{"id":"https://openalex.org/W25365407","doi":null,"title":"Hemodynamic and acid-base effects of meperidine on unanesthetized pregnant sheep and fetus.","display_name":"Hemodynamic and acid-base effects of meperidine on unanesthetized pregnant sheep and fetus.","publication_year":1985,"publication_date":"1985-01-01","ids":{"openalex":"https://openalex.org/W25365407","mag":"25365407","pmid":"https://pubmed.ncbi.nlm.nih.gov/3991252"},"language":"en","primary_location":{"id":"pmid:3991252","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/3991252","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Pediatric pharmacology (New York, N.Y.)","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5058250213","display_name":"Jahangir Ayromlooi","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"J Ayromlooi","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5058250213"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":1,"citation_normalized_percentile":{"value":0.00224845,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"5","issue":"1","first_page":"49","last_page":"55"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10189","display_name":"Anesthesia and Pain Management","score":0.8604000210762024,"subfield":{"id":"https://openalex.org/subfields/2703","display_name":"Anesthesiology and Pain Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10189","display_name":"Anesthesia and Pain Management","score":0.8604000210762024,"subfield":{"id":"https://openalex.org/subfields/2703","display_name":"Anesthesiology and Pain Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10436","display_name":"Anesthesia and Sedative Agents","score":0.037300001829862595,"subfield":{"id":"https://openalex.org/subfields/2703","display_name":"Anesthesiology and Pain Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11905","display_name":"Veterinary Pharmacology and Anesthesia","score":0.033799998462200165,"subfield":{"id":"https://openalex.org/subfields/3404","display_name":"Small Animals"},"field":{"id":"https://openalex.org/fields/34","display_name":"Veterinary"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/meperidine","display_name":"pethidine","score":0.968999981880188},{"id":"https://openalex.org/keywords/placental-drug-transfer","display_name":"maternal-fetal drug transfer","score":0.6850000023841858},{"id":"https://openalex.org/keywords/fetal-hemodynamics","display_name":"fetal hemodynamics","score":0.6800000071525574},{"id":"https://openalex.org/keywords/fetal-acid-base-balance","display_name":"fetal acid-base balance","score":0.7329999804496765},{"id":"https://openalex.org/keywords/respiratory-alkalosis","display_name":"respiratory alkalosis","score":0.9380000233650208},{"id":"https://openalex.org/keywords/uterine-blood-flow","display_name":"uterine blood flow","score":0.9670000076293945},{"id":"https://openalex.org/keywords/pregnant-sheep","display_name":"pregnant sheep","score":0.5529999732971191},{"id":"https://openalex.org/keywords/fetal-oxygenation","display_name":"fetal oxygenation","score":0.49300000071525574}],"concepts":[{"id":"https://openalex.org/C2777140959","wikidata":"https://www.wikidata.org/wiki/Q10343041","display_name":"pCO2","level":2,"score":0.7051939368247986},{"id":"https://openalex.org/C172680121","wikidata":"https://www.wikidata.org/wiki/Q26513","display_name":"Fetus","level":3,"score":0.6818511486053467},{"id":"https://openalex.org/C178853913","wikidata":"https://www.wikidata.org/wiki/Q1642137","display_name":"Hemodynamics","level":2,"score":0.6034325957298279},{"id":"https://openalex.org/C42219234","wikidata":"https://www.wikidata.org/wiki/Q131130","display_name":"Anesthesia","level":1,"score":0.5912635326385498},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5862334966659546},{"id":"https://openalex.org/C2777953023","wikidata":"https://www.wikidata.org/wiki/Q1073121","display_name":"Heart rate","level":3,"score":0.4976835548877716},{"id":"https://openalex.org/C158846371","wikidata":"https://www.wikidata.org/wiki/Q1642137","display_name":"Blood flow","level":2,"score":0.4484293460845947},{"id":"https://openalex.org/C84393581","wikidata":"https://www.wikidata.org/wiki/Q82642","display_name":"Blood pressure","level":2,"score":0.4439132809638977},{"id":"https://openalex.org/C2778917026","wikidata":"https://www.wikidata.org/wiki/Q43041","display_name":"Hemoglobin","level":2,"score":0.4426463842391968},{"id":"https://openalex.org/C2778553927","wikidata":"https://www.wikidata.org/wiki/Q185089","display_name":"Acidosis","level":2,"score":0.4109760522842407},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.25367987155914307},{"id":"https://openalex.org/C2779234561","wikidata":"https://www.wikidata.org/wiki/Q11995","display_name":"Pregnancy","level":2,"score":0.23259297013282776},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.07951635122299194},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000136","descriptor_name":"Acid-Base Equilibrium","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001784","descriptor_name":"Blood Gas Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001794","descriptor_name":"Blood Pressure","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005312","descriptor_name":"Fetal Blood","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D006439","descriptor_name":"Hemodynamics","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D006454","descriptor_name":"Hemoglobins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006863","descriptor_name":"Hydrogen-Ion Concentration","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007263","descriptor_name":"Infusions, Parenteral","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008431","descriptor_name":"Maternal-Fetal Exchange","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008614","descriptor_name":"Meperidine","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D011247","descriptor_name":"Pregnancy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012756","descriptor_name":"Sheep","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014599","descriptor_name":"Uterus","qualifier_ui":"Q000098","qualifier_name":"blood supply","is_major_topic":false}],"locations_count":2,"locations":[{"id":"pmid:3991252","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/3991252","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Pediatric pharmacology (New York, N.Y.)","raw_type":"Journal Article"},{"id":"mag:25365407","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/3991252","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9537000060081482,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":38,"referenced_works":["https://openalex.org/W2025447496","https://openalex.org/W2147288464","https://openalex.org/W2083497059","https://openalex.org/W2141405866","https://openalex.org/W1987996702","https://openalex.org/W1972366842","https://openalex.org/W2121335237","https://openalex.org/W2108717106","https://openalex.org/W2042221145","https://openalex.org/W1973972052","https://openalex.org/W2040051569","https://openalex.org/W1980133234","https://openalex.org/W2165413853","https://openalex.org/W2137633794","https://openalex.org/W2101474847","https://openalex.org/W2025086694","https://openalex.org/W2290912766","https://openalex.org/W2162855483","https://openalex.org/W2135743018","https://openalex.org/W2119533233","https://openalex.org/W1994839137","https://openalex.org/W2170349505","https://openalex.org/W1988682083","https://openalex.org/W2128476271","https://openalex.org/W2037038224","https://openalex.org/W2135665336","https://openalex.org/W1979281945","https://openalex.org/W2028959604","https://openalex.org/W1996962457","https://openalex.org/W2151625863","https://openalex.org/W2042490889","https://openalex.org/W2047211423","https://openalex.org/W1977936584","https://openalex.org/W2101888517","https://openalex.org/W2130141046","https://openalex.org/W2081993949","https://openalex.org/W1987627565","https://openalex.org/W2167852161"],"related_works":["https://openalex.org/W1572399750","https://openalex.org/W2413704508","https://openalex.org/W1988846694","https://openalex.org/W2024318079","https://openalex.org/W2414775321","https://openalex.org/W1590989949","https://openalex.org/W2415331229","https://openalex.org/W1967604749","https://openalex.org/W2401460835","https://openalex.org/W2414531710"],"abstract_inverted_index":{"Meperidine":[0],"hydrochloride":[1],"(MHCl)":[2],"is":[3,136],"one":[4],"of":[5,32,38],"the":[6,39,154,166],"most":[7],"widely":[8],"used":[9,156],"analgesics":[10],"today.":[11],"Its":[12],"effect":[13,162],"upon":[14,170],"maternal":[15,29,66,98,142],"and":[16,20,47,56,75,114,131,182],"fetal":[17],"sheep":[18],"hemodynamics":[19],"acid":[21],"base":[22,103],"were":[23,43,62,120],"investigated":[24],"in":[25,65,86,97,149,157,165],"13":[26],"experiments":[27],"following":[28],"IV":[30],"administration":[31],"100":[33],"mg":[34],"(approximately":[35],"2":[36],"mg/kg)":[37],"drug.":[40],"Blood":[41],"samples":[42],"taken":[44],"at":[45,48,68,88],"baseline":[46],"7.5,":[49],"15,":[50],"30,":[51],"45,":[52],"60,":[53],"75,":[54],"90,":[55],"120":[57,76],"minutes":[58],"postinfusion.":[59],"Significant":[60],"changes":[61,96,148],"an":[63],"increase":[64],"pH":[67],"45":[69,89],"minutes,":[70,77,90],"P":[71,78,91],"less":[72,79,92],"than":[73,80,93],"0.01":[74],".01":[81],"accompanied":[82],"by":[83,179],"a":[84],"decrease":[85],"pCO2":[87],".01.":[94],"No":[95],"pO2,":[99,124],"O2":[100],"saturation":[101],"(O2%),":[102],"excess":[104],"(BE),":[105],"hemoglobin":[106],"(Hb),":[107],"heart":[108],"rate":[109],"(HR),":[110],"blood":[111,116,151],"pressure":[112],"(BP),":[113],"uterine":[115,150],"flow":[117],"(ut.":[118],"BF)":[119],"noted.":[121],"Fetal":[122],"PH,":[123],"pCO2,":[125],"O2%,":[126],"bicarbonate,":[127],"BE,":[128],"Hb,":[129],"HR,":[130],"BP":[132],"remained":[133],"unchanged.":[134],"It":[135],"suggested":[137],"that":[138],"MHCl":[139,173],"causes":[140],"transient":[141],"respiratory":[143],"alkalosis":[144],"without":[145],"any":[146],"significant":[147],"flow.":[152],"With":[153],"dose":[155],"this":[158,171],"study,":[159,172],"no":[160],"adverse":[161],"was":[163],"observed":[164],"fetus.":[167,184],"Therefore,":[168],"based":[169],"seems":[174],"to":[175],"be":[176],"tolerated":[177],"well":[178],"both":[180],"ewe":[181],"her":[183]},"counts_by_year":[],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
