{"id":"https://openalex.org/W2534464495","doi":"https://doi.org/10.1111/bjd.15139","title":"The complex biology and contribution ofStaphylococcus aureusin atopic dermatitis, current and future therapies","display_name":"The complex biology and contribution ofStaphylococcus aureusin atopic dermatitis, current and future therapies","publication_year":2016,"publication_date":"2016-10-25","ids":{"openalex":"https://openalex.org/W2534464495","doi":"https://doi.org/10.1111/bjd.15139","mag":"2534464495","pmid":"https://pubmed.ncbi.nlm.nih.gov/27779765"},"language":"en","primary_location":{"id":"doi:10.1111/bjd.15139","doi":"https://doi.org/10.1111/bjd.15139","is_oa":false,"landing_page_url":"https://doi.org/10.1111/bjd.15139","pdf_url":null,"source":{"id":"https://openalex.org/S45720283","display_name":"British Journal of Dermatology","issn_l":"0007-0963","issn":["0007-0963","1365-2133"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"British Journal of Dermatology","raw_type":"journal-article"},"volume":null,"type":"review","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://dspace.library.uu.nl/handle/1874/455183","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":null,"display_name":"L. Hepburn","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"L. Hepburn","raw_affiliation_strings":["MedImmune; Milstein Building; Granta Park; Cambridge CB21 6GH U.K"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"MedImmune; Milstein Building; Granta Park; Cambridge CB21 6GH U.K","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5090908449","display_name":"DirkJan Hijnen","orcid":"https://orcid.org/0000-0003-3379-3425","observed_orcids":["https://orcid.org/0000-0003-3379-3425"]},"institutions":[{"id":"https://openalex.org/I3018483916","display_name":"University Medical Center Utrecht","ror":"https://ror.org/0575yy874","country_code":"NL","type":"healthcare","lineage":["https://openalex.org/I3018483916"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"D.J. Hijnen","raw_affiliation_strings":["University Medical Center Utrecht; Department of Dermatology; Utrecht the Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University Medical Center Utrecht; Department of Dermatology; Utrecht the Netherlands","institution_ids":["https://openalex.org/I3018483916"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5050859911","display_name":"Bret R. Sellman","orcid":"https://orcid.org/0009-0008-4254-8134","observed_orcids":["https://orcid.org/0009-0008-4254-8134"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"B.R. Sellman","raw_affiliation_strings":["MedImmune; Gaithersburg MD U.S.A"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"MedImmune; Gaithersburg MD U.S.A","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5059779329","display_name":"Tomas Mustelin","orcid":"https://orcid.org/0000-0001-5912-8840","observed_orcids":["https://orcid.org/0000-0001-5912-8840"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"T. Mustelin","raw_affiliation_strings":["MedImmune; Gaithersburg MD U.S.A"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"MedImmune; Gaithersburg MD U.S.A","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5052453109","display_name":"Matthew A. Sleeman","orcid":"https://orcid.org/0000-0003-2945-0315","observed_orcids":["https://orcid.org/0000-0003-2945-0315"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"M.A. Sleeman","raw_affiliation_strings":["MedImmune; Milstein Building; Granta Park; Cambridge CB21 6GH U.K"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"MedImmune; Milstein Building; Granta Park; Cambridge CB21 6GH U.K","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5029309856","display_name":"Richard D. May","orcid":"https://orcid.org/0000-0001-7825-2716","observed_orcids":["https://orcid.org/0000-0001-7825-2716"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"R.D. May","raw_affiliation_strings":["MedImmune; Milstein Building; Granta Park; Cambridge CB21 6GH U.K"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"MedImmune; Milstein Building; Granta Park; Cambridge CB21 6GH U.K","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5007296714","display_name":"Ian Strickland","orcid":"https://orcid.org/0000-0002-5701-1005","observed_orcids":["https://orcid.org/0000-0002-5701-1005"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"I. Strickland","raw_affiliation_strings":["MedImmune; Milstein Building; Granta Park; Cambridge CB21 6GH U.K"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"MedImmune; Milstein Building; Granta Park; Cambridge CB21 6GH U.K","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5007296714"],"corresponding_institution_ids":[],"apc_list":{"value":3731,"currency":"GBP","value_usd":4920},"apc_paid":null,"fwci":1.3871,"has_fulltext":false,"cited_by_count":54,"citation_normalized_percentile":{"value":0.81310419,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":"177","issue":"1","first_page":"63","last_page":"71"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10837","display_name":"Dermatology and Skin Diseases","score":0.9286999702453613,"subfield":{"id":"https://openalex.org/subfields/2708","display_name":"Dermatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10837","display_name":"Dermatology and Skin Diseases","score":0.9286999702453613,"subfield":{"id":"https://openalex.org/subfields/2708","display_name":"Dermatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10195","display_name":"Antimicrobial Resistance in Staphylococcus","score":0.06889999657869339,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12116","display_name":"Dermatological diseases and infestations","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/staphylococcus-aureus","display_name":"Staphylococcus aureus","score":0.9520000219345093},{"id":"https://openalex.org/keywords/atopic-dermatitis","display_name":"atopic dermatitis","score":0.9980000257492065},{"id":"https://openalex.org/keywords/bacterial-colonization","display_name":"bacterial colonization","score":0.5870000123977661},{"id":"https://openalex.org/keywords/skin-barrier-dysfunction","display_name":"skin barrier dysfunction","score":0.6439999938011169},{"id":"https://openalex.org/keywords/exoproteins","display_name":"exoproteins","score":0.8220000267028809},{"id":"https://openalex.org/keywords/antibiotic-resistance","display_name":"antibiotic resistance","score":0.6470000147819519},{"id":"https://openalex.org/keywords/monoclonal-antibodies","display_name":"monoclonal antibodies","score":0.8920000195503235},{"id":"https://openalex.org/keywords/vaccines","display_name":"vaccines","score":0.5899999737739563},{"id":"https://openalex.org/keywords/allergen-sensitization","display_name":"allergen sensitization","score":0.7720000147819519},{"id":"https://openalex.org/keywords/chronic-skin-infection","display_name":"chronic skin infection","score":0.40400001406669617}],"concepts":[{"id":"https://openalex.org/C2779489039","wikidata":"https://www.wikidata.org/wiki/Q188121","display_name":"Staphylococcus aureus","level":3,"score":0.8859812617301941},{"id":"https://openalex.org/C2778329239","wikidata":"https://www.wikidata.org/wiki/Q268667","display_name":"Atopic dermatitis","level":2,"score":0.8513113856315613},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.5905665755271912},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.568452775478363},{"id":"https://openalex.org/C2777014857","wikidata":"https://www.wikidata.org/wiki/Q1383410","display_name":"Exacerbation","level":2,"score":0.5672606229782104},{"id":"https://openalex.org/C501593827","wikidata":"https://www.wikidata.org/wiki/Q12187","display_name":"Antibiotics","level":2,"score":0.5486212968826294},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.434085488319397},{"id":"https://openalex.org/C2777334864","wikidata":"https://www.wikidata.org/wiki/Q34879","display_name":"Staphylococcal infections","level":4,"score":0.43404239416122437},{"id":"https://openalex.org/C2775983603","wikidata":"https://www.wikidata.org/wiki/Q2458539","display_name":"Skin infection","level":4,"score":0.43362659215927124},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.41061341762542725},{"id":"https://openalex.org/C16005928","wikidata":"https://www.wikidata.org/wiki/Q171171","display_name":"Dermatology","level":1,"score":0.35956549644470215},{"id":"https://openalex.org/C89423630","wikidata":"https://www.wikidata.org/wiki/Q7193","display_name":"Microbiology","level":1,"score":0.32179126143455505},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.26653772592544556},{"id":"https://openalex.org/C523546767","wikidata":"https://www.wikidata.org/wiki/Q10876","display_name":"Bacteria","level":2,"score":0.16222313046455383},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.09245559573173523},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000900","descriptor_name":"Anti-Bacterial Agents","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D003876","descriptor_name":"Dermatitis, Atopic","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D003876","descriptor_name":"Dermatitis, Atopic","qualifier_ui":"Q000382","qualifier_name":"microbiology","is_major_topic":false},{"descriptor_ui":"D005544","descriptor_name":"Forecasting","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013207","descriptor_name":"Staphylococcal Skin Infections","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D013211","descriptor_name":"Staphylococcus aureus","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D015603","descriptor_name":"Keratinocytes","qualifier_ui":"Q000382","qualifier_name":"microbiology","is_major_topic":false},{"descriptor_ui":"D015603","descriptor_name":"Keratinocytes","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D016207","descriptor_name":"Cytokines","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1111/bjd.15139","doi":"https://doi.org/10.1111/bjd.15139","is_oa":false,"landing_page_url":"https://doi.org/10.1111/bjd.15139","pdf_url":null,"source":{"id":"https://openalex.org/S45720283","display_name":"British Journal of Dermatology","issn_l":"0007-0963","issn":["0007-0963","1365-2133"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"British Journal of Dermatology","raw_type":"journal-article"},{"id":"pmid:27779765","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/27779765","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The British journal of dermatology","raw_type":"Journal Article"},{"id":"pmh:oai:dspace.library.uu.nl:1874/455183","doi":null,"is_oa":true,"landing_page_url":"https://dspace.library.uu.nl/handle/1874/455183","pdf_url":null,"source":{"id":"https://openalex.org/S4306401649","display_name":"Utrecht University Repository (Utrecht University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I193662353","host_organization_name":"Utrecht University","host_organization_lineage":["https://openalex.org/I193662353"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Article"}],"best_oa_location":{"id":"pmh:oai:dspace.library.uu.nl:1874/455183","doi":null,"is_oa":true,"landing_page_url":"https://dspace.library.uu.nl/handle/1874/455183","pdf_url":null,"source":{"id":"https://openalex.org/S4306401649","display_name":"Utrecht University Repository (Utrecht University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I193662353","host_organization_name":"Utrecht University","host_organization_lineage":["https://openalex.org/I193662353"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9940000176429749,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":95,"referenced_works":["https://openalex.org/W193120383","https://openalex.org/W1454041111","https://openalex.org/W1507420707","https://openalex.org/W1520172273","https://openalex.org/W1813098396","https://openalex.org/W1858234123","https://openalex.org/W1922871350","https://openalex.org/W1947758974","https://openalex.org/W1963581464","https://openalex.org/W1963793707","https://openalex.org/W1966625479","https://openalex.org/W1972724111","https://openalex.org/W1973675012","https://openalex.org/W1979012796","https://openalex.org/W1985776518","https://openalex.org/W1989142603","https://openalex.org/W1991882828","https://openalex.org/W1995105203","https://openalex.org/W2003757881","https://openalex.org/W2004732903","https://openalex.org/W2005032514","https://openalex.org/W2011557906","https://openalex.org/W2013517286","https://openalex.org/W2024392143","https://openalex.org/W2025616695","https://openalex.org/W2029248129","https://openalex.org/W2029948570","https://openalex.org/W2037816205","https://openalex.org/W2042194530","https://openalex.org/W2042433863","https://openalex.org/W2042675697","https://openalex.org/W2042851093","https://openalex.org/W2044226849","https://openalex.org/W2046395583","https://openalex.org/W2047885502","https://openalex.org/W2048032544","https://openalex.org/W2049706385","https://openalex.org/W2049876083","https://openalex.org/W2051918905","https://openalex.org/W2052919523","https://openalex.org/W2053039168","https://openalex.org/W2055411163","https://openalex.org/W2056453328","https://openalex.org/W2057387605","https://openalex.org/W2061742298","https://openalex.org/W2065921144","https://openalex.org/W2066989460","https://openalex.org/W2069963552","https://openalex.org/W2072448884","https://openalex.org/W2079477801","https://openalex.org/W2089755810","https://openalex.org/W2094036101","https://openalex.org/W2096015065","https://openalex.org/W2097039487","https://openalex.org/W2097143106","https://openalex.org/W2097671337","https://openalex.org/W2099791606","https://openalex.org/W2102361871","https://openalex.org/W2103312297","https://openalex.org/W2103799956","https://openalex.org/W2107811099","https://openalex.org/W2107868358","https://openalex.org/W2109056923","https://openalex.org/W2109754026","https://openalex.org/W2122020611","https://openalex.org/W2124145819","https://openalex.org/W2126467473","https://openalex.org/W2129780251","https://openalex.org/W2132657709","https://openalex.org/W2133689462","https://openalex.org/W2137852338","https://openalex.org/W2138415248","https://openalex.org/W2139293168","https://openalex.org/W2141365771","https://openalex.org/W2142327072","https://openalex.org/W2143006279","https://openalex.org/W2144356477","https://openalex.org/W2146802311","https://openalex.org/W2148686923","https://openalex.org/W2151911433","https://openalex.org/W2154284004","https://openalex.org/W2155957426","https://openalex.org/W2157527462","https://openalex.org/W2158614332","https://openalex.org/W2159358925","https://openalex.org/W2159366663","https://openalex.org/W2163107191","https://openalex.org/W2165548861","https://openalex.org/W2167169977","https://openalex.org/W2168579707","https://openalex.org/W2228372403","https://openalex.org/W2243398804","https://openalex.org/W2343165407","https://openalex.org/W4230355606","https://openalex.org/W4232510995"],"related_works":["https://openalex.org/W2061761462","https://openalex.org/W1479480891","https://openalex.org/W2963239111","https://openalex.org/W2155795891","https://openalex.org/W2773553976","https://openalex.org/W2012279519","https://openalex.org/W7220043573","https://openalex.org/W2891039527","https://openalex.org/W2915693817","https://openalex.org/W2801423113"],"abstract_inverted_index":{"Atopic":[0],"dermatitis":[1],"(AD)":[2],"is":[3,18,44,70,127],"a":[4,19],"complex,":[5],"chronic":[6,125],"inflammatory":[7],"skin":[8,60,93,99],"disorder":[9],"affecting":[10],"more":[11],"than":[12],"10%":[13],"of":[14,22,27,42,52,67,115,132,160,165],"U.K.":[15],"children":[16],"and":[17,40,55,88,100,124,145,171],"major":[20],"cause":[21],"occupation-related":[23],"disability.":[24],"A":[25],"subset":[26],"patients,":[28],"particularly":[29],"those":[30],"with":[31,37,47,129],"severe":[32,184],"AD,":[33],"are":[34,107,120,147],"persistently":[35],"colonized":[36],"Staphylococcus":[38,81],"aureus":[39,69,82,141,167,178],"exacerbation":[41],"disease":[43],"commonly":[45],"associated":[46],"this":[48],"bacterium":[49],"by":[50,59,110],"virtue":[51],"increased":[53],"inflammation":[54],"allergic":[56],"sensitization,":[57],"aggravated":[58],"barrier":[61],"defects.":[62],"Understanding":[63],"the":[64,91,98,102,130,157],"complex":[65],"biology":[66,159],"S.":[68,116,140,161,166],"an":[71],"important":[72],"factor":[73],"when":[74],"developing":[75,175],"new":[76,176],"drugs":[77],"to":[78,112,138,155],"combat":[79],"infection.":[80],"generates":[83],"exoproteins":[84],"that":[85,180],"enable":[86],"invasion":[87],"dissemination":[89],"within":[90],"host":[92,103],"but":[94],"can":[95],"also":[96],"damage":[97],"activate":[101],"immune":[104],"system.":[105],"Antibiotics":[106],"often":[108],"used":[109],"dermatologists":[111],"aid":[113],"clearance":[114],"aureus;":[117],"however,":[118],"these":[119],"becoming":[121],"less":[122],"effective":[123],"usage":[126],"discouraged":[128],"emergence":[131],"multiple":[133],"antibiotic-resistant":[134],"strains.":[135],"New":[136],"ways":[137],"target":[139],"using":[142],"monoclonal":[143],"antibodies":[144],"vaccines":[146],"now":[148],"being":[149],"developed.":[150],"This":[151],"review":[152],"will":[153],"attempt":[154],"evaluate":[156],"key":[158],"aureus,":[162],"current":[163],"treatment":[164],"infections":[168],"in":[169,174,183],"AD":[170],"recent":[172],"advances":[173],"anti-S.":[177],"therapies":[179],"have":[181],"potential":[182],"AD.":[185]},"counts_by_year":[{"year":2026,"cited_by_count":3},{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":3},{"year":2023,"cited_by_count":4},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":8},{"year":2020,"cited_by_count":7},{"year":2019,"cited_by_count":8},{"year":2018,"cited_by_count":11},{"year":2017,"cited_by_count":8}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-10-28T00:00:00"}
