{"id":"https://openalex.org/W2534480025","doi":"https://doi.org/10.1371/journal.pone.0164851","title":"Multi-Country Evaluation of Safety of Dihydroartemisinin/Piperaquine Post-Licensure in African Public Hospitals with Electrocardiograms","display_name":"Multi-Country Evaluation of Safety of Dihydroartemisinin/Piperaquine Post-Licensure in African Public Hospitals with Electrocardiograms","publication_year":2016,"publication_date":"2016-10-20","ids":{"openalex":"https://openalex.org/W2534480025","doi":"https://doi.org/10.1371/journal.pone.0164851","mag":"2534480025","pmid":"https://pubmed.ncbi.nlm.nih.gov/27764178"},"language":"en","primary_location":{"id":"doi:10.1371/journal.pone.0164851","doi":"https://doi.org/10.1371/journal.pone.0164851","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pone.0164851","pdf_url":"https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0164851&type=printable","source":{"id":"https://openalex.org/S202381698","display_name":"PLoS ONE","issn_l":"1932-6203","issn":["1932-6203"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","doyens","erih-plus","jufo-1","ki-jl-1","medline","norway-1"],"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS ONE","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0164851&type=printable","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5003048627","display_name":"Abdunoor M. Kabanywanyi","orcid":"https://orcid.org/0000-0002-2980-0429","observed_orcids":["https://orcid.org/0000-0002-2980-0429"]},"institutions":[{"id":"https://openalex.org/I114292369","display_name":"Ifakara Health Institute","ror":"https://ror.org/04js17g72","country_code":"TZ","type":"nonprofit","lineage":["https://openalex.org/I114292369","https://openalex.org/I2801810276"]}],"countries":["TZ"],"is_corresponding":true,"raw_author_name":"Abdunoor M. Kabanywanyi","raw_affiliation_strings":["Ifakara Health Institute, Dar es Salaam, Tanzania"],"raw_orcid":"https://orcid.org/0000-0002-2980-0429","affiliations":[{"raw_affiliation_string":"Ifakara Health Institute, Dar es Salaam, Tanzania","institution_ids":["https://openalex.org/I114292369"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5033436437","display_name":"Rita Baiden","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210127045","display_name":"Indepth Network","ror":"https://ror.org/0326f0a78","country_code":"GH","type":"other","lineage":["https://openalex.org/I4210127045"]}],"countries":["GH"],"is_corresponding":false,"raw_author_name":"Rita Baiden","raw_affiliation_strings":["INDEPTH Network, Accra, Ghana"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"INDEPTH Network, Accra, Ghana","institution_ids":["https://openalex.org/I4210127045"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110953088","display_name":"Ali M. Ali","orcid":"https://orcid.org/0000-0003-4292-5944","observed_orcids":["https://orcid.org/0000-0003-4292-5944"]},"institutions":[{"id":"https://openalex.org/I114292369","display_name":"Ifakara Health Institute","ror":"https://ror.org/04js17g72","country_code":"TZ","type":"nonprofit","lineage":["https://openalex.org/I114292369","https://openalex.org/I2801810276"]}],"countries":["TZ"],"is_corresponding":false,"raw_author_name":"Ali M. Ali","raw_affiliation_strings":["Ifakara Health Institute, Dar es Salaam, Tanzania"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Ifakara Health Institute, Dar es Salaam, Tanzania","institution_ids":["https://openalex.org/I114292369"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5010154254","display_name":"Muhidin Kassim Mahende","orcid":"https://orcid.org/0000-0003-4923-9023","observed_orcids":["https://orcid.org/0000-0003-4923-9023"]},"institutions":[{"id":"https://openalex.org/I114292369","display_name":"Ifakara Health Institute","ror":"https://ror.org/04js17g72","country_code":"TZ","type":"nonprofit","lineage":["https://openalex.org/I114292369","https://openalex.org/I2801810276"]}],"countries":["TZ"],"is_corresponding":false,"raw_author_name":"Muhidin K. Mahende","raw_affiliation_strings":["Ifakara Health Institute, Dar es Salaam, Tanzania"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Ifakara Health Institute, Dar es Salaam, Tanzania","institution_ids":["https://openalex.org/I114292369"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5069843611","display_name":"Bernhards Ragama Ogutu","orcid":"https://orcid.org/0000-0002-0992-5654","observed_orcids":["https://orcid.org/0000-0002-0992-5654"]},"institutions":[{"id":"https://openalex.org/I4210127045","display_name":"Indepth Network","ror":"https://ror.org/0326f0a78","country_code":"GH","type":"other","lineage":["https://openalex.org/I4210127045"]}],"countries":["GH"],"is_corresponding":false,"raw_author_name":"Bernhards R. Ogutu","raw_affiliation_strings":["INDEPTH Network, Accra, Ghana"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"INDEPTH Network, Accra, Ghana","institution_ids":["https://openalex.org/I4210127045"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5029353419","display_name":"Abraham Rexford Oduro","orcid":"https://orcid.org/0000-0002-4191-7419","observed_orcids":["https://orcid.org/0000-0002-4191-7419"]},"institutions":[{"id":"https://openalex.org/I4210142844","display_name":"Navrongo Health Research Centre","ror":"https://ror.org/04n6sse75","country_code":"GH","type":"healthcare","lineage":["https://openalex.org/I4210142844"]}],"countries":["GH"],"is_corresponding":false,"raw_author_name":"Abraham Oduro","raw_affiliation_strings":["Navrongo Health Research Centre, Navrongo, Ghana"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Navrongo Health Research Centre, Navrongo, Ghana","institution_ids":["https://openalex.org/I4210142844"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5020426141","display_name":"Halidou Tinto","orcid":"https://orcid.org/0000-0002-0472-3586","observed_orcids":["https://orcid.org/0000-0002-0472-3586","https://orcid.org/0000-0003-4653-7041"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Halidou Tinto","raw_affiliation_strings":["Nanoro Health Research Centre, Nanoro, Burkina Faso"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Nanoro Health Research Centre, Nanoro, Burkina Faso","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5053573268","display_name":"Margaret Gyapong","orcid":"https://orcid.org/0000-0002-4818-3497","observed_orcids":["https://orcid.org/0000-0002-4818-3497"]},"institutions":[{"id":"https://openalex.org/I4210093684","display_name":"Dodowa Health Research Centre","ror":"https://ror.org/00k6vc568","country_code":"GH","type":"healthcare","lineage":["https://openalex.org/I4210093684"]}],"countries":["GH"],"is_corresponding":false,"raw_author_name":"Margaret Gyapong","raw_affiliation_strings":["Dodowa Health Research Centre, Dodowa, Ghana"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Dodowa Health Research Centre, Dodowa, Ghana","institution_ids":["https://openalex.org/I4210093684"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5032284171","display_name":"Ali Si\u00e9","orcid":"https://orcid.org/0000-0002-3959-2520","observed_orcids":["https://orcid.org/0000-0002-3959-2520"]},"institutions":[{"id":"https://openalex.org/I4210162327","display_name":"Centre de Recherche en Sant\u00e9 de Nouna","ror":"https://ror.org/059vhx348","country_code":"BF","type":"government","lineage":["https://openalex.org/I4210162327"]}],"countries":["BF"],"is_corresponding":false,"raw_author_name":"Ali Sie","raw_affiliation_strings":["Nouna Health Research Centre, Nouna, Burkina Faso"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Nouna Health Research Centre, Nouna, Burkina Faso","institution_ids":["https://openalex.org/I4210162327"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5012661526","display_name":"Esperan\u00e7a Sevene","orcid":"https://orcid.org/0000-0001-9025-4052","observed_orcids":["https://orcid.org/0000-0001-9025-4052"]},"institutions":[{"id":"https://openalex.org/I4210118037","display_name":"Manhi\u00e7a Health Research Centre","ror":"https://ror.org/0287jnj14","country_code":"MZ","type":"facility","lineage":["https://openalex.org/I4210118037"]}],"countries":["MZ"],"is_corresponding":false,"raw_author_name":"Esperanca Sevene","raw_affiliation_strings":["Centro de Investiga\u00e7\u00e3oem Sa\u00fade de Manhi\u00e7a(CISM), Manhi\u00e7a, Mozambique"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centro de Investiga\u00e7\u00e3oem Sa\u00fade de Manhi\u00e7a(CISM), Manhi\u00e7a, Mozambique","institution_ids":["https://openalex.org/I4210118037"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5107849200","display_name":"Eus\u00e9bio Macete","orcid":"https://orcid.org/0000-0002-8071-4761","observed_orcids":["https://orcid.org/0000-0002-8071-4761"]},"institutions":[{"id":"https://openalex.org/I4210118037","display_name":"Manhi\u00e7a Health Research Centre","ror":"https://ror.org/0287jnj14","country_code":"MZ","type":"facility","lineage":["https://openalex.org/I4210118037"]}],"countries":["MZ"],"is_corresponding":false,"raw_author_name":"Eusebio Macete","raw_affiliation_strings":["Centro de Investiga\u00e7\u00e3oem Sa\u00fade de Manhi\u00e7a(CISM), Manhi\u00e7a, Mozambique"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centro de Investiga\u00e7\u00e3oem Sa\u00fade de Manhi\u00e7a(CISM), Manhi\u00e7a, Mozambique","institution_ids":["https://openalex.org/I4210118037"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5010966506","display_name":"Seth Owusu\u2010Agyei","orcid":"https://orcid.org/0000-0002-0807-1781","observed_orcids":["https://orcid.org/0000-0002-0807-1781"]},"institutions":[{"id":"https://openalex.org/I4210152712","display_name":"Kintampo Health Research Centre","ror":"https://ror.org/04zzqmk94","country_code":"GH","type":"healthcare","lineage":["https://openalex.org/I4210152712"]}],"countries":["GH"],"is_corresponding":false,"raw_author_name":"Seth Owusu-Agyei","raw_affiliation_strings":["Kintampo Health Research Centre, Kintampo, Ghana"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Kintampo Health Research Centre, Kintampo, Ghana","institution_ids":["https://openalex.org/I4210152712"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113962365","display_name":"Alex A. Adjei","orcid":"https://orcid.org/0000-0002-8039-6556","observed_orcids":["https://orcid.org/0000-0002-8039-6556"]},"institutions":[{"id":"https://openalex.org/I4210093684","display_name":"Dodowa Health Research Centre","ror":"https://ror.org/00k6vc568","country_code":"GH","type":"healthcare","lineage":["https://openalex.org/I4210093684"]}],"countries":["GH"],"is_corresponding":false,"raw_author_name":"Alex Adjei","raw_affiliation_strings":["Dodowa Health Research Centre, Dodowa, Ghana"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Dodowa Health Research Centre, Dodowa, Ghana","institution_ids":["https://openalex.org/I4210093684"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5027526478","display_name":"Guillaume Compaor\u00e9","orcid":"https://orcid.org/0000-0002-4559-1751","observed_orcids":["https://orcid.org/0000-0002-4559-1751"]},"institutions":[{"id":"https://openalex.org/I4210162327","display_name":"Centre de Recherche en Sant\u00e9 de Nouna","ror":"https://ror.org/059vhx348","country_code":"BF","type":"government","lineage":["https://openalex.org/I4210162327"]}],"countries":["BF"],"is_corresponding":false,"raw_author_name":"Guillaume Compaor\u00e9","raw_affiliation_strings":["Nouna Health Research Centre, Nouna, Burkina Faso"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Nouna Health Research Centre, Nouna, Burkina Faso","institution_ids":["https://openalex.org/I4210162327"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5002994916","display_name":"Innocent Val\u00e9a","orcid":"https://orcid.org/0000-0002-3085-0490","observed_orcids":["https://orcid.org/0000-0002-3085-0490"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Innocent Valea","raw_affiliation_strings":["Nanoro Health Research Centre, Nanoro, Burkina Faso"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Nanoro Health Research Centre, Nanoro, Burkina Faso","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102768846","display_name":"Isaac Osei","orcid":"https://orcid.org/0000-0002-9370-9363","observed_orcids":["https://orcid.org/0000-0002-9370-9363","https://orcid.org/0009-0008-0159-4206"]},"institutions":[{"id":"https://openalex.org/I4210142844","display_name":"Navrongo Health Research Centre","ror":"https://ror.org/04n6sse75","country_code":"GH","type":"healthcare","lineage":["https://openalex.org/I4210142844"]}],"countries":["GH"],"is_corresponding":false,"raw_author_name":"Isaac Osei","raw_affiliation_strings":["Navrongo Health Research Centre, Navrongo, Ghana"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Navrongo Health Research Centre, Navrongo, Ghana","institution_ids":["https://openalex.org/I4210142844"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5091019057","display_name":"Abena Konadu Yawson","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210152712","display_name":"Kintampo Health Research Centre","ror":"https://ror.org/04zzqmk94","country_code":"GH","type":"healthcare","lineage":["https://openalex.org/I4210152712"]}],"countries":["GH"],"is_corresponding":false,"raw_author_name":"Abena Yawson","raw_affiliation_strings":["Kintampo Health Research Centre, Kintampo, Ghana"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Kintampo Health Research Centre, Kintampo, Ghana","institution_ids":["https://openalex.org/I4210152712"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5015249566","display_name":"Martin Adjuik","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210127045","display_name":"Indepth Network","ror":"https://ror.org/0326f0a78","country_code":"GH","type":"other","lineage":["https://openalex.org/I4210127045"]}],"countries":["GH"],"is_corresponding":false,"raw_author_name":"Martin Adjuik","raw_affiliation_strings":["INDEPTH Network, Accra, Ghana"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"INDEPTH Network, Accra, Ghana","institution_ids":["https://openalex.org/I4210127045"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5018765615","display_name":"Raymond Akparibo","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210127045","display_name":"Indepth Network","ror":"https://ror.org/0326f0a78","country_code":"GH","type":"other","lineage":["https://openalex.org/I4210127045"]}],"countries":["GH"],"is_corresponding":false,"raw_author_name":"Raymond Akparibo","raw_affiliation_strings":["INDEPTH Network, Accra, Ghana"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"INDEPTH Network, Accra, Ghana","institution_ids":["https://openalex.org/I4210127045"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5074442267","display_name":"Mwaka A. Kakolwa","orcid":"https://orcid.org/0000-0002-0373-390X","observed_orcids":["https://orcid.org/0000-0002-0373-390X"]},"institutions":[{"id":"https://openalex.org/I114292369","display_name":"Ifakara Health Institute","ror":"https://ror.org/04js17g72","country_code":"TZ","type":"nonprofit","lineage":["https://openalex.org/I114292369","https://openalex.org/I2801810276"]}],"countries":["TZ"],"is_corresponding":false,"raw_author_name":"Mwaka A. Kakolwa","raw_affiliation_strings":["Ifakara Health Institute, Dar es Salaam, Tanzania"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Ifakara Health Institute, Dar es Salaam, Tanzania","institution_ids":["https://openalex.org/I114292369"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5080121371","display_name":"Salim Abdulla","orcid":"https://orcid.org/0000-0001-5071-5205","observed_orcids":["https://orcid.org/0000-0001-5071-5205"]},"institutions":[{"id":"https://openalex.org/I114292369","display_name":"Ifakara Health Institute","ror":"https://ror.org/04js17g72","country_code":"TZ","type":"nonprofit","lineage":["https://openalex.org/I114292369","https://openalex.org/I2801810276"]}],"countries":["TZ"],"is_corresponding":false,"raw_author_name":"Salim Abdulla","raw_affiliation_strings":["Ifakara Health Institute, Dar es Salaam, Tanzania"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Ifakara Health Institute, Dar es Salaam, Tanzania","institution_ids":["https://openalex.org/I114292369"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5074012686","display_name":"Fred Newton Binka","orcid":"https://orcid.org/0000-0002-5693-8829","observed_orcids":["https://orcid.org/0000-0002-5693-8829"]},"institutions":[{"id":"https://openalex.org/I254651091","display_name":"University of Health and Allied Sciences","ror":"https://ror.org/054tfvs49","country_code":"GH","type":"education","lineage":["https://openalex.org/I254651091"]}],"countries":["GH"],"is_corresponding":false,"raw_author_name":"Fred Binka","raw_affiliation_strings":["University for Health and Allied Sciences, Ho, Ghana"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University for Health and Allied Sciences, Ho, Ghana","institution_ids":["https://openalex.org/I254651091"]}]}],"institutions":[],"countries_distinct_count":4,"institutions_distinct_count":8,"corresponding_author_ids":["https://openalex.org/A5003048627"],"corresponding_institution_ids":["https://openalex.org/I114292369"],"apc_list":{"value":2382,"currency":"USD","value_usd":2382},"apc_paid":{"value":2382,"currency":"USD","value_usd":2382},"fwci":1.213,"has_fulltext":true,"cited_by_count":21,"citation_normalized_percentile":{"value":0.83619643,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":99},"biblio":{"volume":"11","issue":"10","first_page":"e0164851","last_page":"e0164851"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10091","display_name":"Malaria Research and Control","score":0.926800012588501,"subfield":{"id":"https://openalex.org/subfields/2739","display_name":"Public Health, Environmental and Occupational Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10091","display_name":"Malaria Research and Control","score":0.926800012588501,"subfield":{"id":"https://openalex.org/subfields/2739","display_name":"Public Health, Environmental and Occupational Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10217","display_name":"Cardiac electrophysiology and arrhythmias","score":0.026599999517202377,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11943","display_name":"Pharmacovigilance and Adverse Drug Reactions","score":0.018200000748038292,"subfield":{"id":"https://openalex.org/subfields/3005","display_name":"Toxicology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/dihydroartemisinin-piperaquine","display_name":"dihydroartemisinin-piperaquine","score":0.9980000257492065},{"id":"https://openalex.org/keywords/qtc-prolongation","display_name":"QTc prolongation","score":0.671999990940094},{"id":"https://openalex.org/keywords/drug-induced-cardiotoxicity","display_name":"drug-induced cardiotoxicity","score":0.4180000126361847},{"id":"https://openalex.org/keywords/antimalarial-drug-safety","display_name":"antimalarial drug safety","score":0.8330000042915344},{"id":"https://openalex.org/keywords/uncomplicated-malaria","display_name":"uncomplicated malaria","score":0.8650000095367432},{"id":"https://openalex.org/keywords/pediatric-malaria","display_name":"pediatric malaria","score":0.6970000267028809},{"id":"https://openalex.org/keywords/ecg-monitoring","display_name":"ECG monitoring","score":0.5429999828338623},{"id":"https://openalex.org/keywords/blood-chemistry","display_name":"serum biochemistry","score":0.6859999895095825},{"id":"https://openalex.org/keywords/hematology","display_name":"hematology","score":0.7519999742507935},{"id":"https://openalex.org/keywords/differential-blood-count","display_name":"differential blood count","score":0.7170000076293945},{"id":"https://openalex.org/keywords/ghana","display_name":"Ghana","score":0.46399998664855957},{"id":"https://openalex.org/keywords/burkina-faso","display_name":"Burkina Faso","score":0.9980000257492065},{"id":"https://openalex.org/keywords/tanzania","display_name":"Tanzania","score":0.9990000128746033},{"id":"https://openalex.org/keywords/mozambique","display_name":"Mozambique","score":1.0},{"id":"https://openalex.org/keywords/adverse-drug-reactions","display_name":"adverse drug reactions","score":0.39100000262260437}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8671107292175293},{"id":"https://openalex.org/C2777616469","wikidata":"https://www.wikidata.org/wiki/Q7197338","display_name":"Piperaquine","level":5,"score":0.769119143486023},{"id":"https://openalex.org/C68443243","wikidata":"https://www.wikidata.org/wiki/Q2786686","display_name":"Quartile","level":3,"score":0.49718645215034485},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.4503065049648285},{"id":"https://openalex.org/C118441451","wikidata":"https://www.wikidata.org/wiki/Q12074763","display_name":"QT interval","level":2,"score":0.44582828879356384},{"id":"https://openalex.org/C2781160685","wikidata":"https://www.wikidata.org/wiki/Q5276420","display_name":"Dihydroartemisinin","level":5,"score":0.43053194880485535},{"id":"https://openalex.org/C44249647","wikidata":"https://www.wikidata.org/wiki/Q208498","display_name":"Confidence interval","level":2,"score":0.40556713938713074},{"id":"https://openalex.org/C42219234","wikidata":"https://www.wikidata.org/wiki/Q131130","display_name":"Anesthesia","level":1,"score":0.3481108546257019},{"id":"https://openalex.org/C2778048844","wikidata":"https://www.wikidata.org/wiki/Q12156","display_name":"Malaria","level":2,"score":0.3387693762779236},{"id":"https://openalex.org/C2778371730","wikidata":"https://www.wikidata.org/wiki/Q311383","display_name":"Plasmodium falciparum","level":3,"score":0.09200388193130493},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.08638378977775574},{"id":"https://openalex.org/C2776120307","wikidata":"https://www.wikidata.org/wiki/Q426921","display_name":"Artemisinin","level":4,"score":0.07490545511245728}],"mesh":[{"descriptor_ui":"D000293","descriptor_name":"Adolescent","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000293","descriptor_name":"Adolescent","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000293","descriptor_name":"Adolescent","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000962","descriptor_name":"Antimalarials","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D000962","descriptor_name":"Antimalarials","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D000962","descriptor_name":"Antimalarials","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D000962","descriptor_name":"Antimalarials","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D000962","descriptor_name":"Antimalarials","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D000962","descriptor_name":"Antimalarials","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D000962","descriptor_name":"Antimalarials","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D000962","descriptor_name":"Antimalarials","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D000962","descriptor_name":"Antimalarials","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D001772","descriptor_name":"Blood Cell Count","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001772","descriptor_name":"Blood Cell Count","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001772","descriptor_name":"Blood Cell Count","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001774","descriptor_name":"Blood Chemical Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001774","descriptor_name":"Blood Chemical Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001774","descriptor_name":"Blood Chemical Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002050","descriptor_name":"Burkina Faso","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002050","descriptor_name":"Burkina Faso","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002050","descriptor_name":"Burkina Faso","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002648","descriptor_name":"Child","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002648","descriptor_name":"Child","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002648","descriptor_name":"Child","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002675","descriptor_name":"Child, Preschool","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002675","descriptor_name":"Child, Preschool","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002675","descriptor_name":"Child, Preschool","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003627","descriptor_name":"Data Interpretation, Statistical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003627","descriptor_name":"Data Interpretation, Statistical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003627","descriptor_name":"Data Interpretation, Statistical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004562","descriptor_name":"Electrocardiography","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004562","descriptor_name":"Electrocardiography","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004562","descriptor_name":"Electrocardiography","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005869","descriptor_name":"Ghana","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005869","descriptor_name":"Ghana","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005869","descriptor_name":"Ghana","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006321","descriptor_name":"Heart","qualifier_ui":"Q000000981","qualifier_name":"diagnostic imaging","is_major_topic":false},{"descriptor_ui":"D006321","descriptor_name":"Heart","qualifier_ui":"Q000000981","qualifier_name":"diagnostic imaging","is_major_topic":false},{"descriptor_ui":"D006321","descriptor_name":"Heart","qualifier_ui":"Q000000981","qualifier_name":"diagnostic imaging","is_major_topic":false},{"descriptor_ui":"D006321","descriptor_name":"Heart","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D006321","descriptor_name":"Heart","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D006321","descriptor_name":"Heart","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D006779","descriptor_name":"Hospitals, Public","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006779","descriptor_name":"Hospitals, Public","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006779","descriptor_name":"Hospitals, Public","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008288","descriptor_name":"Malaria","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D008288","descriptor_name":"Malaria","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D008288","descriptor_name":"Malaria","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009073","descriptor_name":"Mozambique","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009073","descriptor_name":"Mozambique","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009073","descriptor_name":"Mozambique","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010879","descriptor_name":"Piperazines","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011804","descriptor_name":"Quinolines","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D011804","descriptor_name":"Quinolines","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D011804","descriptor_name":"Quinolines","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D011804","descriptor_name":"Quinolines","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D011804","descriptor_name":"Quinolines","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D011804","descriptor_name":"Quinolines","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D011804","descriptor_name":"Quinolines","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D011804","descriptor_name":"Quinolines","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D011804","descriptor_name":"Quinolines","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D013636","descriptor_name":"Tanzania","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013636","descriptor_name":"Tanzania","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013636","descriptor_name":"Tanzania","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018754","descriptor_name":"Ventricular Dysfunction","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":false},{"descriptor_ui":"D018754","descriptor_name":"Ventricular Dysfunction","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":false},{"descriptor_ui":"D018754","descriptor_name":"Ventricular Dysfunction","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":false},{"descriptor_ui":"D037621","descriptor_name":"Artemisinins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D037621","descriptor_name":"Artemisinins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D037621","descriptor_name":"Artemisinins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D037621","descriptor_name":"Artemisinins","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D037621","descriptor_name":"Artemisinins","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D037621","descriptor_name":"Artemisinins","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D037621","descriptor_name":"Artemisinins","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D037621","descriptor_name":"Artemisinins","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D037621","descriptor_name":"Artemisinins","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D044383","descriptor_name":"Black People","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D044383","descriptor_name":"Black People","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D044383","descriptor_name":"Black People","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D055815","descriptor_name":"Young Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D055815","descriptor_name":"Young Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D055815","descriptor_name":"Young Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":7,"locations":[{"id":"doi:10.1371/journal.pone.0164851","doi":"https://doi.org/10.1371/journal.pone.0164851","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pone.0164851","pdf_url":"https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0164851&type=printable","source":{"id":"https://openalex.org/S202381698","display_name":"PLoS ONE","issn_l":"1932-6203","issn":["1932-6203"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","doyens","erih-plus","jufo-1","ki-jl-1","medline","norway-1"],"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS ONE","raw_type":"journal-article"},{"id":"pmid:27764178","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/27764178","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PloS one","raw_type":"Journal Article"},{"id":"pmh:oai:ihi.eprints.org:3999","doi":null,"is_oa":false,"landing_page_url":"http://ihi.eprints.org/3999/1/Abdunoor%20M.%20Kabanywanyi.PDF","pdf_url":"http://ihi.eprints.org/3999/1/Abdunoor%20M.%20Kabanywanyi.PDF","source":{"id":"https://openalex.org/S4406922887","display_name":"IHI Repository","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"","raw_type":"Article"},{"id":"pmh:oai:researchonline.lshtm.ac.uk:4651283","doi":null,"is_oa":false,"landing_page_url":"https://researchonline.lshtm.ac.uk/view/creators/idcvsowu.html>;","pdf_url":null,"source":{"id":"https://openalex.org/S4306402527","display_name":"LSHTM Research Online (London School of Hygiene and Tropical Medicine)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210089966","host_organization_name":"London School of Hygiene & Tropical Medicine","host_organization_lineage":["https://openalex.org/I4210089966"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":null,"raw_type":"Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:5072600","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/5072600","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS One","raw_type":"Text"},{"id":"pmh:oai:doaj.org/article:3d451ccfdd6c48b3a58ac3d40f494746","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/3d451ccfdd6c48b3a58ac3d40f494746","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS ONE, Vol 11, Iss 10, p e0164851 (2016)","raw_type":"article"},{"id":"pmh:oai:figshare.com:article/4050135","doi":null,"is_oa":true,"landing_page_url":"https://figshare.com/articles/dataset/Multi-Country_Evaluation_of_Safety_of_Dihydroartemisinin_Piperaquine_Post-Licensure_in_African_Public_Hospitals_with_Electrocardiograms/4050135","pdf_url":null,"source":{"id":"https://openalex.org/S4377196282","display_name":"Figshare","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210132348","host_organization_name":"Figshare (United Kingdom)","host_organization_lineage":["https://openalex.org/I4210132348"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Dataset"}],"best_oa_location":{"id":"doi:10.1371/journal.pone.0164851","doi":"https://doi.org/10.1371/journal.pone.0164851","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pone.0164851","pdf_url":"https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0164851&type=printable","source":{"id":"https://openalex.org/S202381698","display_name":"PLoS ONE","issn_l":"1932-6203","issn":["1932-6203"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","doyens","erih-plus","jufo-1","ki-jl-1","medline","norway-1"],"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS ONE","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":1.0}],"sustainable_development_goals_aurora":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.8500000238418579}],"study_designs":[],"awards":[{"id":"https://openalex.org/G6960601633","display_name":null,"funder_award_id":"48363.01","funder_id":"https://openalex.org/F4320306137","funder_display_name":"Bill and Melinda Gates Foundation"}],"funders":[{"id":"https://openalex.org/F4320306137","display_name":"Bill and Melinda Gates Foundation","ror":"https://ror.org/0456r8d26"},{"id":"https://openalex.org/F4320323307","display_name":"University of Ghana","ror":"https://ror.org/01r22mr83"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2534480025.pdf","grobid_xml":"https://content.openalex.org/works/W2534480025.grobid-xml"},"referenced_works_count":20,"referenced_works":["https://openalex.org/W160020775","https://openalex.org/W314623014","https://openalex.org/W1964015794","https://openalex.org/W1966015998","https://openalex.org/W1981589246","https://openalex.org/W2000992267","https://openalex.org/W2022957088","https://openalex.org/W2040159048","https://openalex.org/W2063384200","https://openalex.org/W2095934992","https://openalex.org/W2109901137","https://openalex.org/W2112658233","https://openalex.org/W2120605254","https://openalex.org/W2128743785","https://openalex.org/W2139876108","https://openalex.org/W2139891194","https://openalex.org/W2140422694","https://openalex.org/W2157261068","https://openalex.org/W2168375705","https://openalex.org/W2171199763"],"related_works":["https://openalex.org/W2268089110","https://openalex.org/W3026402288","https://openalex.org/W3193685371","https://openalex.org/W1974700114","https://openalex.org/W2358766868","https://openalex.org/W2155629163","https://openalex.org/W2381983647","https://openalex.org/W2150522686","https://openalex.org/W2100582618","https://openalex.org/W2371844130"],"abstract_inverted_index":{"The":[0,91,222,284],"antimalarial":[1],"drug":[2,282,297],"piperaquine":[3],"is":[4,22],"associated":[5,398],"with":[6,119,387,399],"delayed":[7],"ventricular":[8,17],"depolarization,":[9],"causing":[10],"prolonged":[11],"QT":[12],"interval":[13],"(time":[14],"taken":[15],"for":[16,31,54,152],"de-polarisation":[18],"and":[19,68,73,80,88,113,125,142,164,173,184,205,216,239,259,274,304,344,354,371,390],"re-polarisation).":[20],"There":[21,318],"a":[23,44,185,334],"lack":[24],"of":[25,34,58,65,76,94,106,108,116,137,145,187,195,242,255,271,323,336,368],"safety":[26,56],"data":[27],"regarding":[28],"dihydroartemisinin/piperaquine":[29,66],"(DHA/PPQ)":[30],"the":[32,55,63,77,95,104,114,132,155,188,243,269,310],"treatment":[33,244,256],"uncomplicated":[35,388],"malaria,":[36],"which":[37,146,211,328],"has":[38],"limited":[39],"its":[40],"use.":[41],"We":[42,375],"created":[43],"platform":[45],"where":[46],"electrocardiograms":[47],"(ECG)":[48],"were":[49,143,167,190,209,226,276,319,329,341],"performed":[50],"in":[51,98,121,201,350,363,382,385,395],"public":[52],"hospitals":[53],"assessment":[57,97],"DHA/PPQ,":[59],"at":[60],"baseline":[61,290],"before":[62,238,296],"use":[64],"(Eurartesim\u00ae),":[67],"on":[69,110,230,235,248,278,293,306],"day":[70,81,231,236,249,279,294,307],"3":[71,237,280,295,308,343],"(before":[72],"after":[74,131,240,253,281,309],"administration":[75,107,241],"final":[78],"dose)":[79],"7":[82],"post-administration.":[83],"Laboratory":[84],"analyses":[85],"included":[86],"haematology":[87],"clinical":[89,214],"chemistry.":[90],"main":[92],"objective":[93],"ECG":[96],"this":[99],"study":[100],"was":[101,180,291,397],"to":[102],"evaluate":[103],"effect":[105],"DHA/PPQ":[109,133],"QTc":[111,117,403],"intervals":[112,118],"association":[115],"changes":[120],"blood":[122,127,202,207],"biochemistry,":[123,203],"full":[124,204],"differential":[126,206],"count":[128,208],"over":[129],"time":[130],"administration.":[134],"A":[135],"total":[136],"1315":[138],"patients":[139,157,189,362,386],"gave":[140],"consent":[141],"enrolled":[144,156],"1147":[147],"(87%)":[148],"had":[149,356],"complete":[150],"information":[151],"analyses.":[153],"Of":[154],"488":[158],"(42%),":[159],"323":[160],"(28%),":[161],"213":[162],"(19%)":[163],"123":[165],"(11%)":[166],"from":[168,289],"Ghana,":[169],"Burkina":[170,351],"Faso,":[171,352],"Tanzania":[172,355],"Mozambique,":[174],"respectively.":[175,374],"Median":[176],"(lower-upper":[177],"quartile)":[178],"age":[179,196,267],"8":[181],"(5-14)":[182],"years":[183,194],"quarter":[186],"children":[191],"under":[192],"five":[193],"(n":[197,338],"=":[198,302,316,339],"287).":[199],"Changes":[200],"temporal":[210],"remained":[212],"within":[213],"thresholds":[215],"did":[217],"not":[218,330],"require":[219],"any":[220],"intervention.":[221],"mean":[223,285,325,359],"QTcF":[224,273,287,326,360],"values":[225,270],"significantly":[227,357],"higher":[228],"than":[229,361],"1":[232],"when":[233],"measured":[234],"as":[245,247],"well":[246],"7,":[250],"four":[251],"days":[252],"completion":[254],"(12,":[257],"22":[258],"4":[260,370],"higher,":[261],"p":[262],"<":[263],"0.001).":[264],"In":[265],"all":[266],"groups":[268],"QT,":[272],"QTcB":[275],"highest":[277,305],"intake.":[283],"extreme":[286,324],"prolongation":[288,327],"lowest":[292],"intake":[298],"(33":[299],"ms,":[300,314,373],"SD":[301,315],"19)":[303],"last":[311],"dose":[312],"(60":[313],"31).":[317],"79":[320],"(7%)":[321],"events":[322],"clinically":[331,401],"significant.":[332],"Nearly":[333],"half":[335],"them":[337],"37)":[340],"grade":[342],"mainly":[345],"among":[346],"males":[347],"(33/37).":[348],"Patients":[349],"Mozambique":[353],"lower":[358],"Ghana":[364],"by":[365],"an":[366],"average":[367],"3,":[369],"11":[372],"found":[376],"no":[377,391],"evidence":[378],"that":[379],"Eurartesim\u00ae":[380],"administered":[381],"therapeutic":[383],"doses":[384],"malaria":[389],"predisposing":[392],"cardiac":[393],"conditions":[394],"Africa":[396],"adverse":[400],"significant":[402],"prolongation.":[404]},"counts_by_year":[{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":4},{"year":2021,"cited_by_count":9},{"year":2020,"cited_by_count":2},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":2},{"year":2017,"cited_by_count":1}],"updated_date":"2026-09-27T08:07:27.782135","created_date":"2025-10-10T00:00:00"}
