{"id":"https://openalex.org/W2535686641","doi":"https://doi.org/10.1039/c6md00432f","title":"Hypoxia inducible factor down-regulation, cancer and cancer stem cells (CSCs): ongoing success stories","display_name":"Hypoxia inducible factor down-regulation, cancer and cancer stem cells (CSCs): ongoing success stories","publication_year":2016,"publication_date":"2016-10-18","ids":{"openalex":"https://openalex.org/W2535686641","doi":"https://doi.org/10.1039/c6md00432f","mag":"2535686641","pmid":"https://pubmed.ncbi.nlm.nih.gov/30108689","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/6071925"},"language":"en","primary_location":{"id":"doi:10.1039/c6md00432f","doi":"https://doi.org/10.1039/c6md00432f","is_oa":false,"landing_page_url":"https://doi.org/10.1039/c6md00432f","pdf_url":null,"source":{"id":"https://openalex.org/S191926780","display_name":"MedChemComm","issn_l":"2040-2503","issn":["2040-2503","2040-2511"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","ki-jl-1","norway-1","poland-70"],"host_organization":"https://openalex.org/P4310320556","host_organization_name":"Royal Society of Chemistry","host_organization_lineage":["https://openalex.org/P4310320556"],"host_organization_lineage_names":["Royal Society of Chemistry"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"MedChemComm","raw_type":"journal-article"},"volume":null,"type":"review","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"http://europepmc.org/pmc/articles/PMC6071925","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5018849034","display_name":"Anthony R. Martin","orcid":"https://orcid.org/0000-0001-6187-6979","observed_orcids":["https://orcid.org/0000-0001-6187-6979"]},"institutions":[{"id":"https://openalex.org/I1294671590","display_name":"Centre National de la Recherche Scientifique","ror":"https://ror.org/02feahw73","country_code":"FR","type":"government","lineage":["https://openalex.org/I1294671590"]},{"id":"https://openalex.org/I201841394","display_name":"Universit\u00e9 C\u00f4te d'Azur","ror":"https://ror.org/019tgvf94","country_code":"FR","type":"education","lineage":["https://openalex.org/I201841394"]},{"id":"https://openalex.org/I4210086528","display_name":"Institut de Chimie de Nice","ror":"https://ror.org/000pvc513","country_code":"FR","type":"facility","lineage":["https://openalex.org/I1294671590","https://openalex.org/I201841394","https://openalex.org/I4210086528","https://openalex.org/I4210128300"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Anthony R. Martin","raw_affiliation_strings":["CNRS","France","Institut de Chimie de Nice UMR 7272 - 06108 Nice","Universit\u00e9 C\u00f4te d'Azur"],"raw_orcid":"https://orcid.org/0000-0001-6187-6979","affiliations":[{"raw_affiliation_string":"CNRS","institution_ids":["https://openalex.org/I1294671590"]},{"raw_affiliation_string":"France","institution_ids":[]},{"raw_affiliation_string":"Institut de Chimie de Nice UMR 7272 - 06108 Nice","institution_ids":["https://openalex.org/I4210086528"]},{"raw_affiliation_string":"Universit\u00e9 C\u00f4te d'Azur","institution_ids":["https://openalex.org/I201841394"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5035512825","display_name":"Cyril Ronco","orcid":"https://orcid.org/0000-0002-9023-5940","observed_orcids":["https://orcid.org/0000-0002-9023-5940"]},"institutions":[{"id":"https://openalex.org/I1294671590","display_name":"Centre National de la Recherche Scientifique","ror":"https://ror.org/02feahw73","country_code":"FR","type":"government","lineage":["https://openalex.org/I1294671590"]},{"id":"https://openalex.org/I201841394","display_name":"Universit\u00e9 C\u00f4te d'Azur","ror":"https://ror.org/019tgvf94","country_code":"FR","type":"education","lineage":["https://openalex.org/I201841394"]},{"id":"https://openalex.org/I4210086528","display_name":"Institut de Chimie de Nice","ror":"https://ror.org/000pvc513","country_code":"FR","type":"facility","lineage":["https://openalex.org/I1294671590","https://openalex.org/I201841394","https://openalex.org/I4210086528","https://openalex.org/I4210128300"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Cyril Ronco","raw_affiliation_strings":["CNRS","France","Institut de Chimie de Nice UMR 7272 - 06108 Nice","Universit\u00e9 C\u00f4te d'Azur"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"CNRS","institution_ids":["https://openalex.org/I1294671590"]},{"raw_affiliation_string":"France","institution_ids":[]},{"raw_affiliation_string":"Institut de Chimie de Nice UMR 7272 - 06108 Nice","institution_ids":["https://openalex.org/I4210086528"]},{"raw_affiliation_string":"Universit\u00e9 C\u00f4te d'Azur","institution_ids":["https://openalex.org/I201841394"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5055177972","display_name":"Luc Demange","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1294671590","display_name":"Centre National de la Recherche Scientifique","ror":"https://ror.org/02feahw73","country_code":"FR","type":"government","lineage":["https://openalex.org/I1294671590"]},{"id":"https://openalex.org/I201841394","display_name":"Universit\u00e9 C\u00f4te d'Azur","ror":"https://ror.org/019tgvf94","country_code":"FR","type":"education","lineage":["https://openalex.org/I201841394"]},{"id":"https://openalex.org/I4210086528","display_name":"Institut de Chimie de Nice","ror":"https://ror.org/000pvc513","country_code":"FR","type":"facility","lineage":["https://openalex.org/I1294671590","https://openalex.org/I201841394","https://openalex.org/I4210086528","https://openalex.org/I4210128300"]}],"countries":["FR"],"is_corresponding":true,"raw_author_name":"Luc Demange","raw_affiliation_strings":["CNRS","France","Institut de Chimie de Nice UMR 7272 - 06108 Nice","UFR des Sciences Pharmaceutiques","Universit\u00e9 C\u00f4te d'Azur"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"CNRS","institution_ids":["https://openalex.org/I1294671590"]},{"raw_affiliation_string":"France","institution_ids":[]},{"raw_affiliation_string":"Institut de Chimie de Nice UMR 7272 - 06108 Nice","institution_ids":["https://openalex.org/I4210086528"]},{"raw_affiliation_string":"UFR des Sciences Pharmaceutiques","institution_ids":[]},{"raw_affiliation_string":"Universit\u00e9 C\u00f4te d'Azur","institution_ids":["https://openalex.org/I201841394"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5054373904","display_name":"Rachid Benhida","orcid":"https://orcid.org/0000-0003-3419-5697","observed_orcids":["https://orcid.org/0000-0003-3419-5697"]},"institutions":[{"id":"https://openalex.org/I1294671590","display_name":"Centre National de la Recherche Scientifique","ror":"https://ror.org/02feahw73","country_code":"FR","type":"government","lineage":["https://openalex.org/I1294671590"]},{"id":"https://openalex.org/I201841394","display_name":"Universit\u00e9 C\u00f4te d'Azur","ror":"https://ror.org/019tgvf94","country_code":"FR","type":"education","lineage":["https://openalex.org/I201841394"]},{"id":"https://openalex.org/I4210086528","display_name":"Institut de Chimie de Nice","ror":"https://ror.org/000pvc513","country_code":"FR","type":"facility","lineage":["https://openalex.org/I1294671590","https://openalex.org/I201841394","https://openalex.org/I4210086528","https://openalex.org/I4210128300"]}],"countries":["FR"],"is_corresponding":true,"raw_author_name":"Rachid Benhida","raw_affiliation_strings":["CNRS","France","Institut de Chimie de Nice UMR 7272 - 06108 Nice","Universit\u00e9 C\u00f4te d'Azur"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"CNRS","institution_ids":["https://openalex.org/I1294671590"]},{"raw_affiliation_string":"France","institution_ids":[]},{"raw_affiliation_string":"Institut de Chimie de Nice UMR 7272 - 06108 Nice","institution_ids":["https://openalex.org/I4210086528"]},{"raw_affiliation_string":"Universit\u00e9 C\u00f4te d'Azur","institution_ids":["https://openalex.org/I201841394"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5054373904","https://openalex.org/A5055177972"],"corresponding_institution_ids":["https://openalex.org/I1294671590","https://openalex.org/I201841394","https://openalex.org/I4210086528"],"apc_list":null,"apc_paid":null,"fwci":0.249,"has_fulltext":false,"cited_by_count":27,"citation_normalized_percentile":{"value":0.21555669,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"8","issue":"1","first_page":"21","last_page":"52"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10631","display_name":"Cancer, Hypoxia, and Metabolism","score":0.9887999892234802,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10631","display_name":"Cancer, Hypoxia, and Metabolism","score":0.9887999892234802,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10336","display_name":"Cancer Cells and Metastasis","score":0.0038999998942017555,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10422","display_name":"Angiogenesis and VEGF in Cancer","score":0.0012000000569969416,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/hypoxia-inducible-factor-1","display_name":"HIF-1","score":0.9940000176429749},{"id":"https://openalex.org/keywords/cancer-stem-cells","display_name":"cancer stem cells","score":0.8840000033378601},{"id":"https://openalex.org/keywords/transcription-factor-downregulation","display_name":"transcription factor downregulation","score":0.7250000238418579},{"id":"https://openalex.org/keywords/tumor-vascularity","display_name":"tumor vascularity","score":0.9620000123977661},{"id":"https://openalex.org/keywords/metastasis","display_name":"metastasis","score":0.9779999852180481},{"id":"https://openalex.org/keywords/self-renewal","display_name":"self-renewal","score":0.8510000109672546},{"id":"https://openalex.org/keywords/tumor-hypoxia","display_name":"tumor hypoxia","score":0.7519999742507935}],"concepts":[{"id":"https://openalex.org/C86339819","wikidata":"https://www.wikidata.org/wiki/Q407384","display_name":"Transcription factor","level":3,"score":0.7023909091949463},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.5931136012077332},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.5780786275863647},{"id":"https://openalex.org/C207001950","wikidata":"https://www.wikidata.org/wiki/Q141124","display_name":"In vivo","level":2,"score":0.5279214382171631},{"id":"https://openalex.org/C160450060","wikidata":"https://www.wikidata.org/wiki/Q104598479","display_name":"Hypoxia-inducible factors","level":3,"score":0.5214825868606567},{"id":"https://openalex.org/C55427017","wikidata":"https://www.wikidata.org/wiki/Q1638475","display_name":"Cancer stem cell","level":3,"score":0.508897066116333},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.5069947242736816},{"id":"https://openalex.org/C7836513","wikidata":"https://www.wikidata.org/wiki/Q1641506","display_name":"Hypoxia (environmental)","level":3,"score":0.4935833215713501},{"id":"https://openalex.org/C96232424","wikidata":"https://www.wikidata.org/wiki/Q4118072","display_name":"Cancer cell","level":3,"score":0.48914507031440735},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4654458463191986},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.3827541172504425},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.3436514139175415},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.33881786465644836},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.31232351064682007},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.28323471546173096},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.14996996521949768},{"id":"https://openalex.org/C150903083","wikidata":"https://www.wikidata.org/wiki/Q7108","display_name":"Biotechnology","level":1,"score":0.12221288681030273},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.10704502463340759},{"id":"https://openalex.org/C540031477","wikidata":"https://www.wikidata.org/wiki/Q629","display_name":"Oxygen","level":2,"score":0.0},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.0}],"mesh":[],"locations_count":5,"locations":[{"id":"doi:10.1039/c6md00432f","doi":"https://doi.org/10.1039/c6md00432f","is_oa":false,"landing_page_url":"https://doi.org/10.1039/c6md00432f","pdf_url":null,"source":{"id":"https://openalex.org/S191926780","display_name":"MedChemComm","issn_l":"2040-2503","issn":["2040-2503","2040-2511"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","ki-jl-1","norway-1","poland-70"],"host_organization":"https://openalex.org/P4310320556","host_organization_name":"Royal Society of Chemistry","host_organization_lineage":["https://openalex.org/P4310320556"],"host_organization_lineage_names":["Royal Society of Chemistry"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"MedChemComm","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:5037371","doi":null,"is_oa":true,"landing_page_url":"http://europepmc.org/pmc/articles/PMC6071925","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"","raw_type":"Text"},{"id":"pmid:30108689","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/30108689","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"MedChemComm","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:6071925","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC6071925/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Medchemcomm","raw_type":"Text"},{"id":"pmh:oai:HAL:hal-01589485v1","doi":null,"is_oa":false,"landing_page_url":"https://hal.science/hal-01589485","pdf_url":null,"source":{"id":"https://openalex.org/S4306402512","display_name":"HAL","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4405252976","host_organization_name":"Centre pour la Communication Scientifique Directe","host_organization_lineage":["https://openalex.org/I4405252976"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"MedChemComm, 2016, ⟨10.1039/C6MD00432F⟩","raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":{"id":"pmh:oai:europepmc.org:5037371","doi":null,"is_oa":true,"landing_page_url":"http://europepmc.org/pmc/articles/PMC6071925","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"","raw_type":"Text"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9391000270843506,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":273,"referenced_works":["https://openalex.org/W52324175","https://openalex.org/W576850159","https://openalex.org/W1482157065","https://openalex.org/W1484020898","https://openalex.org/W1496587817","https://openalex.org/W1505814592","https://openalex.org/W1544611835","https://openalex.org/W1595957120","https://openalex.org/W1684164190","https://openalex.org/W1735268000","https://openalex.org/W1790297113","https://openalex.org/W1822869875","https://openalex.org/W1844622693","https://openalex.org/W1851544119","https://openalex.org/W1859576612","https://openalex.org/W1861759122","https://openalex.org/W1872331731","https://openalex.org/W1894488062","https://openalex.org/W1899346463","https://openalex.org/W1899746275","https://openalex.org/W1916004087","https://openalex.org/W1929032511","https://openalex.org/W1963954523","https://openalex.org/W1963995164","https://openalex.org/W1964081206","https://openalex.org/W1965331098","https://openalex.org/W1965654886","https://openalex.org/W1965810575","https://openalex.org/W1966796326","https://openalex.org/W1967194906","https://openalex.org/W1969530780","https://openalex.org/W1971026321","https://openalex.org/W1972565370","https://openalex.org/W1973541913","https://openalex.org/W1975071040","https://openalex.org/W1976980661","https://openalex.org/W1977242675","https://openalex.org/W1977444445","https://openalex.org/W1978981032","https://openalex.org/W1979561126","https://openalex.org/W1980784952","https://openalex.org/W1980807219","https://openalex.org/W1981253971","https://openalex.org/W1982861439","https://openalex.org/W1983567075","https://openalex.org/W1986912321","https://openalex.org/W1987761993","https://openalex.org/W1989160344","https://openalex.org/W1991241647","https://openalex.org/W1991880013","https://openalex.org/W1992082275","https://openalex.org/W1992301683","https://openalex.org/W1997404096","https://openalex.org/W1998664010","https://openalex.org/W2000463365","https://openalex.org/W2001412601","https://openalex.org/W2002486813","https://openalex.org/W2003336769","https://openalex.org/W2004023427","https://openalex.org/W2004262765","https://openalex.org/W2004894691","https://openalex.org/W2004941068","https://openalex.org/W2005480612","https://openalex.org/W2006460892","https://openalex.org/W2006833515","https://openalex.org/W2007138098","https://openalex.org/W2009500274","https://openalex.org/W2011424390","https://openalex.org/W2011572975","https://openalex.org/W2011650177","https://openalex.org/W2011810742","https://openalex.org/W2013933294","https://openalex.org/W2014925826","https://openalex.org/W2015207840","https://openalex.org/W2015532594","https://openalex.org/W2016626122","https://openalex.org/W2018008610","https://openalex.org/W2021983664","https://openalex.org/W2022366125","https://openalex.org/W2022433397","https://openalex.org/W2022451432","https://openalex.org/W2022694136","https://openalex.org/W2022896276","https://openalex.org/W2023567389","https://openalex.org/W2024076573","https://openalex.org/W2024486369","https://openalex.org/W2024903578","https://openalex.org/W2026380190","https://openalex.org/W2026888844","https://openalex.org/W2028203050","https://openalex.org/W2029443168","https://openalex.org/W2029839190","https://openalex.org/W2029968342","https://openalex.org/W2030505215","https://openalex.org/W2031248825","https://openalex.org/W2031613073","https://openalex.org/W2032074604","https://openalex.org/W2033279684","https://openalex.org/W2035266548","https://openalex.org/W2035508274","https://openalex.org/W2037082338","https://openalex.org/W2039277373","https://openalex.org/W2039412091","https://openalex.org/W2040176379","https://openalex.org/W2040509262","https://openalex.org/W2040876612","https://openalex.org/W2042030878","https://openalex.org/W2044858560","https://openalex.org/W2044864652","https://openalex.org/W2044905529","https://openalex.org/W2045133943","https://openalex.org/W2045181115","https://openalex.org/W2045296432","https://openalex.org/W2045355003","https://openalex.org/W2046624043","https://openalex.org/W2046889690","https://openalex.org/W2047057500","https://openalex.org/W2047116883","https://openalex.org/W2049165261","https://openalex.org/W2050182398","https://openalex.org/W2050281334","https://openalex.org/W2051976149","https://openalex.org/W2053890812","https://openalex.org/W2055192249","https://openalex.org/W2055534473","https://openalex.org/W2056660135","https://openalex.org/W2057617621","https://openalex.org/W2057909622","https://openalex.org/W2059154212","https://openalex.org/W2060111886","https://openalex.org/W2063185497","https://openalex.org/W2064630223","https://openalex.org/W2064669289","https://openalex.org/W2064770926","https://openalex.org/W2065085988","https://openalex.org/W2066705975","https://openalex.org/W2067382049","https://openalex.org/W2068181025","https://openalex.org/W2068902895","https://openalex.org/W2070247734","https://openalex.org/W2070405720","https://openalex.org/W2070407539","https://openalex.org/W2070692392","https://openalex.org/W2074089637","https://openalex.org/W2075394689","https://openalex.org/W2079481037","https://openalex.org/W2079605491","https://openalex.org/W2079729042","https://openalex.org/W2079935694","https://openalex.org/W2080100938","https://openalex.org/W2082493554","https://openalex.org/W2085609942","https://openalex.org/W2086989758","https://openalex.org/W2089421959","https://openalex.org/W2089459615","https://openalex.org/W2089692551","https://openalex.org/W2090395289","https://openalex.org/W2092050966","https://openalex.org/W2092083815","https://openalex.org/W2095320189","https://openalex.org/W2095382041","https://openalex.org/W2096398695","https://openalex.org/W2098532354","https://openalex.org/W2098550464","https://openalex.org/W2099791897","https://openalex.org/W2100893406","https://openalex.org/W2101911974","https://openalex.org/W2102476325","https://openalex.org/W2105310773","https://openalex.org/W2107838011","https://openalex.org/W2110362102","https://openalex.org/W2110806607","https://openalex.org/W2111469031","https://openalex.org/W2113523455","https://openalex.org/W2114090713","https://openalex.org/W2114768355","https://openalex.org/W2116361774","https://openalex.org/W2118605659","https://openalex.org/W2118655588","https://openalex.org/W2118841717","https://openalex.org/W2119092375","https://openalex.org/W2120129511","https://openalex.org/W2122271737","https://openalex.org/W2122931876","https://openalex.org/W2124435317","https://openalex.org/W2126244927","https://openalex.org/W2127096730","https://openalex.org/W2127491141","https://openalex.org/W2127609327","https://openalex.org/W2128777602","https://openalex.org/W2129789838","https://openalex.org/W2131802255","https://openalex.org/W2134361367","https://openalex.org/W2135401734","https://openalex.org/W2135664375","https://openalex.org/W2136374331","https://openalex.org/W2137132470","https://openalex.org/W2137465719","https://openalex.org/W2139593382","https://openalex.org/W2140399705","https://openalex.org/W2141719786","https://openalex.org/W2144670533","https://openalex.org/W2144954025","https://openalex.org/W2145636146","https://openalex.org/W2147268550","https://openalex.org/W2150365399","https://openalex.org/W2154589460","https://openalex.org/W2155862106","https://openalex.org/W2156928849","https://openalex.org/W2158018814","https://openalex.org/W2158305336","https://openalex.org/W2158535498","https://openalex.org/W2158821976","https://openalex.org/W2158873041","https://openalex.org/W2158916045","https://openalex.org/W2159106436","https://openalex.org/W2160222685","https://openalex.org/W2163069245","https://openalex.org/W2164001677","https://openalex.org/W2164494194","https://openalex.org/W2165060728","https://openalex.org/W2165578745","https://openalex.org/W2169654762","https://openalex.org/W2170682201","https://openalex.org/W2171620027","https://openalex.org/W2171937543","https://openalex.org/W2174197315","https://openalex.org/W2179161607","https://openalex.org/W2189641304","https://openalex.org/W2209368665","https://openalex.org/W2217759329","https://openalex.org/W2218000911","https://openalex.org/W2226069319","https://openalex.org/W2240434829","https://openalex.org/W2255357451","https://openalex.org/W2268683612","https://openalex.org/W2272431413","https://openalex.org/W2277737065","https://openalex.org/W2278333513","https://openalex.org/W2285780854","https://openalex.org/W2287802389","https://openalex.org/W2290048652","https://openalex.org/W2295557285","https://openalex.org/W2296920821","https://openalex.org/W2301957251","https://openalex.org/W2303475727","https://openalex.org/W2306179365","https://openalex.org/W2310677154","https://openalex.org/W2314305710","https://openalex.org/W2320271732","https://openalex.org/W2322645003","https://openalex.org/W2327922861","https://openalex.org/W2330978498","https://openalex.org/W2332099868","https://openalex.org/W2333614838","https://openalex.org/W2342252157","https://openalex.org/W2342510238","https://openalex.org/W2347179388","https://openalex.org/W2396016364","https://openalex.org/W2396911170","https://openalex.org/W2400616832","https://openalex.org/W2402465348","https://openalex.org/W2407282814","https://openalex.org/W2408743616","https://openalex.org/W2410006827","https://openalex.org/W2413654992","https://openalex.org/W2416096426","https://openalex.org/W2426003472","https://openalex.org/W2474112260","https://openalex.org/W2608188974","https://openalex.org/W4293162689","https://openalex.org/W4294718043","https://openalex.org/W4405993542"],"related_works":["https://openalex.org/W3096919639","https://openalex.org/W2090395289","https://openalex.org/W7154980754","https://openalex.org/W2979930460","https://openalex.org/W4408914433","https://openalex.org/W2804573719","https://openalex.org/W1973541913","https://openalex.org/W190161368","https://openalex.org/W1966381192","https://openalex.org/W4318459841"],"abstract_inverted_index":{"In":[0],"cancers,":[1],"hypoxia":[2],"inducible":[3],"factor":[4],"1":[5],"(HIF-1)":[6],"is":[7],"an":[8],"over-expressed":[9],"transcription":[10],"factor,":[11],"which":[12],"regulates":[13],"a":[14],"large":[15],"set":[16],"of":[17],"genes":[18],"involved":[19],"in":[20],"tumour":[21],"vascularization,":[22],"metastases,":[23],"and":[24,30],"cancer":[25],"stem":[26],"cells":[27],"(CSCs)":[28],"formation":[29],"self-renewal.":[31]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":3},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":3},{"year":2021,"cited_by_count":5},{"year":2020,"cited_by_count":5},{"year":2019,"cited_by_count":2},{"year":2018,"cited_by_count":3},{"year":2017,"cited_by_count":3}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2016-10-28T00:00:00"}