{"id":"https://openalex.org/W2535540203","doi":null,"title":"MicroRNA-494 inhibits proliferation and metastasis of osteosarcoma through repressing insulin receptor substrate-1.","display_name":"MicroRNA-494 inhibits proliferation and metastasis of osteosarcoma through repressing insulin receptor substrate-1.","publication_year":2016,"publication_date":"2016-01-01","ids":{"openalex":"https://openalex.org/W2535540203","mag":"2535540203","pmid":"https://pubmed.ncbi.nlm.nih.gov/27648134","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/5009396"},"language":"en","primary_location":{"id":"pmh:oai:europepmc.org:3984374","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/5009396","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/5009396","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5100882918","display_name":"Xiaodong Zhi","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210098305","display_name":"First Affiliated Hospital of Liaoning Medical University","ror":"https://ror.org/00yx0s761","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210098305"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xiaodong Zhi","raw_affiliation_strings":["Department of Spine Surgery, The First Affiliate Hospital of Liaoning Medical University Jinzhou 121000, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Spine Surgery, The First Affiliate Hospital of Liaoning Medical University Jinzhou 121000, China","institution_ids":["https://openalex.org/I4210098305"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5054579907","display_name":"Kai Wu","orcid":"https://orcid.org/0000-0002-4437-9468","observed_orcids":["https://orcid.org/0000-0002-4437-9468","https://orcid.org/0000-0003-4467-1597"]},"institutions":[{"id":"https://openalex.org/I4210098305","display_name":"First Affiliated Hospital of Liaoning Medical University","ror":"https://ror.org/00yx0s761","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210098305"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Kai Wu","raw_affiliation_strings":["Department of Spine Surgery, The First Affiliate Hospital of Liaoning Medical University Jinzhou 121000, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Spine Surgery, The First Affiliate Hospital of Liaoning Medical University Jinzhou 121000, China","institution_ids":["https://openalex.org/I4210098305"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5005739616","display_name":"Deshui Yu","orcid":"https://orcid.org/0000-0002-4372-4303","observed_orcids":["https://orcid.org/0000-0002-4372-4303"]},"institutions":[{"id":"https://openalex.org/I4210098305","display_name":"First Affiliated Hospital of Liaoning Medical University","ror":"https://ror.org/00yx0s761","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210098305"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Deshui Yu","raw_affiliation_strings":["Department of Spine Surgery, The First Affiliate Hospital of Liaoning Medical University Jinzhou 121000, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Spine Surgery, The First Affiliate Hospital of Liaoning Medical University Jinzhou 121000, China","institution_ids":["https://openalex.org/I4210098305"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100700123","display_name":"Yansong Wang","orcid":"https://orcid.org/0000-0002-4532-9921","observed_orcids":["https://orcid.org/0000-0002-4532-9921"]},"institutions":[{"id":"https://openalex.org/I4210098305","display_name":"First Affiliated Hospital of Liaoning Medical University","ror":"https://ror.org/00yx0s761","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210098305"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yansong Wang","raw_affiliation_strings":["Department of Trauma, The First Affiliate Hospital of Liaoning Medical University Jinzhou 121000, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Trauma, The First Affiliate Hospital of Liaoning Medical University Jinzhou 121000, China","institution_ids":["https://openalex.org/I4210098305"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101611226","display_name":"Yang Yu","orcid":"https://orcid.org/0000-0002-0549-8755","observed_orcids":["https://orcid.org/0000-0002-0549-8755"]},"institutions":[{"id":"https://openalex.org/I4210098305","display_name":"First Affiliated Hospital of Liaoning Medical University","ror":"https://ror.org/00yx0s761","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210098305"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yang Yu","raw_affiliation_strings":["Department of Spine Surgery, The First Affiliate Hospital of Liaoning Medical University Jinzhou 121000, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Spine Surgery, The First Affiliate Hospital of Liaoning Medical University Jinzhou 121000, China","institution_ids":["https://openalex.org/I4210098305"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Peng Yan","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210098305","display_name":"First Affiliated Hospital of Liaoning Medical University","ror":"https://ror.org/00yx0s761","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210098305"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Peng Yan","raw_affiliation_strings":["Department of Joint, The First Affiliate Hospital of Liaoning Medical University Jinzhou 121000, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Joint, The First Affiliate Hospital of Liaoning Medical University Jinzhou 121000, China","institution_ids":["https://openalex.org/I4210098305"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5100656700","display_name":"Gang Lv","orcid":"https://orcid.org/0000-0001-9888-7516","observed_orcids":["https://orcid.org/0000-0001-9888-7516"]},"institutions":[{"id":"https://openalex.org/I4210098305","display_name":"First Affiliated Hospital of Liaoning Medical University","ror":"https://ror.org/00yx0s761","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210098305"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Gang Lv","raw_affiliation_strings":["Department of Spine Surgery, The First Affiliate Hospital of Liaoning Medical University Jinzhou 121000, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Spine Surgery, The First Affiliate Hospital of Liaoning Medical University Jinzhou 121000, China","institution_ids":["https://openalex.org/I4210098305"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I4210098305"],"apc_list":null,"apc_paid":null,"fwci":1.8821,"has_fulltext":false,"cited_by_count":24,"citation_normalized_percentile":{"value":0.83855816,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":"8","issue":"8","first_page":"3439","last_page":"47"},"is_retracted":true,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10062","display_name":"MicroRNA in disease regulation","score":0.9965999722480774,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10062","display_name":"MicroRNA in disease regulation","score":0.9965999722480774,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10253","display_name":"Sarcoma Diagnosis and Treatment","score":0.002099999925121665,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10515","display_name":"Cancer-related molecular mechanisms research","score":0.000699999975040555,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/microrna-494","display_name":"microRNA-494","score":0.9649999737739563},{"id":"https://openalex.org/keywords/osteosarcoma","display_name":"osteosarcoma","score":0.9980000257492065},{"id":"https://openalex.org/keywords/irs-1","display_name":"IRS-1","score":0.9150000214576721},{"id":"https://openalex.org/keywords/tumor-suppressor-microrna","display_name":"tumor suppressor microRNA","score":0.8579999804496765},{"id":"https://openalex.org/keywords/cell-proliferation","display_name":"cell proliferation","score":0.9679999947547913},{"id":"https://openalex.org/keywords/metastasis","display_name":"metastasis","score":0.7699999809265137},{"id":"https://openalex.org/keywords/cell-migration-and-invasion","display_name":"cell migration and invasion","score":0.9120000004768372},{"id":"https://openalex.org/keywords/akt-signaling","display_name":"Akt signaling","score":0.9710000157356262},{"id":"https://openalex.org/keywords/microrna-target-genes","display_name":"miRNA target genes","score":0.6629999876022339}],"concepts":[{"id":"https://openalex.org/C201624660","wikidata":"https://www.wikidata.org/wiki/Q15334084","display_name":"IRS1","level":5,"score":0.8208473920822144},{"id":"https://openalex.org/C2777760704","wikidata":"https://www.wikidata.org/wiki/Q549534","display_name":"Osteosarcoma","level":2,"score":0.7881699800491333},{"id":"https://openalex.org/C127561419","wikidata":"https://www.wikidata.org/wiki/Q224527","display_name":"Downregulation and upregulation","level":3,"score":0.7042661905288696},{"id":"https://openalex.org/C145059251","wikidata":"https://www.wikidata.org/wiki/Q310899","display_name":"microRNA","level":3,"score":0.6512613296508789},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.6350109577178955},{"id":"https://openalex.org/C62112901","wikidata":"https://www.wikidata.org/wiki/Q189159","display_name":"Cell growth","level":2,"score":0.6187545657157898},{"id":"https://openalex.org/C97037327","wikidata":"https://www.wikidata.org/wiki/Q5334291","display_name":"Ectopic expression","level":3,"score":0.58623206615448},{"id":"https://openalex.org/C2779013556","wikidata":"https://www.wikidata.org/wiki/Q181876","display_name":"Metastasis","level":3,"score":0.47019800543785095},{"id":"https://openalex.org/C137738243","wikidata":"https://www.wikidata.org/wiki/Q189092","display_name":"Cell migration","level":3,"score":0.4609030485153198},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4412422180175781},{"id":"https://openalex.org/C75217442","wikidata":"https://www.wikidata.org/wiki/Q423650","display_name":"Protein kinase B","level":3,"score":0.439893513917923},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.40207889676094055},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3706052899360657},{"id":"https://openalex.org/C81885089","wikidata":"https://www.wikidata.org/wiki/Q189082","display_name":"Cell culture","level":2,"score":0.3545173108577728},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.3273383378982544},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.3249613046646118},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.3205350339412689},{"id":"https://openalex.org/C112446052","wikidata":"https://www.wikidata.org/wiki/Q422579","display_name":"Insulin receptor","level":4,"score":0.3189392685890198},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.2637866139411926},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.24895194172859192},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.2329081892967224},{"id":"https://openalex.org/C2779306644","wikidata":"https://www.wikidata.org/wiki/Q2002370","display_name":"Insulin","level":2,"score":0.2117222547531128},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.10215479135513306},{"id":"https://openalex.org/C2777391703","wikidata":"https://www.wikidata.org/wiki/Q1053470","display_name":"Insulin resistance","level":3,"score":0.08399155735969543},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.05358037352561951},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0}],"mesh":[],"locations_count":4,"locations":[{"id":"pmh:oai:europepmc.org:3984374","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/5009396","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmid:27648134","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/27648134","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"American journal of translational research","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:5009396","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC5009396/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Am J Transl Res","raw_type":"Text"},{"id":"mag:2535540203","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/27648134","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":{"id":"pmh:oai:europepmc.org:3984374","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/5009396","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},"sustainable_development_goals":[{"score":0.9537000060081482,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":33,"referenced_works":["https://openalex.org/W181426613","https://openalex.org/W1522157027","https://openalex.org/W1579128894","https://openalex.org/W1660389086","https://openalex.org/W1660874906","https://openalex.org/W1861073500","https://openalex.org/W1862251752","https://openalex.org/W1918657120","https://openalex.org/W1955477988","https://openalex.org/W1975304818","https://openalex.org/W1988325237","https://openalex.org/W1991723098","https://openalex.org/W1995150074","https://openalex.org/W2002995168","https://openalex.org/W2004622459","https://openalex.org/W2014900267","https://openalex.org/W2014950255","https://openalex.org/W2016693512","https://openalex.org/W2026697437","https://openalex.org/W2034741183","https://openalex.org/W2062177162","https://openalex.org/W2063744345","https://openalex.org/W2063879050","https://openalex.org/W2068368007","https://openalex.org/W2094950042","https://openalex.org/W2208910019","https://openalex.org/W2214877925","https://openalex.org/W2239781562","https://openalex.org/W2305712353","https://openalex.org/W2336781799","https://openalex.org/W2342448277","https://openalex.org/W2597632520","https://openalex.org/W4237011200"],"related_works":["https://openalex.org/W4297938684","https://openalex.org/W2378676718","https://openalex.org/W2913631768","https://openalex.org/W2265311593","https://openalex.org/W2731624285","https://openalex.org/W2763547176","https://openalex.org/W2892296516","https://openalex.org/W2969411032","https://openalex.org/W2939286020","https://openalex.org/W2620656599"],"abstract_inverted_index":{"Despite":[0],"microRNA-494":[1],"(miR-494)":[2],"has":[3,24],"a":[4,119,179],"well-established":[5],"role":[6,38],"in":[7,20,45,55,95,103,124,137,182,186],"many":[8],"types":[9],"of":[10,18,30,42,83,122,145,160,164],"cancer;":[11],"the":[12,37,63,149],"biological":[13],"function":[14],"and":[15,39,58,69,93,109,131,158],"potential":[16],"mechanism":[17,41],"miR-494":[19,43,51,84,123,135,161,165,176],"human":[21,70],"osteosarcoma":[22],"(OS)":[23],"not":[25],"been":[26],"elucidated.":[27],"The":[28],"aim":[29],"this":[31],"study":[32],"was":[33,52,129],"therefore":[34],"to":[35,62],"investigate":[36],"underlying":[40],"expression":[44,128,136],"osteosarcoma.":[46],"Here,":[47],"we":[48],"found":[49],"that":[50,80,175],"significantly":[53,86],"decreased":[54,167],"OS":[56,125,139],"tissues":[57,67,140],"cell":[59,88,153],"lines":[60],"compared":[61],"adjacent":[64],"noncancerous":[65],"bone":[66],"(P<0.01)":[68],"normal":[71],"osteoblast":[72],"cells":[73],"(NHOst)":[74],"(P<0.05),":[75],"respectively.":[76],"Functional":[77],"assays":[78],"demonstrated":[79],"ectopic":[81],"overexpression":[82],"could":[85],"inhibit":[87],"proliferation,":[89,154],"colony":[90,155],"formation,":[91,156],"migration":[92,157],"invasion":[94,159],"vitro,":[96],"as":[97,99,118,178],"well":[98],"suppress":[100],"tumor":[101,180],"growth":[102],"nude":[104],"mice":[105],"model.":[106],"Further":[107],"integrative":[108],"functional":[110],"studies":[111],"suggested":[112,174],"insulin":[113],"receptor":[114],"substrate":[115],"1":[116],"(IRS1)":[117],"target":[120],"gene":[121],"cells.":[126],"IRS1":[127,146],"upregulated,":[130],"inversely":[132],"correlated":[133],"with":[134],"clinical":[138],"(r=-0.589,":[141],"P=0.001).":[142],"Moreover,":[143],"downregulation":[144],"had":[147],"similar":[148],"inhibition":[150],"effect":[151],"on":[152],"overexpression.":[162],"Overexpresion":[163],"obviously":[166],"AKT":[168],"signal":[169],"pathway":[170],"activation.":[171],"These":[172],"findings":[173],"functioned":[177],"suppressor":[181],"OS,":[183],"at":[184],"least":[185],"part,":[187],"by":[188],"targeting":[189],"IRS1.":[190]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2022,"cited_by_count":3},{"year":2021,"cited_by_count":3},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":2},{"year":2018,"cited_by_count":11},{"year":2017,"cited_by_count":2},{"year":2016,"cited_by_count":1}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2016-10-28T00:00:00"}