{"id":"https://openalex.org/W2535239189","doi":"https://doi.org/10.1371/journal.pone.0164796","title":"The Specific \u03b11-Adrenergic Receptor Antagonist Prazosin Influences the Urine Proteome","display_name":"The Specific \u03b11-Adrenergic Receptor Antagonist Prazosin Influences the Urine Proteome","publication_year":2016,"publication_date":"2016-10-25","ids":{"openalex":"https://openalex.org/W2535239189","doi":"https://doi.org/10.1371/journal.pone.0164796","mag":"2535239189","pmid":"https://pubmed.ncbi.nlm.nih.gov/27780262","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/5079574"},"language":"en","primary_location":{"id":"doi:10.1371/journal.pone.0164796","doi":"https://doi.org/10.1371/journal.pone.0164796","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pone.0164796","pdf_url":"https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0164796&type=printable","source":{"id":"https://openalex.org/S202381698","display_name":"PLoS ONE","issn_l":"1932-6203","issn":["1932-6203"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","erih-plus","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS ONE","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0164796&type=printable","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5055184754","display_name":"Mindi Zhao","orcid":"https://orcid.org/0000-0003-2005-5140","observed_orcids":["https://orcid.org/0000-0003-2005-5140"]},"institutions":[{"id":"https://openalex.org/I200296433","display_name":"Chinese Academy of Medical Sciences & Peking Union Medical College","ror":"https://ror.org/02drdmm93","country_code":"CN","type":"education","lineage":["https://openalex.org/I200296433"]},{"id":"https://openalex.org/I4391767653","display_name":"Institute of Basic Medical Sciences of the Chinese Academy of Medical Sciences","ror":"https://ror.org/055qbch41","country_code":"CN","type":"facility","lineage":["https://openalex.org/I200296433","https://openalex.org/I4391767653"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Mindi Zhao","raw_affiliation_strings":["Department of Pathophysiology, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences, School of Basic Medicine, Peking Union Medical College, Beijing, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathophysiology, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences, School of Basic Medicine, Peking Union Medical College, Beijing, China","institution_ids":["https://openalex.org/I200296433","https://openalex.org/I4391767653"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100677627","display_name":"Jianqiang Wu","orcid":"https://orcid.org/0000-0001-6773-9289","observed_orcids":["https://orcid.org/0000-0001-6773-9289"]},"institutions":[{"id":"https://openalex.org/I200296433","display_name":"Chinese Academy of Medical Sciences & Peking Union Medical College","ror":"https://ror.org/02drdmm93","country_code":"CN","type":"education","lineage":["https://openalex.org/I200296433"]},{"id":"https://openalex.org/I4391767653","display_name":"Institute of Basic Medical Sciences of the Chinese Academy of Medical Sciences","ror":"https://ror.org/055qbch41","country_code":"CN","type":"facility","lineage":["https://openalex.org/I200296433","https://openalex.org/I4391767653"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jianqiang Wu","raw_affiliation_strings":["Department of Pathophysiology, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences, School of Basic Medicine, Peking Union Medical College, Beijing, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathophysiology, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences, School of Basic Medicine, Peking Union Medical College, Beijing, China","institution_ids":["https://openalex.org/I200296433","https://openalex.org/I4391767653"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5109270296","display_name":"Youhe Gao","orcid":"https://orcid.org/0000-0001-7159-2558","observed_orcids":["https://orcid.org/0000-0001-7159-2558"]},"institutions":[{"id":"https://openalex.org/I200296433","display_name":"Chinese Academy of Medical Sciences & Peking Union Medical College","ror":"https://ror.org/02drdmm93","country_code":"CN","type":"education","lineage":["https://openalex.org/I200296433"]},{"id":"https://openalex.org/I25254941","display_name":"Beijing Normal University","ror":"https://ror.org/022k4wk35","country_code":"CN","type":"education","lineage":["https://openalex.org/I25254941"]},{"id":"https://openalex.org/I4391767653","display_name":"Institute of Basic Medical Sciences of the Chinese Academy of Medical Sciences","ror":"https://ror.org/055qbch41","country_code":"CN","type":"facility","lineage":["https://openalex.org/I200296433","https://openalex.org/I4391767653"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Youhe Gao","raw_affiliation_strings":["Department of Biochemistry and Molecular Biology, Beijing Normal University, Gene Engineering and Biotechnology Beijing Key Laboratory, Beijing, China","Department of Pathophysiology, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences, School of Basic Medicine, Peking Union Medical College, Beijing, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry and Molecular Biology, Beijing Normal University, Gene Engineering and Biotechnology Beijing Key Laboratory, Beijing, China","institution_ids":["https://openalex.org/I25254941"]},{"raw_affiliation_string":"Department of Pathophysiology, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences, School of Basic Medicine, Peking Union Medical College, Beijing, China","institution_ids":["https://openalex.org/I200296433","https://openalex.org/I4391767653"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5109270296"],"corresponding_institution_ids":["https://openalex.org/I200296433","https://openalex.org/I25254941","https://openalex.org/I4391767653"],"apc_list":{"value":2382,"currency":"USD","value_usd":2382},"apc_paid":{"value":2382,"currency":"USD","value_usd":2382},"fwci":1.1618,"has_fulltext":true,"cited_by_count":12,"citation_normalized_percentile":{"value":0.74522223,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"11","issue":"10","first_page":"e0164796","last_page":"e0164796"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10519","display_name":"Advanced Proteomics Techniques and Applications","score":0.9570000171661377,"subfield":{"id":"https://openalex.org/subfields/1607","display_name":"Spectroscopy"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T10519","display_name":"Advanced Proteomics Techniques and Applications","score":0.9570000171661377,"subfield":{"id":"https://openalex.org/subfields/1607","display_name":"Spectroscopy"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10836","display_name":"Metabolomics and Mass Spectrometry Studies","score":0.009600000455975533,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10279","display_name":"Urinary Bladder and Prostate Research","score":0.004999999888241291,"subfield":{"id":"https://openalex.org/subfields/2748","display_name":"Urology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/prazosin","display_name":"prazosin","score":0.9779999852180481},{"id":"https://openalex.org/keywords/urinary-proteome","display_name":"urinary proteome","score":0.9559999704360962},{"id":"https://openalex.org/keywords/urinary-biomarkers","display_name":"urinary biomarkers","score":0.996999979019165},{"id":"https://openalex.org/keywords/sympathetic-nervous-system","display_name":"sympathetic nervous system","score":0.9819999933242798},{"id":"https://openalex.org/keywords/angiotensinogen","display_name":"angiotensinogen","score":0.9760000109672546},{"id":"https://openalex.org/keywords/haptoglobin","display_name":"haptoglobin","score":1.0},{"id":"https://openalex.org/keywords/beta2-microglobulin","display_name":"beta2-microglobulin","score":0.949999988079071},{"id":"https://openalex.org/keywords/hypertension","display_name":"hypertension","score":0.7089999914169312},{"id":"https://openalex.org/keywords/posttraumatic-stress-disorder","display_name":"post-traumatic stress disorder","score":0.8460000157356262},{"id":"https://openalex.org/keywords/benign-prostatic-hyperplasia","display_name":"benign prostatic hyperplasia","score":0.9750000238418579},{"id":"https://openalex.org/keywords/rat-model","display_name":"rat model","score":0.6140000224113464}],"concepts":[{"id":"https://openalex.org/C104397665","wikidata":"https://www.wikidata.org/wiki/Q860947","display_name":"Proteome","level":2,"score":0.8317962884902954},{"id":"https://openalex.org/C2780648677","wikidata":"https://www.wikidata.org/wiki/Q425296","display_name":"Prazosin","level":4,"score":0.7516478300094604},{"id":"https://openalex.org/C2780026642","wikidata":"https://www.wikidata.org/wiki/Q40924","display_name":"Urine","level":2,"score":0.6424563527107239},{"id":"https://openalex.org/C2781197716","wikidata":"https://www.wikidata.org/wiki/Q864574","display_name":"Biomarker","level":2,"score":0.46920695900917053},{"id":"https://openalex.org/C124535831","wikidata":"https://www.wikidata.org/wiki/Q4915074","display_name":"Biomarker discovery","level":4,"score":0.43377137184143066},{"id":"https://openalex.org/C77411442","wikidata":"https://www.wikidata.org/wiki/Q181100","display_name":"Urinary system","level":2,"score":0.4247896671295166},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3689976930618286},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.36560288071632385},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.3585026264190674},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.33275219798088074},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.33230066299438477},{"id":"https://openalex.org/C46111723","wikidata":"https://www.wikidata.org/wiki/Q471857","display_name":"Proteomics","level":3,"score":0.32356417179107666},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.2821430563926697},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.27451983094215393},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.2628399729728699},{"id":"https://openalex.org/C2776885963","wikidata":"https://www.wikidata.org/wiki/Q245204","display_name":"Antagonist","level":3,"score":0.2609434127807617},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.13953661918640137},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002853","descriptor_name":"Chromatography, Liquid","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011224","descriptor_name":"Prazosin","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D011224","descriptor_name":"Prazosin","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D011897","descriptor_name":"Random Allocation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013564","descriptor_name":"Sympathetic Nervous System","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D015415","descriptor_name":"Biomarkers","qualifier_ui":"Q000652","qualifier_name":"urine","is_major_topic":true},{"descriptor_ui":"D017207","descriptor_name":"Rats, Sprague-Dawley","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020543","descriptor_name":"Proteome","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D023421","descriptor_name":"Models, Animal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D040901","descriptor_name":"Proteomics","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D053719","descriptor_name":"Tandem Mass Spectrometry","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D058668","descriptor_name":"Adrenergic alpha-1 Receptor Antagonists","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D058668","descriptor_name":"Adrenergic alpha-1 Receptor Antagonists","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false}],"locations_count":5,"locations":[{"id":"doi:10.1371/journal.pone.0164796","doi":"https://doi.org/10.1371/journal.pone.0164796","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pone.0164796","pdf_url":"https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0164796&type=printable","source":{"id":"https://openalex.org/S202381698","display_name":"PLoS ONE","issn_l":"1932-6203","issn":["1932-6203"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","erih-plus","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS ONE","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:4042262","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/5079574","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:5079574","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/5079574","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS One","raw_type":"Text"},{"id":"pmid:27780262","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/27780262","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PloS one","raw_type":"Journal Article"},{"id":"pmh:oai:doaj.org/article:bfc2c469c85a426f8441c93b1346a487","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/bfc2c469c85a426f8441c93b1346a487","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS ONE, Vol 11, Iss 10, p e0164796 (2016)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1371/journal.pone.0164796","doi":"https://doi.org/10.1371/journal.pone.0164796","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pone.0164796","pdf_url":"https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0164796&type=printable","source":{"id":"https://openalex.org/S202381698","display_name":"PLoS ONE","issn_l":"1932-6203","issn":["1932-6203"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","erih-plus","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS ONE","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.9537000060081482,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1954613835","display_name":null,"funder_award_id":"2016 YFC 1306300","funder_id":"https://openalex.org/F4320335777","funder_display_name":"National Key Research and Development Program of China"},{"id":"https://openalex.org/G2827715632","display_name":null,"funder_award_id":"10300-310421102","funder_id":"https://openalex.org/F4320321432","funder_display_name":"Beijing Normal University"},{"id":"https://openalex.org/G3740191150","display_name":null,"funder_award_id":"11100704, 10300-310421102","funder_id":"https://openalex.org/F4320321432","funder_display_name":"Beijing Normal University"},{"id":"https://openalex.org/G418079849","display_name":null,"funder_award_id":"11100704","funder_id":"https://openalex.org/F4320321432","funder_display_name":"Beijing Normal University"},{"id":"https://openalex.org/G7640239696","display_name":null,"funder_award_id":"2013CB530805","funder_id":"https://openalex.org/F4320335777","funder_display_name":"National Key Research and Development Program of China"},{"id":"https://openalex.org/G932521738","display_name":null,"funder_award_id":"11100704","funder_id":"https://openalex.org/F4320335777","funder_display_name":"National Key Research and Development Program of China"}],"funders":[{"id":"https://openalex.org/F4320321432","display_name":"Beijing Normal University","ror":"https://ror.org/022k4wk35"},{"id":"https://openalex.org/F4320335777","display_name":"National Key Research and Development Program of China","ror":null}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2535239189.pdf","grobid_xml":"https://content.openalex.org/works/W2535239189.grobid-xml"},"referenced_works_count":37,"referenced_works":["https://openalex.org/W1845673212","https://openalex.org/W1939063201","https://openalex.org/W1996614257","https://openalex.org/W2006613730","https://openalex.org/W2015556811","https://openalex.org/W2017233149","https://openalex.org/W2024214521","https://openalex.org/W2030398903","https://openalex.org/W2037199116","https://openalex.org/W2039532230","https://openalex.org/W2045153875","https://openalex.org/W2051558560","https://openalex.org/W2062975285","https://openalex.org/W2063229995","https://openalex.org/W2069880108","https://openalex.org/W2085049910","https://openalex.org/W2086157441","https://openalex.org/W2089337540","https://openalex.org/W2096326357","https://openalex.org/W2109639594","https://openalex.org/W2111404966","https://openalex.org/W2112153024","https://openalex.org/W2117518755","https://openalex.org/W2134584677","https://openalex.org/W2136581383","https://openalex.org/W2141148134","https://openalex.org/W2145006924","https://openalex.org/W2153492611","https://openalex.org/W2168270559","https://openalex.org/W2177772195","https://openalex.org/W2201609364","https://openalex.org/W2249469622","https://openalex.org/W2306460108","https://openalex.org/W2408857555","https://openalex.org/W2418811485","https://openalex.org/W2481541110","https://openalex.org/W4242872483"],"related_works":["https://openalex.org/W2777556543","https://openalex.org/W2609392537","https://openalex.org/W2618347628","https://openalex.org/W4248189584","https://openalex.org/W4245960612","https://openalex.org/W2406316512","https://openalex.org/W4405735678","https://openalex.org/W2553059678","https://openalex.org/W2196485855","https://openalex.org/W139722078"],"abstract_inverted_index":{"Urine,":[0],"reflecting":[1],"many":[2],"changes":[3,36,159],"in":[4,75,153],"the":[5,21,53,67,72,108,192],"body,":[6],"is":[7,150],"a":[8,76,113],"better":[9],"source":[10],"than":[11],"blood":[12,142,184],"for":[13],"biomarker":[14,198],"discovery.":[15],"However,":[16],"even":[17],"under":[18],"physiological":[19,44,179],"conditions,":[20],"urine":[22,32,38,60,73,117,193],"proteome":[23,33,39,74,194],"often":[24],"varies.":[25],"Understanding":[26],"how":[27],"various":[28],"regulating":[29],"factors":[30],"affect":[31,191],"helps":[34],"link":[35],"to":[37,138],"with":[40,141],"urinary":[41,127],"biomarkers":[42],"of":[43,56,66,92,99,181],"conditions":[45],"as":[46,48,126,168],"well":[47],"corresponding":[49,165],"diseases.":[50],"To":[51],"evaluate":[52],"possible":[54],"impact":[55,115],"\u03b11-adrenergic":[57],"receptor":[58],"on":[59,71,116],"proteome,":[61],"this":[62],"study":[63],"investigated":[64],"effects":[65],"specific":[68],"inhibitor":[69],"prazosin":[70,104],"rat":[77],"model":[78],"by":[79,103],"using":[80],"tandem":[81],"mass":[82,88],"tagging":[83],"and":[84,132,173,186,195],"two-dimensional":[85],"liquid":[86],"chromatography-tandem":[87],"spectrometry.":[89],"A":[90],"total":[91],"775":[93],"proteins":[94,122],"were":[95,101,123,136,144],"identified,":[96],"approximately":[97],"half":[98],"which":[100,135],"influenced":[102],"treatment,":[105],"indicating":[106],"that":[107],"sympathetic":[109],"nervous":[110],"system":[111],"exerts":[112],"significant":[114],"proteome.":[118],"Eight":[119],"significantly":[120,190],"changed":[121],"previously":[124],"annotated":[125],"candidate":[128],"biomarkers.":[129],"Angiotensinogen,":[130],"haptoglobin,":[131],"beta-2":[133],"microglobulin,":[134],"reported":[137],"be":[139,161],"associated":[140],"pressure,":[143],"validated":[145],"via":[146],"Western":[147],"blot.":[148],"Prazosin":[149],"widely":[151],"used":[152],"clinical":[154],"practice;":[155],"thus,":[156],"these":[157],"protein":[158],"should":[160],"considered":[162],"when":[163],"studying":[164],"diseases":[166],"such":[167],"hypertension,":[169],"post-traumatic":[170],"stress":[171],"disorder":[172],"benign":[174],"prostatic":[175],"hyperplasia.":[176],"The":[177],"related":[178],"activities":[180],"\u03b11-receptors,":[182],"controlling":[183],"pressure":[185],"fear":[187],"response":[188],"might":[189],"warrant":[196],"further":[197],"studies.":[199]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":2},{"year":2021,"cited_by_count":1},{"year":2019,"cited_by_count":2},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":4}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-10-28T00:00:00"}
