{"id":"https://openalex.org/W2535451111","doi":"https://doi.org/10.1182/blood.v122.21.398.398","title":"Single-Cell Genetic Analysis Reveals The Genetic Composition Of Founder Clones, Phylogenetic Patterns Of Branching and Parallel Evolution, and Clonal Fluctuations Following Patient Treatment In Multiple Myeloma","display_name":"Single-Cell Genetic Analysis Reveals The Genetic Composition Of Founder Clones, Phylogenetic Patterns Of Branching and Parallel Evolution, and Clonal Fluctuations Following Patient Treatment In Multiple Myeloma","publication_year":2013,"publication_date":"2013-11-15","ids":{"openalex":"https://openalex.org/W2535451111","doi":"https://doi.org/10.1182/blood.v122.21.398.398","mag":"2535451111"},"language":"en","primary_location":{"id":"doi:10.1182/blood.v122.21.398.398","doi":"https://doi.org/10.1182/blood.v122.21.398.398","is_oa":false,"landing_page_url":"https://doi.org/10.1182/blood.v122.21.398.398","pdf_url":null,"source":{"id":"https://openalex.org/S200071133","display_name":"Blood","issn_l":"0006-4971","issn":["0006-4971","1528-0020"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Blood","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5035296945","display_name":"Lorenzo Melchor","orcid":"https://orcid.org/0000-0002-5322-2817","observed_orcids":["https://orcid.org/0000-0002-5322-2817"]},"institutions":[{"id":"https://openalex.org/I142947616","display_name":"Institute of Cancer Research","ror":"https://ror.org/043jzw605","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I142947616"]}],"countries":["GB"],"is_corresponding":true,"raw_author_name":"Lorenzo Melchor","raw_affiliation_strings":["Centre for Myeloma Research, Division of Molecular Pathology, The Institute of Cancer Research, London, United Kingdom,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centre for Myeloma Research, Division of Molecular Pathology, The Institute of Cancer Research, London, United Kingdom,","institution_ids":["https://openalex.org/I142947616"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5030849615","display_name":"Annamaria Brioli","orcid":"https://orcid.org/0000-0002-4072-7592","observed_orcids":["https://orcid.org/0000-0002-4072-7592"]},"institutions":[{"id":"https://openalex.org/I9360294","display_name":"University of Bologna","ror":"https://ror.org/01111rn36","country_code":"IT","type":"education","lineage":["https://openalex.org/I9360294"]}],"countries":["IT"],"is_corresponding":true,"raw_author_name":"Annamaria Brioli","raw_affiliation_strings":["Ser\u00e0gnoli Institute of Hematology, Bologna University School of Medicine, Bologna, Italy,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Ser\u00e0gnoli Institute of Hematology, Bologna University School of Medicine, Bologna, Italy,","institution_ids":["https://openalex.org/I9360294"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5084133067","display_name":"Christopher P. Wardell","orcid":"https://orcid.org/0000-0002-9416-7818","observed_orcids":["https://orcid.org/0000-0002-9416-7818"]},"institutions":[{"id":"https://openalex.org/I142947616","display_name":"Institute of Cancer Research","ror":"https://ror.org/043jzw605","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I142947616"]}],"countries":["GB"],"is_corresponding":true,"raw_author_name":"Christopher P Wardell","raw_affiliation_strings":["Centre for Myeloma Research, Division of Molecular Pathology, The Institute of Cancer Research, London, United Kingdom,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centre for Myeloma Research, Division of Molecular Pathology, The Institute of Cancer Research, London, United Kingdom,","institution_ids":["https://openalex.org/I142947616"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112032670","display_name":"Alexander J. Murison","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I142947616","display_name":"Institute of Cancer Research","ror":"https://ror.org/043jzw605","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I142947616"]}],"countries":["GB"],"is_corresponding":true,"raw_author_name":"Alexander Murison","raw_affiliation_strings":["Centre for Myeloma Research, Division of Molecular Pathology, The Institute of Cancer Research, London, United Kingdom,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centre for Myeloma Research, Division of Molecular Pathology, The Institute of Cancer Research, London, United Kingdom,","institution_ids":["https://openalex.org/I142947616"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5082035471","display_name":"Nicola E. Potter","orcid":"https://orcid.org/0000-0002-8256-9350","observed_orcids":["https://orcid.org/0000-0002-8256-9350"]},"institutions":[{"id":"https://openalex.org/I142947616","display_name":"Institute of Cancer Research","ror":"https://ror.org/043jzw605","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I142947616"]}],"countries":["GB"],"is_corresponding":true,"raw_author_name":"Nicola E Potter","raw_affiliation_strings":["Haemato-Oncology Research Unit, Division of Molecular Pathology, The Institute of Cancer Research, London, United Kingdom,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Haemato-Oncology Research Unit, Division of Molecular Pathology, The Institute of Cancer Research, London, United Kingdom,","institution_ids":["https://openalex.org/I142947616"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5073477610","display_name":"Martin Kaiser","orcid":"https://orcid.org/0000-0002-3677-4804","observed_orcids":["https://orcid.org/0000-0002-3677-4804"]},"institutions":[{"id":"https://openalex.org/I142947616","display_name":"Institute of Cancer Research","ror":"https://ror.org/043jzw605","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I142947616"]}],"countries":["GB"],"is_corresponding":true,"raw_author_name":"Martin F Kaiser","raw_affiliation_strings":["Centre for Myeloma Research, Division of Molecular Pathology, The Institute of Cancer Research, London, United Kingdom,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centre for Myeloma Research, Division of Molecular Pathology, The Institute of Cancer Research, London, United Kingdom,","institution_ids":["https://openalex.org/I142947616"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5071593674","display_name":"Rosemary A Fryer","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I142947616","display_name":"Institute of Cancer Research","ror":"https://ror.org/043jzw605","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I142947616"]}],"countries":["GB"],"is_corresponding":true,"raw_author_name":"Rosemary A Fryer","raw_affiliation_strings":["Centre for Myeloma Research, Division of Molecular Pathology, The Institute of Cancer Research, London, United Kingdom,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centre for Myeloma Research, Division of Molecular Pathology, The Institute of Cancer Research, London, United Kingdom,","institution_ids":["https://openalex.org/I142947616"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108460251","display_name":"David C. Johnson","orcid":"https://orcid.org/0000-0003-0887-3343","observed_orcids":["https://orcid.org/0000-0003-0887-3343"]},"institutions":[{"id":"https://openalex.org/I142947616","display_name":"Institute of Cancer Research","ror":"https://ror.org/043jzw605","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I142947616"]}],"countries":["GB"],"is_corresponding":true,"raw_author_name":"David C Johnson","raw_affiliation_strings":["Centre for Myeloma Research, Division of Molecular Pathology, The Institute of Cancer Research, London, United Kingdom,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centre for Myeloma Research, Division of Molecular Pathology, The Institute of Cancer Research, London, United Kingdom,","institution_ids":["https://openalex.org/I142947616"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110454718","display_name":"Dil B Begum","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I142947616","display_name":"Institute of Cancer Research","ror":"https://ror.org/043jzw605","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I142947616"]}],"countries":["GB"],"is_corresponding":true,"raw_author_name":"Dil Begum","raw_affiliation_strings":["Centre for Myeloma Research, Division of Molecular Pathology, The Institute of Cancer Research, London, United Kingdom,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centre for Myeloma Research, Division of Molecular Pathology, The Institute of Cancer Research, London, United Kingdom,","institution_ids":["https://openalex.org/I142947616"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112369249","display_name":"Sanna Hulkki Wilson","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I142947616","display_name":"Institute of Cancer Research","ror":"https://ror.org/043jzw605","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I142947616"]}],"countries":["GB"],"is_corresponding":true,"raw_author_name":"Sanna Hulkki","raw_affiliation_strings":["Centre for Myeloma Research, Division of Molecular Pathology, The Institute of Cancer Research, London, United Kingdom,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centre for Myeloma Research, Division of Molecular Pathology, The Institute of Cancer Research, London, United Kingdom,","institution_ids":["https://openalex.org/I142947616"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5043193479","display_name":"Gowri Vijayaraghavan","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I142947616","display_name":"Institute of Cancer Research","ror":"https://ror.org/043jzw605","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I142947616"]}],"countries":["GB"],"is_corresponding":true,"raw_author_name":"Gowri Vijayaraghavan","raw_affiliation_strings":["Division of Cancer Therapeutics, The Institute of Cancer Research, London, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Cancer Therapeutics, The Institute of Cancer Research, London, United Kingdom","institution_ids":["https://openalex.org/I142947616"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5054629049","display_name":"Ian Titley","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I142947616","display_name":"Institute of Cancer Research","ror":"https://ror.org/043jzw605","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I142947616"]}],"countries":["GB"],"is_corresponding":true,"raw_author_name":"Ian Titley","raw_affiliation_strings":["Haemato-Oncology Research Unit, Division of Molecular Pathology, The Institute of Cancer Research, London, United Kingdom,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Haemato-Oncology Research Unit, Division of Molecular Pathology, The Institute of Cancer Research, London, United Kingdom,","institution_ids":["https://openalex.org/I142947616"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5071926851","display_name":"Mich\u00e8le Cavo","orcid":"https://orcid.org/0000-0003-4514-3227","observed_orcids":["https://orcid.org/0000-0003-4514-3227"]},"institutions":[{"id":"https://openalex.org/I9360294","display_name":"University of Bologna","ror":"https://ror.org/01111rn36","country_code":"IT","type":"education","lineage":["https://openalex.org/I9360294"]}],"countries":["IT"],"is_corresponding":true,"raw_author_name":"Michele Cavo","raw_affiliation_strings":["Ser\u00e0gnoli Institute of Hematology, Bologna University School of Medicine, Bologna, Italy,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Ser\u00e0gnoli Institute of Hematology, Bologna University School of Medicine, Bologna, Italy,","institution_ids":["https://openalex.org/I9360294"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5034560778","display_name":"Faith E. Davies","orcid":"https://orcid.org/0000-0002-3971-2393","observed_orcids":["https://orcid.org/0000-0002-3971-2393"]},"institutions":[{"id":"https://openalex.org/I142947616","display_name":"Institute of Cancer Research","ror":"https://ror.org/043jzw605","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I142947616"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Faith E Davies","raw_affiliation_strings":["Centre for Myeloma Research, Division of Molecular Pathology, The Institute of Cancer Research, London, United Kingdom,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centre for Myeloma Research, Division of Molecular Pathology, The Institute of Cancer Research, London, United Kingdom,","institution_ids":["https://openalex.org/I142947616"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5042516164","display_name":"Brian A. Walker","orcid":"https://orcid.org/0000-0002-8615-6254","observed_orcids":["https://orcid.org/0000-0002-8615-6254"]},"institutions":[{"id":"https://openalex.org/I142947616","display_name":"Institute of Cancer Research","ror":"https://ror.org/043jzw605","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I142947616"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Brian A Walker","raw_affiliation_strings":["Centre for Myeloma Research, Division of Molecular Pathology, The Institute of Cancer Research, London, United Kingdom,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centre for Myeloma Research, Division of Molecular Pathology, The Institute of Cancer Research, London, United Kingdom,","institution_ids":["https://openalex.org/I142947616"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5100632493","display_name":"Gareth John Morgan","orcid":"https://orcid.org/0000-0002-4271-6360","observed_orcids":["https://orcid.org/0000-0002-4271-6360","https://orcid.org/0000-0002-1275-2010","https://orcid.org/0000-0001-7073-2723"]},"institutions":[{"id":"https://openalex.org/I142947616","display_name":"Institute of Cancer Research","ror":"https://ror.org/043jzw605","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I142947616"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Gareth J Morgan","raw_affiliation_strings":["Centre for Myeloma Research, Division of Molecular Pathology, The Institute of Cancer Research, London, United Kingdom,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centre for Myeloma Research, Division of Molecular Pathology, The Institute of Cancer Research, London, United Kingdom,","institution_ids":["https://openalex.org/I142947616"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5030849615","https://openalex.org/A5035296945","https://openalex.org/A5043193479","https://openalex.org/A5054629049","https://openalex.org/A5071593674","https://openalex.org/A5071926851","https://openalex.org/A5073477610","https://openalex.org/A5082035471","https://openalex.org/A5084133067","https://openalex.org/A5108460251","https://openalex.org/A5110454718","https://openalex.org/A5112032670","https://openalex.org/A5112369249"],"corresponding_institution_ids":["https://openalex.org/I142947616","https://openalex.org/I9360294"],"apc_list":{"value":5500,"currency":"USD","value_usd":5500},"apc_paid":null,"fwci":0.2375,"has_fulltext":false,"cited_by_count":2,"citation_normalized_percentile":{"value":0.66735529,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":94},"biblio":{"volume":"122","issue":"21","first_page":"398","last_page":"398"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10649","display_name":"Multiple Myeloma Research and Treatments","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10649","display_name":"Multiple Myeloma Research and Treatments","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11287","display_name":"Cancer Genomics and Diagnostics","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11157","display_name":"Chronic Lymphocytic Leukemia Research","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/2716","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/multiple-myeloma","display_name":"multiple myeloma","score":1.0},{"id":"https://openalex.org/keywords/intra-tumour-heterogeneity","display_name":"intra-tumour heterogeneity","score":0.9010000228881836},{"id":"https://openalex.org/keywords/subclonal-populations","display_name":"subclonal populations","score":0.6970000267028809},{"id":"https://openalex.org/keywords/clonal-evolution","display_name":"clonal evolution","score":0.6639999747276306},{"id":"https://openalex.org/keywords/kras-mutation","display_name":"KRAS mutation","score":0.7480000257492065},{"id":"https://openalex.org/keywords/nras-mutation","display_name":"NRAS mutation","score":0.8669999837875366},{"id":"https://openalex.org/keywords/braf-mutation","display_name":"BRAF mutation","score":0.9959999918937683},{"id":"https://openalex.org/keywords/copy-number-alterations","display_name":"copy number alterations","score":0.8849999904632568},{"id":"https://openalex.org/keywords/clonal-architecture","display_name":"clonal architecture","score":0.5929999947547913},{"id":"https://openalex.org/keywords/relapse","display_name":"relapse","score":0.6140000224113464},{"id":"https://openalex.org/keywords/engraftment","display_name":"engraftment","score":0.7319999933242798},{"id":"https://openalex.org/keywords/nod-scid-mice","display_name":"NOD/SCID mice","score":0.7590000033378601}],"concepts":[{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.765203595161438},{"id":"https://openalex.org/C21790070","wikidata":"https://www.wikidata.org/wiki/Q18030215","display_name":"Neuroblastoma RAS viral oncogene homolog","level":5,"score":0.7363184094429016},{"id":"https://openalex.org/C113968399","wikidata":"https://www.wikidata.org/wiki/Q7559241","display_name":"Somatic evolution in cancer","level":3,"score":0.7173786163330078},{"id":"https://openalex.org/C2780265364","wikidata":"https://www.wikidata.org/wiki/Q5009957","display_name":"CDKN2A","level":3,"score":0.5893492102622986},{"id":"https://openalex.org/C2781187634","wikidata":"https://www.wikidata.org/wiki/Q20969980","display_name":"KRAS","level":4,"score":0.5885039567947388},{"id":"https://openalex.org/C64618202","wikidata":"https://www.wikidata.org/wiki/Q3733697","display_name":"Genetic heterogeneity","level":4,"score":0.5320077538490295},{"id":"https://openalex.org/C99983632","wikidata":"https://www.wikidata.org/wiki/Q1087765","display_name":"Chromothripsis","level":5,"score":0.49572741985321045},{"id":"https://openalex.org/C2777306565","wikidata":"https://www.wikidata.org/wiki/Q15917291","display_name":"Tumour heterogeneity","level":3,"score":0.4773404896259308},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.468520849943161},{"id":"https://openalex.org/C2776364478","wikidata":"https://www.wikidata.org/wiki/Q467635","display_name":"Multiple myeloma","level":2,"score":0.4642907381057739},{"id":"https://openalex.org/C2776950831","wikidata":"https://www.wikidata.org/wiki/Q15635432","display_name":"Single-cell analysis","level":3,"score":0.450040727853775},{"id":"https://openalex.org/C192800701","wikidata":"https://www.wikidata.org/wiki/Q6784807","display_name":"Massive parallel sequencing","level":4,"score":0.4482463002204895},{"id":"https://openalex.org/C206936463","wikidata":"https://www.wikidata.org/wiki/Q634179","display_name":"Breakpoint","level":4,"score":0.41991138458251953},{"id":"https://openalex.org/C166608930","wikidata":"https://www.wikidata.org/wiki/Q5169175","display_name":"Copy number analysis","level":5,"score":0.4178086519241333},{"id":"https://openalex.org/C120821319","wikidata":"https://www.wikidata.org/wiki/Q1501491","display_name":"Copy-number variation","level":4,"score":0.3687874674797058},{"id":"https://openalex.org/C501734568","wikidata":"https://www.wikidata.org/wiki/Q42918","display_name":"Mutation","level":3,"score":0.3441144824028015},{"id":"https://openalex.org/C138626823","wikidata":"https://www.wikidata.org/wiki/Q916504","display_name":"Chromosomal translocation","level":3,"score":0.31663602590560913},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.2889357805252075},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.282676100730896},{"id":"https://openalex.org/C51679486","wikidata":"https://www.wikidata.org/wiki/Q380546","display_name":"DNA sequencing","level":3,"score":0.20873266458511353},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.18186506628990173},{"id":"https://openalex.org/C141231307","wikidata":"https://www.wikidata.org/wiki/Q7020","display_name":"Genome","level":3,"score":0.13763555884361267},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.13686257600784302},{"id":"https://openalex.org/C127716648","wikidata":"https://www.wikidata.org/wiki/Q104053","display_name":"Phenotype","level":3,"score":0.135016530752182},{"id":"https://openalex.org/C178169997","wikidata":"https://www.wikidata.org/wiki/Q2892636","display_name":"Genome instability","level":4,"score":0.09589883685112},{"id":"https://openalex.org/C143425029","wikidata":"https://www.wikidata.org/wiki/Q5205747","display_name":"DNA damage","level":3,"score":0.0},{"id":"https://openalex.org/C552990157","wikidata":"https://www.wikidata.org/wiki/Q7430","display_name":"DNA","level":2,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1182/blood.v122.21.398.398","doi":"https://doi.org/10.1182/blood.v122.21.398.398","is_oa":false,"landing_page_url":"https://doi.org/10.1182/blood.v122.21.398.398","pdf_url":null,"source":{"id":"https://openalex.org/S200071133","display_name":"Blood","issn_l":"0006-4971","issn":["0006-4971","1528-0020"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Blood","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.8999999761581421,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2004300203","https://openalex.org/W2581357176","https://openalex.org/W2559098034","https://openalex.org/W4243839628","https://openalex.org/W2530506542","https://openalex.org/W2059581635","https://openalex.org/W2596095744","https://openalex.org/W3212614699","https://openalex.org/W2509559102","https://openalex.org/W3097039401"],"abstract_inverted_index":{"Abstract":[0],"Multiple":[1],"Myeloma":[2,574],"(MM)":[3],"is":[4,260,341,602],"a":[5,83,267,272,290,302,342,385,557,560,579],"proliferation":[6],"of":[7,51,65,85,134,153,167,193,201,214,217,227,237,245,262,282,370,403,413,453,536,541,549,565,570,578,592,616,625],"aberrant":[8],"plasma":[9],"cells":[10,27,234],"in":[11,24,28,35,82,114,141,219,280,298,306,313,322,346,359,376,392,424,459,477,495,619],"the":[12,49,62,66,76,135,165,168,177,189,212,215,225,238,243,249,252,295,331,360,367,390,401,411,420,425,471,475,496,505,539,547,571,590,614],"bone":[13,361],"marrow.":[14],"Ig":[15,125],"translocations":[16],"or":[17,271,315,526,534,559],"hyperdiploidy":[18],"are":[19,554,576],"MM":[20,87,203,259,291,347,380,551],"initiating":[21,292],"events":[22,194],"present":[23],"all":[25],"clonal":[26,54,220,325,354,482,543,583,586],"contrast":[29],"to":[30,70,163,181,187,223,352,395,406,427,465,473,523,530,532,589,627],"other":[31,506],"secondary":[32],"lesions":[33],"involved":[34],"progression":[36,612],"(e.g.":[37],"RASmutations),":[38],"which":[39,327],"may":[40],"be":[41,71],"subclonal.":[42],"We":[43,256,337,364,399,545],"and":[44,79,97,138,171,185,247,373,443,511,528,585,613],"others":[45],"have":[46,520],"recently":[47],"described":[48,447],"presence":[50,166],"different":[52,521],"tumour":[53,67,80,283],"populations\u2014a":[55],"phenomenon":[56],"called":[57],"intra-tumour":[58,77,421,600],"heterogeneity\u2014in":[59],"MM,":[60,299],"yet":[61],"phylogenetic":[63],"relationships":[64],"subclones":[68,358,445,456,552,575],"remains":[69],"fully":[72],"elucidated.":[73],"To":[74,450],"describe":[75,301],"heterogeneity":[78,422,601],"phylogenies":[81],"series":[84,200],"t(11;14)":[86,120,136,277],"patients":[88,204],"characterised":[89],"by":[90,389,410,504,538,595],"KRAS/NRAS/BRAF":[91],"mutations,":[92],"we":[93,230,300,469],"combined":[94],"whole-exome":[95],"sequencing":[96],"single-cell":[98,105,178],"genetic":[99],"analysis.":[100],"A":[101],"novel":[102],"approach":[103],"for":[104,132,139,150,195,211,356,568,606],"multiplex-qPCR":[106],"analysis":[107,412],"using":[108,124],"nano-fluidic":[109],"arrays":[110],"(Fluidigm)":[111],"was":[112,122,209,278,501],"followed":[113],"100-250":[115],"single-cells":[116],"per":[117],"sample.":[118],"The":[119,276],"breakpoint":[121],"defined":[123],"regions-targeted":[126],"massively-parallel":[127],"sequencing.":[128],"Taqman":[129],"assays":[130,149],"specific":[131],"detection":[133],"breakpoints":[137],"mutations":[140,170,318,372,391,458],"selected":[142],"genes":[143],"were":[144,155,319,328],"custom-made":[145],"designed.":[146],"Copy":[147],"number":[148,173],"chromosomal":[151],"regions":[152],"interest":[154,626],"also":[156,365,437,480],"used.":[157],"This":[158,382,498],"strategy":[159],"allowed":[160],"us:":[161],"first,":[162],"report":[164,366],"t(11;14),":[169],"copy":[172],"aberrations":[174],"(gains/losses)":[175],"at":[176,207,240,448,488,492],"level;":[179],"second,":[180],"define":[182],"subclonal":[183,228,404,431,518],"populations;":[184],"third,":[186],"delineate":[188],"most":[190],"plausible":[191],"sequence":[192],"each":[196],"case.":[197],"An":[198],"additional":[199],"14":[202],"with":[205,251,484,563],"paired-samples":[206],"presentation/relapse":[208],"included":[210],"study":[213],"effect":[216,387],"treatment":[218,409,510,525,617],"architecture.":[221],"Lastly,":[222],"analyse":[224],"engraftment-ability":[226],"populations,":[229],"injected":[231],"1x106":[232],"CD138+":[233],"from":[235,330,441],"one":[236],"patient-samples":[239],"diagnosis":[241],"into":[242],"tibia":[244],"NOD/SCIDyc(null)-mice":[246],"compared":[248],"engrafted-myeloma":[250],"paired":[253,414],"presentation-relapse":[254,415],"samples.":[255,416],"demonstrate":[257],"that":[258,309,339,430,517,553],"comprised":[261],"2-6":[263],"clones,":[264],"related":[265,555],"through":[266,556],"linear":[268,558],"(3/7":[269],"cases)":[270],"branching":[273,561],"(4/7)":[274],"phylogeny.":[275],"seen":[279],"91-100%":[281],"cells,":[284],"supporting":[285],"its":[286],"aetiological":[287],"role":[288],"as":[289,348],"event.":[293],"For":[294],"first":[296],"time":[297],"parallel":[303,566],"evolutionary":[304],"pattern":[305],"two":[307,323],"samples":[308],"carried":[310],"double":[311],"hits":[312],"KRAS":[314],"KRAS/NRAS.":[316],"These":[317],"acquired":[320,457],"separately":[321],"divergent":[324],"lineages,":[326],"derived":[329],"same":[332],"ancestor":[333],"but":[334,436],"evolved":[335],"independently.":[336],"suggest":[338,516],"RAS":[340,371],"true":[343],"driver":[344],"mutation":[345,375],"such":[349],"alterations":[350],"seem":[351],"provide":[353],"advantages":[355],"myeloma":[357,397,537],"marrow":[362],"environment.":[363],"concomitant":[368],"acquisition":[369],"IRF4p.K123R":[374],"2%":[377],"(9/453)":[378],"screened":[379],"patients.":[381],"finding":[383],"suggests":[384],"collaborative":[386],"provided":[388],"both":[393,610],"pathways":[394],"trigger":[396],"development.":[398],"examine":[400],"ability":[402,472],"populations":[405,432,519],"survive":[407,524],"patient":[408,509],"Not":[417],"only":[418],"did":[419],"shift":[423],"transition":[426],"relapse":[428,533],"meaning":[429],"fluctuated":[433],"during":[434,461,508],"treatment,":[435],"new":[438,455,542],"clones":[439,486,507],"emerged":[440],"early":[442],"late":[444],"formerly":[446],"diagnosis.":[449],"note,":[451],"some":[452],"these":[454,514],"KRAS/BRAF":[460],"transition,":[462],"likely":[463],"leading":[464],"relapse.":[466],"In":[467,598],"parallel,":[468],"tested":[470],"recapitulate":[474],"disease":[476,611],"NOD/SCIDyc(null)-mice.":[478],"Engrafted-myelomas":[479],"had":[481],"fluctuations":[483],"1/3":[485],"shown":[487],"patient-diagnosis":[489],"neither":[490],"found":[491],"relapse,":[493],"nor":[494],"engrafted-MM.":[497],"missing":[499],"clone":[500],"similarly":[502],"outcompeted":[503],"xeno-transplantation.":[512],"Altogether,":[513],"results":[515],"abilities":[522],"xeno-transplantation":[527],"hence,":[529],"lead":[531],"reconstitution":[535],"generation":[540],"subpopulations.":[544],"confirm":[546],"existence":[548],"distinct":[550],"phylogeny,":[562],"examples":[564],"evolution":[567],"alteration":[569],"RAS/MAPK":[572],"pathway.":[573],"subject":[577],"selection":[580,608],"process":[581],"involving":[582],"extinction":[584],"tides,":[587],"similar":[588],"theory":[591],"Natural":[593],"Selection":[594],"Charles":[596],"Darwin.":[597],"conclusion,":[599],"an":[603],"elementary":[604],"foundation":[605],"Darwinian":[607],"underlying":[609],"development":[615],"resistance":[618],"MM.":[620],"Disclosures:":[621],"No":[622],"relevant":[623],"conflicts":[624],"declare.":[628]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2014,"cited_by_count":1}],"updated_date":"2026-10-16T09:59:22.235173","created_date":"2016-10-28T00:00:00"}