{"id":"https://openalex.org/W2535901072","doi":null,"title":"Presynaptic Regulation of Carotid Body Type I Cells by Histaminergic and Muscarinic Receptors","display_name":"Presynaptic Regulation of Carotid Body Type I Cells by Histaminergic and Muscarinic Receptors","publication_year":2010,"publication_date":"2010-01-01","ids":{"openalex":"https://openalex.org/W2535901072","mag":"2535901072"},"language":"en","primary_location":{"id":"pmh:oai:corescholar.libraries.wright.edu:etd_all-2144","doi":null,"is_oa":true,"landing_page_url":"https://corescholar.libraries.wright.edu/etd_all/1005","pdf_url":"https://corescholar.libraries.wright.edu/cgi/viewcontent.cgi?article=2144&context=etd_all","source":{"id":"https://openalex.org/S2737205702","display_name":"Journal of Bioresource Management","issn_l":"2309-3854","issn":["2309-3854"],"is_oa":false,"is_in_doaj":true,"is_core":false,"listed_in":["doaj","erih-plus"],"host_organization":"https://openalex.org/P4310316536","host_organization_name":"Bioresource Research Center (BRC), Islamabad","host_organization_lineage":["https://openalex.org/P4310316536"],"host_organization_lineage_names":["Bioresource Research Center (BRC), Islamabad"],"type":"journal"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Browse all Theses and Dissertations","raw_type":"text"},"volume":null,"type":"article","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://corescholar.libraries.wright.edu/cgi/viewcontent.cgi?article=2144&context=etd_all","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5028873459","display_name":"Carrie M. Thompson","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I19648265","display_name":"Wright State University","ror":"https://ror.org/04qk6pt94","country_code":"US","type":"education","lineage":["https://openalex.org/I19648265"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Carrie M. Thompson","raw_affiliation_strings":["Wright State University;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Wright State University;","institution_ids":["https://openalex.org/I19648265"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5028873459"],"corresponding_institution_ids":["https://openalex.org/I19648265"],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11456","display_name":"Neuroscience of respiration and sleep","score":0.98580002784729,"subfield":{"id":"https://openalex.org/subfields/2807","display_name":"Endocrine and Autonomic Systems"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11456","display_name":"Neuroscience of respiration and sleep","score":0.98580002784729,"subfield":{"id":"https://openalex.org/subfields/2807","display_name":"Endocrine and Autonomic Systems"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11178","display_name":"Receptor Mechanisms and Signaling","score":0.004600000102072954,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10077","display_name":"Neuroscience and Neuropharmacology Research","score":0.002899999963119626,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/histamine","display_name":"histamine","score":0.8289999961853027},{"id":"https://openalex.org/keywords/muscarinic-receptors","display_name":"muscarinic receptors","score":0.8109999895095825},{"id":"https://openalex.org/keywords/histamine-h3-receptor","display_name":"histamine H3 receptor","score":0.8080000281333923},{"id":"https://openalex.org/keywords/intracellular-calcium-signaling","display_name":"intracellular calcium signaling","score":0.8429999947547913},{"id":"https://openalex.org/keywords/camp","display_name":"cyclic AMP","score":0.7210000157356262},{"id":"https://openalex.org/keywords/epac","display_name":"Epac","score":0.7590000033378601},{"id":"https://openalex.org/keywords/protein-kinase-a","display_name":"protein kinase A","score":0.7319999933242798},{"id":"https://openalex.org/keywords/presynaptic-modulation","display_name":"presynaptic modulation","score":0.6850000023841858},{"id":"https://openalex.org/keywords/neurotransmitter-modulation","display_name":"neurotransmitter modulation","score":0.6520000100135803},{"id":"https://openalex.org/keywords/hypoxia","display_name":"hypoxia","score":0.6840000152587891},{"id":"https://openalex.org/keywords/carotid-sinus-nerve","display_name":"carotid sinus nerve","score":0.7760000228881836},{"id":"https://openalex.org/keywords/chemoreceptors","display_name":"chemoreceptors","score":0.5130000114440918}],"concepts":[{"id":"https://openalex.org/C2778501154","wikidata":"https://www.wikidata.org/wiki/Q18349602","display_name":"Histaminergic","level":3,"score":0.9621552228927612},{"id":"https://openalex.org/C33789571","wikidata":"https://www.wikidata.org/wiki/Q410959","display_name":"Muscarinic acetylcholine receptor","level":3,"score":0.7382587194442749},{"id":"https://openalex.org/C2778113364","wikidata":"https://www.wikidata.org/wiki/Q1532008","display_name":"Carotid body","level":3,"score":0.5715106725692749},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.5393720865249634},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.4619176387786865},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.4174751043319702},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.40494492650032043},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3312300443649292},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.3253463804721832},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.2578674554824829},{"id":"https://openalex.org/C24998067","wikidata":"https://www.wikidata.org/wiki/Q4114622","display_name":"Stimulation","level":2,"score":0.09896805882453918}],"mesh":[],"locations_count":3,"locations":[{"id":"pmh:oai:corescholar.libraries.wright.edu:etd_all-2144","doi":null,"is_oa":true,"landing_page_url":"https://corescholar.libraries.wright.edu/etd_all/1005","pdf_url":"https://corescholar.libraries.wright.edu/cgi/viewcontent.cgi?article=2144&context=etd_all","source":{"id":"https://openalex.org/S2737205702","display_name":"Journal of Bioresource Management","issn_l":"2309-3854","issn":["2309-3854"],"is_oa":false,"is_in_doaj":true,"is_core":false,"listed_in":["doaj","erih-plus"],"host_organization":"https://openalex.org/P4310316536","host_organization_name":"Bioresource Research Center (BRC), Islamabad","host_organization_lineage":["https://openalex.org/P4310316536"],"host_organization_lineage_names":["Bioresource Research Center (BRC), Islamabad"],"type":"journal"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Browse all Theses and Dissertations","raw_type":"text"},{"id":"pmh:oai:etd.ohiolink.edu:wright1283278640","doi":null,"is_oa":false,"landing_page_url":"http://rave.ohiolink.edu/etdc/view?acc_num=wright1283278640","pdf_url":null,"source":{"id":"https://openalex.org/S4377196344","display_name":"OhioLink ETD Center (Ohio Library and Information Network)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210155183","host_organization_name":"Ohio Library and Information Network","host_organization_lineage":["https://openalex.org/I4210155183"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"http://rave.ohiolink.edu/etdc/view?acc_num=wright1283278640","raw_type":"text"},{"id":"mag:2535901072","doi":null,"is_oa":false,"landing_page_url":"https://corescholar.libraries.wright.edu/cgi/viewcontent.cgi?article=2144&context=etd_all","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":{"id":"pmh:oai:corescholar.libraries.wright.edu:etd_all-2144","doi":null,"is_oa":true,"landing_page_url":"https://corescholar.libraries.wright.edu/etd_all/1005","pdf_url":"https://corescholar.libraries.wright.edu/cgi/viewcontent.cgi?article=2144&context=etd_all","source":{"id":"https://openalex.org/S2737205702","display_name":"Journal of Bioresource Management","issn_l":"2309-3854","issn":["2309-3854"],"is_oa":false,"is_in_doaj":true,"is_core":false,"listed_in":["doaj","erih-plus"],"host_organization":"https://openalex.org/P4310316536","host_organization_name":"Bioresource Research Center (BRC), Islamabad","host_organization_lineage":["https://openalex.org/P4310316536"],"host_organization_lineage_names":["Bioresource Research Center (BRC), Islamabad"],"type":"journal"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Browse all Theses and Dissertations","raw_type":"text"},"sustainable_development_goals":[{"score":0.6240000128746033,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2535901072.pdf","grobid_xml":"https://content.openalex.org/works/W2535901072.grobid-xml"},"referenced_works_count":88,"referenced_works":["https://openalex.org/W14391214","https://openalex.org/W20224721","https://openalex.org/W1530666455","https://openalex.org/W1547589333","https://openalex.org/W1564487131","https://openalex.org/W1593537432","https://openalex.org/W1599174528","https://openalex.org/W1815358919","https://openalex.org/W1880484442","https://openalex.org/W1900961504","https://openalex.org/W1963719129","https://openalex.org/W1964320031","https://openalex.org/W1968885616","https://openalex.org/W1970225649","https://openalex.org/W1970684904","https://openalex.org/W1979803052","https://openalex.org/W1982836796","https://openalex.org/W1983565569","https://openalex.org/W1987048520","https://openalex.org/W1987095470","https://openalex.org/W1988884715","https://openalex.org/W1996459115","https://openalex.org/W2001079294","https://openalex.org/W2001409949","https://openalex.org/W2002533373","https://openalex.org/W2002999036","https://openalex.org/W2004209949","https://openalex.org/W2004741695","https://openalex.org/W2007143312","https://openalex.org/W2007559599","https://openalex.org/W2010618201","https://openalex.org/W2018016689","https://openalex.org/W2020927614","https://openalex.org/W2032091460","https://openalex.org/W2033791434","https://openalex.org/W2035633278","https://openalex.org/W2040048554","https://openalex.org/W2040328845","https://openalex.org/W2040641770","https://openalex.org/W2041050549","https://openalex.org/W2043381835","https://openalex.org/W2044709180","https://openalex.org/W2046133716","https://openalex.org/W2047277170","https://openalex.org/W2048888172","https://openalex.org/W2054445291","https://openalex.org/W2056299379","https://openalex.org/W2060564059","https://openalex.org/W2064454767","https://openalex.org/W2072079353","https://openalex.org/W2073282010","https://openalex.org/W2077687762","https://openalex.org/W2079413658","https://openalex.org/W2080913911","https://openalex.org/W2082177070","https://openalex.org/W2087004550","https://openalex.org/W2100288030","https://openalex.org/W2106838679","https://openalex.org/W2107522886","https://openalex.org/W2111698016","https://openalex.org/W2113065956","https://openalex.org/W2113166898","https://openalex.org/W2115145156","https://openalex.org/W2124451529","https://openalex.org/W2130019684","https://openalex.org/W2140994013","https://openalex.org/W2141174309","https://openalex.org/W2148912607","https://openalex.org/W2153134407","https://openalex.org/W2157189345","https://openalex.org/W2159308549","https://openalex.org/W2159310780","https://openalex.org/W2160176954","https://openalex.org/W2160279245","https://openalex.org/W2161057669","https://openalex.org/W2163585457","https://openalex.org/W2169089690","https://openalex.org/W2169527010","https://openalex.org/W2171648839","https://openalex.org/W2173317528","https://openalex.org/W2178849834","https://openalex.org/W2275333482","https://openalex.org/W2340363156","https://openalex.org/W2413669248","https://openalex.org/W2553315459","https://openalex.org/W2727895029","https://openalex.org/W2841390334","https://openalex.org/W3110735418"],"related_works":["https://openalex.org/W2054445291","https://openalex.org/W2115145156","https://openalex.org/W2022997798","https://openalex.org/W2100840772","https://openalex.org/W182822382","https://openalex.org/W2794262707","https://openalex.org/W2004741695","https://openalex.org/W2159308549","https://openalex.org/W2603642104","https://openalex.org/W37709560"],"abstract_inverted_index":{"Type":[0],"I":[1,92,184],"cells":[2,16,185],"are":[3,55],"one":[4],"of":[5,33,73,100,139,146,151,157,189],"two":[6,66,163],"main":[7],"cell":[8],"types":[9],"located":[10],"within":[11],"the":[12,34,63,71,74,98,116,127,137,169,187],"carotid":[13,35,75],"body.":[14,76],"These":[15],"respond":[17],"to":[18,43,83,96],"hypoxia,":[19],"hypercapnia,":[20],"and":[21,26,38,142],"acidosis":[22],"by":[23,135,186,193],"releasing":[24],"excitatory":[25,56,102],"inhibitory":[27],"neurotransmitters.":[28],"This":[29],"causes":[30],"increased":[31],"firing":[32],"sinus":[36],"nerve":[37],"restores":[39],"blood":[40],"gas":[41],"levels":[42,145],"their":[44],"physiological":[45],"values.":[46],"While":[47],"previous":[48],"studies":[49],"have":[50,84],"shown":[51,82],"whether":[52],"individual":[53],"neurotransmitters":[54,67],"or":[57],"inhibitory,":[58],"this":[59,110],"work":[60,111],"demonstrates":[61],"how":[62],"interplay":[64],"between":[65],"may":[68,94,131,177],"potentially":[69],"shape":[70],"output":[72],"Histamine,":[77,124],"which":[78],"has":[79],"previously":[80],"been":[81],"no":[85],"effect":[86],"on":[87,126],"intracellular":[88,122],"Ca2+":[89,153,180],"in":[90,121,182],"type":[91,183],"cells,":[93],"function":[95],"modulate":[97],"actions":[99,134],"an":[101],"neurotransmitter":[103],"such":[104],"as":[105,162],"acetylcholine.":[106],"Using":[107],"Ca2+-imaging":[108],"techniques,":[109],"shows":[112],"that":[113,173],"histamine":[114],"inhibits":[115],"acetylcholine":[117],"muscarinic":[118,152,179],"receptor-induced":[119],"rise":[120],"Ca2+.":[123],"acting":[125],"Gi-coupled":[128,174],"H3":[129],"receptor,":[130],"exert":[132],"its":[133],"inhibiting":[136],"activation":[138,176],"adenylate":[140],"cyclase":[141],"therefore":[143],"reducing":[144],"cAMP.":[147],"The":[148],"observed":[149],"inhibition":[150,188],"signaling":[154,181],"seems":[155],"independent":[156],"protein":[158],"kinase":[159],"A":[160],"(PKA),":[161],"PKA":[164],"inhibitors":[165],"did":[166],"not":[167],"mimic":[168],"inhibition.":[170],"Data":[171],"suggest":[172],"receptor":[175],"inhibit":[178],"Exchange":[190],"Proteins":[191],"Activated":[192],"cAMP":[194],"(Epac).":[195]},"counts_by_year":[],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-10-28T00:00:00"}