concepts":[{"id":"https://openalex.org/C184235292","wikidata":"https://www.wikidata.org/wiki/Q421851","display_name":"Kinase","level":2,"score":0.7279289960861206},{"id":"https://openalex.org/C2910050888","wikidata":"https://www.wikidata.org/wiki/Q4857068","display_name":"Protein-Serine-Threonine Kinases","level":4,"score":0.6212270259857178},{"id":"https://openalex.org/C134121241","wikidata":"https://www.wikidata.org/wiki/Q899301","display_name":"Yield (engineering)","level":2,"score":0.46306127309799194},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.4005153179168701},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.39658498764038086},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3375629782676697},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.32650336623191833},{"id":"https://openalex.org/C97029542","wikidata":"https://www.wikidata.org/wiki/Q281417","display_name":"Protein kinase A","level":3,"score":0.25381261110305786},{"id":"https://openalex.org/C192562407","wikidata":"https://www.wikidata.org/wiki/Q228736","display_name":"Materials science","level":0,"score":0.06292983889579773},{"id":"https://openalex.org/C191897082","wikidata":"https://www.wikidata.org/wiki/Q11467","display_name":"Metallurgy","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007093","descriptor_name":"Imidazoles","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D011759","descriptor_name":"Pyrrolidines","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D017346","descriptor_name":"Protein Serine-Threonine Kinases","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":true},{"descriptor_ui":"D017346","descriptor_name":"Protein Serine-Threonine Kinases","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D017346","descriptor_name":"Protein Serine-Threonine Kinases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D064466","descriptor_name":"Solute Carrier Family 12, Member 1","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D064466","descriptor_name":"Solute Carrier Family 12, Member 1","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false}],"locations_count":5,"locations":[{"id":"doi:10.1126/scisignal.aaj2227","doi":"https://doi.org/10.1126/scisignal.aaj2227","is_oa":false,"landing_page_url":"https://doi.org/10.1126/scisignal.aaj2227","pdf_url":null,"source":{"id":"https://openalex.org/S155937366","display_name":"Science Signaling","issn_l":"1937-9145","issn":["1937-9145","1945-0877"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310315823","host_organization_name":"American Association for the Advancement of Science","host_organization_lineage":["https://openalex.org/P4310315823"],"host_organization_lineage_names":["American Association for the Advancement of Science"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Science Signaling","raw_type":"journal-article"},{"id":"pmid:27811182","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/27811182","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Science signaling","raw_type":"Journal Article"},{"id":"pmh:oai:ore.exeter.ac.uk:10871/33391","doi":null,"is_oa":false,"landing_page_url":"http://hdl.handle.net/10871/33391","pdf_url":null,"source":{"id":"https://openalex.org/S4306401998","display_name":"Open Research Exeter (University of Exeter)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I23923803","host_organization_name":"University of Exeter","host_organization_lineage":["https://openalex.org/I23923803"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":null,"raw_type":"Article"},{"id":"pmh:oai:discovery.dundee.ac.uk:openaire/e4b9adba-660d-4a3f-afa3-7783e26b4c78","doi":null,"is_oa":true,"landing_page_url":"https://discovery.dundee.ac.uk/files/10795485/author_accepted_manuscript.pdf","pdf_url":"https://discovery.dundee.ac.uk/ws/files/10795485/author_accepted_manuscript.pdf","source":{"id":"https://openalex.org/S4306400523","display_name":"Discovery Research Portal (University of Dundee)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I177639307","host_organization_name":"University of Dundee","host_organization_lineage":["https://openalex.org/I177639307"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Zhang, J, Deng, X & Kahle, K T 2016, 'Leveraging unique structural characteristics of WNK kinases to achieve therapeutic inhibition', Science Signaling, vol. 9, no. 450, pe3, pp. 1-3. https://doi.org/10.1126/scisignal.aaj2227","raw_type":"info:eu-repo/semantics/review"},{"id":"pmh:oai:figshare.com:article/29745062","doi":null,"is_oa":false,"landing_page_url":"https://figshare.com/articles/journal_contribution/Leveraging_unique_structural_characteristics_of_WNK_kinases_to_achieve_therapeutic_inhibition/29745062","pdf_url":null,"source":{"id":"https://openalex.org/S4377196282","display_name":"Figshare","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210132348","host_organization_name":"Figshare (United Kingdom)","host_organization_lineage":["https://openalex.org/I4210132348"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Text"}],"best_oa_location":{"id":"pmh:oai:discovery.dundee.ac.uk:openaire/e4b9adba-660d-4a3f-afa3-7783e26b4c78","doi":null,"is_oa":true,"landing_page_url":"https://discovery.dundee.ac.uk/files/10795485/author_accepted_manuscript.pdf","pdf_url":"https://discovery.dundee.ac.uk/ws/files/10795485/author_accepted_manuscript.pdf","source":{"id":"https://openalex.org/S4306400523","display_name":"Discovery Research Portal (University of Dundee)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I177639307","host_organization_name":"University of Dundee","host_organization_lineage":["https://openalex.org/I177639307"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Zhang, J, Deng, X & Kahle, K T 2016, 'Leveraging unique structural characteristics of WNK kinases to achieve therapeutic inhibition', Science Signaling, vol. 9, no. 450, pe3, pp. 1-3. https://doi.org/10.1126/scisignal.aaj2227","raw_type":"info:eu-repo/semantics/review"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.5683000087738037,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2536633292.pdf","grobid_xml":"https://content.openalex.org/works/W2536633292.grobid-xml"},"referenced_works_count":15,"referenced_works":["https://openalex.org/W1895676524","https://openalex.org/W1966285532","https://openalex.org/W1977620650","https://openalex.org/W2007770885","https://openalex.org/W2081347564","https://openalex.org/W2097799706","https://openalex.org/W2124663880","https://openalex.org/W2129352375","https://openalex.org/W2133185088","https://openalex.org/W2142766228","https://openalex.org/W2166518300","https://openalex.org/W2168248904","https://openalex.org/W2225705468","https://openalex.org/W2314655039","https://openalex.org/W2516723064"],"related_works":["https://openalex.org/W2940769527","https://openalex.org/W90599856","https://openalex.org/W2527765961","https://openalex.org/W2017368695","https://openalex.org/W7098248734","https://openalex.org/W7093520156","https://openalex.org/W2000518178","https://openalex.org/W130139888","https://openalex.org/W2052434740","https://openalex.org/W2516723064"],"abstract_inverted_index":{"cotransporters,":[0],"including":[1],"the":[2,24,49,53],"renal-specific":[3],"NCC":[4],"and":[5,32,47],"NKCC2":[6],"cotransporters.":[7],"The":[8],"discovery":[9],"of":[10,23,38,52,57],"WNK463,":[11],"an":[12],"orally":[13],"bioavailable":[14],"pan-WNK":[15],"kinase":[16,33,41],"inhibitor":[17],"that":[18],"exploits":[19],"unique":[20],"structural":[21],"properties":[22],"WNK":[25,58],"catalytic":[26],"domain":[27],"to":[28,43],"achieve":[29],"high":[30],"affinity":[31],"selectivity,":[34],"illustrates":[35],"a":[36],"strategy":[37],"leveraging":[39],"distinct":[40],"features":[42],"develop":[44],"specific":[45],"inhibitors":[46],"validates":[48],"genetic":[50],"predictions":[51],"in":[54],"vivo":[55],"pharmacology":[56],"inhibition.":[59]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":1},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":4},{"year":2021,"cited_by_count":4},{"year":2020,"cited_by_count":4},{"year":2019,"cited_by_count":2},{"year":2018,"cited_by_count":4},{"year":2017,"cited_by_count":2}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-10-28T00:00:00"}
